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Peer Reviewed Scientific Research Reports.
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1. Introducing HPV triage into the English cervical cancer screening program: consequences for participation.
Match Strength: 3.947
OBJECTIVE: To predict the likely impact of adding human papillomavirus (HPV) triage for minor abnormalities on participation in the English cervical cancer screening program. METHOD: Contingent valuations of the existing Pap program and a possible HPV-augmented screening program, obtained from questionnaires completed by 1141 women in east-central England. RESULTS: The value of participating in Pap screening was negatively associated with age, positively associated with educational level, and positively associated with the level of household income. Higher levels of worry about cervical cancer ... Read More »
» Published in Women Health. 2006;43(2):17-34.
2. Venlafaxine-induced ecchymoses and impaired platelet aggregation.
Match Strength: 3.874
OBJECTIVE: To describe a case of venlafaxine-induced ecchymoses. METHODS: A patient with a history of ecchymoses coincident with venlafaxine therapy was rechallenged with the drug. Her platelet function was assessed with aggregation and ATP release studies before the rechallenge and after she developed ecchymoses. In addition, the effect of venlafaxine on platelet aggregation and ATP release was studied in vitro by adding the drug to platelet-rich plasma from normal donors. RESULTS: After 4 wk of treatment with venlafaxine our patient developed extensive ecchymoses. At that time her platelet ... Read More »
» Published in Eur J Haematol. 2006 Dec;77(6):533-7. Epub 2006 Sep 15.
3. Case-control study of postmenopausal hormone replacement therapy and endometrial cancer.
Match Strength: 3.719
This study evaluated recent inconsistent findings that adding progestins to postmenopausal estrogen replacement therapy protects against endometrial cancer. Using a population-based case-control study, the authors compared 511 endometrial cancer cases aged 50-79 years in the Philadelphia, Pennsylvania, region during 1999-2002 with 1,412 random-digit-dialing controls regarding postmenopausal hormone replacement therapy (HRT) use. Telephone interviews were performed with memory aids mailed in advance. An increased risk of endometrial cancer was observed among postmenopausal women using only ... Read More »
» Published in Am J Epidemiol. 2006 Oct 15;164(8):775-86. Epub 2006 Sep 22.
4. Iron uptake by Caco-2 cells from NaFeEDTA and FeSO4: Effects of ascorbic acid, pH, and a Fe(II) chelating agent.
Match Strength: 3.536
Sodium iron(III) ethylenediaminetetraacetate (NaFeEDTA) has considerable promise as an iron fortificant because of its high bioavailability in foods containing iron absorption inhibitors. In this study, uptakes of iron from NaFeEDTA, FeSO4, and FeCl3 by Caco-2 cells were compared in the absence or presence of ascorbic acid (AA), an iron absorption enhancer; at selected pH levels; and in the absence or presence of an iron absorption inhibitor, bathophenanthroline disulfonic acid (BPDS). Ferritin formation in the cells was used as the indicator of iron uptake. Uptake from all three Fe sources ... Read More »
» Published in J Agric Food Chem. 2006 Oct 4;54(20):7924-8.
5. Adding value with 3D visualization and haptic forces to radiosurgery--a small theory-based, quasi-experimental study.
Match Strength: 3.107
This study investigates the use of 3D representation and haptic technology in radiosurgery. The users, experienced users of the Leksell GammaKnife, prefer the 3D representation for constructing a first draft of their plan for neurosurgical intervention. When it comes to the final adjustments, however, they still choose the traditional 2D representation and interaction devices. The perceived control over the radiosurgical process is not considered adequate using the 3D interaction methods. Practitioners do not consider the haptic forces implemented in this test system useful. Possible ... Read More »
» Published in J Med Syst. 2006 Aug;30(4):293-301.
6. Proteome informatics II: bioinformatics for comparative proteomics.
Match Strength: 2.771
The present review attempts to cover the most recent initiatives directed towards representing, storing, displaying and processing protein-related data suited to undertake "comparative proteomics" studies. Data interpretation is brought into focus. Efforts invested into analysing and interpreting experimental data increasingly express the need for adding meaning. This trend is perceptible in work dedicated to determining ontologies, modelling interaction networks, etc. In parallel, technical advances in computer science are spurred by the development of the Web and the growing need to channel ... Read More »
» Published in Proteomics. 2006 Oct;6(20):5445-66. Erratum in: Proteomics. 2006 Dec;6(23):6380.
7. Controllable organization of a carboxylic acid type gemini surfactant at different pH values by adding Copper(II) ions.
Match Strength: 2.711
The gemini surfactant sodium 4,8-dioctyl-3,9-dioxo-6-hydroxy-4,8-diaza-1,11-undecanedicarboxylate (SDUC), bearing two carboxylic headgroups and two hydrocarbon chains, has been synthesized, and its self-organization characteristics at strong basic and neutral environments have been studied. The results reveal that a transition from micelles to vesicles in SDUC aqueous solution occurs when the pH drops from 12.0 to 7.0. When a small amount of Cu(2+) ion is added to the SDUC solutions at both pH 12.0 and 7.0, remarkable transformations were observed within the SDUC aggregate structures. At pH 12 ... Read More »
» Published in J Phys Chem B Condens Matter Mater Surf Interfaces Biophys. 2006 Oct 5;110(39):19479-86.
