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Anti Inflammatory
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1. Evaluation of Anti-Inflammatory and Analgesic Properties of L-Glutamine
Match Strength: 9.479

It was established that L-glutamine, an aminoacid, has marked anti-inflammatory activity and moderate analgesic activity. The drug was effective orally in suppressing various experimentally induced inflammatory reactions and did not show any gastric irritation in anti-inflammatory doses. It is observed that the anti-inflammatory effect of L-glutamine is not due to counter irritant action. It is suggested that it may partially mediate its anti-inflammatory activity by interfering with the action and/or synthesis of prostaglandins. Its anti-inflammatory activity is comparable to that of ... Read More »
» Published in Agents Actions. 1981 May;11(3):243-9.

2. Design, synthesis and in vivo activity of 9-(S)-dihydroerythromycin derivatives as potent anti-inflammatory agents.
Match Strength: 9.176

The synthesis of a new class of 9-(S)-dihydroerythromycin derivatives and their anti-inflammatory activity on in vivo PMA assay are described. Modifying the desosamine sugar on the C-3' amino group, it was possible to differentiate between anti-biotic and anti-inflammatory action. The compounds are completely devoid of anti-microbial effects but their anti-inflammatory properties are enhanced. These results strongly suggest the potential of macrolides as a new class of anti-inflammatory agents ... Read More »
» Published in Bioorg Med Chem Lett. 2006 Nov 15;16(22):5801-4. Epub 2006 Sep 18.

3. Anti-Inflammatory Actions of Dapsone and Its Related Biochemistry
Match Strength: 9.111

Dapsone has been examined by two established animal anti-inflammatory models and found to possess anti-inflammatory activity comparable with established non-steroidal anti-inflammatory drugs. Dapsone also possess some biochemical properties common to other anti-inflammatory drugs ... Read More »
» Published in J Pharm Pharmacol. 1976 Jul;28(7):555-8.

4. The Anti-Inflammatory Action of Nepitrin, a Flavonoid
Match Strength: 9.055

The anti-inflammatory efficacy of nepitrin (5,3',4'-trihydroxy-6-methoxy flavone), a flavonoid, was investigated in both acute and chronic models of inflammation in rats. Nepitrin was found to possess significant anti-inflammatory activity in the exudative and proliferative phases of inflammation. This action of nepitrin could be due to its anti-bradykinin and anti-angiotensin action. Nepitrin also possessed anti-pyretic and weak analgesic activity. The study reveals that nepitrin may be useful as an anti-inflammatory and anti-arthritic agent ... Read More »
» Published in Agents Actions. 1982 Jul;12(3):298-302.

5. Lipoxin Analogs: Novel Anti-Inflammatory Mediators
Match Strength: 8.800

Most pharmacological anti-inflammatory agents are designed to inhibit the enzymes or receptors that are directly involved in mediating inflammation. In contrast, lipoxin analogs utilize an entirely different anti-inflammatory paradigm, namely that of activating the endogenous anti-inflammatory signaling pathways by which inflammation is normally resolved. Specifically, synthetic stable analogs of the endogenous anti-inflammatory eicosanoid lipoxin A4 (LXA4) have been shown to mimic the anti-inflammatory actions of LXA4 in a variety of inflammation models and display desirable pharmacological ... Read More »
» Published in Curr Opin Investig Drugs. 2005 Nov;6(11):1112-5.

6. Studies on the Anti-Inflammatory Activity of Creatine
Match Strength: 8.709

Creatine is an aminoacid which has been found to posses anti-inflammatory activity. It is orally effective in modifying the inflammatory response in all of the test models employed. It does not produce gastrointestinal ulceration in the effective doses. In common with many of the nonsteroidal anti-inflammatory agents creatin exhibits analgesic activity. Anti-inflammatory activity is comparable to that of phenylbutazone and merits further studies ... Read More »
» Published in Arch Int Pharmacodyn Ther. 1978 Feb;231(2):340-50.

7. Anti-inflammatory effects of IL-4 and IL-10 on human polymorphonuclear leukocytes
Match Strength: 8.708

Inflammatory responses are strictly regulated by coordination of pro-inflammatory and anti-inflammatory mediators. Interleukin-4 (IL-4) and interleukin-10 (IL-10) have typically the biologic anti-inflammatory effects on monocytes, but uncertain effects on polymorphonuclear leukocytes (PMNs). The PMNs are the first line of cellular response for host defense during acute inflammation. To modify hyper-inflammatory reaction with biologic anti-inflammatory mediators, we have determined the biologic anti-inflammatory activities of IL-4 and IL-10 on human PMNs. Human PMNs were pretreated with IL-4 or ... Read More »
» Published in J Korean Med Sci. 2002 Feb;17(1):7-14.

