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Peer Reviewed Scientific Research Reports.
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1. Hepcidin the link between inflammation and anemia in chronic renal failure.
Match Strength: 3.579
A chronic inflammatory state characterized the patients with chronic renal failure. The causes of this situation are multiple and inter-connected. The break of the equilibrium between pro-inflammatory agents and anti-inflammatory ones in haemodialysis patients leads to anemia of chronic inflammation, characterized by a functional iron deficiency. Very recently it was discovered a peptide produced by the liver, named hepcidin, that provides a good link between inflammation and metabolism of iron, rendering more understandable the interdependence of inflammation and anemia ... Read More »
» Published in Rom J Intern Med. 2006;44(1):25-33.
2. Low-grade inflammation in chronic diseases: An integrative pathophysiology anticipated by homeopathy?
Match Strength: 3.527
Pro-inflammatory cytokines and their chronic effect - low-grade inflammation - have been associated with diverse chronic conditions. Nonsteroidal anti-inflammatory drugs (NSAIDs) were recently proposed as a treatment strategy. Samuel Hahnemann, the founder of homeopathy, had already hypothesized a systemic and progressive disorder as the cause of many chronic diseases - the Psora theory. He also advised of the consequences of palliative use for chronic diseases, as a contrary effect of the "of the life-preserving principle" could worsen the course of those diseases. The hypotheses presented ... Read More »
» Published in Med Hypotheses. 2011 Jan 28.
3. Do non-steroidal anti-inflammatory drugs influence chronic inflammation? The effects of piroxicam on chronic antigen-induced arthritis in rats.
Match Strength: 3.493
OBJECTIVE: The effects of non-steroidal anti-inflammatory drugs (NSAIDs) on acute inflammation have been thoroughly investigated. NSAIDs are, however, also prescribed for patients with chronic inflammation, such as rheumatoid arthritis (RA), and objective improvement suggestive of anti-inflammatory action from NSAIDs has not been convincingly shown in chronic RA. An antigen-induced arthritis (AIA) model was used to investigate the effects of piroxicam on chronic inflammation. METHODS: AIA was induced by injecting methylated bovine serum albumin (mBSA) into the knee joints of previously ... Read More »
» Published in Scand J Rheumatol. 2008 Nov-Dec;37(6):469-76.
4. General model of inflammation.
Match Strength: 3.492
Dysfunctions in the immune system, due to genetics, disease or environmental factors, can cause bacterial colonization and chronic inflammation. In cystic fibrosis and chronic obstructive pulmonary disease, respiratory infections can initiate inflammation of the airway. We propose a system of nonlinear ordinary differential equations to describe interactions between macrophages, both inflammatory and anti-inflammatory cytokines, and bacteria. Small changes in parameters governing inflammatory cytokine production and macrophage sensitivity to cytokines result in dramatically different model ... Read More »
» Published in Bull Math Biol. 2010 May;72(4):765-79. Epub 2009 Oct 23.
5. Inflammation-associated cancer: NF-kappaB is the lynchpin.
Match Strength: 3.339
It has long been suspected that NF-kappaB signaling has a pivotal role in chronic inflammation-associated malignancies, although genetic evidence for this hypothesis has been lacking. However, recent papers have lent credence to this concept and show that NF-kappaB activation in pre-malignant cells contributes to cell survival and metastatic potential. Furthermore, NF-kappaB activation in tumor-associated leukocytes, especially macrophages, contributes towards tumorigenesis by upregulating tumor-promoting proinflammatory proteins. This emphasizes the importance of NF-kappaB inhibitors as ... Read More »
» Published in Trends Immunol. 2005 Jun;26(6):318-25.
6. Multimodal therapy for chronic prostatitis/chronic pelvic pain syndrome.
Match Strength: 3.338
Category III chronic prostatitis/chronic pelvic pain syndrome is a syndrome rather than a specific disease and the cause can be multifactorial. In clinical practice, monotherapy often has proven ineffective. Multimodal therapy, which sequentially or simultaneously can address infection, inflammation, and neuromuscular spasm appears to have the greatest potential for symptom improvement, especially in patients with longstanding symptoms ... Read More »
» Published in Curr Urol Rep. 2005 Jul;6(4):296-9.
7. Stimulation of lymphangiogenesis via VEGFR-3 inhibits chronic skin inflammation.
Match Strength: 3.318
The role of lymphangiogenesis in inflammation has remained unclear. To investigate the role of lymphatic versus blood vasculature in chronic skin inflammation, we inhibited vascular endothelial growth factor (VEGF) receptor (VEGFR) signaling by function-blocking antibodies in the established keratin 14 (K14)-VEGF-A transgenic (Tg) mouse model of chronic cutaneous inflammation. Although treatment with an anti-VEGFR-2 antibody inhibited skin inflammation, epidermal hyperplasia, inflammatory infiltration, and angiogenesis, systemic inhibition of VEGFR-3, surprisingly, increased inflammatory edema ... Read More »
» Published in J Exp Med. 2010 Sep 27;207(10):2255-69. Epub 2010 Sep 13.
