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Peer Reviewed Scientific Research Reports.
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1. Effect of sildenafil citrate treatment on serum dehydroepiandrosterone sulfate levels in patients with erectile dysfunction.
Match Strength: 6.508
OBJECTIVES: To investigate the effect of sildenafil citrate treatment on serum dehydroepiandrosterone sulfate (DHEAS) levels in patients with erectile dysfunction (ED). METHODS: A total of 124 men with a mean age of 45.9 years were included in the study. Group 1 consisted of 78 patients with ED, as determined by the Sexual Health Inventory of Male (SHIM) scale (score less than 21). Group 2 consisted of 46 healthy men with a SHIM score of 21 or greater. The 78 patients with ED took 100 mg sildenafil citrate at least eight times in 1 month. The SHIM scale was administered and serum DHEAS levels ... Read More »
» Published in Urology. 2006 Sep;68(3):626-30. Epub 2006 Sep 18.
2. Select patients with hypogonadotropic hypogonadism may respond to treatment with clomiphene citrate.
Match Strength: 6.400
OBJECTIVE: To review the management of male hypogonadotropic hypogonadism (HH) and evaluate the efficacy of clomiphene citrate (CC). DESIGN: Retrospective review. SETTING: Two university-based urology clinics. PATIENT(S): Ten patients referred for male infertility evaluation. INTERVENTION(S): Patients were treated with either clomiphene citrate or injectable gonadotropins. MAIN OUTCOME MEASURE(S): Changes in seminal parameters, gonadotropin levels, serum testosterone, and pregnancy. RESULT(S): Ten men who were evaluated for infertility were diagnosed with HH. Four had Kallmann's syndrome, four ... Read More »
» Published in Fertil Steril. 2006 Dec;86(6):1664-8. Epub 2006 Sep 27.
3. A prospective randomized trial comparing anastrozole and clomiphene citrate in an ovulation induction protocol using gonadotropins.
Match Strength: 5.767
OBJECTIVE: To compare the ovarian and endometrial effects of anastrozole and clomiphene when used with gonadotropins in a combination protocol. DESIGN: Prospective randomized trial. SETTING: Academic infertility center. PATIENT(S): Fifty infertile women. INTERVENTIONS(S): Women were randomized to receive either 1 mg anastrozole or 100 mg clomiphene citrate for 5 days (cycle days 3-7) followed by FSH injections (days 7-11) for ovulation induction. A subset participated in a crossover arm of the study. MAIN OUTCOME MEASURE(S): Ovarian follicle number and size, E(2) levels, endometrial thickness, ... Read More »
» Published in Fertil Steril. 2006 Dec;86(6):1676-81. Epub 2006 Sep 27.
4. Kosmotropic salt activation and substrate specificity of poliovirus protease 3C.
Match Strength: 5.686
Picornaviruses produce a large polyprotein, which is cleaved by virally encoded cysteine peptidases, picornain-2A and -3C. Picornain-3C has characteristics of both the serine peptidase chymotrypsin and the cysteine peptidase papain in that the 3D structure resembles chymotrypsin, but its nucleophile is a cysteine SH rather than a serine OH group. We investigated the specificity of poliovirus picornain-3C (PV3C) protease and the influence of kosmotropic salts on catalytic activity, using FRET peptides related to a cleavable segment of the virus polyprotein. The peptidase activity of PV3C was ... Read More »
» Published in Biochemistry. 2006 Oct 3;45(39):12083-9.
5. A prospective study to assess the efficacy and patient tolerance of three bowel preparations for colonoscopy.
Match Strength: 4.899
The adherence to the required clear liquid diet and a high-volume bowel cleansing solution prior to colonoscopy often leads to poor patient compliance and inadequate exams. This study evaluated the efficacy and patient tolerance of three bowel preparation regimens prior to colonoscopy. One hundred fourteen patients were randomized to one of three preparations. Group 1 was assigned a clear liquid diet/magnesium citrate and bisacodyl prep; group 2 was assigned to receive a diet kit/magnesium citrate and bisacodyl prep; and group 3 received a diet kit/polyethylene glycol electrolyte prep. The ... Read More »
» Published in Gastroenterol Nurs. 2006 Jul-Aug;29(4):305-8.
