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Ageing
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1. Ageing changes in the eye.
Match Strength: 11.708

Ageing changes occur in all the structures of the eye causing varied effects. This article attempts to review the parameters of what is considered within the "normal limits" of ageing so as to be able to distinguish those conditions from true disease processes. Improving understanding of the ageing changes will help understand some of the problems that the ageing population faces. Publication Types: ... Read More »
» Published in Postgrad Med J. 2006 Sep;82(971):581-7.

2. The pathology of ageing: concepts and mechanisms.
Match Strength: 10.926

The rising numbers and proportion of aged individuals in the population is a global demographic trend. The diseases associated with ageing are becoming more prevalent, and the associated healthcare costs are having a significant economic impact in all countries. With these changes have come great advances in our understanding of the mechanisms of ageing. The mechanisms of cellular ageing at a genetic, protein and organelle level are becoming clearer, as are some of the more complex associations between environment and ageing. System ageing is also becoming better understood, and the potential ... Read More »
» Published in J Pathol. 2007 Jan;211(2):111-3.

3. The pathology of ageing: concepts and mechanisms.
Match Strength: 10.926

The rising numbers and proportion of aged individuals in the population is a global demographic trend. The diseases associated with ageing are becoming more prevalent, and the associated healthcare costs are having a significant economic impact in all countries. With these changes have come great advances in our understanding of the mechanisms of ageing. The mechanisms of cellular ageing at a genetic, protein and organelle level are becoming clearer, as are some of the more complex associations between environment and ageing. System ageing is also becoming better understood, and the potential ... Read More »
» Published in J Pathol. 2007 Jan;211(2):111-3.

4. Ageing across the life span: time to think again.
Match Strength: 10.556

Living organisms are subject to ageing. This natural process has gained greater importance in socially and medically affluent societies. For many, ageing connotes unattractive changes in the appearance of the skin. The gross morphological changes of ageing skin are mirrored by a range of more profound age-associated physiological declines. Thus, skin ageing can be put into other perspectives which lie at the interfaces of molecular biology, cellular biology, oncology and cosmetic dermatology. Genetically programmed replicative senescence and stress-induced premature senescence (SIPS) are two ... Read More »
» Published in J Cosmet Dermatol. 2004 Jan;3(1):50-3.

5. Effects of ageing on touch.
Match Strength: 10.213

A decline in the main sensory modalities is well reported to occur with ageing. This article outlines the normal pathways involved in touch sensation and includes a review of available evidence relating to the study of ageing and touch. The authors try to use what is known about the neuroanatomy and neurophysiology of ageing to explain the impact on some broad functional deficits seen in the elderly population. The importance of understanding how the normal ageing process affects touch sensation is emphasised. Publication Types: ... Read More »
» Published in Postgrad Med J. 2006 May;82(967):301-4.

6. Mitochondrial DNA and ageing.
Match Strength: 10.201

The accumulation of mitochondrial DNA mutations has been proposed as a potential mechanism in the physiological processes of ageing and age-related disease. Although mitochondria have long been anticipated as a perpetrator of ageing, there was little experimental evidence to link these changes directly with the cellular pathology of ageing. Recently, considerable progress in understanding basic mitochondrial genetics and in identifying acquired mtDNA mutations in ageing has been made. Furthermore, the creation of mtDNA-mutator mice has provided the first direct evidence that accelerating the ... Read More »
» Published in Biochim Biophys Acta. 2006 May-Jun;1757(5-6):611-7. Epub 2006 Mar 31.

7. Theories of ageing.
Match Strength: 10.180

Ageing is a universal, intrinsic, progressive and deleterious process. Understanding it is of major interest to scientist, physicians as well as to the general population. Critical to this understanding is to formulate comprehensive theories of aging with high predictive and explanatory power. More than 300 theories have been postulated and are reviewed here. The free radical theory of ageing is one of the most prominent and well studied. It was further developed by one of us (JM) in what has become known as the mitochondrial theory of ageing. These theories provide new experimental approaches ... Read More »
» Published in IUBMB Life. 2007 Apr;59(4):249-54.