8. Synthesis and biological activity of new anti-inflammatory compounds containing the 1,4-benzodioxine and/or pyrrole system.
Match Strength: 8.665

A series of substituted derivatives containing the 1,4-benzodioxine or pyrrole nucleus are described. All the newly synthesized compounds were examined for their in vitro and in vivo anti-inflammatory activity. Several derivatives, including (S)-2, 14 and 17, showed more anti-inflammatory activity in vivo in these assays (rat paw oedema induced by carrageenan) than the known classical anti-inflammatory agent ibuprofen, whereas other compounds like 1 were equipotent to ibuprofen. Compound 17 was the most outstanding derivative because of its remarkable in vivo anti-inflammatory activity. In ... Read More »
» Published in Bioorg Med Chem. 2007 Jul 15;15(14):4876-90. Epub 2007 May 3.

9. Practical Points on Nonsteroidal Anti-Inflammatory Drugs
Match Strength: 8.444

All nonsteroidal anti-inflammatory drugs act by inhibiting prostaglandin synthesis, but the particular agent that will best suit an individual patient's needs cannot be predicted. Each drug should be tried for at least three weeks at maximal dosage before it is considered ineffective. When a particular nonsteroidal anti-inflammatory agent is not effective, one from another class should be tried. Levels of drugs metabolized by the liver are altered by nonsteroidal anti-inflammatory agents. Costs are quite variable ... Read More »
» Published in Am Fam Physician. 1984 Mar;29(3):258-62.

10. Asthma. Anti-inflammatory therapies
Match Strength: 8.435

It is likely that airway inflammation has an central role in the development and maintenance of the structural and functional abnormalities that characterise asthma. The recognition that asthma is a chronic inflammatory disorder of the airways has resulted in an increased emphasis on the use of anti-inflammatory drugs. The principal anti-inflammatory drugs are corticosteroids and to a lesser extent sodium cromoglycate and nedocromil sodium. Several other drugs and therapies may also have anti-inflammatory effects in asthma. The early use of prophylactic anti-inflammatory agents is advocated in ... Read More »
» Published in Br Med Bull. 1992 Jan;48(1):205-20.

11. Antibiotics as anti-inflammatory agents
Match Strength: 8.340

Although the empirical use of some antibacterial agents in various inflammatory diseases has proved beneficial in the past, it is only recently that the therapeutic anti-inflammatory potential of cyclines and macrolides has received attention worldwide. Other drugs like fosfomycin and some quinolones are also contenders for this role. Owing to the complexity of the inflammatory process, which involves many redundant cellular effectors and soluble mediators, and the obscure etiopathogenesis of many inflammatory diseases (some of which may be secondary to persistent infections), the precise ... Read More »
» Published in Curr Opin Investig Drugs. 2002 Jan;3(1):61-8.

12. Synthesis and Anti-Inflammatory Activity of Certain New N,N'-Oxamides
Match Strength: 8.335

Some new amides of substituted oxamic acid which embody different moieties of the anti-inflammatory drugs were prepared through two routes of synthesis. The physico-chemical properties as well as the anti-inflammatory activity of these compounds were determined. Preliminary pharmacological testing revealed the superiority of most of the screened compounds as anti-inflammatory agents with relatively low toxicity as compared with acetylsalicylic acid. Correlation between structure and biological activity was suggested ... Read More »
» Published in Pharmazie. 1980;35(7):394-8.

13. Have the Anti-Inflammatory Drugs Helped Our Understanding in Rheumatology?
Match Strength: 8.270

The author discusses the part that certain anti-inflammatory drugs have played in increasing our understanding of the pathogenesis of rheumatoid arthritis and in adding to our knowledge of the mediators of the inflammatory response. Increasingly, the therapeutic agents under discussion have directed attention to the role of the macrophage in inflammation. Closer examination of existing anti-inflammatory or anti-rheumatic drugs and their mode of action has more recently directed attention towards immunomodulation ... Read More »
» Published in J Int Med Res. 1977;5 Suppl 2:30-7.

