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Asthma
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 << Prev 20  Showing 1 to 20 of 52 Matches Next 20 >>



1. Clinical characteristics and diabetes associated autoantibodies in patients with both type 1 diabetes mellitus and asthma.
Match Strength: 7.625

OBJECTIVE: Type 1 diabetes mellitus (DM1) and asthma are mediated by opposite arms of the cellular immune system, namely T helper (Th)1 and Th2 CD4+ cells, respectively. It is not known whether their coexistence affects their clinical manifestations. METHODS: The number of asthma exacerbations, frequency of hypoglycemic events, HbA1c levels, diabetes associated autoantibody status and diabetes associated late complications were determined in three paired groups of patients (n = 11) matched by gender and age: DM1 and asthma, asthma only, and DM1 only. RESULTS: Patients with both diseases had a ... Read More »
» Published in J Pediatr Endocrinol Metab. 2006 Aug;19(8):1001-6.

2. The relationship of air pollution to ED visits for asthma differ between children and adults.
Match Strength: 7.243

The purpose of this study was to evaluate the relationship between air pollution and asthma exacerbation in children and adults. Pearson analysis was used to establish correlations between air pollutants-sulfur dioxide, nitrogen dioxide, ozone, carbon monoxide, and particles with an aerodynamic diameter of 10 microm or less (PM(10))--and ED visits for asthma in 2004. Among children, there were significant positive correlations between nitrogen dioxide (r = 0.72), carbon monoxide (r = 0.65), and PM(10) (r = 0.63) and ED visits for asthma. Among adults, only weakly positive, non significant ... Read More »
» Published in Am J Emerg Med. 2006 Oct;24(6):709-13.

3. The role of respiratory viruses in the pathogenesis of pediatric asthma.
Match Strength: 7.019

The role of respiratory viral infection in the development of asthma remains unclear. A number of factors play crucial roles, including the type of virus, the severity of the disease, the time of the infection, and, most important, the host predisposition. On the other hand, there is little doubt that a strong association exists between viral respiratory infections and induction of wheezing illnesses and asthma exacerbations. The underlying mechanisms, although not fully clarified, are likely to be multifactorial, involving inflammation of the bronchial mucosa, which interacts under certain ... Read More »
» Published in Pediatr Ann. 2006 Sep;35(9):637-42.

4. Regular smoking and asthma incidence in adolescents.
Match Strength: 6.995

RATIONALE: Although involuntary exposure to maternal smoking during the in utero period and to secondhand smoke are associated with occurrence of childhood asthma, few studies have investigated the role of active cigarette smoking on asthma onset during adolescence. OBJECTIVES: To determine whether regular smoking is associated with the new onset of asthma during adolescence. METHODS: We conducted a prospective cohort study among 2,609 children with no lifetime history of asthma or wheezing who were recruited from fourth- and seventh-grade classrooms and followed annually in schools in 12 ... Read More »
» Published in Am J Respir Crit Care Med. 2006 Nov 15;174(10):1094-100. Epub 2006 Sep 14.

5. Risk factors for work disability in severe adult asthma.
Match Strength: 6.778

PURPOSE: We aimed to elucidate the prevalence of and risk factors for work disability in severe adult asthma and to evaluate the impact of work disability on downstream health outcomes. METHODS: We used data from a prospective cohort study of 465 adults with severe asthma. Structured telephone interviews ascertained asthma status and employment history. A job exposure matrix (JEM) was used to characterize the likelihood of workplace exposure to "asthmagens." RESULTS: The prevalence of asthma-related complete work disability was 14% among working-age adults with severe asthma (95% confidence ... Read More »
» Published in Am J Med. 2006 Oct;119(10):884-91.

6. Asthma hospitalization rates among children, and school building conditions, by New York State school districts, 1991-2001.
Match Strength: 6.597

School-age children spend a significant portion of their day at school where they can be exposed to asthma triggers, but little information exists regarding potential relationships between childhood asthma and school environmental factors. This study examined patterns of asthma hospitalization and possible factors contributing to asthma hospitalizations, including sociodemographics and school environmental factors, among school-age children (5-18 years) in New York State (NYS) over an 11-year period (1991-2001). Asthma hospitalization data from the Statewide Planning and Research Cooperative ... Read More »
» Published in J Sch Health. 2006 Oct;76(8):408-13.

7. Combination Therapy with a Long-Acting beta-Agonist and a Leukotriene Antagonist in Moderate Asthma.
Match Strength: 6.583

Rationale: Long-acting beta-agonists (LABAs) and inhaled corticosteroids administered together appear to be complementary in terms of effects on asthma control. The elements of asthma control achieved by LABAs (improved lung function) and leukotriene receptor antagonists (LTRAs; protection against exacerbations) may be complementary as well. Objective: We sought to determine whether the combination of the LTRA montelukast and the LABA salmeterol could provide an effective therapeutic strategy for asthma. Methods and Measurements: In a randomized, placebo-controlled, crossover study of 192 ... Read More »
» Published in Am J Respir Crit Care Med. 2007 Feb 1;175(3):228-34. Epub 2006 Sep 14.

