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Chronic Low-level Inflammation
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1. Use of ultrapure dialysate in reduction of chronic inflammation during hemodialysis
Match Strength: 9.404

Chronic inflammation contributes to the pathogenesis of several complications of hemodialysis therapy. It is thought that backfiltration of bacteria-derived contaminations during dialysis may induce a chronic inflammatory state. High-sensitivity C-reactive protein (hs-CRP) is one of the tools which can take a hold on such a chronic inflammatory condition. We examined the effect of ultrapure dialysate which contributes to chronic inflammation with hs-CRP and tried to reduce endotoxin (ET) levels at the end of the dialysate from 70 EU/l to <1.0 EU/l (ultrapure dialysate). Other dialysis ... Read More »
» Published in Blood Purif. 2004;22 Suppl 2:26-9.

2. Study on carcinogenesis in chronic cholecystitis
Match Strength: 8.195

Not only bile but also chronic cholecystitis may play a role in gallbladder carcinogenesis. Numerous studies have revealed a close correlation between chronic inflammation and neoplasia. The experiments were conducted on paraffin sections, obtained from 377 surgically resected gallbladders with chronic cholecystitis. Immunohistochemical reaction was conducted on deparaffinized sections, using a monoclonal antibody against 8-hydroxydeoxyguanosine (8-OHdG), a biomarker of oxidative DNA damage. An increase was found in the expression of 8-hydroxydeoxyguanosine in chronic cholecystitis. The level ... Read More »
» Published in Rocz Akad Med Bialymst. 2004;49 Suppl 1:49-51.

3. The serum immunoglobulins level in maxillofacial bacterial infections
Match Strength: 8.037

The IgG, IgA and IgM levels in the serum of 23 patients with maxillofacial bacterial infections were determined. The high IgG level noted on admission further increased in the serum of 14 patients with acute inflammation and decreased in the serum of 10 patients with a chronic course. The level of IgM in the serum of patients with acute inflammation was higher than in the patients with chronic inflammation and decreased in both groups on the 7th day of treatment. The IgA level was high on admission in both groups and fell on the 7th day of treatment. Our results suggest that analysis of the ... Read More »
» Published in Rocz Akad Med Bialymst. 1992;37:64-70.

4. Relation Between Acute Urinary Retention, Chronic Prostatic Inflammation and Accompanying Elevated Prostate-Specific Antigen
Match Strength: 7.776

OBJECTIVE: To determine if there is a relationship between acute urinary retention (AUR), the prostate-specific antigen (PSA) level and chronic inflammation of the prostate. We therefore studied patients with benign prostatic obstruction (BPO) with (n = 64) or without (n = 168) acute urinary retention (AUR) who underwent transurethral resection of the prostate (TURP) in a retrospective case control study. MATERIAL AND METHODS: Between 2001 and 2004, a total of 232 patients underwent TURP due to BPO with or without AUR. The mean values of age, prostate volume, weight of resected prostate and ... Read More »
» Published in Scand J Urol Nephrol. 2006;40(2):155-60.

5. Relation between acute urinary retention, chronic prostatic inflammation and accompanying elevated prostate-specific antigen.
Match Strength: 7.776

OBJECTIVE: To determine if there is a relationship between acute urinary retention (AUR), the prostate-specific antigen (PSA) level and chronic inflammation of the prostate. We therefore studied patients with benign prostatic obstruction (BPO) with (n = 64) or without (n = 168) acute urinary retention (AUR) who underwent transurethral resection of the prostate (TURP) in a retrospective case control study. MATERIAL AND METHODS: Between 2001 and 2004, a total of 232 patients underwent TURP due to BPO with or without AUR. The mean values of age, prostate volume, weight of resected prostate and ... Read More »
» Published in Scand J Urol Nephrol. 2006;40(2):155-60.

6. Inflammation of the abdominal aortic aneurysm wall.
Match Strength: 7.748

Inflammation and fibrosis do not only appear in an "inflammatory" aneurysm, but also in "ordinary" abdominal aortic aneurysms. In this study inflammatory changes in 130 abdominal aortic aneurysms were studied and related to patients' clinical records. According to histopathological criteria five different degrees of inflammation (Histological Inflammation Scale of Aneurysms) were found and patients were classified according to these criteria: grade A or mixed acute/chronic inflammation (4.5%); grade 0 or no inflammation (16.2%); grade 1 or mild chronic (57.7%); grade 2 or moderate chronic (16 ... Read More »
» Published in Eur J Vasc Surg. 1994 Jan;8(1):41-6.