8. Programmed and altruistic ageing.
Match Strength: 10.036

Ageing is widely believed to be a non-adaptive process that results from a decline in the force of natural selection. However, recent studies in Saccharomyces cerevisiae are consistent with the existence of a programme of altruistic ageing and death. We suggest that the similarities between the molecular pathways that regulate ageing in yeast, worms, flies and mice, together with evidence that is consistent with programmed death in salmon and other organisms, raise the possibility that programmed ageing or death can also occur in higher eukaryotes. Publication Types: ... Read More »
» Published in Nat Rev Genet. 2005 Nov;6(11):866-72.

9. How Much Do We Understand About the Effects of Ageing on Healing?
Match Strength: 10.032

Poor experimental design has contributed to a perceived association of ageing with delayed wound healing. Continuing research on the influence of ageing will allow more focused therapeutic strategies ... Read More »
» Published in J Wound Care. 2005 Nov;14(10):472-4, 476.

10. Biological ageing research in the Netherlands.
Match Strength: 9.984

After an introduction on the development of biological ageing research in the Netherlands during the past decades, 606 papers on aging published by Dutch institutes in the period 1991-2000, collected from PubMed, were analysed for their relevance to research into biological ageing. For the period 1996-2000, the total number of research papers on biological ageing amounted to 142, which accounts for 23% of all publications on ageing in that period. The number of publications per year did not change.On the basis of these papers and additional information provided by research groups a ... Read More »
» Published in Exp Gerontol. 2001 Aug;36(8):1221-49.

11. Ageing and apoptosis.
Match Strength: 9.933

Ageing is accompanied by a general decline of physiological function, especially at later stages, and significant increases in the incidence of cancer and other degenerative diseases. It has recently been hypothesized that alterations in apoptosis may contribute to these age-associated changes. However, whether there is a role for apoptosis in the ageing process and how ageing may modify the regulatory machinery of apoptosis remains obscure. Although the literature addressing these issues is scarce, research in this area is gaining momentum. Molecules involved in apoptosis signaling in mammals ... Read More »
» Published in Mech Ageing Dev. 2002 Feb;123(4):245-60.

12. Insulin Receptor and Ageing
Match Strength: 9.839

The number of elderly people is increasing worldwide as well as the age-associated diseases, such as the type 2 diabetes. The consequences are disastrous for elderly patients as well as for healthy ageing. It has been clinically demonstrated that with physiological ageing it exists already a resistance to the action of insulin leading to slightly increased glycemia and insulin levels. Several causes have been postulated for this insulin resistance with ageing, among them the alteration of insulin receptor (IR) number, of IR signal transduction as well as environmental changes. Much more ... Read More »
» Published in Pathol Biol (Paris). 2003 Dec;51(10):574-80.

13. Vertebrate ageing: an evolutionary process with a genetic basis?
Match Strength: 9.590

Theories that explain the persistence of ageing in the face of natural selection implicitly assume that there is a genetic basis for ageing. This has now for the first time been shown to be the case in two free-living populations of mammals ... Read More »
» Published in Curr Biol. 2008 Feb 12;18(3):R130-1.

14. Longevity and ageing in parasitic and free-living nematodes.
Match Strength: 9.327

In the developing field of biological gerontology, rapid advances have recently been made in the genetics of ageing in the nematode Caenorhabditis elegans. The aim of this work is to develop an understanding of the general mechanisms determining the ageing process. Within the last decade the prospect of actually achieving this somewhat hubristic aim has begun to look startlingly real. In this context, knowledge of every aspect of the biology of ageing in nematodes is of added interest. Here the patterns of ageing observed among parasitic and free-living nematodes are surveyed and compared. ... Read More »
» Published in Biogerontology. 2000;1(4):289-307.

