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Peer Reviewed Scientific Research Reports.
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1. The Community Balance and Mobility Scale--a balance measure for individuals with traumatic brain injury.
Match Strength: 5.397
OBJECTIVE: To provide evidence for the validity and reliability of a new outcome measure of balance, the Community Balance and Mobility Scale, developed for the ambulatory individual with traumatic brain injury. DESIGN: A validity and reliability study. SETTING: Acute care, in- and outpatient rehabilitation and day hospital settings. SUBJECTS: Two convenience samples (n=36, 32) of ambulatory patients with traumatic brain injury. MAIN MEASURES: The content and construct validity, test-retest, inter- and intra-rater reliability and internal consistency of the Community Balance and Mobility Scale ... Read More »
» Published in Clin Rehabil. 2006 Oct;20(10):885-95.
2. Balance performance in adult epilepsy patients.
Match Strength: 5.207
PURPOSE: To evaluate the magnitude of subclinical balance dysfunction in adult epilepsy patients and to assess the relative contribution of different variables to balance impairment. METHODS: Balance performance was evaluated by computerized dynamic platform posturography (CDPP) in 25 adult patients following a generalized tonic-clonic seizure (GTCS) and in 11 healthy subjects. RESULTS: The GTCS was a breakthrough seizure in 20 patients with epilepsy and a first seizure in 5. Seven of the patients had localization-related epilepsy and 13 had generalized epilepsy. Mean epilepsy duration was 6.6 ... Read More »
» Published in Seizure. 2006 Dec;15(8):582-9. Epub 2006 Sep 15.
3. Task-oriented intervention in chronic stroke: changes in clinical and laboratory measures of balance and mobility.
Match Strength: 4.898
OBJECTIVE: The objective of this study was to evaluate whether, after a task-oriented exercise program, the changes in clinical measures of balance and mobility were paralleled by changes in biomechanical parameters in subjects with chronic stroke. DESIGN: Ten stroke subjects took part in an 8-wk exercise program aimed at improving balance and mobility through various functional tasks. Subjects were evaluated before and after the exercise intervention. Clinical measures included the Berg Balance Scale and the Timed-Up-and-Go and laboratory measures included ground reaction forces and center of ... Read More »
» Published in Am J Phys Med Rehabil. 2006 Oct;85(10):820-30.
4. Mathematical modeling of living cell metabolism using the method of steady-state stoichiometric flux balance.
Match Strength: 4.720
This approach uses a set of algebraic linear equations for reaction rates (the method of steady-state stoichiometric flux balance) to model the purposeful metabolism of the living self-reproducing biochemical system (i.e. cell), which persists in steady-state growth. Linear programming (SIMPLEX method) is used to derive the solution for the model equations set (determining reaction rates which provide flux balance at given conditions). Here, we demonstrate the approach through the mathematical modeling of steady-state metabolism in Saccharomyces cerevisiae mitochondria ... Read More »
» Published in J Bioinform Comput Biol. 2006 Aug;4(4):865-85.
5. An analysis of sagittal spinal alignment following long adult lumbar instrumentation and fusion to L5 or S1: can we predict ideal lumbar lordosis?
Match Strength: 4.667
STUDY DESIGN: A retrospective study. OBJECTIVE: To determine factors controlling sagittal spinal balance after long adult lumbar instrumentation and fusion from the thoracolumbar spine to L5 or S1. SUMMARY OF BACKGROUND DATA: To our knowledge, no study on postoperative sagittal balance following long adult spinal instrumentation and fusion to L5 or S1 has been published. METHODS: A clinical and radiographic assessment of 80 patients with adult lumbar deformity (average age 53.4 years) who underwent long (average 7.6 vertebrae, 5-11 vertebrae) segmental posterior spinal instrumentation and ... Read More »
» Published in Spine. 2006 Sep 15;31(20):2343-52.
6. Testing for renewal and detailed balance violations in single-molecule blinking processes.
Match Strength: 4.481
This paper examines methods to test one- and two-dimensional histograms for several features including the renewal properties, detailed balance violations, and experimental condition dependences. The tests are simple to implement and allow rigorous statistical determination of the existence of these kinetic features. The tests are used to determine the lower bound on the number of measurements necessary to differentiate underlying kinetic models. Publication Types: Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S ... Read More »
» Published in J Phys Chem B Condens Matter Mater Surf Interfaces Biophys. 2006 Sep 28;110(38):19009-17.
7. Effect of central administration of QRFP(26) peptide on energy balance and characterization of a second QRFP receptor in rat.
Match Strength: 4.154
The recently identified neuropeptide QRFP(26) is predominantly expressed in the hypothalamus and was suggested to play a role in the regulation of food intake following the observation of an acute orexigenic effect after central administration in mice. QRFP(26) exerts its effect via GPR103 and a newly identified receptor in mouse. The aim of our study was (a) to investigate the distribution of QRFP(26) and a newly discovered QRFP receptor mRNA in rat and (b) to further characterize the effects of central administration of QRFP(26) on energy balance in rats. QRFP(26) mRNA was detected in the ... Read More »
» Published in Brain Res. 2006 Nov 13;1119(1):133-49. Epub 2006 Sep 22.
