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1. Atherogenic diet causes lethal ileo-ceco-colitis in cyclooxygenase-2 deficient mice.
Match Strength: 5.969

Cyclooxygenases (COX) regulate a variety of inflammatory diseases, including inflammatory bowel disease (IBD). While the pathological effects of COX-1 inhibition by NSAIDs on intestinal ulceration are well established, the role of COX-2 on intestinal inflammation remains under investigation. In this paper, we report a protective role for COX-2 against diet-mediated intestinal inflammation in mice. COX-2(-/-) mice fed an atherogenic diet or diet containing cholate, but not chow or fat alone, had a high mortality whereas COX-1(-/-) mice and wild-type mice were unaffected by the dietary changes. ... Read More »
» Published in Prostaglandins Other Lipid Mediat. 2007 Nov;84(3-4):98-107. Epub 2007 Apr 25.

2. Reduced pain and inflammation in juvenile and adult rats fed a ketogenic diet.
Match Strength: 5.337

The ketogenic diet is a high-fat, low-carbohydrate regimen that forces ketone-based rather than glucose-based cellular metabolism. Clinically, maintenance on a ketogenic diet has been proven effective in treating pediatric epilepsy and type II diabetes, and recent basic research provides evidence that ketogenic strategies offer promise in reducing brain injury. Cellular mechanisms hypothesized to be mobilized by ketone metabolism and underlying the success of ketogenic diet therapy, such as reduced reactive oxygen species and increased central adenosine, suggest that the ketolytic metabolism ... Read More »
» Published in PLoS One. 2009 Dec 23;4(12):e8349.

3. Effect of the cannabinoid receptor-1 antagonist rimonabant on inflammation in mice with diet-induced obesity.
Match Strength: 5.326

We studied whether cannabinoid receptor (CB1) blockade with rimonabant has an anti-inflammatory effect in obese mice, and whether this effect depends on weight loss and/or diet consumption. High-fat diet (HFD)-induced obese mice were treated orally with rimonabant (HFD-R) or vehicle (HFD-V) for 4 weeks. Paired-feeding was conducted in two additional groups of obese mice to achieve either the same body weight (HFD-BW) or the same HFD intake (HFD DI) as HFD-R. All these groups of mice were maintained on HFD throughout, with mice on normal diet (ND) throughout as lean controls. Rimonabant ... Read More »
» Published in Obesity (Silver Spring). 2011 Mar;19(3):505-13. Epub 2010 Sep 30.

4. The effects of diet on inflammation: emphasis on the metabolic syndrome.
Match Strength: 5.269

Reducing the incidence of coronary heart disease with diet is possible. The main dietary strategies include adequate omega-3 fatty acids intake, reduction of saturated and trans-fats, and consumption of a diet high in fruits, vegetables, nuts, and whole grains and low in refined grains. Each of these strategies may be associated with lower generation of inflammation. This review examines the epidemiologic and clinical evidence concerning diet and inflammation. Dietary patterns high in refined starches, sugar, and saturated and trans-fatty acids, poor in natural antioxidants and fiber from ... Read More »
» Published in J Am Coll Cardiol. 2006 Aug 15;48(4):677-85. Epub 2006 Jul 24.

5. Mediterranean diet and metabolic syndrome: the evidence.
Match Strength: 5.227

BACKGROUND: The Mediterranean diet has long been related to a lower cardiovascular disease risk; however, more recent evidences also indicate that it has a favourable effect on adiposity and type 2 diabetes. DESIGN: Review of the available literature in relation to Mediterranean diet and metabolic syndrome. RESULTS: Several components of Mediterranean diet patterns have been inversely related with body mass index. They are considered to be modulators of insulin resistance, can exert beneficial effects on blood pressure, improve atherogenic dyslipidemia or attenuate the inflammatory burden ... Read More »
» Published in Public Health Nutr. 2009 Sep;12(9A):1607-17.