15. Ageing and ART: a waste of time and money?
Match Strength: 9.248

In many societies, more and more young women are delaying childbearing until the fourth decade of life. It is well known that fertility is remarkably reduced with increasing age of women in both natural conceptions and assisted reproductive technology (ART). In this chapter, the effect of ageing on the pregnancy rate in ART, and the options available to improve the reproductive outcomes in women of advanced age will be presented after understanding the mechanism of reproductive ageing and the effects of ageing on the reproductive outcomes in normal women. It is important to identify the ... Read More »
» Published in Best Pract Res Clin Obstet Gynaecol. 2006 Oct 14;

16. Physiological ageing: role of p53 and PARP-1 tumor suppressors in the regulation of terminal senescence.
Match Strength: 9.180

Ageing of organisms is among the most complex processes currently known. Understanding the molecular mechanism of physiological ageing is one of the most essential issues in biology and medicine because it is not possible to predict when and how a certain individual will start ageing. In the past centuries human life expectancies increased. Extension of life span is associated with increased susceptibility to a number of chronic diseases. Insight into the cellular and molecular targets of the ageing process would offer the opportunity to prevent at least some of the destructive processes. In ... Read More »
» Published in J Physiol Pharmacol. 2005 Mar;56 Suppl 2:77-88.

17. Stress and ageing interactions: A paradox in the context of shared etiological and physiopathological processes.
Match Strength: 9.167

Gerontology has made considerable progress in the understanding of the mechanisms underlying the ageing process and age-related neurodegenerative disorders. However, ways to improve quality of life in the elderly remain to be elucidated. It is now clear that stress and the ageing process share a number of underlying mechanisms bound in a very close, if not indissociable, relationship. The ageing process is regulated by the factors underlying the ability to adjust to stress, whilst stress has an influence on the life span and the quality of ageing. In addition, the ability to cope with stress ... Read More »
» Published in Brain Res Rev. 2007 Jun;54(2):251-73. Epub 2007 Mar 1.

18. Genome-wide approaches to understanding human ageing.
Match Strength: 9.165

The use of genomic technologies in biogerontology has the potential to greatly enhance our understanding of human ageing. High-throughput screens for alleles correlated with survival in long-lived people have uncovered novel genes involved in age-associated disease. Genome-wide longevity studies in simple eukaryotes are identifying evolutionarily conserved pathways that determine longevity. It is hoped that validation of these 'public' aspects of ageing in mice, along with analyses of variation in candidate human ageing genes, will provide targets for future interventions to slow the ageing ... Read More »
» Published in Hum Genomics. 2006 Jun;2(6):422-8.

19. Research into ageing and older people.
Match Strength: 9.123

Aim The aim of this paper is to consider the process of ageing, the effects of ageing and research related to ageing. Background In most countries of the world, the UK being no exception, the population is ageing in terms of the absolute numbers of and relative proportion of older people. This has resulted from economic, scientific and medical progress. However, it poses challenges for health and social services. Method Selective review of the literature. Conclusion Ageing is an inevitable part of life and, while not in itself debilitating, can be accompanied by a range of debilitating ... Read More »
» Published in J Nurs Manag. 2008 Mar;16(2):99-104.

20. Enthalpy relaxation of gelatin in the glassy state.
Match Strength: 9.003

The enthalpy relaxation during the ageing of gelatin in the glassy state was studied for partially crystalline or amorphous materials at different water contents and ageing temperatures. The extent and rate of this relaxation associated with physical ageing were found to increase when the shifted temperature parameter (Ta-Tg) increased. This parameter was able to account for the effects of structure and water content (through Tg) and ageing temperature (Ta). Publication Types: Research Support, Non-U.S. Gov ... Read More »
» Published in Int J Biol Macromol. 2005 Sep 15;36(4):263-9.