8. Social sex selection and the balance of the sexes: empirical evidence from Germany, the UK, and the US.
Match Strength: 4.146
Preconception sex selection for nonmedical reasons is one of the most controversial issues in bioethics today. The most powerful objection to social sex selection is based on the assumption that it may severely distort the natural sex ratio and lead to a socially disruptive imbalance of the sexes. Based on representative social surveys conducted in Germany, the United Kingdom, and the United States, this paper argues that the fear of an impending sex ratio distortion is unfounded. Given the predominant preference for a "gender balanced family," a widely available service for social sex ... Read More »
» Published in J Assist Reprod Genet. 2006 Jul-Aug;23(7-8):311-8. Epub 2006 Sep 17.
9. Increased bacterial burden and infection: the story of NERDS and STONES.
Match Strength: 4.074
PURPOSE: The purpose of this article is to provide practitioners with an overview of wound infection/inflammation and bacterial balance and to offer a guide to assessment and treatment of chronic wounds. TARGET AUDIENCE: This continuing education activity is intended for physicians and nurses who assess and treat wound infections. OBJECTIVES: After reading this article and taking this test, the participant should be able to: 1. Discuss factors associated with infection of the chronic wound, including the concept of bacterial balance and burden. 2. Identify signs of infection in the chronic ... Read More »
» Published in Adv Skin Wound Care. 2006 Oct;19(8):447-61; quiz 461-3.
10. The effect of insulin infusion upon protein metabolism in neonates on extracorporeal life support.
Match Strength: 3.791
OBJECTIVE: Critically ill neonates on extracorporeal life support (ECLS) demonstrate elevated rates of protein breakdown that, in turn, are associated with increased morbidity and mortality. This study sought to determine if the administration of the anabolic hormone insulin improved net protein balance in neonates on ECLS. METHODS: Twelve parenterally fed neonates, on ECLS, were enrolled in a randomized, prospective, crossover trial. Subjects were administered a hyperinsulinemic euglycemic clamp and a control saline infusion. Protein metabolism was quantified using ring-D5-phenylyalanine and ... Read More »
» Published in Ann Surg. 2006 Oct;244(4):536-44.
11. The history of the angiogenic switch concept.
Match Strength: 3.632
Spontaneously arising tumor cells are not usually angiogenic at first. The phenotypic switch to angiogenesis is usually accomplished by a substet that induces new capillaries that then converge toward the tumor. The switch clearly involves more than simple upregulation of angiogenic activity and is thought to be the result of a net balance of positive and negative regulators. Tumor growth is although to require disruption of this balance and hence this switch must turned on for cancer progression. Progenitor endothelial cells, the crosstalk between angiogenic factors and their receptors and ... Read More »
» Published in Leukemia. 2007 Jan;21(1):44-52. Epub 2006 Sep 21.
12. Redox regulation of human thioredoxin network.
Match Strength: 3.524
Oxidative stresses are largely mediated by intracellular protein oxidations by reactive oxygen species (ROS). Host cells are equipped with antioxidants that scavenge ROS. The cellular reduction/oxidation (redox) balance is maintained by ROS and antioxidants. Accumulating evidence suggests that the redox balance plays an important role in cellular signaling through the redox modification of cysteine residues in various important components of the signal transduction pathway. Thioredoxin (TRX) is a small protein playing important roles in cellular responses, including cell growth, cell cycle, ... Read More »
» Published in Antioxid Redox Signal. 2006 Sep-Oct;8(9-10):1881-90.
13. Redefining oxidative stress.
Match Strength: 3.211
Oxidative stress is often defined as an imbalance of pro-oxidants and antioxidants, which can be quantified in humans as the redox state of plasma GSH/GSSG. Plasma GSH redox in humans becomes oxidized with age, in response to oxidative stress (chemotherapy, smoking), and in common diseases (type 2 diabetes, cardiovascular disease). However, data also show that redox of plasma GSH/GSSG is not equilibrated with the larger plasma cysteine/cystine (Cys/CySS) pool, indicating that the "balance" of pro-oxidants and antioxidants cannot be defined by a single entity. The major cellular thiol/disulfide ... Read More »
» Published in Antioxid Redox Signal. 2006 Sep-Oct;8(9-10):1865-79.
14. The vascular endothelium in hypertension.
Match Strength: 3.092
The vascular endothelium plays a fundamental role in the basal and dynamic regulation of the circulation. Thus, it has a crucial role in the pathogenesis of hypertension. A spectrum of vasoactive substances is synthesised in the endothelium; of these, nitric oxide (NO), prostacyclin (PGI2) and endothelin (ET)-1 are the most important. There is a continuous basal release of NO determining the tone of peripheral blood vessels. Systemic inhibition of NO synthesis or scavenging of NO through oxidative stress causes an increase in arterial blood pressure. Also, the renin-angiotensin-aldosterone ... Read More »
» Published in Handb Exp Pharmacol. 2006;(176 Pt 2):249-83.
