Hendra Virus Disease
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Peer Reviewed Scientific Research Reports.
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1. Crystal structures of Nipah and Hendra virus fusion core proteins.
Match Strength: 11.738
The Nipah and Hendra viruses are highly pathogenic paramyxoviruses that recently emerged from flying foxes to cause serious disease outbreaks in humans and livestock in Australia, Malaysia, Singapore and Bangladesh. Their unique genetic constitution, high virulence and wide host range set them apart from other paramyxoviruses. These characteristics have led to their classification into the new genus Henpavirus within the family Paramyxoviridae and to their designation as Biosafety Level 4 pathogens. The fusion protein, an enveloped glycoprotein essential for viral entry, belongs to the family ... Read More »
» Published in FEBS J. 2006 Oct;273(19):4538-47.
2. Feline model of acute nipah virus infection and protection with a soluble glycoprotein-based subunit vaccine.
Match Strength: 7.365
Nipah virus (NiV) and Hendra virus (HeV) are paramyxoviruses capable of causing considerable morbidity and mortality in a number of mammalian species, including humans. Case reports from outbreaks and previous challenge experiments have suggested that cats were highly susceptible to NiV infection, responding with a severe respiratory disease and systemic infection. Here we have assessed the cat as a model of experimental NiV infection and use it in the evaluation of a subunit vaccine comprised of soluble G glycoprotein (sG). Two groups of two adult cats each were inoculated subcutaneously with ... Read More »
» Published in J Virol. 2006 Dec;80(24):12293-302. Epub 2006 Sep 27.
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