21. A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition.
Match Strength: 8.902

ABSTRACT: BACKGROUND: Non-pathological cognitive ageing is a distressing condition affecting an increasing number of people in our ageing society. Oxidative stress is hypothesised to have a major role in cellular ageing, including brain ageing. RESULTS: Associations between cognitive ageing and 325 single nucleotide polymorphisms (SNPs), located in 109 genes implicated in oxidative stress and/or cognition, were examined in a unique cohort of relatively healthy older people, on whom we have cognitive ability scores at ages 11 and 79 years (LBC1921). SNPs showing a significant positive ... Read More »
» Published in BMC Genet. 2007 Jul 2;8(1):43

22. Transcription-coupled repair and premature ageing.
Match Strength: 8.865

During the past decades, several cellular pathways have been discovered to be connected with the ageing process. These pathways, which either suppress or enhance the ageing process, include regulation of the insulin/growth hormone axis, pathways involved with caloric restriction, ROS metabolism and DNA repair. In this review, we will provide a comprehensive overview of cancer and/or accelerated ageing pathologies associated with defects in the multi-step nucleotide excision repair pathway. Moreover, we will discuss evidence suggesting that there is a causative link between transcription ... Read More »
» Published in Mutat Res. 2005 Sep 4;577(1-2):179-94.

23. Symposium on Mechanisms of Ageing and Longevity.
Match Strength: 8.832

The Symposium on 'Mechanisms of Ageing and Longevity' was held at the Royal Free Campus, Royal Free and University College Medical School, London, on 17 September 1999. It was organised and sponsored by the Anatomical Society of Great Britain and Northern Ireland with generous contributions from BBSRC, AgeNet and Research into Ageing.THE SYMPOSIUM WAS ORGANISED AS A RESULT OF RECENT DISCOVERIES IN TWO PRINCIPAL AREAS: the genetics of longevity regulation in the nematode worm, Caenorhabditis elegans, and the cell biology of ageing in mammalian cells. Papers were presented covering the role of ... Read More »
» Published in J Anat. 2000 Nov;197(Pt 4):i.

24. Opinion: Radical medicine: treating ageing to cure disease.
Match Strength: 8.808

The incidence of many diseases rises sharply with age. Although clearly separable, ageing and certain age-related diseases might share common mechanisms. Cellular metabolism and subsequent generation of reactive oxygen species might contribute both to the rate at which we age and to our susceptibility to numerous chronic diseases, therefore therapies that directly target the ageing process might provide new ways to treat human diseases ... Read More »
» Published in Nat Rev Mol Cell Biol. 2005 Dec;6(12):971-6.

25. The ageing hand. A study to evaluate the chronological ageing process of the hand.
Match Strength: 8.804

The rejuvenation of the hand has received increased attention recently. Although many different methods have been advocated, only little is known about the chronological ageing process of the Caucasian hand. A qualitative study was performed to evaluate ageing changes. One hundred and forty-three volunteers were enrolled. Standardised pictures of both hands were obtained and evaluated by one observer in regard to wrinkling pattern, visibility of subcutaneous structures and trophic changes. We found that both males and females showed a distinct progression of the wrinkling pattern. Dorsal veins ... Read More »
» Published in J Plast Reconstr Aesthet Surg. 2008 Feb 8

26. Tyrannosaur ageing.
Match Strength: 8.721

Rate of ageing in tyrannosaurs was calculated from parameters of Weibull functions fitted to survival curves based on the estimated ages at death of fossilized remains. Although tyrannosaurs are more closely related to birds than to mammals, they apparently aged at rates similar to mammals of comparable size. Rate of growth in body mass of tyrannosaurs was similar to that of large mammals, and their rates of ageing were consistent with the estimated extrinsic mortality, which is strongly correlated with the rate of ageing across birds and mammals. Thus, tyrannosaurs appear to have had life ... Read More »
» Published in Biol Lett. 2007 Feb 6;

27. Increased p53 activity does not accelerate telomere-driven ageing.
Match Strength: 8.637

There is a great interest in determining the impact of p53 on ageing and, for this, it is important to discriminate among the known causes of ageing. Telomere loss is a well-established source of age-associated damage, which by itself can recapitulate ageing in mouse models. Here, we have used a genetic approach to interrogate whether p53 contributes to the elimination of telomere-damaged cells and its impact on telomere-driven ageing. We have generated compound mice carrying three functional copies of the p53 gene (super-p53) in a telomerase-deficient background and we have measured the ... Read More »
» Published in EMBO Rep. 2006 May;7(5):546-52. Epub 2006 Mar 31.

