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Peer Reviewed Scientific Research Reports.
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1. Adjusting i.v. iron and EPO doses in patients on hemodialysis prior to continuing surgery: can we protect our patients education from iron-deficiency anemia?
Match Strength: 7.098
Ongoing blood loss and iron-deficiency anemia are common problems in patients on hemodialysis; therefore, nephrology clinicians are particularly concerned with their patients who are scheduled for surgery Surgery can cause significant blood and iron losses, thereby worsening their preexisting anemia. However, patients on hemodialysis can be effectively treated preoperatively by adjusting their continued doses of intravenous (i.v.) iron and recombinant human erythropoietin (EPO) therapy, based on expected blood and iron losses. This valuable strategy can help improve surgical and anemia ... Read More »
» Published in Nephrol Nurs J. 2006 Jul-Aug;33(4):430-7; quiz 438.
2. Sampling for international normalized ratios in patients on hemodialysis with central venous catheters.
Match Strength: 6.417
The primary objectives of this study were to evaluate the effect of varying heparin concentrations on International Normalized Ratio values and to assess the accuracy of these values deter mined through the arterial line of the dialysis circuit Twenty-two patients on hemodialysis with central venous catheters were studied After a peripheral venipuncture, timed samples from the arterial line of the hemodialysis circuit were obtained after dialysis was initiated and prior to initiating heparin. Assays for coagulation parameters were performed. There was no signifcant difference in any ... Read More »
» Published in Nephrol Nurs J. 2006 Jul-Aug;33(4):408-11.
3. Self-care management in adults undergoing hemodialysis.
Match Strength: 6.247
The research literature on self-care management for adults with end stage renal disease being treated with hemodialysis was reviewed to ascertain the current state of knowledge, identify gaps, and propose future research. Sixty-four studies were reviewed. Many studies focused on compliance and whether subjects were meeting predetermined values of outcome variables set by professionals. Self-care management of ESRD is multidimensional and warrants further research from the client professional, and health care system perspectives ... Read More »
» Published in Nephrol Nurs J. 2006 Jul-Aug;33(4):387-94; quiz 395-6.
4. Adequacy of glycemic control in hemodialysis patients with diabetes.
Match Strength: 6.011
OBJECTIVE: We sought to measure the prevalence of inadequate glycemic control in prevalent hemodialysis patients with diabetes and to examine independent predictors of inadequate glycemic control in these patients. RESEARCH DESIGN AND METHODS: This is a cross-sectional study of prevalent hemodialysis patients with diabetes in southeastern Ontario (n = 100). Data were collected by chart review and interview. The outcome variable was inadequate glycemic control defined as HbA1c (A1C) >0.07. Other measured variables were diabetes type, diabetes duration, diabetes physician, blood glucose ... Read More »
» Published in Diabetes Care. 2006 Oct;29(10):2247-51.
5. Peritoneal dialysis or hemodialysis? A dilemma for the nephrologist.
Match Strength: 5.560
Selection of the initial dialysis modality is crucial in the treatment of end-stage renal disease (ESRD) patients. Several patient- and physician-related factors play important roles in the decision between peritoneal dialysis (PD) and hemodialysis (HD). Although HD is the most common dialysis modality in the United States, in some studies PD has shown a survival advantage over HD, at least in the first 2 years of dialysis treatment, especially in non-diabetic patients and in young patients with diabetes. Other advantages accrue to early PD use in many patients. An integrated care approach ... Read More »
» Published in Adv Perit Dial. 2006;22:180-5.
6. Detection of SEN virus in the general population and different risk groups in Slovakia.
Match Strength: 5.485
Sera of 426 adult persons were examined to assess the prevalence of SEN virus (SENV) infection in Slovakia and to determine the importance of different risk factors for parenteral transmission. SENV prevalence was determined by the PCR method using primers of SENV-D and SENV-H strains. Positive results were found in 10 of 37 patients with acute hepatitis of unknown etiology, 7 of 38 with acute hepatitis B, 17 of 44 with chronic hepatitis B, 29 of 102 with chronic hepatitis C, 36 of 72 hemodialysis patients, 2 of 33 health care workers and 24 of 100 persons from the control group. The highest ... Read More »
» Published in Folia Microbiol (Praha). 2006;51(3):223-8.