14. Anti-Inflammatory Effect of Warfarin and Vitamin K1
Match Strength: 8.268

1. Sodium warfarin, given by oral or by parenteral route, displays a pronounced anti-inflammatory effect in the formaldehyde and carrageenan induced rat paw edema. This effect becomes patent not only when the warfarin application precedes the local injection of the irritant substance (prophylactic effect), but also when it is given to animals with already developed inflammatory reactions (therapeutic effect). 2. The active doses of Na warfarin lie between 0.5 and 5.0 mg/kg. Smaller as well as higher doses show a reduced anti-inflammatory effect. 3. A marked anti-inflammatory effect can be ... Read More »
» Published in Naunyn Schmiedebergs Arch Pharmacol. 1979 Jun 18;307(2):185-90.

15. Characterization of a novel anti-inflammatory factor produced by RM3/1 macrophages derived from glucocorticoid treated human monocytes.
Match Strength: 8.242

Glucocorticoids exert their anti-inflammatory activity by modulating the functions of various cell types including macrophages. They also induce the generation of a distinct macrophage subtype defined by the surface antigen RM3/1 which appears to be associated with the down-regulation of inflammation. Supernatants from these cells were found to exert a dose-dependent anti-inflammatory effect, particularly in the early phase as shown in the 5-hydroxytryptamine (5-HT) induced footpad edema of mice. By using conventional purification methods the anti-inflammatory factor was found to have a ... Read More »
» Published in Inflamm Res. 1995 Dec;44(12):535-40.

16. Non-steroidal anti-inflammatory drugs and cyclooxygenase in Alzheimer's disease
Match Strength: 8.216

Epidemiological studies indicate that anti-inflammatory drugs, especially the non-steroidal anti-inflammatory drugs (NSAIDs), decrease the risk of developing Alzheimer's disease (AD). Their beneficial effects may be due to interference in the chronic inflammatory reaction, that takes place in AD. The best-characterized action of NSAIDs is the inhibition of cyclooxygenase (COX). There is special interest for anti-inflammatory treatment of AD using selective COX-2 inhibitors. These inhibitors reduce the inflammatory reaction but lack the side effects observed with non-selective NSAIDs. So far, ... Read More »
» Published in Curr Drug Targets. 2003 Aug;4(6):461-8.

17. Nonsteroidal anti-inflammatory drug gastrointestinal toxicity.
Match Strength: 8.205

Toxic effects in the upper gastrointestinal tract, primarily complicated gastric and intestinal ulcers, are the most common undesirable effects of the nonsteroidal anti-inflammatory drugs. During the last several years, there have been several advances, both in the laboratory and clinically, toward reducing nonsteroidal anti-inflammatory drugs' gastrointestinal toxicity. Some of these important developments are the delineation of mechanisms of nonsteroidal anti-inflammatory drug-induced gastrointestinal toxicity, identification of groups at highest risk for development of nonsteroidal anti ... Read More »
» Published in Curr Opin Gastroenterol. 2001 Nov;17(6):503-12.

18. The therapeutic potential of anti-cytokine antibodies in the treatment of chronic inflammatory disease.
Match Strength: 8.161

The outcome of inflammatory diseases is likely to be dependent upon the relative balance of pro- versus anti-inflammatory cytokines. Control of this balance through the use of anti-cytokine monoclonal antibodies (mAbs) promises to be an effective means of disease therapy. The treatment of rheumatoid arthritis (RA) or inflammatory bowel disease (IBD) with anti- tumour necrosis factor alpha (TNF-alpha) mAb has dramatically ameliorated disease symptoms, indicating that such a treatment approach can be highly successful. Similarly, based on animal studies, the use of neutralising anti-interleukin ... Read More »
» Published in Expert Opin Investig Drugs. 1998 Jul;7(7):1115-20.

19. Local anti-inflammatory activity and systemic side effects of NM-135, a new prodrug glucocorticoid, in an experimental inflammatory rat model
Match Strength: 8.139

The local anti-inflammatory activity and systemic side effects of NM-135 (6alpha,9-difluoro-11beta-hydroxy-16alpha-methyl-21[[2 ,3,4,6-tetrakis-O-(4-methylbenzoyl)-beta-D-glucopyranosyl]oxy]-pregna-1, 4-diene-3,20-dione) in croton oil-induced granuloma pouches and ear edema in rats were studied. The local anti-inflammatory activity of NM-135 was stronger than that of betamethasone 17-valerate (BV). As to systemic side effects, BV and diflucortolon valerate (DFV) caused thymolysis at the doses required for the anti-inflammatory activity. In contrast, no clear systemic side effect was observed ... Read More »
» Published in Jpn J Pharmacol. 1998 Dec;78(4):505-9.