7. The codependence of angiogenesis and chronic inflammation.
Match Strength: 7.687

Angiogenesis is the growth of new blood vessels from existing ones. It is an important aspect of new tissue development, growth, and tissue repair. It is also a component of many diseases including cancer, blindness, and chronic inflammation such as rheumatoid arthritis (RA) and psoriasis. There is considerable evidence to suggest that angiogenesis and chronic inflammation are codependent; recent studies have begun to reveal the nature of this link, which involves both augmentation of cellular infiltration and proliferation and overlapping roles of regulatory growth factors and cytokines. ... Read More »
» Published in FASEB J. 1997 May;11(6):457-65.

8. Angiogenesis as an Immunopharmacologic Target in Inflammation and Cancer
Match Strength: 7.682

Many pathological processes including wound healing, chronic inflammation and cancer require angiogenesis, i.e., the formation of new vasculature in the lesions. Accumulating evidence indicates that angiogenesis is crucial for both chronic inflammation and the growth of malignant tumors with the participation of diverse cytokines, chemokines and growth factors. It is nevertheless believed that differences exist in angiogenesis between cancer and chronic inflammatory diseases. The aim of this review is to outline the characteristics of angiogenesis in chronic inflammation and cancer. A better ... Read More »
» Published in Int Immunopharmacol. 2004 Nov;4(12):1537-47. Erratum in: Int Immunopharmacol. 2005 Mar;5(3):627.

9. Prostate-specific antigen levels in acute and chronic bacterial prostatitis
Match Strength: 7.583

Prostate-specific antigen (PSA) is now widely accepted as a useful tumor marker for the diagnosis and follow-up of prostatic cancer. An elevated level of PSA has been asserted to be highly specific for prostate cancer, although patients with large benign prostate glands and those with bacterial prostatitis may also have slightly elevated levels. We measured the serum PSA level in the patients with acute and chronic bacterial prostatitis and consecutively monitored the PSA level in 6 patients who had acute prostatitis and an elevated PSA level. The PSA level was found to be elevated during the ... Read More »
» Published in Hinyokika Kiyo. 1993 May;39(5):445-9.

10. The Incidence and Clinical Relevance of Chronic Inflammation in the Pancreas in Autopsy Material
Match Strength: 7.532

In 394 consecutive autopies, tissue from the body of the pancreas showed chronic inflammation in 52 cases (13%); 32 were mild, 11 moderate and 9 severe. Only two of these cases had the clinical diagnosis chronic pancreatitis. The incidence of inspissated plugs of protein in the ducts, dilated ducts and acinar ectasia was significantly higher when chronic inflammation was present. There was a significant higher incidence of chronic inflammation in the pancreas in patients with diabetes mellitus. No significant correlation was noted between chronic inflammation in the pancreas and cholelithiasis ... Read More »
» Published in Acta Pathol Microbiol Scand [A]. 1978 Sep;86A(5):361-5.

11. Modulation of inflammatory mediators by ibuprofen and curcumin treatment during chronic inflammation in rat
Match Strength: 7.527

Inflammation is a protective tissue response occurring in three distinct phases, acute, subacute and a chronic proliferative phase. We undertook the present study to understand the overall immune response of the body during adjuvant induced chronic inflammation in rat and the effect of ibuprofen and curcumin on this response. Inflammatory mediators were estimated on day 21 and day 35 after adjuvant injection. The level of C-reactive protein increased to 200% on day 21 and then reduced to 50% on day 35 compared to control. Curcumin and ibuprofen further reduced the increased levels at both the ... Read More »
» Published in Immunopharmacol Immunotoxicol. 2003 May;25(2):213-24.

12. Very low level laser therapy attenuates edema and pain in experimental models
Match Strength: 7.435

In this study, we tested a new square wave microprocessor-controlled red laser with an extremely low peak power output (<3 mW; very low level laser therapy [vLLLT]) in experimental pain in the rat. Acute inflammation was induced by intraplantar injection of carrageenan, chronic inflammation was induced by complete Freund's adjuvant (CFA) and neuropathic pain was produced by sciatic nerve chronic constriction injury (CCI). In our study vLLLT was effective in reducing edema and hyperalgesia in acute and chronic inflammation if administered at the points usually selected for acupuncture. Moreover ... Read More »
» Published in Int J Tissue React. 2004;26(1-2):29-37.

