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Peer Reviewed Scientific Research Reports.
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1. Long-term lamotrigine plus lithium for bipolar disorder: One year outcome.
Match Strength: 9.888
OBJECTIVE: To obtain pilot data in an observational setting on the use of lamotrigine plus lithium in the long-term treatment of patients with bipolar disorder, 87% of whom had failed to respond to at least one previous mood stabilizer. METHODS: Charts of 21 patients (11 females, 10 males, mean age 43.2 years) treated with the combination of lithium and lamotrigine were reviewed retrospectively for treatment response using the Clinical Global Impression-Bipolar Disorder-Improvement scale, divided into benefit for acute depressive symptoms, acute manic symptoms, and overall illness (including ... Read More »
» Published in J Psychiatr Pract. 2006 Sep;12(5):300-5.
2. Hypomethylation of MB-COMT promoter is a major risk factor for schizophrenia and bipolar disorder.
Match Strength: 9.661
The variability in phenotypic presentations and the lack of consistency of genetic associations in mental illnesses remain a major challenge in molecular psychiatry. Recently, it has become increasingly clear that altered promoter DNA methylation could play a critical role in mediating differential regulation of genes and in facilitating short-term adaptation in response to the environment. Here, we report the investigation of the differential activity of membrane-bound catechol-O-methyltransferase (MB-COMT) due to altered promoter methylation and the nature of the contribution of COMT ... Read More »
» Published in Hum Mol Genet. 2006 Nov 1;15(21):3132-45. Epub 2006 Sep 19.
3. Comparison of clinical characteristics in episodic and chronic obsessive-compulsive disorder.
Match Strength: 9.088
Our objective in this study was to compare the demographics and clinical characteristics of patients with episodic and chronic obsessive-compulsive disorder (OCD). We recruited 128 outpatients with a primary diagnosis of OCD according to DSM-IV diagnostic criteria. The episodic (n=24) and chronic (n=104) OCD patient groups were compared with respect to demographic variables and scores from various psychiatric rating scales. The severity of compulsions was found to be significantly lower in the episodic OCD group than in the chronic OCD group. When the frequency of Axis I disorders was assessed ... Read More »
» Published in Depress Anxiety. 2006 Sep 27;
4. Dimensions underlying outcome criteria in bipolar I disorder.
Match Strength: 8.949
OBJECTIVE: Various subjective and objective criteria are used to assess outcome in bipolar disorder. In this study, we explored to what extent they reflect distinct categories and whether underlying dimensions can be identified. PATIENTS AND METHODS: One-hundred and twenty-one subjects with at least three episodes of bipolar I disorder (DSM-IV) were assessed on average 4.8 years after hospitalization. We assessed 14 variables reflecting different outcome criteria including subjective quality of life (SQOL), self-rated and observer-rated psychopathology, and functioning and disability. A ... Read More »
» Published in J Affect Disord. 2006 Sep 20;
5. Obesity in bipolar disorder and major depressive disorder: results from a national community health survey on mental health and well-being.
Match Strength: 8.164
OBJECTIVE: We aimed to ascertain the prevalence of obesity in individuals with a mood disorder (MD) (that is, bipolar disorder or major depressive disorder), compared with the general population. We further aimed to examine the likelihood of an association between obesity and MD, while controlling for the influence of sociodemographic variables. METHOD: The analysis was based on data from Statistics Canada's Canadian Community Health Survey: Mental Health and Well-Being (CCHS 1.2), conducted in 2002. The sample (n = 36 984; > or = aged 15 years) was drawn from the Canadian household ... Read More »
» Published in Can J Psychiatry. 2006 Apr;51(5):274-80.
6. Maintenance treatment of bipolar disorder: Applying research to clinical practice.
Match Strength: 7.413
The authors review available controlled trials of bipolar maintenance treatment and discuss the strengths and weaknesses of various study designs. Bipolar maintenance trials are organized according to the features of their designs, such as use of responder-enriched samples; inclusion following an index manic versus an index depressive episode; outcome defined as relapse into mania, depression, or either; and use of survival analysis. Pivotal studies of lithium, divalproex, lamotrigine, olanzapine, aripiprazole, and other medications are reviewed. The directional efficacy of the different ... Read More »
» Published in J Psychiatr Pract. 2006 Sep;12(5):283-99.