28. Increase in the intensity of thermoluminescence Q-band during leaf ageing is due to a block in the electron transfer from Q( A) to Q( B).
Match Strength: 8.622

The thermoluminescence (TL) parameters in intact leaves and thylakoids isolated from leaves showed a different pattern of change during leaf ageing. Ageing of leaves brought about a decrease in the B-band and a simultaneous increase in the Q-band. Thylakoids showed only a decrease in the B-band. The TL bands further show that there is generation of an endogenous electron transport inhibitor during leaf ageing. Copyright 2001 John Wiley & Sons, Ltd ... Read More »
» Published in Luminescence. 2001 Sep-Oct;16(5):309-13.

29. Caloric Restriction, Body Fat and Ageing in Experimental Models
Match Strength: 8.617

Caloric restriction in animal models delays many age-related pathological conditions. Ageing rats have characteristically increased body weight, fat mass and a specific body fat distribution. This report will focus on the potential cause-effect relationship between increased fat mass and accelerated ageing. In humans, increased fat mass (obesity), and in particular increases in abdominal obesity as a result of deposition of visceral fat, are associated with the metabolic syndrome of ageing. This syndrome is associated with hyperinsulinaemia, dyslipidaemia, type 2 diabetes mellitus, ... Read More »
» Published in Obes Rev. 2004 Feb;5(1):13-9.

30. Signaling pathways regulating protein synthesis during ageing.
Match Strength: 8.562

Ageing in many organisms, including humans, is accompanied by marked alterations in both general and specific protein synthesis. Protein synthesis is normally under tight control by a broad array of regulatory factors, which facilitate appropriate rates of mRNA translation. Are the wide changes in protein synthesis simply a corollary of the ageing process or do they have a causative role in senescent decline? The jury is still out on this important question. Nevertheless, recent studies reveal an intimate interface between mechanisms that govern the translation of mRNA and molecular pathways ... Read More »
» Published in Exp Gerontol. 2006 Oct;41(10):1020-5. Epub 2006 Jul 7.

31. Application of advanced technologies in ageing research.
Match Strength: 8.548

Several technologies that emerged in the post-genomic era have been particularly useful in dissecting the molecular mechanisms of complex biological processes through the systems approach. Here, we review how three of these technologies, namely transcriptional profiling, large-scale RNA interference (RNAi) and genome-wide location analysis of protein-DNA interactions, have been used in the study of ageing in metazoans. We also highlight recent developments of these three technologies and how these developments are applicable to ageing research ... Read More »
» Published in Mech Ageing Dev. 2007 Jan;128(1):149-60. Epub 2006 Nov 17.

32. Keynote lecture: an update on the what, why and how questions of ageing.
Match Strength: 8.518

In this keynote address, we briefly consider three global questions on the biology of ageing. What is it? While it is certainly the case that development has a major impact upon ageing, gerontologists characterize ageing as gradual, insidious, post-maturational declines in the structure and function of multiple organ systems, certainly to include reproduction. This is accompanied by increasing rates of mortality within populations. Comprehensive, longitudinal physiological assessments are not commonly pursued in their experiments, however; this deficiency limits one's ability to interpret the ... Read More »
» Published in Exp Gerontol. 2006 May;41(5):460-3. Epub 2006 Apr 18.

33. Beyond the evolutionary theory of ageing, from functional genomics to evo-gero.
Match Strength: 8.488

By the mid 1970s, the mechanisms by which ageing can evolve had a secure theoretical basis in population genetics. Here, we discuss how subsequent evolutionary work has focussed on testing and extending this theory, and on attempting to integrate it with other emerging facets of the biology of ageing, such as genetic studies of long-lived mutants and of phenotypic plasticity in ageing, such as in response to nutritional status. We also describe how functional genomic studies are providing new insights into the evolutionary forces shaping genome evolution and lifespan control. Future challenges ... Read More »
» Published in Trends Ecol Evol. 2006 Jun;21(6):334-40. Epub 2006 Mar 10.

