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Peer Reviewed Scientific Research Reports.
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1. Novel solvent-free fabrication of biodegradable poly-lactic-glycolic acid (PLGA) capsules for antibiotics and rhBMP-2 delivery.
Match Strength: 7.225
Osteomyelitis has been one of the most common causes of post-operative problems and complications despite the advances in surgical techniques and the availability of newly developed antibiotics. Local antibiotic and growth factor delivery devices for treatment of various surgical infections have been studied recently, especially in the case of orthopedic infections. The report was to develop novel solvent-free biodegradable capsules for antibiotics and growth factors delivery. To fabricate a biodegradable capsule, polylactide-polyglycolide copolymers were pre-mixed with vancomycin. The mixture ... Read More »
» Published in Int J Pharm. 2007 Feb 7;330(1-2):45-53. Epub 2006 Aug 30.
2. Alkylcyanoacrylate nanocapsules prepared from mini-emulsions: a comparison with the conventional approach.
Match Strength: 6.466
Polyalkylcyanoacrylate nanocapsules are being prepared using two different types of o/w-emulsions: a conventional emulsion generated by intensive stirring with a home-made device and a mini-emulsion produced by the action of ultrasonic dispersion, using the alkylcyanoacrylate monomer as a hydrophobic agent. The emulsions and the resulting nanocapsule dispersions are compared using various methods of physical characterization. The formation of solid capsules is indicated by solid state NMR spectra and atomic force microscopy. Differences between the results of both synthetic approaches are ... Read More »
» Published in J Microencapsul. 2006 Aug;23(5):567-81.
3. Regional variation is present in elbow capsules after injury.
Match Strength: 6.458
Myofibroblast numbers and alpha-smooth muscle actin expression are increased in anterior joint capsules of patients with posttraumatic elbow contractures. The purpose of our study was to determine whether these changes occur regionally or throughout the entire joint capsule. We hypothesized that the alpha-smooth muscle actin mRNA expression and the myofibroblast numbers in posterior joint capsules would be elevated in elbows obtained from patients with posttraumatic joint contractures compared with joint capsules obtained from organ donor elbows without contractures. Semiquantitative reverse ... Read More »
» Published in Clin Orthop Relat Res. 2006 Sep;450:219-24.
4. Strategies to Promote Chondrogenesis and Osteogenesis from Human Bone Marrow Cells and Articular Chondrocytes Encapsulated in Polysaccharide Templates.
Match Strength: 5.211
The aim of this study was to synthesize functional in vitro and in vivo 3-dimensional (3D) constructs using a mix of human mesenchymal populations and articular chondrocytes encapsulated in biomineralized polysaccharide templates. Single-cell-type populations or mixtures of both cell types were encapsulated in alginate/chitosan and cultured within a rotating-bioreactor, perfused bioreactor system, or static conditions for 28 days. Within single cell-type populations, type II collagen immunopositive cells were present within lacunae in rotating-bioreactor capsules, with an increased proportion ... Read More »
» Published in Tissue Eng. 2006 Sep 1;
5. Formulation and development of gastroretentive drug delivery system for ofloxacin.
Match Strength: 4.940
The aim of the present study was to develop a delivery system wherein the retention of ofloxacin could be achieved for increased local action in gastric region against Helicobacter pylori infection. The formulation was optimized on the basis of in vitro buoyancy and in vitro release in citrate phosphate buffer (pH 3). The hydrodynamically balanced capsules were prepared by physical mixing of various grades of HPMC and poly(ethylene oxide) (PEO) alone as well as in combinations. Cellulose acetate pthalate, liquid paraffin, and ethyl cellulose were used as release modifiers so as to maintain ... Read More »
» Published in Methods Find Exp Clin Pharmacol. 2006 Sep;28(7):433-9.
6. Dynamics of benzene guest inside a self-assembled cylindrical capsule: a combined solid-state 2H NMR and molecular dynamics simulation study.
Match Strength: 3.818
The reorientational dynamics of benzene-d(6) molecules hosted into the cavity of a cavitand-based, self-assembled capsule was investigated by Molecular Dynamics (MD) simulations and temperature-dependent solid-state (2)H NMR spectroscopy. MD simulations were preliminarily performed to assess the motional models of the guest molecules inside the capsules. An in-plane fast reorientation of the benzene guest around the C(6) symmetry axis (B1 motion), characterized by correlation times of the order of picoseconds, was predicted with an activation barrier ( approximately 8 kJ/mol) very similar to ... Read More »
» Published in J Phys Chem B Condens Matter Mater Surf Interfaces Biophys. 2006 Oct 5;110(39):19207-14.
7. Analysis of different beta-lactams antibiotics in pharmaceutical preparations using micellar electrokinetic capillary chromatography.
Match Strength: 3.135
The potential of micellar electrokinetic capillary chromatography (MEKC) for analyzing nine beta-lactams antibiotics (cloxacillin, dicloxacillin, oxacillin, penicillin G, penicillin V, ampicillin, nafcillin, piperacillin, amoxicillin) in different pharmaceutical preparations, have been demonstrated. An experimental design strategy has been applied to optimize the main variables: pH and buffer concentration, concentration of the micellar medium, separation voltage and capillary temperature. Borate buffer (26mM) at pH 8.5 containing 100mM sodium dodecyl sulphate (SDS) was used as the background ... Read More »
» Published in J Pharm Biomed Anal. 2007 Jan 17;43(2):746-52. Epub 2006 Sep 15.
