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Peer Reviewed Scientific Research Reports.
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1. Radiological assessment of the adult chest: implications for chest compressions.
Match Strength: 4.118
The recommended depth for chest compression during adult cardiopulmonary resuscitation (CPR) is 4-5 cm, and for children one-third the anterior-posterior (AP) chest diameter. A compression depth of one-third of the AP chest diameter has also been suggested for adult CPR. We have assessed chest CT scans to measure what proportion of the adult AP chest diameter is compressed during CPR. Measurements of AP diameter of chest CT scans were taken from the skin anteriorly at the middle of the lower half of the sternum, perpendicularly to the skin on the posterior thorax. The anatomical structure that ... Read More »
» Published in Resuscitation. 2006 Dec;71(3):387-90. Epub 2006 Sep 18.
2. Bcl-2 enhances neurogenesis and inhibits apoptosis of newborn neurons in adult rat brain following a transient middle cerebral artery occlusion.
Match Strength: 3.415
To determine whether Bcl-2 could influence adult neurogenesis and prevent apoptosis of newborn neurons, we injected Bcl-2 expressing plasmid into the lateral ventricle of rat brain immediately following a 30-min occlusion of the middle cerebral artery (MCAO). We found that Bcl-2 increased neural progenitor cells (BrdU+-DCX+) in the ipsilateral striatum, newborn immature neurons (BrdU+-Tuj-1+) and newborn mature neurons (BrdU+-MAP-2+) in the ipsilateral striatum and frontal cortex at 1 to 4 weeks following MCAO. Bcl-2 overexpression promoted development of newborn neurons into GABAergic and ... Read More »
» Published in Neurobiol Dis. 2006 Nov;24(2):345-56. Epub 2006 Sep 25.
3. NARP syndrome and adult-onset generalised seizures.
Match Strength: 3.380
The neurogenic muscle weakness, ataxia and retinitis pigmentosa (NARP) syndrome is a maternally inherited disorder attributable to a heteroplasmic mtDNA point mutation. Catastrophic epilepsy may accompany severe, early onset forms of NARP, but seizures seem to be rare in cases with adolescent and adult onset. We describe a patient who developed clumsiness and visual problems in her teens. She had no clinical seizures but an EEG showed generalized spike and wave discharges. At this time the patient remained without a specific diagnosis. At the age of 21, the patient developed progressive ataxia ... Read More »
» Published in Epileptic Disord. 2006 Sep;8(3):200-3.
4. Adult attachment security and college student substance use.
Match Strength: 3.366
Previous research has demonstrated strong links between quality of adult attachment styles and various forms of psychological distress. A burgeoning literature further points to a relationship between insecure attachment and drug use, particularly alcohol consumption. In the present study, we expanded upon the existing literature by examining the relationship between adult attachment style and use of cigarettes, alcohol, and marijuana in a sample of 212 college students. Moreover, based on our previous work [Hankin, B.L., Kassel, J.D., and Abela, J.R.Z. (2005). Adult attachment dimensions and ... Read More »
» Published in Addict Behav. 2006 Sep 20;
5. Balance performance in adult epilepsy patients.
Match Strength: 3.338
PURPOSE: To evaluate the magnitude of subclinical balance dysfunction in adult epilepsy patients and to assess the relative contribution of different variables to balance impairment. METHODS: Balance performance was evaluated by computerized dynamic platform posturography (CDPP) in 25 adult patients following a generalized tonic-clonic seizure (GTCS) and in 11 healthy subjects. RESULTS: The GTCS was a breakthrough seizure in 20 patients with epilepsy and a first seizure in 5. Seven of the patients had localization-related epilepsy and 13 had generalized epilepsy. Mean epilepsy duration was 6.6 ... Read More »
» Published in Seizure. 2006 Dec;15(8):582-9. Epub 2006 Sep 15.
6. Genomic diversity of cultivable Lactobacillus populations residing in the neonatal and adult gastrointestinal tract.
Match Strength: 3.316
The objective of this study was to investigate the cultivable Lactobacillus population in adult and infant faecal material to identify strains shared across a number of individuals. A range of lactobacilli isolated on Lactobacillus-selective agar from faeces of 16 infants and 11 adults were genetically fingerprinted and further characterized by 16S rRNA gene sequencing. The relatedness of all the Lactobacillus strains isolated to known species was also determined both genetically and phenotypically. This study revealed that the human intestine is initially colonized by only a few (1-2) ... Read More »
» Published in FEMS Microbiol Ecol. 2007 Jan;59(1):127-37. Epub 2006 Sep 18.
7. Adult intussusception: a retrospective review.
Match Strength: 3.282
PURPOSE: Whereas intussusception is relatively common in children, it is clinically rare in adults. The condition is usually secondary to a definable lesion. This study was designed to review adult intussusception, including presentation, diagnosis, and optimal treatment. METHODS: A retrospective review of 22 cases of intussusception occurring in individuals older than aged 18 years encountered at two university-affiliated hospitals in Winnipeg between 1989 and 2000. The 22 cases were divided to benign and malignant enteric, ileocolic, colonic lesions respectively. The diagnosis and treatment ... Read More »
» Published in Dis Colon Rectum. 2006 Oct;49(10):1546-51.