8. Rollercoaster asthma: When positive emotional stress interferes with dyspnea perception.
Match Strength: 6.433

The current study assessed how negative and positive stress is related to dyspnea perception. The participants were 25 young women with a medical diagnosis of severe asthma, and 15 matched controls. Stress was induced during repeated rollercoaster rides. Results showed that negative emotional stress and blood pressure peaked just before, and positive emotional stress and heart beat peaked immediately after rollercoaster rides. Dyspnea in women with asthma was higher just before than immediately after rollercoaster rides, even in women with asthma with a rollercoaster-evoked reduction in lung ... Read More »
» Published in Behav Res Ther. 2006 Sep 19;

9. Providing asthma care in elementary schools: understanding barriers to determine best practices.
Match Strength: 6.335

School nurses play a critical role in the management of children's asthma, yet they face barriers in their efforts to deliver quality care. In this qualitative study involving focus groups with school nurses, we identified key barriers in order to inform best practices. School nurses identified 4 main barriers to effective asthma care in elementary schools: lack of education, lack of communication, lack of resources, and lack of respect. An analysis of the barriers suggests that best practices for asthma care in elementary school settings require collaborative strategies that involve schools, ... Read More »
» Published in Fam Community Health. 2006 Oct-Dec;29(4):256-65.

10. Involvement of TNFalpha -308A promoter polymorphism in the development of asthma in children infected with Chlamydophila pneumoniae.
Match Strength: 6.007

Several data indicate a connection between Chlamydophila pneumoniae infection and asthma. Although C. pneumoniae is a common cause of infection, not all infected patients develop asthma. This suggests that certain individuals may be genetically predisposed to the chronic effects of C. pneumoniae infection on airway functions. We investigated the possible modifying effect of different polymorphisms on C. pneumoniae infection and on the susceptibility to asthma in 318 children, among those 144 had asthma and 174 had no asthmatic symptoms. C. pneumoniae-specific antibodies were measured by ELISA. ... Read More »
» Published in Pediatr Res. 2006 Nov;60(5):543-8. Epub 2006 Sep 20.

11. Childhood obesity increases duration of therapy during severe asthma exacerbations.
Match Strength: 5.762

OBJECTIVES: Childhood obesity contributes to a wide array of medical conditions, including asthma. There is also increasing evidence in adult patients admitted to the intensive care unit (ICU) that obesity contributes to increased morbidity and to a prolonged length of stay. We hypothesized that obesity is associated with the need for increased duration of therapy in children admitted to the ICU with status asthmaticus. DESIGN: Retrospective cohort study. SETTING: A tertiary pediatric ICU in a university-affiliated children's hospital. PATIENTS: We retrospectively examined data from all ... Read More »
» Published in Pediatr Crit Care Med. 2006 Nov;7(6):527-31.

12. Complement in asthma: sensitivity to activation and generation of C3a and C5a via the different complement pathways.
Match Strength: 5.567

Studies in rodent models suggested that complement may play a critical role in susceptibility to airway hyperresponsiveness (AHR) and as a mediator of bronchial obstruction and inflammation in asthma. Complement may participate in susceptibility to asthma because of an intrinsic abnormality in complement activation and generation of C3a, C5a, or other products that affect cellular responses, resulting in T(H)2 predominance and asthma susceptibility. Alternatively, an intrinsic abnormality in the cellular response to complement activation products could determine susceptibility to asthma. In ... Read More »
» Published in Transl Res. 2006 Oct;148(4):157-63.

13. Impact of a continuing education activity on the quality of telephone interventions by nurses in an adult asthma client base.
Match Strength: 4.949

The objectives of this study were to evaluate the effect of a continuing education activity on the clinical evaluation and advice provided by nurses working for a telephone triage service with an asthmatic client base, and to measure the number of referrals to Asthma Education Centers (AECs). The results suggest a positive impact on the quality of the telephone intervention in the short term, but this was not sustained over time. Few patients were referred to an AEC. Publication Types: Evaluation ... Read More »
» Published in J Nurs Care Qual. 2006 Oct-Dec;21(4):335-43.