34. Telomeres and telomerase biology in vertebrates: progress towards a non-human model for replicative senescence and ageing.
Match Strength: 8.460

Studies on telomere and telomerase biology are fundamental to the understanding of human ageing and age-related diseases such as cancer. However, human studies of whole body ageing are hampered by the lack of suitable fully reflective animal model systems, the wild-type mouse model being unsuitable due to differences in telomere biology. Here we summarise recent data on the biology of telomeres, telomerase, and the tumour suppressor protein p53 in various animals, and examine their possible roles in replicative senescence, ageing, and tumourigenesis. The advantages and disadvantages of various ... Read More »
» Published in Biogerontology. 2005 Dec;6(6):371-85.

35. Telomere attrition as ageing biomarker.
Match Strength: 8.455

Telomeres, the tandem-repeated hexamers at the termini of mammalian chromosomes, form protective complexes in association with specific proteins that together with telomerase, a specialised telomere-synthesizing enzyme, regulate telomere length. Telomere shortening is associated with cellular senescence and is implicated in tumorigenesis and cancer. Hence, mean telomere length has emerged as a replicative clock within each population of cells and the tissues and organs they build up in vitro and, consequently, as a biomarker for biological ageing in vivo. Chronological ageing per se does not ... Read More »
» Published in Anticancer Res. 2005 Jul-Aug;25(4):3011-21.

36. Health Capital, Life Course and Ageing.
Match Strength: 8.422

Background: The difference in individual ageing remains a not fully understood subject. Objective: To discuss the use of the health capital concept and its application to the life course approach as an alternative to understand factors involved on individual ageing and identify genetic, socioeconomic, psychological and biological influences. Results: The initial capital (genetics and development in uterus) and other lifelong assets like education, social status, locus of control, cognitive reserve, and humor are important modulators of ageing. The biological assets like basal metabolism, ... Read More »
» Published in Gerontology. 2006 Oct 20;53(2):96-101

37. The Gompertz function does not measure ageing.
Match Strength: 8.401

The Gompertz transform of the distribution function for the age at death expresses mortality in a form R = R0e(alphat) where R0 is the mortality at time zero and alpha is the rate of increase of mortality, frequently taken as the rate of ageing. The slope of the line alpha is frequently used as a measure of the rate of ageing. It is argued that it is incorrect to use alpha in this way. To support this contention, a paradox is produced whereby selection for longevity increases alpha, which could lead to the absurd conclusion that selection for longevity increases the rate of ageing. Publication ... Read More »
» Published in Biogerontology. 2001;2(1):61-5. Comment on: Biogerontology. 2000;1(1):3-13.

38. Embryo development and ageing in birds and mammals.
Match Strength: 8.367

The rate of ageing is a genetically influenced feature of an individual's life history that responds to selection on lifespan. Various costs presumably constrain the evolution of prolonged life, but these have not been well characterized and their general nature is unclear. The analyses presented here demonstrate a correlation among birds and mammals between rates of embryonic growth and ageing-related mortality, which are quantified by the exponents of fitted power functions. This relationship suggests that rapid early development leads to accelerated ageing, presumably by influencing some ... Read More »
» Published in Proc Biol Sci. 2006 Aug 22;273(1597):2077-82.

39. An analysis of psychosocial theories of ageing and their relevance to practical gerontological nursing in Sweden.
Match Strength: 8.359

BACKGROUND: Theories exist to challenge current practice, create new approaches to practice and remodel the structure of rules and principles. One question is whether nurses could find in psychosocial theories of ageing a theoretical foundation on which to base support of older people in their ageing process. AIM: The aim of the present paper was to analyse five psychosocial theories of ageing and to discover what they could mean for gerontological nursing in Sweden. METHOD: A literature search was conducted to find original works. Research questions inspired by Fawcett's framework guided the ... Read More »
» Published in Scand J Caring Sci. 2006 Sep;20(3):347-54.

