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Hypercholesterolemia
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1. Cholestasis and hypercholesterolemia in SCD1-deficient mice fed a low-fat, high-carbohydrate diet.
Match Strength: 6.495

Stearoyl-coenzyme A desaturase 1-deficient (SCD1(-/-)) mice have impaired MUFA synthesis. When maintained on a very low-fat (VLF) diet, SCD1(-/-) mice developed severe hypercholesterolemia, characterized by an increase in apolipoprotein B (apoB)-containing lipoproteins and the appearance of lipoprotein X. The rate of LDL clearance was decreased in VLF SCD1(-/-) mice relative to VLF SCD1(+/+) mice, indicating that reduced apoB-containing lipoprotein clearance contributed to the hypercholesterolemia. Additionally, HDL-cholesterol was dramatically reduced in these mice. The presence of increased ... Read More »
» Published in J Lipid Res. 2006 Dec;47(12):2668-80. Epub 2006 Sep 27.

2. Redox-sensitive myocardial remodeling and dysfunction in swine diet-induced experimental hypercholesterolemia.
Match Strength: 4.667

OBJECTIVES: The effects of hypercholesterolemia (HC) on the myocardium and the underlying mechanisms are unclear. We tested the hypothesis that diet-induced HC-induced myocardial fibrosis by regulating the transforming growth factor (TGF)-beta pathway and apoptosis through increased oxidative stress, and that these would be functionally consequential. METHODS: Three groups of pigs (n=6 each) were studied after 12 weeks of normal or 2% HC diet, or HC+antioxidant supplementation. Cardiac function was evaluated by electron beam computed tomography, while fibrogenic mechanisms and apoptosis were ... Read More »
» Published in Atherosclerosis. 2006 Sep 20;

3. Lipid profile, waist circumference, and body mass index in a high altitude population.
Match Strength: 4.621

Some studies have found different distribution patterns for the lipid profile of high altitude populations, having found the majority of them a more favorable one in these subjects. The objective of this study is to describe the lipid profile of a high altitude population and relate it to the waist circumference, body mass index, gender, and age. A descriptive study was done in an adult population, 30 yr old and above, of the town of San Pedro de Cajas (SPC), Peru, located at 4100 m (13,450 ft) above sea level. One hundred and two representative individuals (38 males and 64 females) were ... Read More »
» Published in High Alt Med Biol. 2006 Fall;7(3):245-55.

4. The C679X mutation in PCSK9 is present and lowers blood cholesterol in a Southern African population.
Match Strength: 3.284

OBJECTIVE: Missense mutations in the proprotein convertase subtilisin/kexin type 9 gene (PCSK9) can cause familial hypercholesterolemia. However, two nonsense variants of PCSK9, Y142X and C679X, found in approximately 2% of black American subjects, are associated with a 28% reduction in mean low density lipoprotein (LDL)-cholesterol. We sought to determine the frequency and effect of these nonsense variants in an African population. METHODS AND RESULTS: PCSK9 genotypes were determined in 653 black African women attending two antenatal clinics in Zimbabwe. C679X occurred in 3.7% of subjects and ... Read More »
» Published in Atherosclerosis. 2006 Sep 19;

5. Tight control of type 1 diabetes: recommendations for patients.
Match Strength: 3.245

Tight control of blood glucose levels and risk factors for cardiovascular disease (e.g., hypertension, hypercholesterolemia) can substantially reduce the incidence of microvascular and macrovascular complications from type 1 diabetes. Physicians play an important role in helping patients make essential lifestyle changes to reduce the risk of these complications. Key recommendations that family physicians can give patients to optimize their outcomes include: take control of daily decisions regarding your health, focus on preventing and controlling risk factors for cardiovascular disease, ... Read More »
» Published in Am Fam Physician. 2006 Sep 15;74(6):971-8.

6. Physician and patient barriers to adherence with cholesterol guidelines.
Match Strength: 2.978

Several national studies have shown poor compliance with National Cholesterol Education Program II (NCEP) goals. A study we conducted of patients in the General Internal Medicine Clinic at the Marshall University Joan C. Edwards School of Medicine in Huntington showed that 46% of them were not at NCEP goals. We hypothesized that both patient and physician barriers were responsible for these findings so we administered two surveys about barriers to cholesterol management to 261 random patients identified with hypercholesterolemia and to all 50 residents and faculty at the clinic. We identified ... Read More »
» Published in W V Med J. 2006 May-Jun;102(3):23-6.