20. Cytokines and hormones with anti-inflammatory effects: new tools for therapeutic intervention
Match Strength: 8.127

The inflammation that is involved in the development of glomerulonephritis is tightly regulated by the expression of anti-inflammatory factors. These include circulating hormones, such as glucocorticoids, and mediators that are produced by intrinsic cells and infiltrating leucocytes. The present review focuses on these anti-inflammatory factors, summarizing in particular their activities in existing models of glomerulonephritis. In addition, experimental evidence is presented that anti-inflammatory mediators are able to increase glucocorticoid binding or signalling in target cells. These data ... Read More »
» Published in Curr Opin Nephrol Hypertens. 2001 Jan;10(1):49-54.

21. Toward the development of chemoprevention agents. Part 1: Design, synthesis, and anti-inflammatory activities of a new class of 2,5-disubstituted-dioxacycloalkanes.
Match Strength: 8.093

A new class of 2,5-disubstituted-dioxacycloalkanes were designed and synthesized via stereoselective synthetic method as cancer chemoprevention agents. The anti-inflammatory activities of these compounds were tested using the xylene-induced mouse ear edema model. Some of these compounds exhibited comparable or better anti-inflammatory activities than that of aspirin suggesting that they can be further developed as potential anti-inflammatory drug lead compounds. In addition, treatment of these anti-inflammatory agents did not prolong tail bleeding time in mice. The structure/activity ... Read More »
» Published in Bioorg Med Chem. 2007 Jul 15;15(14):4775-99. Epub 2007 May 6.

22. The Proinflammatory Function of Lymphocytes in Non-Immune Inflammation: Effect of Steroidal and Non-Steroidal Anti-Inflammatory Agents
Match Strength: 8.084

Leucopenia rendered rats unresponsive to various inflammatory stimuli. The intensity of the inflammatory response in such animals was restored by i.v. administration of suspensions of lymphocytes, but not of granulocytes. This restorative effect was blocked by both steroidal and non-steroidal anti-inflammatory drugs. Utilizing carrageenin to induce inflammatory responses in the rat's paw, the effect of these drugs on lymphocytes was observed in two circumstances. First, following incubation of the cells with the drugs in concentrations not exceeding the peak plasma levels estimated for these ... Read More »
» Published in Br J Exp Pathol. 1977 Dec;58(6):703-11.

23. Therapy with and mechanisms of nonsteroidal anti-inflammatory drugs
Match Strength: 8.038

Nonsteroidal anti-inflammatory drugs have anti-inflammatory, analgesic, and antipyretic properties. Although most nonsteroidal anti-inflammatory drugs inhibit prostaglandin synthesis, these agents also have important pharmacologic actions unrelated to their effects on prostaglandins. Among these properties is the ability to inhibit the release of mediators of inflammation from neutrophils and macrophages. These effects are due to the ability of nonsteroidal anti-inflammatory drugs to intercalate into the lipid bilayer of the plasma membrane and thereby disrupt protein-protein and protein-lipid ... Read More »
» Published in Curr Opin Rheumatol. 1991 Jun;3(3):336-40.

24. Stereoselective synthesis and anti-inflammatory activities of 6- and 7-membered dioxacycloalkanes.
Match Strength: 8.015

A class of 5-trifluoroacetylamino-1,3-dioxacycloalkanes, 5-benzoylamino-1,3-dioxacycloalkanes, and 5-amino-1,3-dioxacycloalkane compounds were stereoselectively synthesized as potential anti-inflammatory drug candidates. The anti-inflammatory activities of these compounds were tested using the xylene-induced mouse ear edema model, from which multiple compounds possessing anti-inflammatory properties which surpass aspirin were identified; these compounds were then compared to establish structure-activity relationships. Publication Types: Comparative Study, Research Support, Non-U.S. Gov ... Read More »
» Published in Bioorg Med Chem. 2006 Mar 1;14(5):1339-47. Epub 2005 Nov 2.

25. Anti-inflammatory activity of immunoglobulin G resulting from Fc sialylation.
Match Strength: 8.014

Immunoglobulin G (IgG) mediates pro- and anti-inflammatory activities through the engagement of its Fc fragment (Fc) with distinct Fcg receptors (FcgRs). One class of Fc-FcgR interactions generates pro-inflammatory effects of immune complexes and cytotoxic antibodies. In contrast, therapeutic intravenous gamma globulin and its Fc fragments are anti-inflammatory. We show here that these distinct properties of the IgG Fc result from differential sialylation of the Fc core polysaccharide. IgG acquires anti-inflammatory properties upon Fc sialylation, which is reduced upon the induction of an ... Read More »
» Published in Science. 2006 Aug 4;313(5787):670-3. Comment in: Science. 2006 Aug 4;313(5787):627-8.