14. Refill adherence for patients with asthma and COPD: comparison of a pharmacy record database with manually collected repeat prescriptions.
Match Strength: 4.602

PURPOSE: To compare refill adherence data based on two different methods of data capturing, that is, manually collected repeat prescriptions and a pharmacy record database. METHODS: The study comprised a comparison of adherence data from manually collected repeat prescriptions of asthma and chronic obstructive pulmonary disease (COPD) drugs with fixed dosages dispensed in 2002 and the corresponding data from a pharmacy record database. Data were collected in the county of Jamtland in Sweden. Refill adherence was calculated for the different collection methods. RESULTS: Data from 285 manually ... Read More »
» Published in Pharmacoepidemiol Drug Saf. 2006 Sep 28;

15. Which clinical signs and symptoms predict hypoxemia in acute childhood asthma?
Match Strength: 4.575

OBJECTIVE: To find the clinical signs that are the best predictors of hypoxemia (SpO2 =92%) in acute asthma in children. METHODS: Color of skin, dyspnea (by single breath counting), alertness, respiratory rate, presence of audible wheeze, wheezing on auscultation, accessory muscle use, nasal flaring, pulse rate, systolic and diastolic blood pressure, pulsus paradoxus and oxygen saturation at room air (by pulse oximetry) were recorded at the time of presentation and one hour after presentation after completion of 3 doses of nebulized salbutamol and budesonide. RESULTS: Hypoxemia (SpO2 92% ... Read More »
» Published in Indian J Pediatr. 2006 Sep;73(9):771-5.

16. Airway eosinophilia in children with severe asthma: predictive values of noninvasive tests.
Match Strength: 4.564

RATIONALE: Children with severe asthma experience persistent symptoms despite maximal conventional treatment. Fraction of exhaled nitric oxide (Fe(NO)) and sputum eosinophils are used as markers of airway inflammation to guide treatment with steroids, but no data are available on how reliable they are in predicting airway eosinophilia assessed bronchoscopically in these children. OBJECTIVES: To determine how Fe(NO) and sputum eosinophils predict airway eosinophilia measured in both bronchoalveolar lavage (BAL) and endobronchial biopsy. METHODS: Twenty-seven children with moderate to severe ... Read More »
» Published in Am J Respir Crit Care Med. 2006 Dec 15;174(12):1286-91. Epub 2006 Sep 14.

17. Immunoglobulin E: Role in asthma and allergic disease: Lessons from the clinic.
Match Strength: 4.541

The role of immunoglobulin E (IgE) in allergic asthmatic disease is well established. Allergen-specific IgE binds to its cognate receptors, thus triggering a series of cellular events. These events include presentation of antigen by dendritic cells and the degranulation of mast cells and basophils to release numerous factors that play an integral part in potentiating the disease symptoms. Studies in the mouse indicate that a reduction in IgE levels could lead to significant attenuation of the allergic inflammatory response associated with diseases such as asthma, making IgE a target for the ... Read More »
» Published in Pharmacol Ther. 2007 Jan;113(1):121-33. Epub 2006 Sep 25.

18. Cost-effectiveness of self-management in asthma: a systematic review of peak flow monitoring interventions.
Match Strength: 4.320

OBJECTIVES: It is generally accepted that home peak flow monitoring increases patients' self-management and could lead to cost savings. The aim of this review was to analyze costs and the cost-effectiveness of self-management based on peak flow monitoring interventions in asthma. METHODS: Twenty-one studies were included in this review. Data were extracted, and methodological and economic quality were assessed. These studies presented economic information regarding self-management interventions based on peak flow monitoring in asthmatics. The mean methodological quality was 4.6 (maximum 8), ... Read More »
» Published in Int J Technol Assess Health Care. 2006 Fall;22(4):436-42.

19. Potential self-selection bias in a nested case-control study on indoor environmental factors and their association with asthma and allergic symptoms among pre-school children.
Match Strength: 4.074

Selection bias means a systematic difference between the characteristics of selected and non-selected individuals in epidemiological studies. Such bias may be introduced if participants select themselves for a study. The present study aims at identifying differences in family characteristics, including health, building characteristics of the home, and socioeconomic factors between participating and non-participating families in a nested case-control study on asthma and allergy among children. Information was collected in a baseline questionnaire to the parents of 14,077 children aged 1-6 years ... Read More »
» Published in Scand J Public Health. 2006;34(5):534-43.

20. Anti-inflammatory Activity of Inhaled Interleukin-4 Receptor-{alpha} Antisense Oligonucleotide in Mice.
Match Strength: 4.010

The Th2 cytokines IL-4 and IL-13 mediate allergic pulmonary inflammation and airways hyper-reactivity (AHR) in asthma models through signaling dependent upon the IL-4 receptor-alpha chain (IL-4Ralpha). IL-13 has been further implicated in the overproduction of mucus by the airway epithelium and in lung remodeling that commonly accompanies chronic inflammation. IL-4Ralpha-deficient mice are resistant to allergen-induced asthma, highlighting the therapeutic promise of selective molecular inhibitors of IL-4Ralpha. We designed a chemically modified IL-4Ralpha antisense oligonucleotide (IL-4Ralpha ... Read More »
» Published in Am J Respir Cell Mol Biol. 2006 Sep 21;

 << Prev 20  Showing results 1 to 20 of 52 Next 20 >>




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