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Peer Reviewed Scientific Research Reports.
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1. Current research in otosclerosis.
Match Strength: 5.861
PURPOSE OF REVIEW: The aim of this article is to summarize and put into historical perspective current advances in research in otosclerosis, a disorder of the human temporal bone with a hereditary predisposition that is among the most common causes of acquired hearing loss. RECENT FINDINGS: Genetic studies have revealed that otosclerosis is heterogeneous, with evidence for defects in at least seven genes associated with six distinct chromosomal loci. Measurements of high levels of osteoprotegerin expression in the normal otic capsule and soft tissues of the cochlea provide the first molecular ... Read More »
» Published in Curr Opin Otolaryngol Head Neck Surg. 2006 Oct;14(5):347-51.
2. Clinical observation on effect of Kaixin capsule in treating 40 patients with diabetic myocardial ischemia.
Match Strength: 4.487
OBJECTIVE: To observe the effect of Kaixin Capsule (KXC) on myocardial ischemia and plasma endothelin (ET) level in patients with diabetic heart disease (DHD). METHODS: The 72 subjects for observation were randomly selected from inpatients whose diagnosis fit to the standard of DHD. The 32 patients allocated in the control group were treated with conventional Western medicine, and the 40 patients in the treated group were treated with conventional Western medicine in combination with KXC, with the therapeutic course for both groups as 60 days. RESULTS: On ECG, the total effective rate and ... Read More »
» Published in Chin J Integr Med. 2006 Sep;12(3):215-7.
3. Dynamics of benzene guest inside a self-assembled cylindrical capsule: a combined solid-state 2H NMR and molecular dynamics simulation study.
Match Strength: 4.341
The reorientational dynamics of benzene-d(6) molecules hosted into the cavity of a cavitand-based, self-assembled capsule was investigated by Molecular Dynamics (MD) simulations and temperature-dependent solid-state (2)H NMR spectroscopy. MD simulations were preliminarily performed to assess the motional models of the guest molecules inside the capsules. An in-plane fast reorientation of the benzene guest around the C(6) symmetry axis (B1 motion), characterized by correlation times of the order of picoseconds, was predicted with an activation barrier ( approximately 8 kJ/mol) very similar to ... Read More »
» Published in J Phys Chem B Condens Matter Mater Surf Interfaces Biophys. 2006 Oct 5;110(39):19207-14.
4. Effects of Quyu Xiaoban Capsule on vascular endothelial function in patients with atherosclerosis.
Match Strength: 4.101
OBJECTIVE: To evaluate the therapeutic effects of Quyu Xiaoban Capsule (QYXBC) on endothelial dependent vascular relaxation (EDVR) function in patients with atherosclerosis (AS) with ultrasonic technique. METHODS: Tested were the endothelial function and blood lipids of 42 patients with AS in the treated group and 30 healthy volunteers in the control group. And re-examination of these parameters was carried out on the AS patients after they had been treated with QYXBC for 10 months. RESULTS: Before treatment, the reactive hyperemia induced changes in artery diameter in the treated group was ... Read More »
» Published in Chin J Integr Med. 2006 Sep;12(3):171-4.
5. Histological assessment of titanium and polypropylene fiber mesh implantation with and without fibrin tissue glue.
Match Strength: 3.870
Polypropylene (PP) and titanium (Ti) meshes are well-known surgical implants that provoke a relative low foreign body reaction. Firm stabilization of the implant is important to prevent migration and subsequent failure of the operation. Fibrin tissue glues are commercially available adhesives and are widely accepted and applied in the medical field for hemorrhage, surgical bleeding, support of wound healing, wound and tissue gluing, sealing, and closure but also as antiadhesive agent in certain applications. The objective of this study was to evaluate the additional histological effect of ... Read More »
» Published in J Biomed Mater Res A. 2007 Feb;80(2):372-80.
6. Regional variation is present in elbow capsules after injury.
Match Strength: 3.843
Myofibroblast numbers and alpha-smooth muscle actin expression are increased in anterior joint capsules of patients with posttraumatic elbow contractures. The purpose of our study was to determine whether these changes occur regionally or throughout the entire joint capsule. We hypothesized that the alpha-smooth muscle actin mRNA expression and the myofibroblast numbers in posterior joint capsules would be elevated in elbows obtained from patients with posttraumatic joint contractures compared with joint capsules obtained from organ donor elbows without contractures. Semiquantitative reverse ... Read More »
» Published in Clin Orthop Relat Res. 2006 Sep;450:219-24.
7. The expression profiles of nuclear receptors in the developing and adult kidney.
Match Strength: 3.598
Nuclear receptors are transcriptional regulators that play important roles in embryonic development and organogenesis. To study the potential roles of nuclear receptors in kidney development, we examined the expression patterns of a subset of nuclear receptors in which specific antibodies are available for profiling using immunohistochemistry. As a prototype for our analysis, we investigated the expression patterns of chicken ovalbumin upstream promoter transcription factor (COUP-TF) -I and -II in more details during embryonic development and in the adult by immunohistochemistry. We showed ... Read More »
» Published in Mol Endocrinol. 2006 Dec;20(12):3412-20. Epub 2006 Sep 14.