13. Plasma and liver carnitine levels of children with chronic hepatitis B
Match Strength: 7.407

BACKGROUND: Carnitine status of children with chronic hepatitis B is not yet clear. Because it is well-known that carnitine interferes with T-cell immunity, which is closely related to spontaneous or treatment-induced seroconversion in hepatitis B, it was hypothesized that carnitine status would be effective on the end of therapy response (ETR). The aim of this study is to investigate both carnitine status of children with chronic HBV infection and its probable effects on liver histology and ETR. METHODS: Thirty-one children with chronic HBV infection, and age and sex matched 20 healthy ... Read More »
» Published in J Clin Gastroenterol. 2004 Feb;38(2):130-3.

14. Chronic inflammation is negatively associated with prostate cancer and high-grade prostatic intraepithelial neoplasia on needle biopsy.
Match Strength: 7.399

Tissue inflammation has been linked to cancer in several disease models. We tested the association between chronic inflammation and prostate cancer (PCa), as well as high-grade prostatic intraepithelial neoplasia (HGPIN), in prostatic needle biopsy specimens. Tissues from 4526 men, who underwent systematic ultrasound-guided sextant needle biopsies of the prostate, were classified in the following order as PCa, or HGPIN, or chronic inflammation or benign. PCa was diagnosed in 1633 (36.1%), HGPIN in 535 (11.8%) and chronic inflammation in 347 (7.7%). Chronic inflammation conferred a protective ... Read More »
» Published in Int J Clin Pract. 2007 Mar;61(3):425-30.

15. Experimental models of acute and chronic sialoadenitis in the guinea pig
Match Strength: 7.353

Acute and chronic sialoadenitis were induced in ovalbumin-immunized guinea pigs by a single or repeated (once a day for 5 days) instillation of antigen into the parotid gland via the parotid duct. The acute sialoadenitis was characterized by infiltration of inflammatory polymorphonuclear leukocytes and the chronic one, by extensive tissue destruction together with infiltration of mononuclear leukocytes. In acute sialoadenitis, myeloperoxidase activity in the parotid gland, which was a marker of accumulation of neutrophils, was elevated, but in the chronic stage, it returned nearly to the ... Read More »
» Published in Jpn J Pharmacol. 1992 Jul;59(3):405-11.

16. Effects of chronic lung inflammation on tryptophan metabolism in piglets
Match Strength: 7.311

A fundamental question in animal nutrition is the amino acid requirement induced by inflammation and immune response. The aim of the present experiment was to study the effect of chronic lung inflammation induced by injection of complete Freund adjuvant on amino acid metabolism in pigs. For 10 days, we compared plasma haptoglobine and amino acid concentrations of piglets with chronic lung inflammation (CFA) with those of pair-fed littermate healthy pigs (CONTROL). Tryptophan was the only amino acid for which the plasma concentration was continously decreasing and did not reach the control ... Read More »
» Published in Adv Exp Med Biol. 2003;527:359-62.

17. Inflammatory markers according to types of atrial fibrillation.
Match Strength: 7.305

BACKGROUND: There is an increasing evidence linking inflammation to some cardiovascular conditions, such as coronary artery disease and hypertension. Similarly, there is emerging data to support the association between inflammation and atrial fibrillation (AF). We also investigated the role of systemic inflammation in different categories of AF. METHODS: Eighty five consecutive patients with AF were enrolled in this study. AF was categorized as new onset, chronic (persistent and permanent) and lone. Age- and sex-matched 30 healthy people consisted of control group. Serum level of high ... Read More »
» Published in Int J Cardiol. 2007 Jan 18;

18. Chronic Pelvic Pain Associated With Autoimmunity and Systemic and Peritoneal Inflammation and Treatment With Immune Modification
Match Strength: 7.297

OBJECTIVE: To determine the prevalence of chronic inflammation of the pelvic peritoneum, systemic inflammation and autoimmunity in chronic pelvic pain and to explore the significance of these findings and assess the response to treatment with immune modification. STUDY DESIGN: Prospective, observational clinical studies from 2 centers were performed on 3,238 women presenting with pelvic pain to determine the prevalence of chronic inflammation by biopsy when endometriosis was absent. A second study included 40 women with chronic pelvic pain not resulting from endometriosis; immunologic ... Read More »
» Published in J Reprod Med. 2005 Oct;50(10):745-58.

19. Microvascular remodelling in chronic airway inflammation in mice
Match Strength: 7.289

1. Chronic inflammation is associated with blood vessel remodelling, including vessel proliferation and enlargement, and changes in vessel phenotype. We sought to characterize these changes in chronic airway inflammation and to determine whether corticosteroids that inhibit inflammation, such as dexamethasone, can also reduce microvascular remodelling. 2. Chronic airway inflammation was induced in C3H mice by infection with Mycoplasmapulmonis and the tracheal vessels treatment also decreased the immunoreactivity for P-selectin and the number of adherent leucocytes (595 +/- 203 vs 2,024 +/- 393 ... Read More »
» Published in Clin Exp Pharmacol Physiol. 2000 Oct;27(10):836-41.