8. Minimally invasive repair of pectus excavatum in adult patients.
Match Strength: 3.205
Since 1996, the technique for minimally invasive repair of pectus excavatum (MIRPE) has gained increasing acceptance among pediatric patients. However, the feasibility of the operation and outcomes have not yet been evaluated in adult patients. This study was a retrospective analysis of the author's experience combined with a survey of members of the American Pediatric Surgical Association in treating adult patients with MIRPE. Thirty adults (age range, 18-32 years; mean, 23 years; 75% men) with severe pectus excavatum (chest index > 3.2) were treated with MIRPE. The main indication for ... Read More »
» Published in Am Surg. 2006 Sep;72(9):837-42.
9. Glutamine gluconeogenesis in the small intestine of 72 h-fasted adult rats is undetectable.
Match Strength: 3.136
Recent reports have indicated that 48-72 h of fasting, Type 1 diabetes and high-protein feeding induce gluconeogenesis in the small intestine of adult rats in vivo. Since this would (i) represent a dramatic revision of the prevailing view that only the liver and the kidneys are gluconeogenic and (ii) have major consequences in the metabolism, nutrition and diabetes fields, we have thoroughly re-examined this question in the situation reported to induce the highest rate of gluconeogenesis. For this, metabolically viable small intestinal segments from 72 h-fasted adult rats were incubated with ... Read More »
» Published in Biochem J. 2007 Jan 15;401(2):465-73.
10. Effects of dibutylphthalate and ethynylestradiol on liver peroxisomes, reproduction, and development of zebrafish (Danio rerio).
Match Strength: 3.126
The aim of the present work was to study the effects of the peroxisome proliferator dibutylphthalate (DBP) and the xenoestrogen 17alpha-ethynylestradiol (EE2) on liver peroxisomes, reproduction, and development of zebrafish (Danio rerio). In experiment 1, newly fertilized zebrafish eggs were exposed for five weeks, covering the entire period of sexual determination, to nominal concentrations of 25 and 100 microg/L of DBP and 5 microg/L of EE2. In experiment 2, adult female zebrafish were exposed for 15 d to 100 and 500 microg/L of DBP and 5 microg/L of EE2, and afterward, they were paired with ... Read More »
» Published in Environ Toxicol Chem. 2006 Sep;25(9):2394-404.
11. Development of theory-based, online health learning modules for older adults: Lessons learned.
Match Strength: 3.095
Recently, the number of older adult online users has increased rapidly. In 2004, 22% of Americans aged 65 years or older (about 8 million) used the Internet, and 66% of them performed online searches for health information. The Web, therefore, can serve as a useful medium to educate older adults on selected health topics. In this study, the researchers developed four Web-based learning modules related to hip fracture prevention and tested the usability of these modules employing eight older adult online users. The findings from the usability tests demonstrated that the online learning modules ... Read More »
» Published in Comput Inform Nurs. 2006 Sep-Oct;24(5):261-8.
12. Endocrine disruptor vinclozolin induced epigenetic transgenerational adult-onset disease.
Match Strength: 3.065
The fetal basis of adult disease is poorly understood on a molecular level and cannot be solely attributed to genetic mutations or a single etiology. Embryonic exposure to environmental compounds has been shown to promote various disease states or lesions in the first generation (F1). The current study used the endocrine disruptor vinclozolin (antiandrogenic compound) in a transient embryonic exposure at the time of gonadal sex determination in rats. Adult animals from the F1 generation and all subsequent generations examined (F1-F4) developed a number of disease states or tissue abnormalities ... Read More »
» Published in Endocrinology. 2006 Dec;147(12):5515-23. Epub 2006 Sep 14. Comment in: Endocrinology. 2006 Dec;147(12):5513-4.
13. Morphophenotype of medulloblastoma in children and adults. The size of nuclei.
Match Strength: 3.055
OBJECTIVE: Uniform cells with round, regular nuclei characterize the typical histologic aspect of medulloblastoma. Enlargement of nuclei distinguishes the large-cell medulloblastoma variant and is associated with a poor prognosis in pediatric medulloblastomas. The aim of the present study was to compare the size of nuclei between pediatric and adult medulloblastomas by a morphometric analysis. MATERIAL AND METHODS: In 79 neurosurgical specimens of cerebellar medulloblastomas, the maximum nuclear diameter of the largest nuclei was measured. Measurements were performed with a digital-image ... Read More »
» Published in Clin Neuropathol. 2006 Sep-Oct;25(5):227-31.