26. Inhibition of Neutrophil Activation by Nonsteroidal Anti-Inflammatory Drugs
Match Strength: 8.003

Nonsteroidal anti-inflammatory drugs are thought to prevent inflammation in rheumatoid arthritis by inhibiting prostaglandin synthesis. This observation does not explain, however, why nonsteroidal anti-inflammatory drugs are able to control inflammation caused by other mediators. To determine whether nonsteroidal anti-inflammatory drugs also exert an effect on neutrophil activation, in vitro and in vivo studies were undertaken. Aggregation, superoxide anion generation, and lysosomal enzyme release were assessed. The nonsteroidal anti-inflammatory drugs were found to inhibit these neutrophil ... Read More »
» Published in Am J Med. 1984 Oct 15;77(4B):3-6.

27. N-Acyl-N-phenyl ureas of piperidine and substituted piperidines endowed with anti-inflammatory and anti-proliferative activities.
Match Strength: 7.994

Six series of N-acyl-N-phenyl ureas 1-6 of piperidine (1), and 2-ethyl- (2), 3-methyl- (3), 4-methyl- (4), 4-phenyl- (5), cis-2,6-dimethyl- (6) piperidine were synthesised and evaluated for their anti-inflammatory, anaesthetic, anti-pyretic properties. Some derivatives of series 1 and 5 were also assayed for anti-proliferative activity. Several compounds showed an anti-inflammatory activity comparable or slighty inferior to that of indomethacin in rats (1c,d, 2a,b,g,h, 3b, 4h, 5d,e). Moreover, an appreciable anti-inflammatory activity was also found in 2c,e, 3e,f,g, 4g, 5a,b,c,f,h, and 6a,b,d. ... Read More »
» Published in Farmaco. 2001 Sep;56(9):647-57.

28. Anti-inflammatory cytokines
Match Strength: 7.984

The anti-inflammatory cytokines are a series of immunoregulatory molecules that control the proinflammatory cytokine response. Cytokines act in concert with specific cytokine inhibitors and soluble cytokine receptors to regulate the human immune response. Their physiologic role in inflammation and pathologic role in systemic inflammatory states are increasingly recognized. Major anti-inflammatory cytokines include interleukin (IL)-1 receptor antagonist, IL-4, IL-6, IL-10, IL-11, and IL-13. Specific cytokine receptors for IL-1, tumor necrosis factor-alpha, and IL-18 also function as ... Read More »
» Published in Chest. 2000 Apr;117(4):1162-72. Comment in: Chest. 2000 Apr;117(4):932-4.

29. Anti-Inflammatory and Anti-Oxidant Activity of a New Class of Phenyl-Pyrazolone Derivatives
Match Strength: 7.962

The anti-inflammatory activity of a new class of phenyl-pyrazolone derivatives, structurally related to phenidone, has been evaluated using the Croton oil ear test in mice as model of acute inflammation. Derivative 5h reduces the percentage of oedema similarly to indomethacin and more efficiently than phenylbutazone. The anti-inflammatory activity of these two reference drugs depends on their COX inhibition, but for the synthesized derivatives it has not been demonstrated a significant COX or LOX inhibition, as previously reported. While the anti-inflammatory activity of phenidone is ... Read More »
» Published in Curr Drug Discov Technol. 2006 Mar;3(1):67-73.

30. New anti-inflammatory agents.
Match Strength: 7.958

The pyrrole derivatives la, b and 2a, b were used as precursors for the preparation of N-substituted pyrrole derivatives 3a, b-9a, b and pyrrolo[2,3-d]pyrimidines 13-16. Also, all the newly prepared products were tested for anti-inflammatory activity as analogues to fenamates, and some of them revealed moderate anti-inflammatory activity compared to the standard drug indomethacin ... Read More »
» Published in Z Naturforsch [C]. 2007 Jan-Feb;62(1-2):27-31.

31. The Nitrosterols--A Step Forward from the Steroid Anti-Inflammatory Drugs?
Match Strength: 7.958

Nitric oxide (NO)-releasing non-steroidal anti-inflammatory drugs have been shown to have improved efficacy and lower toxicity than their parent agents, and are currently in clinical trials as anti-inflammatory agents. The same approach is now being taken with the glucocorticoids, and initial studies show that NO-releasing forms of prednisolone, flunisolide and hydrocortisone (the nitrosterols) are more potent anti-inflammatory agents than their parent molecules in animal models of acute and chronic inflammation. Experimental studies also suggest that the nitrosterols are less likely to cause ... Read More »
» Published in Expert Opin Investig Drugs. 2005 Jul;14(7):823-8.