20. Interaction Between Nutrition and Inflammation in Hemodialysis Patients
Match Strength: 7.236

The excessive cardiovascular mortality of dialysis patients is at least in part related to chronic inflammation, which is associated with the occurrence of malnutrition. The negative effects of chronic inflammation on nutritional status are mediated by proinflammatory cytokines leading to a reduction in appetite and increased muscle catabolism. However, dietary behavior itself may also independently affect inflammation. Reduced dietary supply of vitamins C, B6, B12 and folate, as well as regular coffee consumption and increased intake of dietary advanced glycation end products may trigger ... Read More »
» Published in Contrib Nephrol. 2005;149:200-7.

21. Effects of acute and chronic inflammation on the pharmacokinetics of prednisolone in rats.
Match Strength: 7.219

The effects of acute and chronic stages of carrageenan-induced air-pouch inflammation on the pharmacokinetics of prednisolone were studied in male Wistar rats. Chronic inflammation produced a significant increase in the area under the curve (AUC) of prednisolone compared to control animals (6594 +/- 2144 vs 3530 +/- 2164 micrograms.hr/L). The effect of acute inflammation was not significant (AUC = 4996 +/- 3813). Both acute and chronic inflammation also reduced the in vitro plasma protein binding of prednisolone, the reduction being much greater after chronic inflammation. The AUC of free ... Read More »
» Published in Pharm Res. 1994 Apr;11(4):541-4.

22. Influence of Chronic Inflammation on the Level of Mrna for Acute-Phase Reactants in the Mouse Liver
Match Strength: 7.210

Systemic injuries provoke a coordinate change in the hepatic synthesis and circulating concentration of plasma proteins. To assess the effect of a transition from acute to chronic inflammation on the expression of the plasma protein genes, the qualitative and quantitative changes of liver mRNA were measured in males of the inbred strain C57BL/6 of Mus musculus during a 14-day period of inflammation. Inflammation was induced and maintained by repeated injections of the irritants, turpentine, lipopolysaccharides, and celite. At various times, total RNA was extracted from the liver. The ... Read More »
» Published in J Immunol. 1986 Sep 1;137(5):1616-22.

23. Helicobacter pylori infection, but not mucosal atrophy, significantly affects serum pepsinogen level after gastric cancer surgery.
Match Strength: 7.170

BACKGROUND/AIMS: Helicobacter pylori (Hp) infection is frequently observed in the remnant stomach after gastric cancer surgery, and is considered to play one of the important roles in chronic mucosal inflammation and cancer development. METHODOLOGY: Serum pepsinogen (PG) levels were measured in one hundred and eight patients after gastrectomy performed because of gastric cancer. The correlation between PG levels and the grade of mucosal inflammation in the remnant stomach was investigated together with the status of Hp infection. RESULTS: No statistical difference in serum PG level was found ... Read More »
» Published in Hepatogastroenterology. 2006 Jul-Aug;53(70):619-23.

24. Serum Surfactant Protein D Is Increased in Acute and Chronic Inflammation in Mice
Match Strength: 7.136

Surfactant protein A (SP-A) and surfactant protein D (SP-D) are important components of innate immunity that can modify the inflammatory response. However, alterations and regulation of SP-A and SP-D in acute and chronic inflammation are not well defined. In addition, serum SP-D may serve as a biomarker of lung inflammation. We determined the expression of SP-A and SP-D in murine models. To study acute inflammation, we instilled bleomycin intrabronchially. To study chronic lung inflammation, we used a transgenic mouse that overexpresses tumor necrosis factor (TNF)-alpha under the control of ... Read More »
» Published in Cytokine. 2005 Jul 7;31(1):25-33.

25. Airway hyperreactivity in exacerbation of chronic asthma is independent of eosinophilic inflammation.
Match Strength: 7.085

We have developed an animal model to investigate the mechanisms underlying an acute exacerbation of chronic asthma. Sensitized BALB/c mice were exposed to aerosolized ovalbumin, either as chronic low-level challenge (mass concentration approximately 3 mg/m(3)) for 4 wk, a single moderate-level challenge (approximately 30 mg/m(3)), or chronic low-level followed by single moderate-level challenge (the acute exacerbation group). Compared with animals receiving chronic challenge alone, mice in the acute exacerbation group exhibited a more marked inflammatory response, with involvement of ... Read More »
» Published in Am J Respir Cell Mol Biol. 2006 Nov;35(5):565-70. Epub 2006 Jun 22.