8. Chronic bronchitis sub-phenotype within COPD: inflammation in sputum and biopsies.
Match Strength: 3.304
The presence of chronic bronchitis predicts a more rapid decline of forced expiratory volume in one second (FEV(1)) in patients with chronic obstructive pulmonary disease (COPD). The hallmark of COPD is airway inflammation. It was hypothesised that COPD patients with chronic bronchitis are characterised by a distinct inflammatory cell profile, as measured in bronchial biopsies and sputum. From 114 COPD patients (male/female ratio 99/15, mean+/-sd age 62+/-8 yrs, current smoking 63%, post-bronchodilator FEV(1) 63+/-9% predicted, no steroids), with and without chronic bronchitis, inflammatory ... Read More »
» Published in Eur Respir J. 2008 Jan;31(1):70-7. Epub 2007 Sep 5.
9. Psychological stress reactivates dextran sulfate sodium-induced chronic colitis in mice.
Match Strength: 3.289
Inflammatory bowel disease (IBD) is a chronic condition with alternating active and quiescent phases of inflammation. Stress has been suggested as a factor triggering a relapse of IBD. We investigated the role of repetitive psychological stress [water avoidance stress (WAS)] in reactivating colonic inflammation in a murine model of dextran sulfate sodium (DSS)-induced chronic colitis. Colitis was induced in C57BL/6 female mice by exposure to 3% DSS (5 days). During chronic inflammation(day 34), mice underwent repetitive WAS (1 h/day/7 days) and were given a sub-threshold concentration of DSS ... Read More »
» Published in Stress. 2008;11(5):348-62.
10. Will vitamin D supplementation ameliorate diseases characterized by chronic inflammation and fatigue?
Match Strength: 3.283
Chronic NF-?B activation has been supposed as a key event in chronic fatigue syndrome (CFS) and many other better-defined pro-inflammatory diseases. Knowledge about the impact of deficiency vitamin D on chronic NF-?B activation could open a new disease approach. Whereas NF-?B activation leads at first to a pro-inflammatory immune response, later on a vitamin D-dependent anti-inflammatory response ensues. Binding of the active vitamin D metabolite 1,25(OH)(2)D(3) to vitamin D receptor (VDR) yields a transcription factor which represses NF-?B activation, and additionally modulates and down ... Read More »
» Published in Med Hypotheses. 2011 Feb;76(2):208-13. Epub 2010 Oct 25.
11. Chronic urticaria of neonatal onset: a potential sign of autoinflammation.
Match Strength: 3.260
We present a 6 year old boy with chronic urticaria of neonatal onset associated in childhood with features of neurological and joint inflammation. Genetic analysis confirmed the diagnosis of neonatal onset multi-inflammatory disorder (NOMID). Daily subcutaneous anti-IL-1 receptor antagonist therapy resulted in a dramatic and sustained amelioration of systemic inflammation. NOMID must be considered in any child with chronic urticaria of neonatal/infantile onset, particularly if associated with joint and/or neurological inflammation ... Read More »
» Published in J Paediatr Child Health. 2010 Oct;46(10):608-10. doi: 10.1111/j.1440-1754.2009.01688.x.
12. Skeletal muscle response to inflammation--lessons for chronic obstructive pulmonary disease.
Match Strength: 3.254
To describe how inflammation affects muscle adaptation and performance in people with chronic obstructive pulmonary disease. In chronic obstructive pulmonary disease, an increasingly sedentary lifestyle is a primary contributor to muscle dysfunction that results in a loss of mobility and independence and, ultimately, mortality. Given the systemic chronic inflammation and profound limb muscle atrophy in chronic obstructive pulmonary disease, it is tempting to speculate that the inflammatory process is deleterious to skeletal muscle. In healthy people, however, the inflammatory process initially ... Read More »
» Published in Crit Care Med. 2009 Oct;37(10 Suppl):S372-83.
13. Chronic inflammation is etiology of extrinsic aging.
Match Strength: 3.207
Skin care regimens using active ingredients that are recommended by physicians who treat mucocutaneous conditions including aging should become more focused on reversing and preventing chronic inflammation. This adjustment of therapeutic and preventive strategies is necessary because chronic inflammation appears strongly linked to many preventable and treatable skin diseases and conditions such as visible skin aging. Mucocutaneous inflammation as the final common pathway of many systemic and mucocutaneous diseases including extrinsic aging has been established at the molecular and cellular ... Read More »
» Published in J Cosmet Dermatol. 2008 Mar;7(1):78-82.