6. The treatment with antibody of TNF-alpha reduces the inflammation, necrosis and fibrosis in the non-alcoholic steatohepatitis induced by methionine- and choline-deficient diet.
Match Strength: 5.191

To assess the effects of anti-TNF-alpha antibody (infliximab) in experimental steatohepatitis induced by methionine- and choline-deficient (MCD) diet. The study included thirty rats. One group received normal rat food, and two groups received MCD diet. The treatment group received a single dose intra-peritoneal infliximab (4 mg/kg), at week 8. MCD diet increased levels of AST, ALT, TNF-alpha, TGF-beta(1), tissue and plasma MDA (p < 0.05 for each). Moreover, it led to steatosis, ballooning degeneration, inflammation, fibrosis and increased actin expression, histopathologically (p < 0.05 for ... Read More »
» Published in Inflammation. 2008 Apr;31(2):91-8. Epub 2007 Dec 8.

7. Anti-inflammatory diets for obesity and diabetes.
Match Strength: 5.190

Obesity and type 2 diabetes are strongly associated with increased inflammation. As the inflammation in adipose tissue increases, this becomes a strong driving force for the development of increased systemic inflammation that results in metabolic syndrome, eventually followed by the development of overt type 2 diabetes. The potential reversal of both conditions can be achieved by reducing the levels of inflammation through the use of an anti-inflammatory diet. The composition of such a diet and its molecular mode of action will be discussed ... Read More »
» Published in J Am Coll Nutr. 2009 Aug;28 Suppl:482S-491S.

8. VSL#3 probiotic treatment attenuates fibrosis without changes in steatohepatitis in a diet-induced nonalcoholic steatohepatitis model in mice.
Match Strength: 5.014

Nonalcoholic fatty liver disease (NAFLD) and its advanced stage, nonalcoholic steatohepatitis (NASH), are the most common causes of chronic liver disease in the United States. NASH features the metabolic syndrome, inflammation, and fibrosis. Probiotics exhibit immunoregulatory and anti-inflammatory activity. We tested the hypothesis that probiotic VSL#3 may ameliorate the methionine-choline-deficient (MCD) diet-induced mouse model of NASH. MCD diet resulted in NASH in C57BL/6 mice compared to methionine-choline-supplemented (MCS) diet feeding evidenced by liver steatosis, increased ... Read More »
» Published in Hepatology. 2009 Mar;49(3):989-97.

9. Methanol extract of Sorbus commixta cortex prevents vascular inflammation in rats with a high fructose-induced metabolic syndrome.
Match Strength: 4.941

Feeding high fructose (Frc) to rats induces a moderate increase in blood pressure, which is associated with insulin resistance. The present study was designed to evaluate the effect of the methanol extract of Sorbus commixta cortex (MSC) on vascular inflammation in a rat model of the metabolic syndrome induced by a high Frc-diet. Male Sprague-Dawley rats were divided into 4 groups and treated for 7 weeks as follows: 1) control, 2) high Frc-diet group, 3) Frc/MSC1 group; high Frc-diet group treated with MSC (100 mg/kg/day), and 4) Frc/MSC2 group; high Frc-diet group treated with MSC (200 mg/kg ... Read More »
» Published in Am J Chin Med. 2007;35(2):265-77.

10. Novel anti-inflammatory functions for endothelial and myeloid cyclooxygenase-2 in a new mouse model of Crohn's disease.
Match Strength: 4.931

Cyclooxygenase-2 (COX-2) is an important regulator of inflammation implicated in the development of a variety of diseases, including inflammatory bowel disease (IBD). However, the regulation of intestinal inflammation by COX-2 is poorly understood. We previously reported that COX-2(-/-) mice fed a cholate-containing high-fat (CCHF) diet had high mortality of unknown mechanisms attributable to severe intestinal inflammation in the ileo-ceco-colic junction that presented characteristics similar to Crohn's disease (CD). To further characterize the role of COX-2 in intestinal inflammation, we ... Read More »
» Published in Am J Physiol Gastrointest Liver Physiol. 2010 Jun;298(6):G842-50. Epub 2010 Mar 18.