26. Sunset glow fundus in Vogt-Koyanagi-Harada disease with or without chronic ocular inflammation
Match Strength: 7.047

BACKGROUND: Sunset glow fundus is considered an important ocular finding for diagnosing and understanding the pathogenesis of Vogt-Koyanagi-Harada (VKH) disease. In this study, we investigated the association between the incidence of chronic ocular inflammation in VKH disease and the appearance of sunset glow fundus. METHODS: The study was a retrospective noncomparative interventional case series. Eighty patients with VKH disease treated with high-dose corticosteroid therapy from initial onset were included in the study. We compared the incidence of sunset glow fundus between patients with VKH ... Read More »
» Published in Graefes Arch Clin Exp Ophthalmol. 2002 Oct;240(10):878-82. Epub 2002 Sep 6.

27. Chronic gastrointestinal inflammation
Match Strength: 7.037

Chronic gastrointestinal inflammation is one of the most common types of inflammatory process which affects humans. It is diverse in aetiology, pathogenesis and manifestation. There are also features of chronic inflammation at different sites within the gastrointestinal tract which provide a common thread in terms of the approaches which may be used in investigating these intriguing processes. This paper provides an overview of the mucosal changes in chronic gastrointestinal inflammation. Conserved and variable features of inflammation at different sites extending from the oral cavity to the ... Read More »
» Published in FEMS Immunol Med Microbiol. 1999 Jun;24(2):161-8.

28. Interferon-alpha 2a increases serum concentration of hyaluronic acid and type III procollagen aminoterminal propeptide in patients with chronic hepatitis B virus infection.
Match Strength: 7.006

Interferon-alpha (IFN-alpha) has become an important drug for the treatment of chronic viral liver diseases. However, the action of IFN-alpha remains unclear. We investigated whether human recombinant IFN-alpha modulates serum concentrations of hyaluronic acid (HA) and type III procollagen aminoterminal propeptide (P-III-NP) in 56 patients with chronic hepatitis-B under IFN-alpha therapy. IFN-alpha increased the HA serum level in 44 of 46 patients and, after cessation of treatment, HA serum levels returned to the pretherapy levels. The increase of HA serum level was higher in patients with ... Read More »
» Published in Dig Dis Sci. 1994 Sep;39(9):2007-13.

29. Changes in Functional Ceruloplasmin Concentrations of Plasma and Exudate and the Effect of Exogenous Ceruloplasmin on the Carrageenin-Induced Inflammation in Rats
Match Strength: 6.966

Changes in functional ceruloplasmin (Cp) concentrations of plasma and exudate during acute and chronic inflammatory processes were studied in detail by measuring Cp oxidase activity in the carrageenin-induced inflammation in rats. In contrast with the plasma functional Cp level as an acute-phase reactant, the exudate functional Cp level was very low during the acute phase, increased in the chronic phase and reached a constant value which was only half value of the plasma functional Cp level. The locally injected Cp had no effect on the carrageenin-induced inflammation, suggesting that ... Read More »
» Published in J Pharmacobiodyn. 1984 Oct;7(10):755-9.

30. Cytokines in acute and chronic inflammation.
Match Strength: 6.966

Inflammation is mediated by a variety of soluble factors, including a group of secreted polypeptides known as cytokines. Inflammatory cytokines can be divided into two groups: those involved in acute inflammation and those responsible for chronic inflammation. This review describes the role played in acute inflammation by IL-1, TNF-alpha, IL-6, IL-11, IL-8 and other chemokines, G-CSF, and GM-CSF. It also describes the involvement of cytokines in chronic inflammation. This latter group can be subdivided into cytokines mediating humoral responses such as IL-4, IL-5, IL-6, IL-7, and IL-13, and ... Read More »
» Published in Front Biosci. 1997 Jan 1;2:d12-26.

31. Hyperhomocysteinemia in Relation to Plasma Free Amino Acids, Biomarkers of Inflammation and Mortality in Patients With Chronic Kidney Disease Starting Dialysis Therapy
Match Strength: 6.959

BACKGROUND: Plasma levels of total homocysteine (tHcy) and free amino acids (AAs) are influenced by nutritional status in patients with chronic kidney disease (CKD), whereas the role of chronic inflammation is not clear. METHODS: In a cross-sectional analysis, fasting levels of plasma tHcy, total cysteine (tCys), AA, serum albumin (Alb), and several inflammation markers, including C-reactive protein (CRP), were analyzed in a cohort of 250 patients with CKD starting renal replacement therapy. Patients were followed up during a 4-year period to assess overall mortality in relation to basal tHcy ... Read More »
» Published in Am J Kidney Dis. 2004 Sep;44(3):455-65.