6. Genotoxicity of five food preservatives tested on root tips of Allium cepa L.
Match Strength: 4.786
The effects of the food preservatives sodium benzoate (SB), boric acid (BA), citric acid (CA), potassium citrate (PC) and sodium citrate (SC) have been studied on root tips of Allium cepa L. Roots of A. cepa were treated with a series of concentrations, ranging from 20 to 100 ppm for 5, 10 and 20 h. The results indicate that these food preservatives reduced mitotic division in A. cepa compared with the respective control. Mitotic index values were generally decreased with increasing concentrations and longer treatment times. Additionally, variations in the percentage of mitotic stages were ... Read More »
» Published in Mutat Res. 2007 Jan 10;626(1-2):4-14. Epub 2006 Sep 26.
7. Is the addition of metformin efficacious in the treatment of clomiphene citrate-resistant patients with polycystic ovary syndrome? A structured literature review.
Match Strength: 4.325
OBJECTIVE: The aim of this literature search is to establish if metformin is efficacious when given to clomiphene citrate (CC)-resistant polycystic ovary syndrome (PCOS) patients. DESIGN: Medline database was searched from 1 January 1980 to 1 January 2005. Inclusion criteria were prospective randomized control trials where metformin was randomized either with placebo or CC to induce ovulation in the CC-resistant patient. RESULT(S): Group 1: Four trials were prospective double-blind placebo controlled. When the data of the four trials were pooled, the overall effect of the addition of metformin ... Read More »
» Published in Fertil Steril. 2006 Nov;86(5):1432-7. Epub 2006 Sep 27.
8. Comparison of the efficacy of the aromatase inhibitor letrozole and clomiphene citrate as adjuvants to recombinant follicle-stimulating hormone in controlled ovarian hyperstimulation: a prospective, randomized, blinded clinical trial.
Match Strength: 3.585
OBJECTIVE: To study the efficacy of the aromatase inhibitor letrozole as adjuvant to recombinant FSH (rFSH) in controlled ovarian hyperstimulation (COH). DESIGN: Prospective, randomized, and blinded clinical study. SETTING: Academic tertiary institute. PATIENT(S): Forty-one patients with unexplained infertility undergoing intrauterine insemination (IUI) therapy were randomized to receive either letrozole or clomiphene citrate (CC) as adjuvants to rFSH. INTERVENTION(S): From day 3 to 7 of the cycle 2.5 mg/d letrozole or 100 mg/d CC were administrated. All patients received 75 IU rFSH starting ... Read More »
» Published in Fertil Steril. 2006 Nov;86(5):1428-31. Epub 2006 Sep 14.
9. Lonidamine: basic science and rationale for treatment of prostatic proliferative disorders.
Match Strength: 3.162
Normal and hyperplastic prostatic tissues concentrate citrate within the epithelium; however, a unique biochemical property within prostate epithelial cells renders them dependent on glycolysis, rather than the citric acid cycle, for energy production. Lonidamine, an orally administered small molecule that inhibits glycolysis by the inactivation of hexokinase, may represent a unique and novel approach to the treatment of benign prostatic hyperplasia (BPH). Results of a phase II trial of lonidamine in BPH (described elsewhere in this supplement) are encouraging. Lonidamine is already used in ... Read More »
» Published in Rev Urol. 2005;7 Suppl 7:S21-6.
10. Diversity of 16S rRNA gene, ITS region and aclB gene of the Aquificales.
Match Strength: 3.080
The Aquificales are prevalent members of the microbial communities inhabiting many marine and terrestrial hydrothermal systems. Numerous new strains were obtained from deep-sea and terrestrial hydrothermal systems. In order to resolve the phylogenetic relationships within this group, three different phylogenetic datasets were used, namely the 16S rRNA gene, the intergenic transcribed spacer region between the 16S rRNA and 23S rRNA genes (ITS) and the gene coding for the ATP citrate lyase (aclB), a key enzyme in the reductive TCA cycle. The data were analyzed using neighbor-joining, parsimony ... Read More »
» Published in Extremophiles. 2007 Jan;11(1):57-64. Epub 2006 Sep 20.
