Childhood Type-2 Diabetes
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Peer Reviewed Scientific Research Reports.
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1. Insulin-induced oedema in children and adolescents.
Match Strength: 7.653
Oedema is an uncommon complication of insulin therapy, which has only rarely been reported in childhood. We describe a case of a 12-year-old girl with newly diagnosed type 1 diabetes, who presented with oedema of the lower extremities and periorbitally, one day after the initiation of insulin treatment. Other causes of oedema were excluded. Following administration of frusemide, oedema resolved within ten days. An extended review of the literature revealed only nine cases of insulin-induced oedema in children and adolescents aged =16 years. In conclusion, insulin-induced oedema should be ... Read More »
» Published in J Paediatr Child Health. 2006 Oct;42(10):655-7.
2. Prevention and Treatment of Type 2 Diabetes in Youth.
Match Strength: 6.214
Parallel to the increase in obesity worldwide, there has been a rise in the prevalence of type 2 diabetes mellitus (T2DM) in children and adolescents. The etiology of T2DM in youth, similar to adults, is multifactorial including genetic and environmental factors, among them obesity, sedentary lifestyle, family history of the disease, high-risk ethnicity and insulin resistance phenotype playing major roles. Treatment of T2DM should not have a glucocentric approach; it should rather target improving glycemia, dyslipidemia, hypertension, weight management and the prevention of short- and long ... Read More »
» Published in Horm Res. 2006 Sep 28;67(1):22-34
3. Relationship between lipid abnormalities and insulin resistance in Japanese school children.
Match Strength: 4.064
OBJECTIVE: Dyslipidemia and insulin resistance (IR) are risk factors for coronary heart disease (CHD) in adults. To help prevent the development of CHD, it may be useful to understand the relationship between lipid abnormalities and IR during childhood. METHODS AND RESULTS: IR was assessed by the homeostasis model approximation index. We studied 1175 Japanese school children (642 boys and 533 girls), aged between 7 and 12 years. Obesity was defined by the body mass index standard deviation score (BMISD) (obese: BMISD > or = 2.0). BMISD was most significantly associated with IR in nonobese ... Read More »
» Published in Arterioscler Thromb Vasc Biol. 2006 Dec;26(12):2781-6. Epub 2006 Sep 21.
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