8. Wayfinding with words: spatial learning and navigation using dynamically updated verbal descriptions.
Match Strength: 2.618
This work investigates whether large-scale indoor layouts can be learned and navigated non-visually, using verbal descriptions of layout geometry that are updated, e.g. contingent on a participant's location in a building. In previous research, verbal information has been used to facilitate route following, not to support free exploration and wayfinding. Our results with blindfolded-sighted participants demonstrate that accurate learning and wayfinding performance is possible using verbal descriptions and that it is sufficient to describe only local geometric detail. In addition, no ... Read More »
» Published in Psychol Res. 2006 Sep 16;
9. Perception of initial moving target signals: support for a cumulative lateral inhibition theory.
Match Strength: 2.615
The cumulative lateral inhibition (CLI) theory of the Frohlich effect (perceptual mislocalization of the starting position of a moving target in the direction of movement) proposes that the target is difficult to see early in its trajectory because inhibitory feedback from later target views weakens initial target representations. In contrast, attention shift explanations contend that a phenomenal representation of the target is unavailable until attention has shifted to the vicinity of the target. Experiments 1-3 demonstrated that instructing naive undergraduate participants to accept ... Read More »
» Published in J Exp Psychol Hum Percept Perform. 2006 Oct;32(5):1185-96.
10. Modification of the wettability of a polymeric substrate by pH effect. Determination of the surface acid dissociation constant by contact angle measurements.
Match Strength: 2.537
The wetting properties of a substrate can be changed by chemical reaction. Here, we studied simple materials with acid-base properties, by preparing poly(vinyl chloride) films containing lauric acid. These substrates constitute simple polymeric surfaces the wettability of which can be easily controlled by the acid-base equilibrium. The roughness of the material was then varied by adding Aerosil (hydrophobic fumed silica). We then studied the wettability of these materials toward aqueous buffer solutions between pH 2 and 12 from contact angle measurements. The variation of the contact angle of ... Read More »
» Published in Langmuir. 2006 Sep 26;22(20):8424-30.
11. Dynamics of assembly and reorganization of extracellular matrix proteins.
Match Strength: 2.480
This chapter will review advances in our understanding of the dynamics of assembly and reorganization of extracellular matrix (ECM) proteins and will highlight the role of fibronectin as a key orchestrator for the assembly of multiple ECM proteins. The dynamic rather than static nature of the ECM will be emphasized by reviewing time-lapse imaging studies in living cell and embryo systems, with a particular focus on fibronectin and members of the fibrillin superfamily. These studies have provided new insights into the assembly and reorganization of ECM fibrillar networks, suggesting that fibril ... Read More »
» Published in Curr Top Dev Biol. 2006;75:1-24.
12. Up-regulation of P-glycoprotein expression by catalase via JNK activation in HepG2 cells.
Match Strength: 2.467
Overexpression of the MDR1 gene is one of the reasons for multidrug resistance (MDR). Some studies suggested that antioxidants could down-regulate MDR1 expression as a possible cancer treatment. In this report, we try to determine the effects of antioxidants (catalase or N-acetylcysteine [NAC]) on the regulation of intrinsic MDR1 overexpression in HepG2 cells. Adding catalase or N-acetylcysteine to the HepG2 culture led to a significant increase of MDR1 mRNA and P-glycoprotein drug transporter activity. After catalase or NAC treatment, a reduced intracellular reactive oxygen species (ROS) was ... Read More »
» Published in Redox Rep. 2006;11(4):173-8.
13. Psychosocial factors associated with young elementary school children's intentions to consume legumes: a test of the theory of reasoned action.
Match Strength: 2.442
OBJECTIVE: The purpose of this study was to test the utility of the Theory of Reasoned Action (TRA) in explaining young elementary school children's intention to consume legumes. METHODS: A survey was conducted with children in an urban, multicultural community in Massachusetts. A total of 336 children participated. Logistic regression analysis was used to assess the strength of the relationship between attitude and subjective norm and intention. RESULTS: Although attitude was significantly associated with intention, the pseudo-R2 for the regression model that included only the TRA constructs ... Read More »
» Published in Am J Health Promot. 2006 Sep-Oct;21(1):13-5.
