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1. Activation of pregnane X receptor disrupts glucocorticoid and mineralocorticoid homeostasis.
Match Strength: 4.601
The pregnane X receptor (PXR) was isolated as a xenobiotic receptor that regulates responses to various xenobiotic agents. In this study, we show that PXR plays an important endobiotic role in adrenal steroid homeostasis. Activation of PXR by genetic (transgene) or pharmacological (ligand, such as rifampicin) markedly increased plasma concentrations of corticosterone and aldosterone, the respective primary glucocorticoid and mineralocorticoid in rodents. The increased levels of corticosterone and aldosterone were associated with activation of adrenal steroidogenic enzymes, including cytochrome ... Read More »
» Published in Mol Endocrinol. 2007 Jan;21(1):138-47. Epub 2006 Sep 14.
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