7. Liver steatosis in hepatitis C positive hemodialysis patients and factors affecting IFN-2a treatment.
Match Strength: 5.457
OBJECTIVE: Hepatitis C virus (HCV) infection is endemic among hemodialysis (HD) patients. It is well known that HCV causes approximately 50% of hepatosteatosis in patients with normal renal function and that this rate is higher in patients infected with genotype 3. The aim of this study was to investigate the rate of steatosis, the regression in steatosis with interferon (IFN) treatment and factors affecting IFN treatment in hemodialysis patients with chronic hepatitis C (CHC). MATERIAL AND METHODS: Thirty-seven HD patients with CHC were included in the study. All patients received ... Read More »
» Published in Scand J Gastroenterol. 2006 Oct;41(10):1235-41.
8. Tesio catheter access for long-term maintenance hemodialysis.
Match Strength: 5.322
PURPOSE: To retrospectively determine the long-term outcome (>6 months) of placement of tunneled hemodialysis catheters. MATERIALS AND METHODS: The HIPAA-compliant study protocol was approved by the Committee on Human Research, which waived the requirement for informed consent. The records of patients who underwent hemodialysis with the Tesio system (Medcomp, Harleysville, Pa) at a single outpatient dialysis unit between March 1994 and March 2004 were reviewed. The length of catheter access and the requirements for percutaneous revision were recorded, and unassisted- and assisted-access ... Read More »
» Published in Radiology. 2006 Oct;241(1):284-90.
9. Impact of selectin gene polymorphisms on rapid progression to end-stage renal disease in patients with IgA nephropathy.
Match Strength: 5.159
OBJECTIVE: It is evident that leukocyte infiltration plays an important role in the pathogenesis of IgA nephropathy (IgAN). Selectin is one of the key adhesion molecules involved in leukocyte infiltration. Recent studies demonstrated a significant association between the selectin gene polymorphisms and susceptibility to IgAN. However, the impact of selectin gene polymorphisms on the progression to end-stage renal disease (ESRD) has not been studied. PATIENTS AND METHODS: To evaluate the influence of the selectin gene polymorphisms on the progression of IgAN, we designed specific primers for ... Read More »
» Published in Intern Med. 2006;45(16):947-51. Epub 2006 Sep 15. Comment in: Intern Med. 2006;45(16):939-40.
10. Treatment of post-dialytic orthostatic hypotension with an inflatable abdominal band in hemodialysis patients.
Match Strength: 4.699
The purpose of this study was to ascertain whether abdominal compression with an inflatable abdominal band, a device we developed, improved post-dialytic orthostatic hypotension (OH) in hemodialysis (HD) patients. Twenty-five chronic HD patients with intractable post-dialytic OH were recruited. Post-HD changes in systolic blood pressure (DeltaSBP) in the supine and standing positions were compared in the patients, measured with or without the use of the band. The study showed DeltaSBP after HD without the band was significantly greater than that measured before HD (-36.1+/-18.2 vs -13.1+/-16.8 ... Read More »
» Published in Kidney Int. 2006 Nov;70(10):1793-800. Epub 2006 Sep 27.
11. Efficacy of the world health organization analgesic ladder to treat pain in end-stage renal disease.
Match Strength: 4.445
Pain is the one of the most common symptoms experienced by patients with ESRD; it impairs their quality of life and is undertreated. Most pain clinicians believe that the pain management approach of the World Health Organization (WHO) three-step analgesic ladder is applicable to the treatment of patients with ESRD, but this approach has not been validated for them. A cohort of 45 hemodialysis patients were assessed for type and severity of pain using the Short-Form McGill Pain Questionnaire and then treated during a 4-wk period according to the WHO analgesic ladder. Mean age was 65 +/- 12.5 yr ... Read More »
» Published in J Am Soc Nephrol. 2006 Nov;17(11):3198-203. Epub 2006 Sep 20.
12. Simultaneous heart and kidney transplantation for combined cardiac and renal failure.
Match Strength: 4.038
Simultaneous heart and kidney transplantation (SHKT) is feasible for combined cardiac and renal failure. Herein we reviewed our 10-year experience in SHKT. Six patients underwent SHKT from June 1995 to December 2004. Their ages ranged from 13 to 63 years old with a mean of 45.5 +/- 15.8 years. They were all men except one girl, who was the youngest (aged 13) who suffered from dilated cardiomyopathy with congestive heart failure and chronic renal failure due to systemic lupus erythematosus. Because of aggravating heart failure, she changed from hemodialysis to peritoneal dialysis. Because of ... Read More »
» Published in Transplant Proc. 2006 Sep;38(7):2135-7.
13. Development of a diagnostic method for detecting increased muscle protein degradation in patients with catabolic conditions.
