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Peer Reviewed Scientific Research Reports.
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1. Clonal origin of metastatic testicular teratomas.
Match Strength: 3.836
PURPOSE: Testicular teratomas in adult patients are histologically diverse tumors that frequently coexist with other germ cell tumor (GCT) components. These mixed GCTs often metastasize to retroperitoneal lymph nodes where multiple GCT elements are frequently present in the same metastatic lesion. Neither the genetic relationships among the different components in metastatic lesions nor the relationships between primary and metastatic GCT components have been elucidated. EXPERIMENTAL DESIGN: We examined metastases from 31 patients who underwent primary retroperitoneal lymph node dissection for ... Read More »
» Published in Clin Cancer Res. 2006 Sep 15;12(18):5377-83. Epub 2006 Sep 18.
2. NIH funding in family medicine: an analysis of 2003 awards.
Match Strength: 3.785
PURPOSE: We wanted to analyze National Institutes of Health (NIH) awards to departments of family medicine. METHODS: We obtained the list of NIH awards to departments of family medicine in 2003, and collected additional information from the Internet regarding each principal investigator (PI), including whether he or she worked primarily in a core (central) organizational component within a family medicine department. RESULTS: One hundred forty-nine NIH awards were granted to 45 departments of family medicine, for a total of 60,085,000 dollars. Of 146 awards with a designated PI, approximately ... Read More »
» Published in Ann Fam Med. 2006 Sep-Oct;4(5):437-42.
3. Separate encoding of identity and similarity of complex familiar odors in piriform cortex.
Match Strength: 3.585
Piriform cortical circuits are hypothesized to form perceptions from responses to specific odorant features, but the anterior piriform cortex (aPCX) and posterior piriform cortex (pPCX) differ markedly in their anatomical organization, differences that could lead to distinct roles in odor encoding. Here, we tested whether experience with a complex odorant mixture would modify encoding of the mixture and its components in aPCX and pPCX. Rats were exposed to an odorant mixture and its components in a go/no-go rewarded odor discrimination task. After reaching behavioral performance criterion, ... Read More »
» Published in Proc Natl Acad Sci U S A. 2006 Oct 10;103(41):15206-11. Epub 2006 Sep 27. Comment in: Proc Natl Acad Sci U S A. 2006 Oct 10;103(41):14985-6.
4. Spatial association between speciated fine particles and mortality.
Match Strength: 3.302
Particulate matter (PM) has been linked to a range of serious cardiovascular and respiratory health problems, including premature mortality. The main objective of our research is to quantify uncertainties about the impacts of fine PM exposure on mortality. We develop a multivariate spatial regression model for the estimation of the risk of mortality associated with fine PM and its components across all counties in the conterminous United States. We characterize different sources of uncertainty in the data and model the spatial structure of the mortality data and the speciated fine PM. We ... Read More »
» Published in Biometrics. 2006 Sep;62(3):855-63.
5. Modeling chronic glycemic exposure variables as correlates and predictors of microvascular complications of diabetes.
Match Strength: 3.258
OBJECTIVE: The degree to which chronic glycemic exposure (CGE) (fasting plasma glucose [FPG], HbA1c [A1C], duration of diabetes, age at onset of diabetes, or combinations of these) is associated with or predicts the severity of microvessel complications is unsettled. Specifically, we test whether combinations of components correlate and predict complications better than individual components. RESEARCH DESIGN AND METHODS: Correlations and predictions of CGE and complications were assessed in the Rochester Diabetic Neuropathy Study, a population-based, cross-sectional, and longitudinal ... Read More »
» Published in Diabetes Care. 2006 Oct;29(10):2282-8.
6. Analysis and study of the variation of splitting in the second heartbeat sound of wavelet transform.
Match Strength: 3.136
The second heart sound, S2, consists of two acoustic components, A2 and P2. The former is due to the closure of the aortic valve and the latter is due to the closure of the pulmonary valve. The aortic valve usually closes before the pulmonary valve, introducing a time delay known as the 'split'. A technique based on discrete wavelet transform (DWT) and continuous wavelet transform (CWT) is developed in this paper to measure the split. To quantify splitting, two components in S2 (i.e. A2 and P2) are identified, and the delay between the two components can be estimated. One normal case and three ... Read More »
» Published in J Med Eng Technol. 2006 Sep-Oct;30(5):298-305.
7. Neuroanatomical evidence for distinct cognitive and affective components of self.
Match Strength: 3.121
This study examines whether the cognitive and affective components of self-reflection can be dissociated using functional magnetic resonance imaging. Using a simple paradigm in which subjects judged the personal relevance of personality characteristics that were either favorable (e.g., "honest") or unfavorable (e.g., "lazy", we found that distinct neural circuits in adjacent regions of the prefrontal cortex subserve cognitive and emotional aspects of self-reflection. The medial prefrontal cortex responded only to material that was self-descriptive, and this did not differ as a function of the ... Read More »
» Published in J Cogn Neurosci. 2006 Sep;18(9):1586-94.