11. Effects of Grape Pomace Antioxidant Extract on Oxidative Stress and Inflammation in Diet Induced Obese Mice.
Match Strength: 4.807

Norton grape is one of the most important wine grapes in Southern and Midwestern states and generates massive pomace byproducts. The objective of this study is to characterize the antioxidant compounds and activity in Norton grape pomace extract (GPE) and further assess the potential health promoting properties of Norton GPE using an animal disease model. The total phenolic content and anthocyanins in Norton GPE were 475.4 mg of gallic acid equiv/g and 156.9 mg of cyanidin 3-glucoside equiv/g, respectively. Catechin and epicatechin in GPE were 28.6 and 24.5 mg/g, respectively. Other major ... Read More »
» Published in J Agric Food Chem. 2010 Oct 7.

12. C-C chemokine receptor 2 inhibitor improves diet-induced development of insulin resistance and hepatic steatosis in mice.
Match Strength: 4.781

AIM: Adipose tissue inflammation induced by macrophage infiltration through the MCP-1/CCR2 pathway is considered to play a pivotal role in the development of visceral obesity and insulin resistance. In the present study, therefore, we examined whether pharmacological inhibition of CCR2 is effective against the development of diet-induced metabolic disorders. METHODS: C57BL/6 mice were fed a high fat and sucrose diet with or without propagermanium (CCR2 inhibitor, 5 or 50 mg/kg BW/day) for 12 weeks from 6 weeks of age. Then we analyzed lipid and glucose metabolism and tissue inflammation in the ... Read More »
» Published in J Atheroscler Thromb. 2010 Mar 31;17(3):219-28. Epub 2010 Feb 24.

13. Anti-inflammatory salicylate beneficially modulates pre-existing atherosclerosis through quenching of NF-?B activity and lowering of cholesterol.
Match Strength: 4.687

OBJECTIVE: Inflammation plays an important role in all stages of atherosclerosis, but little is known about the therapeutic effects of quenching inflammation in already existing atherosclerotic lesions. Putative beneficial effects of salicylate, an inhibitor of NF-?B activation, were studied in mice with established lesions. METHODS: ApoE*3-Leiden mice received a high-cholesterol diet (HC) to establish atherosclerotic lesions. Reference mice (REF) were sacrificed to determine the lesion area at the start of two interventions. In one intervention group HC diet feeding was continued, but the ... Read More »
» Published in Atherosclerosis. 2010 Nov;213(1):241-6. Epub 2010 Sep 21.

14. Dietary nitrite prevents hypercholesterolemic microvascular inflammation and reverses endothelial dysfunction.
Match Strength: 4.686

The nitrite anion is an endogenous product of mammalian nitric oxide (NO) metabolism, a key intermediate in the nitrogen cycle in plants, and a constituent of many foods. Research over the past 6 years has revealed surprising biological and cytoprotective activity of this anion. Hypercholesterolemia causes a proinflammatory phenotype in the microcirculation. This phenotype appears to result from a decline in NO bioavailability that results from a reduction in NO biosynthesis, inactivation of NO by superoxide, or both. Since nitrite has been shown to be potently cytoprotective and restore NO ... Read More »
» Published in Am J Physiol Heart Circ Physiol. 2009 May;296(5):H1281-8. Epub 2009 Feb 27.

15. The effects of a calorie-reduced diet on periodontal inflammation and disease in a non-human primate model.
Match Strength: 4.650

BACKGROUND: Low-calorie diets are commonplace for reducing body weight. However, no information is available on the effects of a reduced-calorie diet on periodontal inflammation and disease. The purpose of this study was to evaluate the clinical effects of a long-term calorie-restriction (CR) diet on periodontitis in an animal model of periodontitis. METHODS: Periodontitis was induced in 55 young, healthy, adult rhesus monkeys (Macaca mulatta) by tying 2.0 silk ligatures at the gingival margins of maxillary premolar/molar teeth. Animals on a CR diet (30% CR; N = 23) were compared to ad libitum ... Read More »
» Published in J Periodontol. 2008 Jul;79(7):1184-91.

16. Indirect effect of a turmeric diet: enhanced bile duct proliferation in Syrian hamsters with a combination of partial obstruction by Opisthorchis viverrini infection and inflammation by N-nitrosodimethylamine administration.
Match Strength: 4.594

The present study revealed the indirect effect of a turmeric (TUR) diet on the histopathological changes and proliferating cell nuclear antigen staining in Syrian hamsters with partial obstruction by liver fluke (Opisthorchis viverrini) infection and inflammation by N-nitrosodimethylamine (NDMA) administration. The result of the analysis of histopathological changes shows that a TUR diet has an anti-inflammatory property in the case of a single condition of NDMA administration or O. viverrini infection, as has been reported previously. Unfortunately, an adverse indirect effect of TUR was ... Read More »
» Published in Parasitol Res. 2011 Jan;108(1):7-14. Epub 2010 Sep 7.