32. Anti-inflammatory agents in Alzheimer's disease
Match Strength: 7.940

Epidemiologic studies have raised expectations that existing anti-inflammatory drugs may be useful in slowing the progression of Alzheimer's disease (AD). However, the first large-scale studies of anti-inflammatory drug treatment regimens have been negative. These disappointing results, along with new evidence from cell culture and animal model systems, suggest that the inflammatory hypothesis must be refined. Generalizations about inflammation and anti-inflammatory drugs have not been useful in developing treatment strategies for AD. But new studies suggest that specific anti-inflammatory ... Read More »
» Published in Curr Neurol Neurosci Rep. 2002 Sep;2(5):405-9.

33. Effects of Drugs on Prostaglandin Synthesis
Match Strength: 7.936

The role of prostaglandins in inflammatory processes is now recognized to be more complex than that of mere mediators or modulators of the acute inflammatory response. As well as their obvious vasodilator properties they have profound regulatory effects on cell function, and these may be anti-inflammatory as well as pro-inflammatory. Consequently the use of those effective non-steroid anti-inflammatory drugs which are potent prostaglandin synthesis inhibitors may in fact have detrimental effects in inflammation. Further development of cyclo-oxygenase inhibitors is less likely to lead to ... Read More »
» Published in Rheumatol Rehabil. 1978;Suppl:47-52.

34. Cell stress induced HSP are targets of regulatory T cells: A role for HSP inducing compounds as anti-inflammatory immuno-modulators?
Match Strength: 7.933

T cell responses to heat shock proteins (HSP) have disease suppressive activities through production of anti-inflammatory cytokines in patients and in models of inflammatory diseases. There is evidence that the anti-inflammatory activity of HSP-specific T cells depends on their recognition of endogenous HSP epitopes as expressed by stressed cells at sites of inflammation. Previously, we have demonstrated that such T cells can be induced by conserved sequences of microbial HSP. Now we propose that drug induced up-regulation of endogenous HSP can contribute to anti-inflammatory T cell regulation ... Read More »
» Published in FEBS Lett. 2007 May 8;

35. Marine sponge metabolites for the control of inflammatory diseases.
Match Strength: 7.902

Marine organisms are a rich source of bioactive metabolites. A number of potential anti-inflammatory compounds have been isolated from marine invertebrates that exhibit phospholipase A2 inhibitory activity. A wide range of marine compounds have been investigated for their anti-inflammatory properties. Cacospongionolide B and petrosaspongiolide M are representative examples of anti-inflammatory compounds in experimental models of acute or chronic inflammation. The mechanisms of action of these compounds include phospholipase A, inhibition as well as the control of nuclear factor-B activation ... Read More »
» Published in Curr Opin Investig Drugs. 2006 Nov;7(11):974-9.

36. Parathyroid hormone fragment 1-34 inhibits drug-induced inflammation in various experimental models
Match Strength: 7.898

We investigated the effect of the administration of rat parathyroid hormone-(1-34) on acute or chronic inflammatory processes in different experimental animal models. Fragment 1-34 of parathyroid hormone had an inhibitory effect in all inflammatory acute tests. The dose-response experiments showed that the maximal anti-inflammatory and anti-exudative effects appeared at the dose of 3.30 and 0.33 micrograms/kg, respectively. The anti-inflammatory effect was observed in the first phase of the inflammatory process. In the carrageenin-induced edema test the anti-inflammatory activity began to ... Read More »
» Published in Eur J Pharmacol. 1991 May 30;198(1):85-8.

37. Advances in anti-inflammatory therapy.
Match Strength: 7.885

Anti-inflammatory drugs are widely used in veterinary practice to provide symptomatic relief of acute and chronic inflammatory conditions. Whilst much is already known about the properties of corticosteroid and non-steroidal anti-inflammatory drugs, new findings on their biology and pharmacokinetics continue to emerge. These are discussed, together with some possible novel therapeutic applications. Recent evidence, suggesting that morphine-like analgesic drugs may possess anti-inflammatory activity, is additionally presented. Knowledge of the pathways of formation, actions and interactions of ... Read More »
» Published in Br Vet J. 1994 Mar-Apr;150(2):115-34. Comment in: Br Vet J. 1994 Mar-Apr;150(2):107-9.