7. Persistent tobacco use during pregnancy and the likelihood of psychiatric disorders.
Match Strength: 7.101
OBJECTIVES: We examined the association between psychiatric disorders and tobacco use during pregnancy. METHODS: Data were derived from a population-based cohort of 744 pregnant African American and White low-income women living in urban and rural areas. The Diagnostic Interview Schedule was used to assess women for 20 different psychiatric disorders. RESULTS: In comparison with nonusers, persistent tobacco users (women who had used tobacco after confirmation of their pregnancy) and nonpersistent users (women who had used tobacco but not after pregnancy confirmation) were 2.5 and 2 times as ... Read More »
» Published in Am J Public Health. 2006 Oct;96(10):1799-807.
8. Dietary n-3 PUFA deprivation alters expression of enzymes of the arachidonic and docosahexaenoic acid cascades in rat frontal cortex.
Match Strength: 6.468
The enzymes that regulate the brain arachidonic acid (AA) cascade have been implicated in bipolar disorder and neuroinflammation. Fifteen weeks of dietary n-3 polyunsaturated fatty acid (PUFA) deprivation in rats decreases the concentration of docosahexaenoic acid (DHA) and increases its half-life within the brain. Based on this, we hypothesized that such dietary deprivation would decrease expression of enzymes responsible for the metabolic loss of DHA while increasing expression of those responsible for the metabolism of AA. Fifteen weeks of n-3 PUFA deprivation significantly decreased the ... Read More »
» Published in Mol Psychiatry. 2007 Feb;12(2):151-7. Epub 2006 Sep 19.
9. Bipolar II and anxious reactive "comorbidity": toward better phenotypic characterization suitable for genotyping.
Match Strength: 6.266
OBJECTIVE: In DSM-IV, bipolar II (BP-II) disorder is defined by depression and hypomania. There is little appreciation of affective instability, often associated with anxiety-particularly panic disorder and agoraphobia (PDA)-comorbidity. This association has genetic-familial implications, which we believe must be incorporated in refining the BP-II phenotype suitable for genotyping purposes. METHOD: We examined in a semi-structured format 107 consecutive patients who met DSM-IV criteria for major depressive episode with atypical features and separated them into two subgroups according to the co ... Read More »
» Published in J Affect Disord. 2006 Dec;96(3):239-47. Epub 2006 Sep 14.
10. Prefrontal hyperactivation during working memory task in untreated individuals with major depressive disorder.
Match Strength: 5.156
The prefrontal cortex, a part of the limbic-thalamic-cortical network, participates in regulation of mood, cognition and behavior and has been implicated in the pathophysiology of major depressive disorder (MDD). Many neuropsychological studies demonstrate impairment of working memory in patients with MDD. However, there are few functional neuroimaging studies of MDD patients during working memory processing, and most of the available ones included medicated patients or patients with both MDD and bipolar disorder. We used functional magnetic resonance imaging (fMRI) to measure prefrontal ... Read More »
» Published in Mol Psychiatry. 2007 Feb;12(2):158-66. Epub 2006 Sep 19.
11. Screening for serious mental illness in populations with co-occurring substance use disorders: Performance of the K6 scale.
Match Strength: 5.050
Serious mental illnesses (SMIs) such as schizophrenia, bipolar disorder, and major depression are prevalent among individuals with substance use disorders, particularly those in drug treatment programs. No screening tool has yet become the gold standard for identifying SMI among individuals with substance use disorders. One candidate instrument, the K6 screening scale, is brief, easy to administer and score, and has performed well, detecting SMI in studies using general population samples. We used data from the National Survey on Drug Use and Health to examine the K6's psychometric properties ... Read More »
» Published in J Subst Abuse Treat. 2006 Oct;31(3):287-96. Epub 2006 Jul 18.
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