32. Inhibition of nitric oxide synthesis enhances the expression of inducible nitric oxide synthase mRNA and protein in a model of chronic liver inflammation.
Match Strength: 6.954

In septic shock the inhibition of inducible nitric oxide synthase (iNOS) could be of therapeutic value. However, side effects have to be investigated. Therefore we studied the effects of chronic NOS inhibition on the level of iNOS expression in a model of chronic liver inflammation induced by Corynebacterium parvum (C. parvum) which causes sustained iNOS expression in the liver. NOS inhibitors decreased the rise in plasma levels and urinary excretion of nitrite/nitrate by about 50%; however, iNOS mRNA and protein were increased to 200% and 150%, respectively. Thus chronic inhibition of NOS can ... Read More »
» Published in Biochem Biophys Res Commun. 1994 Oct 28;204(2):635-40.

33. Chronic inflammation in older people: recognition, consequences, and potential intervention.
Match Strength: 6.940

In elderly individuals, some chronic inflammatory diseases appear to occur with increased frequency, and recent evidence suggests that some very common chronic, age-related disorders may be propagated and perpetuated by inflammatory processes, perhaps giving rise to the abnormal acute phase protein levels that are seen with increased frequency with aging. The consequences of chronic inflammation in the elderly undoubtedly contribute to excessive morbidity in this population. Treatment of chronic inflammation in the elderly is often difficult, requiring utmost care and close follow-up by a ... Read More »
» Published in Clin Geriatr Med. 1997 Nov;13(4):653-69.

34. Excess Plasma Proteins As a Cause of Chronic Inflammation and Lymphodema: Quantitative Electron Microscopy
Match Strength: 6.908

The subcutaneous tissue of rats was injected with plasma. PVP, or saline. In spite of precautions to avoid immunological reactions and the release of mediators, it was found that the plasma-injected animals had many of the signs of chronic inflammation-even at 64 days. These were considerably reduced by coumarin, a benzo-pyrone, which is known to enhance the lysis of proteins by macrophages. The numbers of these cells were greatly increased in the injection site-especially with the administration of coumarin. PVP also moderately increased macrophage numbers, but did not cause the increase in ... Read More »
» Published in J Pathol. 1981 Mar;133(3):243-72.

35. Inflammaging as a major characteristic of old people: can it be prevented or cured?
Match Strength: 6.907

Widespread aging at the population level is a recent phenomenon that emerged in affluent societies. Inflammation is necessary to cope with damaging agents and is crucial for survival, particularly to cope with acute inflammation during our reproductive years. But chronic exposure to a variety of antigens, especially to some viruses such as cytomegalovirus, for a period much longer than that predicted by evolution, induces a chronic low-grade inflammatory status that contributes to age-associated morbidity and mortality. This condition carries the proposed name "inflammaging". Centenarians are ... Read More »
» Published in Nutr Rev. 2007 Dec;65(12 Pt 2):S173-6.

36. Inhaled corticosteroid treatment and extracellular matrix in the airways in asthma.
Match Strength: 6.889

Even mild asthmatics with a short duration of the disease show at the morphological level a picture of chronic inflammation with airway epithelial changes and influx of inflammatory cells into the airway mucosa. Several studies have shown that inhaled corticosteroid treatment can ameliorate this inflammation. In addition, even a morphologically normal epithelial structure may be restored. However, factors which may lead to more chronic disease have remained obscure. Recent studies are now focusing on the reversibility of collagen deposition in the airway epithelial basement membrane. Airway ... Read More »
» Published in Int Arch Allergy Immunol. 1995 May-Jun;107(1-3):215-6.

37. Influence of Age, Sex, and Degree of Liver Fibrosis on the Association Between Serum Alanine Aminotransferase Levels and Liver Inflammation in Patients With Chronic Hepatitis C
Match Strength: 6.867

In 504 patients with chronic hepatitis C who underwent liver biopsy, the correlation between serum ALT levels and histologic liver inflammation was investigated, and the effects of age, sex, and degree of histologic liver fibrosis on this correlation were analyzed. Serum ALT levels were significantly higher in male than in female patients only when activity of hepatitis was mild. In contrast, ALT levels were significantly higher in younger (< or = 50 years old) than in older patients only when activity of liver inflammation was severe. Fibrosis was closely associated with activity of hepatitis ... Read More »
» Published in Dig Dis Sci. 2004 Feb;49(2):295-9.