8. Survey of current experimental studies of effects of traditional chinese medicine on peripheral nerve regeneration.
Match Strength: 3.090
The repairing and regeneration of peripheral nerves is a very complex biological and cytological process, its mechanism is unclear so far, and thus results in the lack of specific and effectual therapy and medicament. Chinese herbs and their effective components have their own inimitable predominance in promoting peripheral nerve regeneration, such as their multi-factorial, multi-target and multi-functional action, abundant source, inexpensive, etc. In this paper, the experimental studies reported in recent 5 years concerning the effects of Chinese herbs or their active components on ... Read More »
» Published in Chin J Integr Med. 2006 Sep;12(3):229-33.
9. PP1/PP2A phosphatases are required for the second step of Pre-mRNA splicing and target specific snRNP proteins.
Match Strength: 2.965
Pre-mRNA splicing is a complex and dynamic process in which protein phosphorylation and dephosphorylation both play important roles. Although specific phosphatases, such as PP1 and PP2A, have been implicated in splicing, direct evidence for their involvement has been lacking, and their exact function(s) in this process remain unknown. In this study, we show that PP1 and certain PP2A family phosphatases play essential but redundant roles in splicing. Unexpectedly, we found that these phosphatases are required principally for the second step of the splicing reaction. Furthermore, we provide ... Read More »
» Published in Mol Cell. 2006 Sep 15;23(6):819-29.
10. Intestinal absorption of hawthorn flavonoids--in vitro, in situ and in vivo correlations.
Match Strength: 2.891
Our previous studies identified hyperoside (HP), isoquercitrin (IQ) and epicatechin (EC) to be the major active flavonoid components of the hawthorn phenolic extract from hawthorn fruits demonstrating inhibitory effect on in vitro Cu(+2)-mediated low density lipoproteins oxidation. Among these three hawthorn flavonoids, EC was the only one detectable in plasma after the oral administration of hawthorn phenolic extract to rats. The present study aims to investigate the intestinal absorption mechanisms of these three hawthorn flavonoids by in vitro Caco-2 monolayer model, rat in situ intestinal ... Read More »
» Published in Life Sci. 2006 Nov 25;79(26):2455-62. Epub 2006 Aug 18.
11. Determination of the nonlinear dielectric increment in the Cole-Davidson model.
Match Strength: 2.862
The problem of the nonlinear dielectric relaxation of complex liquids is tackled in the context of the Cole-Davidson [J. Chem. Phys. 19, 1484 (1951)] model. By using an appropriate time derivative of noninteger order, an infinite hierarchy of differential-recurrence relations for the moments (expectation values of the Legendre polynomials) is obtained. The solution is established for the stationary regime of an ensemble of polar and symmetric-top molecules acted on by a strong dc bias electric field superimposed on a weak ac electric field. The results for the first three nonlinear harmonic ... Read More »
» Published in J Chem Phys. 2006 Sep 21;125(11):114503.
12. Quantitative analysis and chromatographic fingerprinting for the quality evaluation of Scutellaria baicalensis Georgi using capillary electrophoresis.
Match Strength: 2.766
Quantitative analysis and chromatographic fingerprinting for the quality evaluation of a Chinese herb Scutellaria baicalensis Georgi using capillary electrophoresis (CE) technique was developed. The separation was performed with a 50.0cm (42.0cm to the detector window)x75mum i.d. fused-silica capillary, and the CE fingerprint condition was optimized using the combination of central composite design and multivariate analysis. The optimized buffer system containing 15mM borate, 40mM phosphate, 15mM SDS, 15% (v/v) acetonitrile and 7.5% (v/v) 2-propanol was employed for the method development, and ... Read More »
» Published in J Pharm Biomed Anal. 2007 Jan 17;43(2):540-8. Epub 2006 Sep 20.
13. Reference models for mitral valve tissue engineering based on valve cell phenotype and extracellular matrix analysis.
Match Strength: 2.754
The advance of mitral valve repair techniques through tissue engineering is impeded by the lack of information regarding the cellular and extracellular components of the mitral valve. The present study aims to expand our understanding of the mitral valve structure by analysing the synthesis of extracellular matrix (ECM) proteins and the expression of nitric oxide synthase (NOS). Valvular endothelial cells (VECs) and valvular interstitial cells (VICs) were isolated from porcine mitral valves. Immunochemical staining of ECM components, including type I, II, III, IV and V collagen, laminin, ... Read More »
» Published in Cells Tissues Organs. 2006;183(1):12-23. Epub 2006 May 11.