14. Abstinence rates following behavioral treatments for marijuana dependence.
Match Strength: 2.422
Previous studies have noted particular difficulty in achieving abstinence among those who are marijuana dependent. The present study employed a dismantling design to determine whether adding contingency management (ContM) to motivational enhancement therapy plus cognitive behavioral therapy (MET+CBT), an intervention used in prior studies of treatment for marijuana dependence, would enhance abstinence outcomes. 240 marijuana dependent participants were recruited via advertisements and assigned to either MET+CBT, ContM-only, MET+CBT+ContM, or to a case-management control condition. All ... Read More »
» Published in Addict Behav. 2006 Sep 20;
15. Immunomodulatory effects of Bacillus firmus on mouse peritoneal cells in vitro.
Match Strength: 2.416
The effect of nonpathogenic G+ bacterium B. firmus (BF) on stimulation of mouse peritoneal cells in vitro was evaluated by testing nitric-oxide-synthesis induction and cytokine formation. The reactivity was compared of peritoneal cells from two inbred mouse strains, C57B1/6 and BALB/c, which differ in their immunological reactivity. Peritoneal macrophages from C57B1/6 produced more nitric oxide after a 1-d cultivation with inactivated BF than those of BALB/c mice. In both strains, production can be further increased by adding exogenous IFN-gamma to the culture. There were no significant ... Read More »
» Published in Folia Microbiol (Praha). 2006;51(3):243-7.
16. Munc18-bound syntaxin readily forms SNARE complexes with synaptobrevin in native plasma membranes.
Match Strength: 2.388
Munc18-1, a protein essential for regulated exocytosis in neurons and neuroendocrine cells, belongs to the family of Sec1/Munc18-like (SM) proteins. In vitro, Munc18-1 forms a tight complex with the SNARE syntaxin 1, in which syntaxin is stabilized in a closed conformation. Since closed syntaxin is unable to interact with its partner SNAREs SNAP-25 and synaptobrevin as required for membrane fusion, it has hitherto not been possible to reconcile binding of Munc18-1 to syntaxin 1 with its biological function. We now show that in intact and exocytosis-competent lawns of plasma membrane, Munc18-1 ... Read More »
» Published in PLoS Biol. 2006 Sep;4(10):e330.
17. Chronic suppurative otitis media in Tanzanian school children and its effects on hearing.
Match Strength: 2.369
OBJECTIVES: To compare different treatment regimens of chronic suppurative otitis media (CSOM) in school children, in regard to their consequence in hearing and discharge from the ear drum perforation. DESIGN: Randomised controlled trial. SETTING: Randomly selected primary schools within Dar es Salaam. SUBJECTS: Three hundred and twenty eight children between 5-17 years of age with CSOM in one or both ears. RESULTS: Three to four months after the onset of treatment 31% of group 1, 54% of group 2, and 56% of group 3, had dry ears. Treatment with dry mopping and boric acid in alcohol ear drops ... Read More »
» Published in East Afr Med J. 2006 Jun;83(6):322-5.
18. Mechanism of augmentation of organotin decomposition by ferripyochelin: formation of hydroxyl radical and organotin-pyochelin-iron ternary complex.
Match Strength: 2.363
Pyochelin (PCH), a kind of siderophore secreted by Pseudomonas aeruginosa, was recently found to have triphenyltin (TPT)-decomposing capacity. In this work, significant augmentation of TPT decomposition by ferripyochelin (FePCH), the chelating compound of PCH with iron, was demonstrated in Tris-HCl buffer (pH 8.0). The generation of hydroxyl radical (HO.) in the presence of FePCH was observed. Inhibition of HO. generation by adding catalase and HO. scavengers (methanol and dimethyl sulfoxide) decreased TPT decomposition, while an increase in HO. formation in the presence of H(2)O(2) enhanced ... Read More »
» Published in Appl Environ Microbiol. 2006 Nov;72(11):7264-9. Epub 2006 Sep 22.
19. Activated sludge diffusion for odour removal --effects of H2S on the biomass.
Match Strength: 2.333
The removal of odours from wastewater treatment plants through diffusion of odour-containing air volumes into the aerated basins was investigated in a bench scale experimental campaign which lasted more than 200 days. Hydrogen sulphide was selected as a model odorous compound and its removal efficiencies were experimentally evaluated along with its effects on the biomass and on the main biochemical processes. Two bench scale sequencing batch reactors were fed in parallel on real primary sewage and monitored for chemical oxygen demand removal, nitrification and denitrification. The balance of ... Read More »
» Published in Environ Technol. 2006 Aug;27(8):875-83.
20. Significant increase of glycolytic flux in Torulopsis glabrata by inhibition of oxidative phosphorylation.
Match Strength: 2.258
This study was aimed at increasing the glycolytic flux of the multivitamin-auxotrophic yeast Torulopsis glabrata by disturbing oxidative phosphorylation. We examined two different strategies to impede oxidative phosphorylation. The first strategy was disruption of the activity of the electron transfer chain (ETC), by either of two approaches. One was separately adding, at 10 mg L1, specific inhibitors of complex I (rotenone) or of the bc1 complex (antimycin A) to the culture broth of T. glabrata CCTCC M202019, which resulted in significantly decreased intracellular ATP levels (43% and 27.7%) ... Read More »
» Published in FEMS Yeast Res. 2006 Dec;6(8):1117-29.
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