40. Skin ageing.
Match Strength: 8.346

Cutaneous ageing manifests itself as a progressive reduction in maximum function and reserve capacity of skin tissue. It is not a unique and uniform biological event. Skin comprises three layers: epidermis, dermis and subcutaneous tissue. Collagen atrophy is a major factor in skin ageing. There is a strong correlation between skin collagen loss and estrogen deficiency due to the menopause. Skin ageing, especially in the face, is associated with a progressive increase in extensibility and a reduction in elasticity. With increasing age, the skin also becomes more fragile and susceptible to ... Read More »
» Published in Menopause Int. 2007 Jun;13(2):60-64.

41. Physical ageing and thermal analysis of PLGA microspheres encapsulating protein or DNA.
Match Strength: 8.315

PLGA microspheres undergo physical ageing but their ageing kinetics have not been reported, nor the effect of encapsulated protein or plasmid DNA on any associated changes to the glass transition. Differential scanning calorimetry (DSC) was used to measure the rate of ageing of various PLGA microsphere formulations, with temperature-modulated DSC used to accurately measure the associated glass transition. The Cowie-Ferguson model was applied to determine the parameters describing the enthalpy relaxation kinetics. We show that encapsulated proteins had no significant effect on the glass ... Read More »
» Published in Int J Pharm. 2007 Jul 18;339(1-2):112-20. Epub 2007 Feb 28.

42. Ageing and the nervous system: insights from studies on invertebrates.
Match Strength: 8.295

Ageing can have profound effects on the post-mitotic organ of behaviour, the brain. As yet the precise causes of these deleterious effects are unknown. However, clear insights into the putative mechanisms and consequences of ageing in the CNS have been achieved through the use of invertebrate models. It is now clear that ageing alters the endogenous properties of neurones, their morphology, the efficacy of the connections that the neurones make with their targets and may even lead to neurone loss. While the precise mechanisms underlying these changes are presently unclear clues from post ... Read More »
» Published in Biogerontology. 2001;2(2):85-97.

43. Which model of successful ageing should be used? Baseline findings from a British longitudinal survey of ageing.
Match Strength: 8.294

BACKGROUND: there is increasing interest in how to age 'successfully' and in reaching consensus over its definition. OBJECTIVE: to assess different models of successful ageing, using a British longitudinal survey of ageing in 2000-1. SETTING: community settings in Britain. METHODS: five models of successful ageing were tested on a British cross-sectional population survey of 999 people aged 65+. The models were biomedical, broader biomedical, social, psychological and lay based. RESULTS: the lay model emerged as the strongest. Respondents who were classified as successfully aged with this ... Read More »
» Published in Age Ageing. 2006 Nov;35(6):607-14. Epub 2006 Sep 2.

44. The effect of ovariectomy on biomarkers of urogenital ageing in old versus young adult rats.
Match Strength: 8.262

The aim of this study was to compare the effects of ageing and ovariectomy on biomarkers of urogenital ageing in old and young-adult rats. Fisher 344 rats (18- and 3-months-old, n = 6 x 2) underwent ovariectomy. Age-matched sham animals received no intervention (n = 6 x 2). One month later, biomarkers of urogenital ageing were evaluated (light microscopic count of urethral and anal canal submucosal blood vessels, Western blot analysis of urethral, and anal canal submucosal collagen I and III and cytoplasmic p27(kip1) expression in the striated urethral and anal sphincters and levator ani and ... Read More »
» Published in Int Urogynecol J Pelvic Floor Dysfunct. 2007 Jan 5;

