Alpha Lipoic Acid ALA for Anti-Inflammatory Diets
Beyond its normal role in metabolism, the nutrient has found uses to help improve or prevent certain conditions. Researchers and physicians, especially in Europe and Japan, use the substance with patients who have either diabetes and/or AIDs. ALA has proven especially valuable in management of AIDs, diabetes and other diseases related to inflammation. Some other uses relate to cyrrosis of the liver, neuropathy and similar conditions.
Management of Diabetic Neuropathy
Physicians tend to recommend doses of only 50 to 100mg/day for most people, and sometimes prescribe 600mg or more per day in divided doses for people suffering from diabetic neuropathy or other conditions related to inflammation or high levels of AGEs (advanced glycation end products). Lipoic acid appears to reduce or slow the formation of these products, which may help manage neuropathy for some patients.
& Other Conditions
Other products that are thought to be helpful for patients with AGE formation problems include benfotiamine, pyridoxamine, aminoguanidine (sold as Pimagedine), carnosine, aspirin, and acetyl-l-carnitine.
ALA is capable of regenerating several other antioxidants to their active states, including vitamin C, vitamin E, glutathione, and coenzyme Q-10. ALA also has several potential benefits for people with diabetes. It enhances glucose uptake in type 2 (non-insulin-dependent) diabetes, inhibits glycosylation (the abnormal attachment of sugar to protein), and has been used to improve diabetic nerve damage and reduce associated pain.
Most studies have used intravenous alpha lipoic acid, but oral supplementation has nonetheless proved partially helpful in treating at least one form of diabetic neuropathy (using 800 mg per day). Preliminary evidence also indicates that 150 mg of alpha lipoic acid, taken daily for one month, improves visual function in people with glaucoma.
Consider taking at least 300mg per day of Alpha Lipoic Acid (ALA). Even higher doses of up to 1.5 grams (1,500mg) per day or more have been used by many physicians to treat active Type-2 Diabetes and Cardiovascular Disease in their patients.
The combination of Vitamin-E and Alpha Lipoic Acid has been shown to significantly improve heart performance and reduce lipid oxidation when added to diets. Alpha Lipoic Acid (ALA) is a powerful antioxidant that helps protect the body from oxidative damage related to aging and exercise.
Scientific Research Supporting
The references below were available from the NIH Pubmed.org site as of July 14, 2008:
Alpha Lipoic Acid Supplementation
- Read over 300 scientific studies reported at Pubmed.org (the web page of the National Library of Medicine, National Institutes of Health, NIH) reporting research about Alpha Lipoic Acid and Diabetes.
- If you have Diabetes, you should consider taking Alpha Lipoic Acid to prevent, control and possibly reverse diabetic neuropathy in your feet and hands* - a condition that is the number one cause of amputation in the U.S. Read over 135 scientific studies reported at Pubmed.org reporting research about Alpha Lipoic Acid and Diabetic Neuropathy.
- Read over 169 scientific studies reported at Pubmed.org about Alpha Lipoic Acid and Vitamin-E, working together.
- Read over 175 scientific studies reported at Pubmed.org about Alpha Lipoic Acid and Vitamin-C, working together.
- Read how Alpha lipoic Acid works with Vitamin-E in this scientific article "Improved cardiac performance after ischemia in aged rats supplemented with vitamin E and alpha -lipoic acid", American Journal of Physiology: Regulatory and Integrative and Comparative Physiology (The American Physiological Society), 2000, 279:R2149-R2155.
Where to buy Alpha Lipoic AcidAlpha Lipoic Acid is not sold everywhere. You may find that some grocery stores and smaller vitamin shops may not carry this powerful antioxidant. Here is a list of a few good places to try.
Today there are many brands of Alpha Lipoic Acid available at reasonable prices. Even Wal-Mart now offers the product in several dosages, such as 100mg and 200mg per capsule. Recently, their on-the-shelf price for the 200mg capsules in a 50 pill bottle was less than $7.00 in one local Wal-Mart we checked. Wal-Mart usually sells these nutrients under a "house brand" product label that you may not be familiar with, but we've found them of good quality.
You should be able to find many brands available now in Walgreens, K-Mart, and many local discount pharmacies. Some grocery store vitamin departments may also carry this product.
Another good source is iHerb.com. iHerb will show you a wide selection of brand names, all a very low prices. They do not carry their own "private label" brands. All brands shown in their online store are well known national brand names. They ship from Los Angeles, California; in most cases the next day after you order. We have no relationship with this company, but have purchased from them before at very reasonable prices.
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* All information on Level1Diet.com is for educational purposes only. These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. Before changing your diet, or adding supplements to your diet, or beginning an exercise program, everyone should consult a qualified and licensed health practitioner; a physician, dietician or similar professional.