14. Differential diagnosis of eosinophilic chronic rhinosinusitis.
Match Strength: 3.201
Eosinophilic chronic rhinosinusitis (ECRS) encompasses a wide variety of etiologies. To date, a unifying pathophysiologic mechanism remains elusive. Eosinophilia is frequently, but not exclusively, caused by immunoglobulin (Ig)E-mediated hypersensitivity and is dominated by the associated cytokine milieu of Th2 inflammation. The provisional subcategories of ECRS include superantigen-induced eosinophilic chronic rhinosinusitis, allergic fungal sinusitis, nonallergic fungal eosinophilic chronic rhinosinusitis, and aspirin-exacerbated eosinophilic chronic rhinosinusitis. Within each subcategory, ... Read More »
» Published in Curr Allergy Asthma Rep. 2006 May;6(3):203-14.
15. Novel targets and new potential: developments in the treatment of inflammation in chronic kidney disease.
Match Strength: 3.140
BACKGROUND: Patients with chronic kidney disease (CKD) of all stages experience extremely high mortality, with cardiovascular causes accounting for about half of all their deaths. Traditional risk factors such as hypertension, hypercholesterolemia and diabetes mellitus cannot explain the excessively high cardiovascular mortality in CKD. Chronic inflammation is one of the novel risk factors that appear to contribute to the increased mortality seen in patients with CKD. Therapeutic interventions targeting chronic inflammation in CKD may lead to improved outcomes. OBJECTIVES: To describe the role ... Read More »
» Published in Expert Opin Investig Drugs. 2008 Apr;17(4):451-67.
16. Delivery of antiinflammatory nutraceuticals by nanoparticles for the prevention and treatment of cancer.
Match Strength: 3.129
Extensive research within the last two decades has revealed that most chronic illnesses, including cancer, diabetes, and cardiovascular and pulmonary diseases, are mediated through chronic inflammation. Thus, suppressing chronic inflammation has the potential to delay, prevent, and even treat various chronic diseases, including cancer. Various nutraceuticals from fruits, vegetables, vitamins, spices, legumes, and traditional Chinese and Ayurvedic medicine have been shown to safely suppress proinflammatory pathways; however, their low bioavailability in vivo limits their use in preventing and ... Read More »
» Published in Biochem Pharmacol. 2010 Dec 15;80(12):1833-43. Epub 2010 Jul 21.
17. Inflammation and cancer: the role of the immune response and angiogenesis.
Match Strength: 3.108
The link with chronic inflammation and cancer has been recognized for certain cancers for several decades. However, only recently has the biology of chronic inflammation begun to be understood, to the point that it may play a major role in tumour development. The biology of chronic inflammation has many similarities with that of wound healing. In particular, local cell mediated immunity is attenuated and angiogenesis is increased along with other growth factors. When present long-term, this provides the ideal environment for mutated cells to be nurtured and escape immune surveillance. It is of ... Read More »
» Published in Cancer Treat Res. 2006;130:1-38.
18. Nutrition, inflammation and chronic kidney disease.
Match Strength: 3.100
PURPOSE OF REVIEW: Protein-energy wasting and chronic inflammation are important comorbid conditions that predict poor clinical outcome in patients with advanced chronic kidney disease. The current article aims to provide a brief overview of the etiology and nutritional consequences of chronic inflammation with an outline of potential treatment options. RECENT FINDINGS: The exact mechanisms leading to these unfavorable conditions are not fully elucidated and are most likely multifactorial. Irrespective of the specific etiologic mechanisms, it appears that the common pathway for all the ... Read More »
» Published in Curr Opin Nephrol Hypertens. 2008 Mar;17(2):162-7.
19. Exercise, inflammation, and innate immunity.
Match Strength: 3.095
Regular exercise is protective against several chronic diseases ranging from physiologic diseases such as cardiovascular disease to neurologic diseases such as dementia and depression. Exciting recent research points to chronic inflammation as an underlying contributor to many age-related chronic diseases. Cross-sectional and longitudinal studies in animals and humans have shown both an acute and a chronic anti-inflammatory effect. Because innate immunity is a key regulator of inflammatory processes, and chronic inflammation contributes to many illnesses, the effect of regular exercise on ... Read More »
» Published in Neurol Clin. 2006 Aug;24(3):585-99.
20. Inflammation and cancer: a failure of resolution?
Match Strength: 3.091
There are clear links between chronic inflammation and cancer; strong epidemiological and genetic evidence indicates that inflammation can drive tumour progression, and more-recent evidence indicates that the disruption of endogenous anti-inflammatory mechanisms in mice can lead to tumour development. The resolution of inflammation is an active coordinated process that requires the production of anti-inflammatory mediators, the termination of proinflammatory signalling pathways and the appropriate clearance or migration of inflammatory cells. Disruption of any of these processes can lead to ... Read More »
» Published in Trends Pharmacol Sci. 2007 Apr;28(4):162-5. Epub 2007 Feb 28.
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