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Peer Reviewed Scientific Research Reports.
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1. Cardiac arrhythmias and conduction disturbances in autoimmune rheumatic diseases.
Match Strength: 5.490
Rhythm and conduction disturbances and sudden cardiac death (SCD) are important manifestations of cardiac involvement in autoimmune rheumatic diseases (ARDs). In patients with rheumatoid arthritis (RA), a major cause of SCD is atherosclerotic coronary artery disease, leading to acute coronary syndrome and ventricular arrhythmias. In systemic lupus erythematosus (SLE), sinus tachycardia, atrial fibrillation and atrial ectopic beats are the major cardiac arrhythmias. In some cases, sinus tachycardia may be the only manifestation of cardiac involvement. The most frequent cardiac rhythm ... Read More »
» Published in Rheumatology (Oxford). 2006 Oct;45 Suppl 4:iv39-iv42.
2. Crystal structure of monomeric native antithrombin reveals a novel reactive center loop conformation.
Match Strength: 3.260
The poor inhibitory activity of circulating antithrombin (AT) is critical to the formation of blood clots at sites of vascular damage. AT becomes an efficient inhibitor of the coagulation proteases only after binding to a specific heparin pentasaccharide, which alters the conformation of the reactive center loop (RCL). The molecular basis of this activation event lies at the heart of the regulation of hemostasis and accounts for the anticoagulant properties of the low molecular weight heparins. Although several structures of AT have been solved, the conformation of the RCL in native AT remains ... Read More »
» Published in J Biol Chem. 2006 Nov 17;281(46):35478-86. Epub 2006 Sep 13.
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