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1. Coagulation disorders and hemostasis in liver disease: pathophysiology and critical assessment of current management.
Match Strength: 3.510
Normal coagulation has classically been conceptualized as a Y-shaped pathway, with distinct "intrinsic" and "extrinsic" components initiated by factor XII or factor VIIa/tissue factor, respectively, and converging in a "common" pathway at the level of the FXa/FVa (prothrombinase) complex. Until recently, the lack of an established alternative concept of hemostasis has meant that most physicians view the "cascade" as a model of physiology. This view has been reinforced by the fact that screening coagulation tests (APTT, prothrombin time--INR) are often used as though they are generally ... Read More »
» Published in Hepatology. 2006 Oct;44(4):1039-46.
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