38. Chronic obstructive pulmonary disease: molecular and cellular mechanisms
Match Strength: 6.866

Chronic obstructive pulmonary disease is a leading cause of death and disability, but has only recently been extensively explored from a cellular and molecular perspective. There is a chronic inflammation that leads to fixed narrowing of small airways and alveolar wall destruction (emphysema). This is characterised by increased numbers of alveolar macrophages, neutrophils and cytotoxic T-lymphocytes, and the release of multiple inflammatory mediators (lipids, chemokines, cytokines, growth factors). A high level of oxidative stress may amplify this inflammation. There is also increased ... Read More »
» Published in Eur Respir J. 2003 Oct;22(4):672-88.

39. Placental Abruption in Term and Preterm Gestations: Evidence for Heterogeneity in Clinical Pathways
Match Strength: 6.856

OBJECTIVE: To estimate the magnitude of associations of acute and chronic processes with abruption in preterm and term gestations. METHODS: A retrospective cohort study was performed using data on women that delivered singleton live births and stillbirths at 20 or more weeks of gestation in the United States, 1995-2002 (n = 30,378,902). Rates of 1) acute-inflammation-associated clinical conditions (premature rupture of membranes and intrauterine infection); 2) chronic processes associated with vascular dysfunction or chronic inflammation (chronic and pregnancy-induced hypertension, preexisting ... Read More »
» Published in Obstet Gynecol. 2006 Apr;107(4):785-92.

40. Interleukin-10 level in sputum is reduced in bronchial asthma, COPD and in smokers
Match Strength: 6.855

Interleukin (IL)-10 is a potent regulatory cytokine that decreases inflammatory responses. This study investigated whether IL-10 levels in the airway are decreased in chronic airway inflammation associated with asthma or chronic obstructive pulmonary disease (COPD). Sputum was obtained from 12 healthy nonsmokers, 10 healthy smokers, 16 asthmatic patients and seven patients with COPD by means of the sputum-induction method. The IL-10 level was measured via enzyme-linked immunosorbent assay and immunocytochemical analysis. The IL-10 level in sputum was significantly lower in asthma and COPD ... Read More »
» Published in Eur Respir J. 1999 Aug;14(2):309-14.

41. New concepts in chronic obstructive pulmonary disease
Match Strength: 6.850

Chronic obstructive pulmonary disease (COPD) is a leading cause of death and disability but has only recently been explored from a cellular and molecular perspective. In COPD, chronic inflammation leads to fixed narrowing of small airways and alveolar wall destruction (emphysema). This is characterized by increased numbers of alveolar macrophages, neutrophils, and cytotoxic T lymphocytes, and the release of multiple inflammatory mediators (lipids, chemokines, cytokines, growth factors). There is also a high level of oxidative stress, which may amplify this inflammation. There is increased ... Read More »
» Published in Annu Rev Med. 2003;54:113-29. Epub 2001 Dec 3.

42. Serum transferrin receptor distinguishes the anemia of chronic disease from iron deficiency anemia
Match Strength: 6.849

Recent studies have shown that the serum transferrin receptor is a sensitive, quantitative measure of tissue iron deficiency. This study was undertaken to determine the serum transferrin receptor's ability to distinguish iron-deficiency anemia from the anemia of chronic inflammation and to identify iron deficiency in patients with liver disease. The mean transferrin receptor level in 17 normal controls was 5.36 +/- 0.82 mg/L compared with 13.91 +/- 4.63 mg/L in 17 patients with iron-deficiency anemia (p less than 0.001). The mean serum receptor level was normal in all 20 patients with acute ... Read More »
» Published in J Lab Clin Med. 1992 Apr;119(4):385-90.

43. Rate of Migration of Oral Leukocytes in Patients with Periodontitis
Match Strength: 6.823

The rate of migration of leukocytes (OMR) was estimated by counts of sequential mouthrinses in 81 human subjects in order to evaluate its usefulness as a laboratory test of oral inflammation. Periodontitis was taken as a model, and neither patients nor controls had any other oral inflammation. Patients with advanced periodontitis, but with periodontal destruction of about the same level, were divided into two groups, acute phase and chronic phase. The mean number of leukocytes entering the oral cavity in 30 s was estimated in these two groups. In the same patients the difference between the ... Read More »
» Published in Scand J Dent Res. 1978 Jan;86(1):43-51.

44. Chronic infection, inflammation, and epithelial ovarian cancer
Match Strength: 6.803

At the present time, the etiology of epithelial ovarian cancer is poorly understood. It has recently been recognized that certain chronic infectious agents may contribute to carcinogenesis by inducing a state of persistent inflammation. Since the female upper genital tract is a frequent site of chronic infections, we propose various strategies that may be useful for determining the potential role of chronic infection and persistent inflammation in the pathogenesis of epithelial ovarian cancer. Copyright 2001 Harcourt Publishers Ltd ... Read More »
» Published in Med Hypotheses. 2001 Oct;57(4):426-8.