15. The effect of the supply of rumen degradable protein and metabolisable protein on negative energy balance and fertility in dairy cows.
Match Strength: 3.066
Reproduction in dairy cattle is negatively affected by a negative energy balance (NEB), a combination of the deposition or mobilisation of fat and protein. The mode of action of NEB on fertility is not always clear, but the severity, length, and probably also the nature of the NEB may be involved. Extensive mobilisation of fat is expected to have detrimental effects on liver function due to the accumulation of non-esterified long chain fatty acids, impairing the detoxification of ammonia into urea. Protein evaluation systems nowadays use the concept of metabolisable protein (MP) and ... Read More »
» Published in Anim Reprod Sci. 2006 Dec;96(3-4):227-39. Epub 2006 Aug 3.
16. Prostaglandin E(2) protects human lung fibroblasts from cigarette smoke extract-induced apoptosis via EP(2) receptor activation.
Match Strength: 3.040
Prostaglandin E(2) (PGE(2)) has been shown to have a strong cytoprotective effect, inhibiting apoptosis. In the present study, we evaluated whether PGE(2) has a protective effect on cigarette smoke extract (CSE)-induced apoptosis in human lung fibroblasts. Apoptosis was assessed by various methods, including DNA content analysis. CSE (15%-20%) led to apoptosis and induced imbalance in favor of pro- over anti-apoptotic protein expression and activated caspases. PGE(2) blocked CSE-induced apoptosis and modulated the balance of pro- and anti-apoptotic proteins and decreased the activation of ... Read More »
» Published in J Cell Physiol. 2007 Jan;210(1):99-110.
17. Circulating hormones and hypothalamic energy balance: regulatory gene expression in the Lou/C and Wistar rats.
Match Strength: 2.985
To ascertain the mechanisms underlying low caloric intake and low body weight in the Lou/C rat, the circulating hormone levels and gene expression of hypothalamic peptides and receptors important in energy balance and the induction of suppressor of cytokine signalling 3 (SOCS3) gene expression in response to leptin challenge were compared with Wistar rats. Plasma leptin levels were lower in the Lou/C rat, as were levels of rat corticosterone, TSH and T4 but not T3. Ghrelin levels were higher in the Lou/C rat. Total leptin receptor (Ob-R) and the long form of the leptin receptor (Ob-Rb) gene ... Read More »
» Published in J Endocrinol. 2006 Sep;190(3):571-9.
18. Critical role of the epithelial Ca2+ channel TRPV5 in active Ca2+ reabsorption as revealed by TRPV5/calbindin-D28K knockout mice.
Match Strength: 2.982
The epithelial Ca(2+) channel TRPV5 facilitates apical Ca(2+) entry during active Ca(2+) reabsorption in the distal convoluted tubule. In this process, cytosolic Ca(2+) remains at low nontoxic concentrations because the Ca(2+) influx is buffered rapidly by calbindin-D(28K). Subsequently, Ca(2+) that is bound to calbindin-D(28K) is shuttled toward the basolateral Ca(2+) extrusion systems. For addressing the in vivo role of TRPV5 and calbindin-D(28K) in the maintenance of the Ca(2+) balance, single- and double-knockout mice of TRPV5 and calbindin-D(28K) (TRPV5(-/-), calbindin-D(28K)(-/-), and ... Read More »
» Published in J Am Soc Nephrol. 2006 Nov;17(11):3020-7. Epub 2006 Sep 27.
19. Effect of a metabolically created systemic acidosis on calcium homeostasis and the diurnal variation in urine pH in the non-lactating pregnant dairy cow.
Match Strength: 2.953
Reducing the dietary cation-anion difference (DCAD) has been shown to be an effective means of preventing parturient paresis in confinement systems where cows are offered a total mixed ration containing DCAD-reducing mineral compounds (anionic salts). Such a supplementation strategy is not possible in cows being group fed forages precalving, and little is known about the effect of supplementing these cows with large amounts of anionic salts twice daily.Eight non-lactating, pregnant Holstein-Friesian cows were allocated to two levels of DCAD (-20 and +18 meq/100 g DM) for 24 d, with an ... Read More »
» Published in J Dairy Res. 2006 Sep 15;:1-6
20. Physiology and gene regulation of the brain NPY Y1 receptor.
Match Strength: 2.920
Neuropeptide Y (NPY) is one of the most prominent and abundant neuropeptides in the mammalian brain where it interacts with a family of G-protein coupled receptors, including the Y(1) receptor subtype (Y(1)R). NPY-Y(1)R signalling plays a prominent role in the regulation of several behavioural and physiological functions including feeding behaviour and energy balance, sexual hormone secretion, stress response, emotional behaviour, neuronal excitability and ethanol drinking. Y(1)R expression is regulated by neuronal activity and peripheral hormones. The Y(1)R gene has been isolated from rodents ... Read More »
» Published in Front Neuroendocrinol. 2006 Sep;27(3):308-39. Epub 2006 Sep 20.
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