17. Quercetin transiently increases energy expenditure but persistently decreases circulating markers of inflammation in C57BL/6J mice fed a high-fat diet.
Match Strength: 4.535

Quercetin, a polyphenolic compound and a major bioflavonoid in the human diet, has anti-inflammatory properties and has been postulated to enhance energy expenditure (EE). We sought to determine whether quercetin alters body weight, body composition, EE, and circulating markers of inflammation. At 6 weeks (W) of age, 2 cohorts of C57BL/6J mice (N = 80) were placed on one of 2 diets for 3W or 8W: (1) high fat (HF) (45% kcal fat) or (2) high fat + quercetin (HF + Q) (45% kcal fat + 0.8% quercetin). Quercetin concentrations in the diet and plasma were evaluated using mass spectrometry. Body ... Read More »
» Published in Metabolism. 2008 Jul;57(7 Suppl 1):S39-46.

18. Rosiglitazone attenuates liver inflammation in a rat model of nonalcoholic steatohepatitis.
Match Strength: 4.493

Rosiglitazone is an insulin-sensitizing agent. We aimed to assess the effects of rosiglitazone on a methionine- and choline-deficient diet (MCDD) model of nonalcoholic steatohepatitis (NASH) in rats. Wistar rats were fed either MCDD or a control diet in the 4-week induction study; they were given saline or 4 mg/kg/day rosiglitazone. After the induction study period, the rats were divided into four groups and fed MCDD or given a control diet for an additional 8 weeks and received saline or rosiglitazone. Serum and tissue samples were obtained. Rosiglitazone improved inflammation in NASH and ... Read More »
» Published in Dig Dis Sci. 2007 Dec;52(12):3465-72. Epub 2007 Apr 10.

19. Intestinal anti-inflammatory activity of combined quercitrin and dietary olive oil supplemented with fish oil, rich in EPA and DHA (n-3) polyunsaturated fatty acids, in rats with DSS-induced colitis.
Match Strength: 4.434

BACKGROUND AND AIMS: Previous studies have described the intestinal anti-inflammatory effects exerted by the bioflavonoid quercitrin (QR) and by an n-3 polyunsaturated fatty acids (PUFA)-enriched diet in experimental models of rat colitis. The aim of the present study was to test if the combination of both treatments would result in an improvement in the intestinal anti-inflammatory effect achieved separately. METHODS: Colitis was induced in female Wistar rats by incorporating dextran sodium sulfate (DSS) in drinking water at 5% (w/v) for 5 days and at 2% (w/v) for the following 10 days. Five ... Read More »
» Published in Clin Nutr. 2006 Jun;25(3):466-76. Epub 2006 May 15.

20. A new immune-modulating diet enriched with whey-hydrolyzed peptide, fermented milk, and isomaltulose attenuates gut ischemia-reperfusion injury in mice.
Match Strength: 4.354

BACKGROUND & AIMS: Gut ischemia-reperfusion (I/R) is considered an important mechanism underlying multiple organ failure after severe surgical insults. We previously demonstrated an enteral diet enriched with whey-hydrolyzed peptide, fermented milk, and isomaltulose to have anti-inflammatory effects in a concanavalin A-induced hepatitis model. Here, we investigated whether the immune-modulating diet (IMD), could prevent systemic inflammation, thereby improving survival in a gut I/R model. METHODS: Mice were randomized into control enteral diet (n = 58) or IMD (n = 56) for 2 weeks' feeding. ... Read More »
» Published in Clin Nutr. 2011 Jan 29.

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* All information on Level1Diet.com is for educational purposes only. These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. Before changing your diet, or adding supplements to your diet, or beginning an exercise program, everyone should consult a qualified and licensed health practitioner; a physician, dietician or similar professional.



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