14. Epirubicin glucuronidation and UGT2B7 developmental expression.
Match Strength: 3.021
The usefulness of epirubicin in the treatment of adult and childhood malignant diseases is related in part to the potential reduction in cardiac toxicity compared with that of other anthracyclines given at equivalent doses. An important pathway for epirubicin detoxification is UGT2B7-dependent glucuronidation. This study was implemented to provide a preclinical evaluation of the metabolism of epirubicin with respect to age-related changes in epirubicin glucuronidation in pediatric liver microsomes. Rates of epirubicin glucuronidation and levels of UGT2B7 were determined for liver microsomes ... Read More »
» Published in Drug Metab Dispos. 2006 Dec;34(12):2097-101. Epub 2006 Sep 19.
15. Behavioral phenotyping of mouse models of neurodevelopmental disorders: Relevant social behavior patterns across the life span.
Match Strength: 2.998
Social responses are a key element for behavioral phenotyping of mouse models of neurodevelopmental disorders associated with social deficits. Here we describe selected behavioral responses that can be measured in developing and adult mice, with special emphasis on ultrasonic vocalizations, a behavioral response not yet systematically characterized in most of the genetic mouse models of social abnormalities. A recently developed task to measure social approach relevant to the first core symptom of autism is highlighted. We also focus on those developmental factors, including litter size, ... Read More »
» Published in Behav Brain Res. 2007 Jan 10;176(1):40-52. Epub 2006 Sep 22.
16. Select patients with hypogonadotropic hypogonadism may respond to treatment with clomiphene citrate.
Match Strength: 2.981
OBJECTIVE: To review the management of male hypogonadotropic hypogonadism (HH) and evaluate the efficacy of clomiphene citrate (CC). DESIGN: Retrospective review. SETTING: Two university-based urology clinics. PATIENT(S): Ten patients referred for male infertility evaluation. INTERVENTION(S): Patients were treated with either clomiphene citrate or injectable gonadotropins. MAIN OUTCOME MEASURE(S): Changes in seminal parameters, gonadotropin levels, serum testosterone, and pregnancy. RESULT(S): Ten men who were evaluated for infertility were diagnosed with HH. Four had Kallmann's syndrome, four ... Read More »
» Published in Fertil Steril. 2006 Dec;86(6):1664-8. Epub 2006 Sep 27.
17. Odor-facilitated reentrainment in male and female juvenile Octodon degus.
Match Strength: 2.969
The social, diurnal rodent, Octodon degus, exhibits faster reentrainment rates of circadian activity when exposed to olfactory social cues from females already entrained to the new light cycle (donors) during reentrainment after a phase shift of the light:dark (LD) cycle. However, adult degus display sex differences in the use of olfactory stimuli to accelerate reentrainment, with intact males requiring odors from at least two females for accelerated reentrainment, while odors from a single female are sufficient for faster recovery for females. In addition, adult gonadal hormones modulate ... Read More »
» Published in Physiol Behav. 2006 Dec 30;89(5):617-22. Epub 2006 Sep 25.
18. Common reasons for hospitalization among adult patients with diabetes.
Match Strength: 2.955
OBJECTIVE: To determine reasons for hospitalization among adult patients with diabetes. METHODS: A cross-sectional analysis was conducted of hospital discharges in the state of Georgia for the years 1998 through 2001 that contained either a primary or a coexisting diagnosis of diabetes. With use of the Clinical Classification Software of the Agency for Healthcare Research and Quality, the principal diagnoses among diabetes-related hospital discharges were organized into diagnostic categories. RESULTS: Diabetes was listed as a diagnosis in 14% of all Georgia hospital discharges of adult ... Read More »
» Published in Endocr Pract. 2006 Jul-Aug;12(4):363-70.
19. Health-related quality of life and adverse late effects in adult (very) long-term childhood cancer survivors.
Match Strength: 2.935
PURPOSE: METHOD: The RAND-36 was used to assess HRQoL in all adult (18 years) survivors who had attended the long-term follow-up clinic since 1995. The survivors were divided into two groups based on the length of follow-up: Group LF (long term follow-up, follow-up 20 years, n=129) and Group VLF (very long-term follow-up, follow-up >20 years, n=184). Data on diagnosis, treatment and complications were obtained from medical records. Late effects were graded using the CTCAEv3. RESULTS: The RAND-36 was completed by 313 (86.2%) out of 363 eligible patients. Except for higher scores on the ... Read More »
» Published in Eur J Cancer. 2007 Jan;43(1):122-30. Epub 2006 Sep 20.
20. The changing scene of adult acute lymphoblastic leukemia.
Match Strength: 2.935
PURPOSE OF REVIEW: The review focuses on the most recent advances in the diagnostic and prognostic work-up of adult acute lymphoblastic leukemia (ALL) and its implications in the clinical management of the disease. RECENT FINDINGS: ALL can be identified on the basis of morphologic, cytochemical and immunophenotypic criteria; modern management of ALL is also based on cytogenetic and genetic evaluations. New technologies, such as gene expression profile analysis, may allow us to further unravel the intrinsic biology of the disease, to improve diagnostic and prognostic stratification, and to ... Read More »
» Published in Curr Opin Oncol. 2006 Nov;18(6):652-9.
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