7. Regulation of Intestinal Cholesterol Absorption.
Match Strength: 2.957

The identification of defective structures in the ATP-binding cassette (ABC) transporters ABCG5 and ABCG8 in patients with sitosterolemia suggests that these two proteins are an apical sterol export pump promoting active efflux of cholesterol and plant sterols from enterocytes back into the intestinal lumen for excretion. The newly identified Niemann-Pick C1-like 1 (NPC1L1) protein is also expressed at the apical membrane of enterocytes and plays a crucial role in the ezetimibe-sensitive cholesterol absorption pathway. These findings indicate that cholesterol absorption is a multistep process ... Read More »
» Published in Annu Rev Physiol. 2006 Sep 20;

8. Safety of adjuvant aromatase inhibitor therapy.
Match Strength: 2.840

The long-term effects of aromatase inhibitors (AIs) on lipids and bone and cardiovascular and gynecological health are of particular interest to clinicians. The safety data of anastrozole, letrozole, and exemestane are limited to trials with follow-up periods of 5 years or less, and much of the data arise from comparisons with tamoxifen, a drug that has both estrogen agonist and antagonist effects. With the lack of extensive long-term data, indirect comparisons between the safety profiles of the AIs provide some insights. Although results from these indirect comparisons should be interpreted ... Read More »
» Published in Cancer Treat Rev. 2006 Nov;32(7):548-56. Epub 2006 Sep 27.

9. Disease-modifying antirheumatic drugs are associated with a reduced risk for cardiovascular disease in patients with rheumatoid arthritis: a case control study.
Match Strength: 2.783

Rheumatoid arthritis (RA) is characterized by inflammation and an increased risk for cardiovascular disease (CVD). This study investigates possible associations between CVD and the use of conventional disease-modifying antirheumatic drugs (DMARDs) in RA. Using a case control design, 613 RA patients (5,649 patient-years) were studied, 72 with CVD and 541 without CVD. Data on RA, CVD and drug treatment were evaluated from time of RA diagnosis up to the first cardiovascular event or the end of the follow-up period. The dataset was categorized according to DMARD use: sulfasalazine (SSZ), ... Read More »
» Published in Arthritis Res Ther. 2006;8(5):R151.

10. Impact of a CART promoter genetic variation on plasma lipid profile in a general population.
Match Strength: 2.781

The cocaine and amphetamine regulated transcript (CART), an anorexigenic peptide responding to leptin, is expressed in various areas of the hypothalamus. The role of CART in humans and its potential contribution to abnormalities in feeding control are mostly unknown. Since CART plays an important role in the hypothalamic regulation of energy balance by reducing food intake and increasing lipid substrate utilization, it might affect cholesterol metabolism as Neuropeptide Y or pro-opiomelanocortin do. In the present work, we studied the potential effects of three SNPs of the CART promoter in a ... Read More »
» Published in Mol Genet Metab. 2007 Feb;90(2):199-204. Epub 2006 Sep 27.

11. Endocrine disruptor vinclozolin induced epigenetic transgenerational adult-onset disease.
Match Strength: 2.693

The fetal basis of adult disease is poorly understood on a molecular level and cannot be solely attributed to genetic mutations or a single etiology. Embryonic exposure to environmental compounds has been shown to promote various disease states or lesions in the first generation (F1). The current study used the endocrine disruptor vinclozolin (antiandrogenic compound) in a transient embryonic exposure at the time of gonadal sex determination in rats. Adult animals from the F1 generation and all subsequent generations examined (F1-F4) developed a number of disease states or tissue abnormalities ... Read More »
» Published in Endocrinology. 2006 Dec;147(12):5515-23. Epub 2006 Sep 14. Comment in: Endocrinology. 2006 Dec;147(12):5513-4.

12. Altered Ca(2+) handling of smooth muscle cells in aorta of apolipoprotein E-deficient mice before development of atherosclerotic lesions.
Match Strength: 2.662

To study the effect of hypercholesterolemia on vascular smooth muscle cell (VSMC) function, atherosclerosis-prone but plaque-free endothelium-denuded aortic rings (width 2mm) from C57Bl6 Wild Type (WT) and apolipoprotein E-deficient (apoE(-/-)) mice (age 4 months) were mounted in a myograph and loaded with Fura-2 AM to simultaneously measure free Ca(2+) ([Ca(2+)](i)) and force development. In comparison with WT, apoE(-/-) mice displayed higher basal [Ca(2+)](i). Moreover, the time constant of the second phase of the biphasic high K(+)-induced [Ca(2+)](i) response was significantly increased in ... Read More »
» Published in Cell Calcium. 2007 Mar;41(3):295-302. Epub 2006 Sep 26.

13. Genetic screening by DNA technology: a systematic review of health economic evidence.
Match Strength: 2.342

OBJECTIVES: The Human Genome Project has led to a multitude of new potential screening targets on the level of human DNA. The aim of this systematic review is to critically summarize the evidence from health economic evaluations of genetic screening in the literature. METHODS: Based on an extensive explorative search, an appropriate algorithm for a systematic database search was developed. Twenty-one health economic evaluations were identified and appraised using published quality criteria. RESULTS: Genetic screening for eight conditions has been found to be investigated by health economic ... Read More »
» Published in Int J Technol Assess Health Care. 2006 Summer;22(3):327-37.

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