38. Exploitation of the nicotinic anti-inflammatory pathway for the treatment of epithelial inflammatory diseases.
Match Strength: 7.883

Discoveries in the first few years of the 21st century have led to an understanding of important interactions between the nervous system and the inflammatory response at the molecular level, most notably the acetylcholine (ACh)-triggered, alpha7-nicotinic acetylcholine receptor (alpha7nAChR)-dependent nicotinic anti-inflammatory pathway. Studies using the alpha7nAChR agonist, nicotine, for the treatment of mucosal inflammation have been undertaken but the efficacy of nicotine as a treatment for inflammatory bowel diseases remains debatable. Further understanding of the nicotinic anti ... Read More »
» Published in World J Gastroenterol. 2006 Dec 14;12(46):7451-9.

39. Role of plasminogen activators and leukocytes in IUD-induced inflammation: effect of some anti-inflammatory agents
Match Strength: 7.862

Insertion of an IUD causes a persistent inflammatory reaction, evident from an increase in the vascular dilatation and permeability of IUD-exposed endometrium. IUD-induced inflammatory changes can be checked by using anti-inflammatory drugs. In this study in rats, we report that IUD-induced inflammatory changes were partially checked by the use of anti-inflammatory drugs, in order of effectiveness, indomethacin greater than naproxen greater than ibuprofen. Histologically, IUDs provoke mild degeneration of uterine epithelium and necrotic changes in the endometrial glands. Heavy infiltration of ... Read More »
» Published in Adv Contracept. 1989 Sep;5(3):173-8.

40. Anti-Inflammatory 1-Substituted 2-Imidazolidinones
Match Strength: 7.862

The synthesis and anti-inflammatory activity of a series of 1-substituted 2-imidazolidinones are reported. These compounds exerted marked anti-inflammatory activity in the carrageenan-induced hindpaw edema assay in the rat in doses that failed to elicit side effects. Their ED50 values were near the value of aspirin but markedly higher than the value of indomethacin ... Read More »
» Published in J Pharm Sci. 1978 Apr;67(4):548-9.

41. Anti-inflammatory and anti-oxidant activity of a new class of phenyl-pyrazolone derivatives.
Match Strength: 7.850

The anti-inflammatory activity of a new class of phenyl-pyrazolone derivatives, structurally related to phenidone, has been evaluated using the Croton oil ear test in mice as model of acute inflammation. Derivative 5h reduces the percentage of oedema similarly to indomethacin and more efficiently than phenylbutazone. The anti-inflammatory activity of these two reference drugs depends on their COX inhibition, but for the synthesized derivatives it has not been demonstrated a significant COX or LOX inhibition, as previously reported. While the anti-inflammatory activity of phenidone is ... Read More »
» Published in Curr Drug Discov Technol. 2006 Mar;3(1):67-73.

42. Inhibition of Nuclear Factor Kappa B (NF-B):: An Emerging Theme in Anti-Inflammatory Therapies
Match Strength: 7.847

The application of anti-inflammatory therapies began thousands of years ago with the use of readily available natural resources. It is only recently, however, that the cellular and molecular mechanisms of inflammation have been appreciated sufficiently to design anti-inflammatory strategies with limited side effects. For example, salicylates and glucocorticoids, two widely used anti-inflammatory drug classes, are now known to inhibit the activation of NF-kappaB, a transcription factor that regulates the inducible expression of a wide range of proinflammatory mediators. New generations of NF ... Read More »
» Published in Mol Interv. 2002 Feb;2(1):22-35.

43. Anti-Inflammatory Action Following Liver Damage in the Rat
Match Strength: 7.846

A high molecular weight protein fraction, obtained by column chromatography of saline extracts of the livers of rats that had previously been treated with dimethylnitrosamine, was found to have anti-inflammatory activity against carrageenin induced inflammation in the rat. Evidence was presented that the anti-inflammatory activity may be due to a protein fragment produced by proteolysis of a larger molecule ... Read More »
» Published in Agents Actions. 1979 Jun;9(2):201-4.

44. Inhibitory effects of anti-inflammatory drugs on interleukin-6 bioactivity
Match Strength: 7.834

Interleukin-6 (IL-6) is known as a proinflammatory cytokine involved in immune response, inflammation, and hematopoiesis. Inhibitory effects of anti-inflammatory drugs on IL-6 bioactivity using IL-6-dependent hybridoma have been evaluated. Three out of 16 nonsteroidal anti-inflammatory drugs (NSAIDs) showed IC50 values of less than 100 microM, which were in the order of oxyphenylbutazone hydrate (IC50=7.5 microM)>meclofenamic acid sodium salt (31.9 microM)>sulindac (74.9 microM). Steroidal anti-inflammatory drugs (SAIDs) exhibited significant inhibitory effects at 100 microM on the IL-6 ... Read More »
» Published in Biol Pharm Bull. 2001 Jun;24(6):701-3.