8. Normal anatomy and common labral lesions at MR arthrography of the shoulder.
Match Strength: 3.387
MR arthrography of the shoulder is the most accurate imaging modality in demonstrating abnormalities of the glenoid labrum and associated structures. Tears of the labrum, the capsule or the gleno-humeral ligaments can lead to pain, catching, popping or instability. The anatomy of this region is complex. We present the normal anatomy of the glenoid labrum, biceps anchor and gleno-humeral ligaments together with their normal variants and then describe common labral-ligamentous pathologies. Publication Types: ... Read More »
» Published in Clin Radiol. 2006 Oct;61(10):805-21.
9. Developing an ELISA using serotype-specific antigens from selected pneumococcal strains of own selection.
Match Strength: 3.123
Streptococcus pneumoniae (pneumococcus) is a significant cause of morbidity and mortality in infants and elderly people. Pneumococcal strains possess a polysaccharide capsule, and 90 different serotypes have been identified. The pneumococcal ELISA suggested by World Health Organization (WHO) guidelines is based on capsular serotypes included in the 23-valent polysaccharide vaccine (Pneumovax((R))). Pneumococcal antigens were developed and applied in an ELISA, which elicited a low baseline cross-reaction with the common cell wall polysaccharide (C-Ps). The aim of this study was to develop an ... Read More »
» Published in Vaccine. 2006 Sep 20;
10. Streptococcus pneumoniae virulence factors and their clinical impact: An update.
Match Strength: 3.083
The morbidity and mortality rates associated with Streptococcus pneumoniae remain very high worldwide. The virulence of this bacterium is largely dependent on its polysaccharide capsule, which is quite heterogeneous and represents a serious obstacle for designing effective vaccines. However, it has been demonstrated that numerous protein virulence factors are involved in the pathogenesis of pneumococcal disease. An important related finding from experimental animal models is that non-capsulated strains of pneumococci are protective against capsulated ones. Hence, new vaccine designs are ... Read More »
» Published in Enferm Infecc Microbiol Clin. 2006 Oct;24(8):512-7.
11. The morphology and function of the quadrate ligament.
Match Strength: 2.931
There is a paucity of information in the literature regarding the quadrate ligament and the information that does exist is extremely conflicting. We dissected 30 cadavers (60 sides) to determine the morphology and function of this enigmatic ligament. A quadrate ligament (thickening of the elbow joint capsule) was found in all specimens. In all specimens this band was distinct from the circumferential fibres of the annular ligament. The length, width, and thickness of the quadrate ligament were found to be 11 mm, 8 mm, and 1 mm respectively. This ligament not only aided in securing the neck of ... Read More »
» Published in Folia Morphol (Warsz). 2006 Aug;65(3):225-7.
12. Osteoarthritis, application of physical therapy proceduers.
Match Strength: 2.859
Osteoarthritis (OA) is a group of overlapping disorders, which may have different aetiology but similar biological, morphologic and clinical outcome. In osteoarthritis, process will not encompass the joint cartilage only, but the entire joint, including sub-hondral bone, ligaments, capsule, and sinovial membrane and surrounding muscles. Osteoarthritis is a multi-factor disorder of sinovial joints, which occurs as result of mechanical and biological factors, which destabilise normal hondrocyte function, partitioning of cartilage, extra-cellular matrix and sub-hondral bone. The earliest changes, ... Read More »
» Published in Bosn J Basic Med Sci. 2006 Aug;6(3):84-8.
13. Alkylcyanoacrylate nanocapsules prepared from mini-emulsions: a comparison with the conventional approach.
Match Strength: 2.826
Polyalkylcyanoacrylate nanocapsules are being prepared using two different types of o/w-emulsions: a conventional emulsion generated by intensive stirring with a home-made device and a mini-emulsion produced by the action of ultrasonic dispersion, using the alkylcyanoacrylate monomer as a hydrophobic agent. The emulsions and the resulting nanocapsule dispersions are compared using various methods of physical characterization. The formation of solid capsules is indicated by solid state NMR spectra and atomic force microscopy. Differences between the results of both synthetic approaches are ... Read More »
» Published in J Microencapsul. 2006 Aug;23(5):567-81.