11. First structure of a eukaryotic phosphohistidine phosphatase.
Match Strength: 3.009
Phosphatases are a diverse group of enzymes that regulate numerous cellular processes. Much of what is known relates to the tyrosine, threonine, and serine phosphatases, whereas the histidine phosphatases have not been studied as much. The structure of phosphohistidine phosphatase (PHPT1), the first identified eukaryotic-protein histidine phosphatase, has been determined to a resolution of 1.9A using multiple-wavelength anomalous dispersion methods. This enzyme can dephosphorylate a variety of proteins (e.g. ATP-citrate lyase and the beta-subunit of G proteins). A putative active site has been ... Read More »
» Published in J Biol Chem. 2006 Nov 10;281(45):33830-4. Epub 2006 Sep 21.
12. Comparative investigation of N,N'-bis-(dithiocarboxy)piperazine and diethyldithiocarbamate as precipitants for Ni(II) in simulated wastewater.
Match Strength: 2.844
The performances of a coordination polymerization precipitant, N,N'-bis-(dithiocarboxy)piperazine (BDP) were compared with the widely used heavy metal precipitant, diethyldithiocarbamate (DDTC), through the treatment of three kinds of nickel-containing wastewaters, NiSO(4), nickel citrate (NiCA) and Ni(2+)-dye. Results indicated that both BDP and DDTC at their stiochiometric doses could reduce 50.00mgl(-1) free nickel(II) to lower than 1.0mgl(-1) (discharge limit of nickel ions in China) and 10% precipitants doses increase could treat NiCA containing 50.00mgl(-1) Ni(2+) to meet the discharge ... Read More »
» Published in J Hazard Mater. 2006 Aug 22;
13. Impact of pH on the kinetics of acrylamide formation/elimination reactions in model systems.
Match Strength: 2.677
The effect of pH on acrylamide formation and elimination kinetics was studied in an equimolar (0.1 M) asparagine-glucose model system in phosphate or citrate buffer, heated at temperatures between 120 and 200 degrees C. To describe the experimental data, a simplified kinetic model was proposed and kinetic parameters were estimated by combined nonlinear regression and numerical integration on the data obtained under nonisothermal conditions. The model was subsequently validated in a more realistic potato-based matrix with varying pH. By increasing acidity, the reaction rate constants at T(ref) ... Read More »
» Published in J Agric Food Chem. 2006 Oct 4;54(20):7847-55.
14. The possible study of HuaXi-1 solution for all intra-abdominal organ preservation: a study in rats.
Match Strength: 2.453
OBJECTIVE: University of Wisconsin (UW) solution continues to be the most commonly used solution for intra-abdominal organs. However, it is expensive. Therefore, we have formulated HuaXi-1 (HX-1) solution. The aim of this research was to assess the effect of HX-1 solution compared to UW, Collins 2, and hypertonic citrate solutions on intra-abdominal organs. METHODS: The effects of HX-1 solution for all intra-abdominal organ preservation were studied in a noncirculated, isolated, perfused rat liver model, in rat pancreas isografts in diabetic rats, and in a kidney autotransplant model. The ... Read More »
» Published in Transplant Proc. 2006 Sep;38(7):2226-30.
15. Efficacy of sildenafil citrate in treatment of erectile dysfunction: impact of associated premature ejaculation and low desire.