45. Role of Nutrition for Cardiovascular Risk Reduction in Chronic Kidney Disease Patients
Match Strength: 6.762

Cardiovascular disease (CVD) is the major cause of death in end-stage renal disease (ESRD) patients. Uremic malnutrition and chronic inflammation are important comorbid conditions, closely associated with CVD risk in ESRD patients. A pathophysiologic link between uremic malnutrition, chronic inflammation, and atherosclerosis has been proposed in this patient population. Uremic malnutrition can result from chronic inflammation and can accelerate the progression of cardiovascular disease. Chronic inflammation can also directly predispose ESRD patients to a proatherogenic state. Both uremic ... Read More »
» Published in Adv Chronic Kidney Dis. 2004 Apr;11(2):162-71.

46. The Interplay Between Innate and Adaptive Immunity Regulates Cancer Development
Match Strength: 6.757

There is increasing clinical and experimental evidence that inflammation and cancer are causally linked. Much progress has been made in understanding how inflammatory cells contribute to cancer development; however, it is still largely unknown which molecular mechanisms are responsible for initiation and maintenance of chronic inflammation associated with developing neoplasms. This review will discuss how the adaptive and innate immune systems interact during physiological and chronic inflammation, with a focus on studies revealing new insights into the role of adaptive immune cells as ... Read More »
» Published in Cancer Immunol Immunother. 2005 Nov;54(11):1143-52. Epub 2005 May 12.

47. MRI of chronic recurrent parotitis in childhood
Match Strength: 6.731

PURPOSE: Chronic recurrent parotitis (CRP) is a rare inflammatory disease characterized by multiple episodes of unilateral or bilateral parotid inflammation over a period of years. The objective of this study was to evaluate the parotid glands using MRI during acute inflammation as well as during symptom-free intervals. METHOD: Twelve children with a history of CRP were included. Four patients were examined during the acute phase and eight children during symptom-free intervals. MR findings were correlated with the clinical status. RESULTS: Two different patterns were identified by MRI: acute ... Read More »
» Published in J Comput Assist Tomogr. 2001 Mar-Apr;25(2):269-73.

48. Chronic inflammation and cancer
Match Strength: 6.729

A substantial body of evidence supports the conclusion that chronic inflammation can predispose an individual to cancer, as demonstrated by the association between chronic inflammatory bowel diseases and the increased risk of colon carcinoma. Chronic inflammation is caused by a variety of factors, including bacterial, viral, and parasitic infections, chemical irritants, and nondigestible particles. The longer the inflammation persists, the higher the risk of associated carcinogenesis. This review describes some of the underlying causes of the association between chronic inflammation and cancer ... Read More »
» Published in Oncology (Williston Park). 2002 Feb;16(2):217-26, 229; discussion 230-2.

49. Placental abruption in term and preterm gestations: evidence for heterogeneity in clinical pathways.
Match Strength: 6.699

OBJECTIVE: To estimate the magnitude of associations of acute and chronic processes with abruption in preterm and term gestations. METHODS: A retrospective cohort study was performed using data on women that delivered singleton live births and stillbirths at 20 or more weeks of gestation in the United States, 1995-2002 (n = 30,378,902). Rates of 1) acute-inflammation-associated clinical conditions (premature rupture of membranes and intrauterine infection); 2) chronic processes associated with vascular dysfunction or chronic inflammation (chronic and pregnancy-induced hypertension, preexisting ... Read More »
» Published in Obstet Gynecol. 2006 Apr;107(4):785-92.

50. Effect of Sevelamer on Dyslipidemia and Chronic Inflammation in Maintenance Hemodialysis Patients
Match Strength: 6.671

BACKGROUND: Hemodialysis (HD) patients often experience cardiovascular events, that might be related to altered calcium-phosphate metabolism, dyslipidemia, and chronic inflammation in addition to hypertension. Sevelamer, a non-calcium-containing phosphate binder, may improve the lipid profile of HD patients. However, the influence of sevelamer on chronic inflammation has not been clarified. METHODS: We enrolled 36 maintenance HD patients with a serum calcium (Ca) or phosphate (P) level constantly greater than 9.5 mg/dL and 5.5 mg/dL, respectively. The dose of sevelamer was titrated to achieve ... Read More »
» Published in Ren Fail. 2005;27(4):361-5.

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