45. The effect of ovariectomy on biomarkers of urogenital ageing in old versus young adult rats.
Match Strength: 8.262

The aim of this study was to compare the effects of ageing and ovariectomy on biomarkers of urogenital ageing in old and young-adult rats. Fisher 344 rats (18- and 3-months-old, n = 6 x 2) underwent ovariectomy. Age-matched sham animals received no intervention (n = 6 x 2). One month later, biomarkers of urogenital ageing were evaluated (light microscopic count of urethral and anal canal submucosal blood vessels, Western blot analysis of urethral, and anal canal submucosal collagen I and III and cytoplasmic p27(kip1) expression in the striated urethral and anal sphincters and levator ani and ... Read More »
» Published in Int Urogynecol J Pelvic Floor Dysfunct. 2007 Jan 5;

46. Skin ageing and its treatment.
Match Strength: 8.242

The effects of chronic sun exposure on skin are readily apparent when skin not typically exposed to the sun and skin regularly exposed to the sun are compared. While the sun is not the only aetiological factor in the dynamic process of skin ageing, it is the primary exogenous cause among several internal and environmental elements. Thus, photo-ageing, the main focus of this article, is a subset of extrinsic skin ageing. The influence of the sun in extrinsic skin ageing, as well as its role in potentially altering the normal course of intrinsic (also known as natural or cellular) ageing, is ... Read More »
» Published in J Pathol. 2007 Jan;211(2):241-51.

47. Ageing and dexamethasone associated sarcopenia: Peculiarities of regeneration.
Match Strength: 8.239

The purpose of this study was to assess the development of ageing- and glucocorticoid-related sarcopenia on the level of myofibrillar apparatus, paying attention to the synthesis (SR) and degradation rate (DR) of contractile proteins, muscle strength, and daily motor activity. We also wanted to test the effect of ageing and dexamethasone (Dex) excess on the regeneration peculiarities of skeletal muscle autografts. Four and 30-month-old male rats of the Wistar strain were used. Ageing associated sarcopenia was calculated from gastrocnemius muscle relative mass decrease (from 5.6+/-0.08 to 3.35+ ... Read More »
» Published in J Steroid Biochem Mol Biol. 2007 May 17;

48. Controversial endocrine interventions for the aged.
Match Strength: 8.235

Specific endocrine changes occur with the ageing process. The last decade has witnessed significant progress in the basic and clinical science of ageing, thereby rejuvenating the interest in anti-ageing medicine, especially that of hormone replacement, by medical professionals and the lay public. However, endocrine manipulation as a therapeutic strategy for ageing is still evolving as continuing research attempts to answer the many questions of what it can achieve at the risk of incurring unknown long-term adverse effects. The current day doctor is confronted with a host of options, and will ... Read More »
» Published in Singapore Med J. 2006 Jul;47(7):569-79.

49. Effects of Ageing on Insulin Secretion and Action
Match Strength: 8.232

One of the many conditions associated with ageing is type 2 diabetes mellitus, the prevalence of which increases from 20-30 years of age onwards. In many cases, type 2 diabetes mellitus is caused by the combination of insulin resistance and poor insulin secretion. Insulin resistance is also a risk factor associated with other disorders, in particular cardiovascular disease. Physiological changes associated with ageing, such as changes in body composition, decreased physical fitness, changes in hormones, and the secondary effects of high levels of free fatty acids and glucose, may also ... Read More »
» Published in Horm Res. 2003;60(Suppl 1):102-4.

50. Neuroprotective and anti-ageing effects of curcumin in aged rat brain regions.
Match Strength: 8.182

This study investigated the influence of chronically administered curcumin on normal ageing-related parameters: lipid peroxidation, lipofuscin concentration and intraneuronal lipofuscin accumulation, activities of the enzymes superoxide dismutase (SOD), glutathione peroxidase (GPx), and Na(+), K(+), -adenosine triphosphatase (Na(+), K(+), -ATPase) in different brain regions (cerebral cortex, hippocampus, cerebellum and medulla) of 6- and 24-month-old rats. In normal ageing, lipid peroxidation and lipofuscin concentration were found to increase with ageing, the activities of SOD, GPx and Na(+), ... Read More »
» Published in Biogerontology. 2006 Apr;7(2):81-9.

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