Match Strength: 2.448
OBJECTIVES: To assess the effect of premature ejaculation (PE) and low desire on the efficacy and satisfaction rate of sildenafil in the treatment of erectile dysfunction (ED). METHODS: A total of 586 male patients with ED in association with and without PE or low desire were enrolled in this study. Patients were screened for ED using the International Index for Erectile Function. All patients were also screened for PE and low desire. We compared the responses to the erectile function domain, questions 3 and 4, before and after sildenafil in patients with and without PE or low desire. Overall ... Read More »
» Published in Urology. 2006 Sep;68(3):642-7. Epub 2006 Sep 18.
16. Maximal fat oxidation rates in endurance trained and untrained women.
Match Strength: 2.421
The aim of the present study was to examine the differences in fat oxidation between endurance trained (ET) and untrained (UT) women. Eight ET and nine UT women performed a progressive cycle ergometer test until exhaustion. The rate of fat oxidation was similar at low work rates (
» Published in Eur J Appl Physiol. 2006 Nov;98(5):497-506. Epub 2006 Sep 28.
17. Thioredoxin1 upregulates mitochondrial proteins related to oxidative phosphorylation and TCA cycle in the heart.
Match Strength: 2.308
Thioredoxin1 (Trx1) inhibits hypertrophy and exhibits protective functions in the heart. To elucidate further the cardiac functions of Trx1, we used a DNA microarray analysis, with hearts from transgenic mice with cardiac- specific overexpression of Trx1 (Tg-Trx1, n = 4) and nontransgenic controls (n = 4). Expression of a large number of genes is regulated in Tg-Trx1, with a greater number of genes downregulated, versus upregulated, at high-fold changes. The peroxisome proliferator-activated receptor gamma coactivator-1alpha (PGC-1gamma) gene was among the top 50 significantly upregulated ... Read More »
» Published in Antioxid Redox Signal. 2006 Sep-Oct;8(9-10):1635-50.
18. Clay charge reversal effects on aqueous polymer sorption on lateritic soils.
Match Strength: 2.307
The effects of charge reversal about the measured point of zero charge (pH(0) approximately 5.2) of untreated and treated Sete Lagoas lateritic soil of Brazil on aqueous polymer sorption was investigated. The polymers are anionic sodium carboxymethyl cellulose (CMCA), nonionic polyethylene oxide (PEO), and cationic polyacrylamide (PAM). They were prepared at aqueous concentrations and pH ranges of 0.1-2.0 g l(-1) and 2-9, respectively. Soil treatment involved the removal of iron oxides by treatment with dithionate-bicarbonate-citrate. Batch sorption test results show that the presence of iron ... Read More »
» Published in Chemosphere. 2007 Jan;66(4):638-43. Epub 2006 Sep 18.
19. Efficacy and safety of combined piroxicam, dexamethasone, orphenadrine, and cyanocobalamin treatment in mandibular molar surgery.
Match Strength: 2.289
Third molar extraction is a common procedure frequently accompanied by moderate or severe pain, and involves sufficient numbers of patients to make studies relatively easy to perform. The aim of the present study was to determine the efficacy and safety of the therapeutic combination of 10 mg piroxicam, 1 mg dexamethasone, 35 mg orphenadrine citrate, and 2.5 mg cyanocobalamin (Rheumazin) when compared with 20 mg piroxicam alone (Feldene) in mandibular third molar surgery. Eighty patients scheduled for removal of the third molar were included in this randomized and double-blind study. They ... Read More »
» Published in Braz J Med Biol Res. 2006 Sep;39(9):1241-7.
20. Mammalian Sperm Energy Resources Management and Survival during Conservation in Refrigeration.
Match Strength: 2.250
The present review has as its main aim to present an overview regarding the mechanisms utilized by mammalian sperm to manage its intracellular energy levels. This management will strongly influence the sperm's ability to maintain its overall function during its entire life span. Thus, the precise knowledge of these mechanisms will be of the utmost interest to optimize the systems utilized to conserve mammalian sperm for a medium-to-long time-lapse. Briefly, utilization of hexoses as energy substrates by mammalian sperm is very finely regulated from the very first step of its metabolization. ... Read More »
» Published in Reprod Domest Anim. 2006 Oct;41 Suppl 2:11-20.
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