Match Strength: 3.892
Muscle atrophy in catabolic illnesses is due largely to accelerated protein degradation. Unfortunately, methods for detecting accelerated muscle proteolysis are cumbersome. The goal of this study was to develop a method for detecting muscle protein breakdown and assess the effectiveness of anticatabolic therapy. In rodent models of catabolic conditions, it was found that accelerated muscle protein degradation is triggered by activation of caspase-3. Caspase-3 cleaves actomyosin/myofibrils to form substrates for the ubiquitin-proteasome system and leaves a characteristic 14-kD actin fragment in ... Read More »
» Published in J Am Soc Nephrol. 2006 Nov;17(11):3233-9. Epub 2006 Sep 27.
14. Prevention of membrane damage in patient on peritoneal dialysis with new peritoneal dialysis solutions.
Match Strength: 3.494
Peritoneal dialysis (PD) is now an established and successful alternative to hemodialysis. Multiple studies have confirmed its equivalent dialysis adequacy, mortality and fluid balance status, at least for the first 4-5 years. Peritoneal membrane failure is now one of the leading cause of technique failure. This review describes the role of glucose, glucose degradation product, pH, lactate, advanced glycosylation end product (AGE) in causing this membrane damage, and gives insight how the use of newer peritoneal dialysis fluids (PDFs) containing icodextrin, amino acids and bicarbonate buffer ... Read More »
» Published in Int Urol Nephrol. 2006 Sep 27;
15. Meeting the guidelines for end-of-life care.
Match Strength: 2.852
The number of patients initiating dialysis in most countries continues to increase, with the greatest increase being in the oldest age group. Clinical practice guidelines have been developed to help the nephrology team with end-of-life carefor patients on dialysis. The aim of the project reported here was to assess if we were meeting the guidelines. We conducted a retrospective cohort study of all patients 80 years of age and older who had started dialysis at our center Our cohort included 105 patients (50% men; median age: 84.5 years; age range: 80-95 years), of whom 55% were on hemodialysis ... Read More »
» Published in Adv Perit Dial. 2006;22:175-9.
16. Frequency of low carnitine levels in children on dialysis.
Match Strength: 2.668
To determine the frequency of low carnitine levels, we measured serum carnitine in pediatric patients on peritoneal dialysis (PD) and hemodialysis (HD). Our prospective cross-sectional study was conducted from September 2004 to March 2005 in a single pediatric center, and included patients under 17 years of age who had been on HD or PD for more than 3 months. Patients with primary carnitine deficiency were excluded. A 4-day food diary was used for carnitine intake quantification. Serum total and free carnitine and acylcarnitine were measured. We compared patients with low and normal carnitine ... Read More »
» Published in Adv Perit Dial. 2006;22:208-10.
17. Causes of hypercalcemia in a population of military veterans in the United States.
Match Strength: 2.497
OBJECTIVE: To determine the various causes of hypercalcemia in a population of US veterans at the San Diego Veterans Affairs Medical Center. METHODS: A retrospective analysis of medical records was performed on 212 US veterans encountered between 1998 and 2002 with serum calcium measurements between 10.5 and 10.9 mg/dL on multiple readings or 11.0 mg/dL (or greater) on any single determination. Data were collected from the clinical records for each patient and used to determine the cause of each patient's hypercalcemia. Patients undergoing hemodialysis were excluded from this study. RESULTS: ... Read More »
» Published in Endocr Pract. 2006 Sep-Oct;12(5):535-41.
18. Acute renal failure associated with inhaled tobramycin.
Match Strength: 2.379
PURPOSE: A case of nephrotoxicity possibly caused by tobramycin inhalation solution is presented. SUMMARY: A 62-year-old Caucasian woman was admitted for treatment of decreased urine output and sepsis secondary to Pseudomonas aeruginosa. Her past medical history was significant for multiple diseases, including chronic renal insufficiency (baseline serum creatinine concentration [SCr] 2 mg/dL). One month postadmission, the patient was diagnosed with health care-associated pneumonia. The patient was initiated on piperacillin-tazobactam and tobramycin 2 mg/kg i.v. She was changed to imipenem ... Read More »
» Published in Am J Health Syst Pharm. 2006 Oct 1;63(19):1858-61.
19. Association between calciphylaxis and inflammation in two patients on chronic dialysis.
Match Strength: 2.274
The pathogenesis of calciphylaxis, which has a rising incidence in the chronic dialysis population and a high mortality rate, is poorly understood. Abnormalities in the calcium-phosphorus-parathyroid axis are clinically related to calciphylaxis, but alone, they cannot explain this condition. Here, we present two patients who had chronic inflammatory conditions and hyperparathyroidism and who developed calciphylaxis. A 41-year-old white woman on hemodialysis following scleroderma, hepatitis C, liver transplant, and failed kidney transplant, developed progressive ulcerative lower extremity ... Read More »
» Published in Adv Perit Dial. 2006;22:171-4.
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