14. Chronodromotropic coordination in cats.
Match Strength: 2.749
The coordinated nervous influences on HR and atrioventricular conduction velocity (chronodromotropic coordination) were examined in wakeful cats. The wave structure and reflex reactions of RR and atrioventricular (AV) intervals to stress noise stimulation were studied under normal conditions and during the action of blockers of peripheral receptors in ANS. Variations of both intervals had similar wave structure (power spectrum) and similar reactions to noise stimulus. Atropine pronouncedly decreased all components of the spectra in the high, low, and very low frequency ranges. It eliminated ... Read More »
» Published in Bull Exp Biol Med. 2006 Feb;141(2):187-92.
15. Cell signaling pathways to alphaB-crystallin following stresses of the cytoskeleton.
Match Strength: 2.743
Small heat shock proteins (sHSPs) act as chaperone, but also in protecting the different cytoskeletal components. Recent results suggest that alphaB-crystallin, a member of sHSPs family, might regulate actin filament dynamics, stabilize them in a phosphorylation dependent manner, and protect the integrity of intermediate filaments (IF) against extracellular stress. We demonstrate that vinblastin and cytochalasin D, which respectively disorganize microtubules and actin microfilaments, trigger the activation of the p38/MAPKAP2 kinase pathway and lead to the specific alphaB-crystallin ... Read More »
» Published in Exp Cell Res. 2006 Nov 1;312(18):3570-84. Epub 2006 Aug 9.
16. Hepatectomy for colorectal liver metastases with macroscopic intrabiliary tumor growth.
Match Strength: 2.648
OBJECTIVES: We set out to clarify the clinicopathologic characteristics of colorectal liver metastases with macroscopic intrabiliary tumor growth and to determine optimal surgical management. METHODS: Over 15 years, 6 of 103 patients undergoing hepatectomy for colorectal liver metastases had macroscopic intrabiliary tumor growth and were analyzed retrospectively. RESULTS: We performed 11 operations for the 6 patients, consisting of 10 hepatectomies (including 1 hepatopancreatoduodenectomy) and 1 pancreatoduodenectomy. Three patients survived more than 5 years: 1 died of pulmonary emphysema ... Read More »
» Published in World J Surg. 2006 Oct;30(10):1902-8.
17. Functional components in soybean cake and their effects on antioxidant activity.
Match Strength: 2.596
The antioxidant activities of four fractions of isoflavones from soybean cake were evaluated and compared with those of ISO-1 and ISO-2 fractions, five isoflavone standards, and mixtures of two or four isoflavone standards, as well as four commercial antioxidants, using DPPH, TEAC, reducing power, metal ion chelating, conjugated diene, and TBARS assays. Both malonylglucoside and glucoside fractions were isolated using preparative chromatography with Diaion HP-20 as adsorbent, whereas acetylglucoside and aglycone fractions were separated with silica gel as adsorbent. The other two fractions, ... Read More »
» Published in J Agric Food Chem. 2006 Oct 4;54(20):7544-55.
18. sli-3 negatively regulates the LET-23/epidermal growth factor receptor-mediated vulval induction pathway in Caenorhabditis elegans.
Match Strength: 2.590
The LIN-3-LET-23-mediated inductive signaling pathway plays a major role during vulval development in C. elegans. Studies on the components of this pathway have revealed positive as well as negative regulators that function to modulate the strength and specificity of the signal transduction cascade. We have carried out genetic screens to identify new regulators of this pathway by screening for suppressors of lin-3 vulvaless phenotype. The screens recovered three loci including alleles of gap-1 and a new gene represented by sli-3. Our genetic epistasis experiments suggest that sli-3 functions ... Read More »
» Published in Genetics. 2006 Nov;174(3):1315-26. Epub 2006 Sep 15.
19. Advanced computing for systems biology.
Match Strength: 2.553
Systems biology is based on computational modelling and simulation of large networks of interacting components. Models may be intended to capture processes, mechanisms, components and interactions at different levels of fidelity. Input data are often large and geographically disperse, and may require the computation to be moved to the data, not vice versa. In addition, complex system-level problems require collaboration across institutions and disciplines. Grid computing can offer robust, scaleable solutions for distributed data, compute and expertise. We illustrate some of the range of ... Read More »
» Published in Brief Bioinform. 2006 Dec;7(4):390-8. Epub 2006 Sep 25.
20. Positively coded photoaffinity label for altering isoelectric points of proteins.
Match Strength: 2.538
Novel diazirinyl photoaffinity ligand, which contains (3-trifluoromethyl) phenyldiazirine and penta(epsilon-Boc-Lys) as a photoreactive code, allows the introduction of a positive cascade to alter the pI value of labeled components, facilitating the isolation of photolabeled biocomponents with isoelectric focusing techniques. Publication Types: Research Support, Non-U.S. Gov ... Read More »
» Published in Bioorg Med Chem Lett. 2006 Dec 1;16(23):5998-6000. Epub 2006 Sep 18.
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