14. Real-time imaging of transscleral diode laser cyclophotocoagulation by optical coherence tomography.
Match Strength: 2.714
PURPOSE: To present optical coherence tomography (OCT) for real-time imaging of cyclophotocoagulation effects. METHODS: In a pilot study, real-time transscleral OCT images were generated during diode laser cyclophotocoagulation in four eyes of four patients suffering from uncontrolled glaucoma using a specially designed contact applicator containing the OCT fiber, a focussing fiber optic and the fiber of the diode laser. RESULTS: When the contact system was used, two layers could be differentiated: a superficial thick hyperreflective complex representing conjunctiva, Tenon's capsule, episclera ... Read More »
» Published in Graefes Arch Clin Exp Ophthalmol. 2006 Sep 28;
15. Evidence for oxidative stress in lens epithelial cells in pseudoexfoliation syndrome.
Match Strength: 2.653
PurposeTo investigate the oxidative status in lens epithelial cells of patients with pseudoexfoliation (PEX) syndrome.MethodsLens capsule samples obtained during cataract surgery of patients with PEX syndrome and normal age-matched control subjects were examined for changes in the levels of glutathione (GSH), glutathione disulphide (GSSG), protein concentration, and lipid peroxidation. Concentrations of GSH, GSSG, lipid peroxidation, and protein concentration were determined by specific fluorescent assays.ResultsThis study shows a 2.2- and 2.0-fold decrease in GSH and GSSG levels, respectively ... Read More »
» Published in Eye. 2006 Sep 22;
16. Magnetic resonance imaging of gadolinium-labeled pancreatic islets for experimental transplantation.
Match Strength: 2.554
New imaging techniques that couple anatomical resolution to sensitivity may greatly contribute to improving islet transplantation. In the present work, a report is given of the direct detection of islets by magnetic resonance imaging (MRI) after ex vivo cell labeling with the MRI T(1) contrast agent GdHPDO3A. Experiments on mouse and human islets demonstrated well-tolerated uptake of GdHPDO3A, based on morphology, viability, glucose-dependent insulin response and apoptosis/toxicity gene array profile. GdHPDO3A loading was sufficient for in vitro MRI cell detection. In vivo isotransplanted ... Read More »
» Published in NMR Biomed. 2007 Feb;20(1):40-8.
17. Single dose of tiotropium improves the 6-minute walk distance in chronic obstructive pulmonary disease.
Match Strength: 2.419
The aim of this study was to evaluate the effect of a single dose of tiotropium on the exercise capacity of stable chronic obstructive pulmonary disease (COPD) patients. The study was a randomized, placebo-controlled, double-blind, cross-over study. Forty-four stable COPD patients with moderate to severe airway obstruction were selected according to the GOLD criteria. The regular anticholinergic therapies of the patients were interrupted one week before the test. In the morning hours of the first day, half the group was given one capsule (18 mcg) of tiotropium and the other half was given ... Read More »
» Published in Lung. 2006 Jul-Aug;184(4):201-4.
18. A new structural domain in the Escherichia coli RcsC hybrid sensor kinase connects histidine kinase and phosphoreceiver domains.
Match Strength: 2.417
The Rcs signalling pathway controls a variety of physiological functions like capsule synthesis, cell division or motility in prokaryotes. The Rcs regulation cascade, involving a multi-step phosphorelay between the two membrane-bound hybrid sensor kinases RcsC and RcsD and the global regulator RcsB, is, up to now, one of the most complicated regulatory systems in bacteria. To understand the structural basis of Rcs signal transduction, NMR spectroscopy was employed to determine the solution structure of the RcsC C terminus, possessing a phosphoreceiver domain (RcsC-PR), and a region previously ... Read More »
» Published in J Mol Biol. 2006 Nov 17;364(1):68-79. Epub 2006 Jul 29.
19. Novel solvent-free fabrication of biodegradable poly-lactic-glycolic acid (PLGA) capsules for antibiotics and rhBMP-2 delivery.
Match Strength: 2.374
Osteomyelitis has been one of the most common causes of post-operative problems and complications despite the advances in surgical techniques and the availability of newly developed antibiotics. Local antibiotic and growth factor delivery devices for treatment of various surgical infections have been studied recently, especially in the case of orthopedic infections. The report was to develop novel solvent-free biodegradable capsules for antibiotics and growth factors delivery. To fabricate a biodegradable capsule, polylactide-polyglycolide copolymers were pre-mixed with vancomycin. The mixture ... Read More »
» Published in Int J Pharm. 2007 Feb 7;330(1-2):45-53. Epub 2006 Aug 30.
20. Comparative analysis of the excretory-secretory proteome of the muscle larva of Trichinella pseudospiralis and Trichinella spiralis.
Match Strength: 2.332
The nematodes Trichinella spiralis and Trichinella pseudospiralis are both intracellular parasites of skeletal muscle cells and induce profound alterations in the host cell resulting in a re-alignment of muscle-specific gene expression. While T. spiralis induces the production of a collagen capsule surrounding the host-parasite complex, T. pseudospiralis exists in a non-encapsulated form and is also characterised by suppression of the host inflammatory response in the muscle. These observed differences between the two species are thought to be due to variation in the proteins excreted or ... Read More »
» Published in Int J Parasitol. 2007 Feb;37(2):139-48. Epub 2006 Sep 15.
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