45. Pharmacologic Properties of Fenbufen
Match Strength: 7.825

Fenbufen (Cinopal) is an orally active nonsteroidal anti-inflammatory drug with analgesic and antipyretic activity. Like clinically used nonsteroidal anti-inflammatory drugs, it shows activity in a wide spectrum of laboratory tests in mice, rats, guinea pigs, and dogs. Fenbufen has a long duration of anti-inflammatory and analgesic activity. Mechanistic studies indicate that fenbufen has no intrinsic effect on cyclooxygenase activity, whereas its major metabolite, biphenylacetic acid, is a potent inhibitor of prostaglandin synthesis. These observations indicate that fenbufen is a pro-drug and ... Read More »
» Published in Am J Med. 1983 Oct 31;75(4B):62-9.

46. Anti-inflammatory Constituents of the Red Alga Gracilaria verrucosa and Their Synthetic Analogues.
Match Strength: 7.820

A chemical study on the anti-inflammatory components of the red alga Gracilaria verrucosa led to the isolation of new 11-deoxyprostaglandins ( 1- 4), a ceramide ( 5), and a C 16 keto fatty acid ( 6), along with known oxygenated fatty acids ( 7- 14). Their structures were elucidated on the basis of NMR and MS data. The absolute configurations of compounds 1- 5 were determined by Mosher's method. The anti-inflammatory activity of the isolated compounds ( 1- 14) was evaluated by determining their inhibitory effects on the production of pro-inflammatory mediators (NO, IL-6, and TNF-alpha) in ... Read More »
» Published in J Nat Prod. 2008 Jan 26

47. The Possible Occurrence of Endogenous Anti-Inflammatory Substances in the Blood of Injured Rats
Match Strength: 7.806

1 Using the carrageenin rat paw oedema test as an assay, an attempt has been made to confirm the presence of anti-inflammatory activity in the blood of rats with a chronic inflammatory lesion induced by a polyester sponge, and to relate such activity to the systemic anti-inflammatory effect exerted in situ by the lesion. In addition, plasma from rats given acetic acid intraperitoneally has been examined for anti-inflammatory properties. 2 The activity of serum obtained from sponge-bearing adrenalectomized Wistar rats did not differ significantly from that obtained from animals without implants ... Read More »
» Published in Br J Pharmacol. 1975 Jan;53(1):85-91.

48. Immunosuppressive agents and nonsteroidal anti-inflammatory drugs for ocular immune and inflammatory disorders.
Match Strength: 7.804

We now have at our disposal several nonsteroidal immunosuppressive and anti-inflammatory agents that may be used in addition to or instead of corticosteroids to treat ocular diseases. This article discusses some of the nonsteroidal immunosuppressive and anti-inflammatory agents available to the ophthalmologist. Publication Types: ... Read More »
» Published in Ophthalmol Clin North Am. 2005 Dec;18(4):511-28, vi.

49. Anti-inflammatory potential of melanocortin receptor-directed drugs
Match Strength: 7.791

Melanocortin receptor-based drug discovery is particularly active in the field of neuroendocrine systems and is mostly related to food intake and novel obesity therapies. The immunomodulatory and anti-inflammatory effects of nonpeptidic, low molecular weight compounds activating the melanocortin-1 receptor (MC1R) provide a new principle for treating various types of inflammation, such as dermal, joint, and gastrointestinal, probably by virtue of the effects acting through modulation of proinflammatory and anti-inflammatory cytokines. Several reports demonstrate that alpha-MSH, for example, has ... Read More »
» Published in Ann N Y Acad Sci. 2003 Jun;994:84-9.

50. COX-1, COX-2, and COX-3 and the future treatment of chronic inflammatory disease
Match Strength: 7.788

A new generation of non-steroidal anti-inflammatory drugs has been described that selectively targets the inducible isoform of cyclo-oxygenase, cyclo-oxygenase 2 (COX-2). This isoform is expressed at sites of inflammation, which has led to the speculation that its inhibition could provide all the benefits of current nonsteroidal anti-inflammatory drugs, but without their major side-effects on the gastrointestinal system (which are due to inhibition of COX-1). We have shown that COX-2 (identified by use of specific antibodies) is induced during the resolution of an inflammatory response, ... Read More »
» Published in Lancet. 2000 Feb 19;355(9204):646-8.

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