8. A new myxozoan parasite from the Amazonian fish Metynnis argenteus (Teleostei, Characidae): light and electron microscope observations.
Match Strength: 2.725
Myxobolus metynnis n. sp. (Phylum Myxozoa) is described in the connective subcutaneous tissues of the orbicular region of the fish, Metynnis argenteus (Characidae), collected in the lower Amazon River, near the city of Peixe Boi, Para State, Brazil. Polysporic, histozoic plasmodia were delimited by a double membrane with numerous microvilli on the peripheral cytoplasm. Several life-cycle stages, including mature spores, were observed. An envelope formed by numerous fine and anastomosed microfibrils was observed at the spore surface. The spore body presented an ellipsoidal shape and was about ... Read More »
» Published in J Parasitol. 2006 Aug;92(4):817-21.
9. Effect of dietary sodium chloride on gastro-oesophageal reflux: a randomized controlled trial.
Match Strength: 2.644
OBJECTIVE: It has been suggested that a high consumption of sodium chloride (NaCl) is associated with reflux symptoms. The objective of this study was to investigate the effect of increased dietary NaCl intake on gastro-oesophageal reflux and reflux mechanisms. MATERIAL AND METHODS: In this double-blind, placebo-controlled, crossover study 10 healthy male subjects received 5 g NaCl or placebo in capsules per day for one week, after which concurrent manometric, pH and impedance monitoring was carried out for 4.5 h. RESULTS: Oesophageal acid exposure time (pH < 4) was similar for placebo ... Read More »
» Published in Scand J Gastroenterol. 2006 Oct;41(10):1141-6.
10. Delivery of esomeprazole magnesium through nasogastric and gastrostomy tubes using an oral liquid vehicle as a suspending agent in vitro.
Match Strength: 2.507
PURPOSE: The optimal delivery medium for esomeprazole magnesium enteric-coated pellets dispersed in various concentrations of Ora-Plus suspension through commonly used nasogastric and gastrostomy tubes using a previously used standardized in vitro protocol was studied. METHODS: The study was conducted in two phases. In phase A, 60 size 14 French nasogastric tubes were used to compare esomeprazole pellet delivery via tap water or 30, 50, or 70% Ora-Plus concentrations (15 tubes for each). In phase B, tap water and the concentration that yielded the best pellet delivery from phase A were used ... Read More »
» Published in Am J Health Syst Pharm. 2006 Oct 1;63(19):1882-7.
11. Histological assessment of titanium and polypropylene fiber mesh implantation with and without fibrin tissue glue.
Match Strength: 2.492
Polypropylene (PP) and titanium (Ti) meshes are well-known surgical implants that provoke a relative low foreign body reaction. Firm stabilization of the implant is important to prevent migration and subsequent failure of the operation. Fibrin tissue glues are commercially available adhesives and are widely accepted and applied in the medical field for hemorrhage, surgical bleeding, support of wound healing, wound and tissue gluing, sealing, and closure but also as antiadhesive agent in certain applications. The objective of this study was to evaluate the additional histological effect of ... Read More »
» Published in J Biomed Mater Res A. 2007 Feb;80(2):372-80.
12. The structure, location, and function of perlecan, a prominent pericellular proteoglycan of fetal, postnatal, and mature hyaline cartilages.
Match Strength: 2.429
The aim of this study was to immunolocalize perlecan in human fetal, postnatal, and mature hyaline cartilages and to determine information on the structure and function of chondrocyte perlecan. Perlecan is a prominent component of human fetal (12-14 week) finger, toe, knee, and elbow cartilages; it was localized diffusely in the interterritorial extracellular matrix, densely in the pericellular matrix around chondrocytes, and to small blood vessels in the joint capsules and perichondrium. Aggrecan had a more intense distribution in the marginal regions of the joint rudiments and in para ... Read More »
» Published in J Biol Chem. 2006 Dec 1;281(48):36905-14. Epub 2006 Sep 19.
13. Immunity and antioxidant capacity in humans is enhanced by consumption of a dried, encapsulated fruit and vegetable juice concentrate.
Match Strength: 2.400
The daily consumption of fruits and vegetables is a common dietary recommendation to support good health. We hypothesized that a commercially available encapsulated fruit and vegetable juice powder concentrate (FVJC) could support functional indices of health due to increased intake of various phytonutrients. This was a double-blind, randomized, placebo-controlled investigation of 59 healthy law students who consumed either FVJC or placebo capsules for 77 d. Blood was collected on d 1, 35, and 77 to examine the number of circulating alphabeta- and gammadelta-T cells, cytokine production, ... Read More »
» Published in J Nutr. 2006 Oct;136(10):2606-10.
14. Osteoinductivity of demineralized bone matrix in immunocompromised mice and rats is decreased by ovariectomy and restored by estrogen replacement.
Match Strength: 2.136
The osteoinduction potential of human demineralized bone matrix (DBM) in females with low estrogen (E2) is unknown. Moreover, the osteoinductivity of commercial human DBM is tested in male athymic rats and mice, but DBM performance in these animals may not reflect performance in female animals or provide information on E2's role in the process. To gain insight, human DBM was implanted bilaterally in the gastrocnemius of twenty-four athymic female mice (10 mg/implant) and twenty-four athymic female rats (15 mg/implant). Eight animals in each group were sham-operated (SHAM), ovariectomized (OVX) ... Read More »
» Published in Bone. 2007 Jan;40(1):111-21. Epub 2006 Sep 14.
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