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1. Surgical outcome of posterior decompression for cervical spondylosis with unilateral upper extremity amyotrophy.
Match Strength: 6.666

STUDY DESIGN: Case studies of patients with cervical spondylosis with unilateral upper extremity amyotrophy. OBJECTIVE: To clarify the surgical outcome of posterior decompression for this amyotrophy. SUMMARY OF BACKGROUND DATA: Cervical spondylosis sometimes causes a characteristic severe muscular atrophy without sensory disturbance or lower-extremity dysfunction, which is the so-called "cervical spondylotic amyotrophy." However, response to treatment, especially to posterior decompression, has not been well understood. METHOD: This study included 32 patients. All underwent posterior cervical ... Read More »
» Published in Spine. 2006 Sep 15;31(20):E728-32.

2. The solution structure of the membrane-proximal cytokine receptor domain of the human interleukin-6 receptor.
Match Strength: 5.998

The members of the interleukin-6-type family of cytokines interact with receptors that have a modular structure and are built of several immunoglobulin-like and fibronectin type III-like domains. These receptors have a characteristic cytokine receptor homology region consisting of two fibronectin type III-like domains defined by a set of four conserved cysteines and a tryptophan-serine-X-tryptophan-serine sequence motif. On target cells, interleukin-6 (IL-6) initially binds to its cognate alpha-receptor and subsequently to a homodimer of the signal transducer receptor gp130. The IL-6 receptor ... Read More »
» Published in Biol Chem. 2006 Sep;387(9):1255-9.

3. Systematic regulation of the enzymatic activity of phenylacetaldoxime dehydratase by exogenous ligands.
Match Strength: 5.791

Phenylacetaldoxime dehydratase from Bacillus sp. OxB-1 (OxdB) contains a heme that acts as the active site for the dehydration reaction of aldoxime. Ferrous heme is the active form, in which the heme is five coordinate with His282 as a proximal ligand. In this work, we evaluated the functional role of the proximal ligand for the catalytic properties of the enzyme by "the cavity mutant technique". The H282G mutant of OxdB lost enzymatic activity, although the heme, which was five coordinate with a water molecule (or OH-) as an axial ligand, existed in the protein matrix. The enzymatic activity ... Read More »
» Published in Chembiochem. 2006 Dec;7(12):2004-9.

4. Intramedullary nailing of proximal quarter tibial fractures.
Match Strength: 5.551

OBJECTIVE: To report the results of intramedullary nailing of proximal quarter tibial fractures with special emphasis on techniques of reduction. DESIGN: Retrospective clinical study. SETTING: Level 1 trauma center. PATIENTS: During a 36-month period, 456 patients with fractures of the tibial shaft (OTA type 42) or proximal tibial metaphysis (OTA type 41A2, 41A3, and 41C2) were treated operatively at a level 1 trauma center. Thirty-five patients with 37 fractures were treated primarily with intramedullary nailing of their proximal quarter tibial fractures and formed the study group. Thirteen ... Read More »
» Published in J Orthop Trauma. 2006 Sep;20(8):523-8.

5. Iatrogenic type A dissection after attempted stenting of a descending aortic aneurysm.
Match Strength: 5.344

This case demonstrates an iatrogenic acute retrograde type A dissection of the aortic arch and ascending aorta during elective endovascular stenting of a proximal descending aortic aneurysm. This devastating complication necessitated emergent surgery with unfavorable postoperative outcome. Other than the known causes, the described retrograde type A dissection resulted from guidewire manipulation and iatrogenic creation of a false lumen, which was erroneously dilated and stented. Publication Types: Case ... Read More »
» Published in Ann Thorac Surg. 2006 Oct;82(4):1523-5.

6. Mechanism of active renal tubular efflux of tenofovir.
Match Strength: 4.811

Tenofovir (TFV) undergoes renal elimination by a combination of glomerular filtration and active tubular secretion. While transporter-mediated uptake of TFV from the blood into proximal-tubule cells has been well characterized, comparatively little is known about the efflux system responsible for transporting TFV into the lumen during active tubular secretion. Therefore, members of the ATP-binding cassette family of efflux pumps expressed at the apical side of proximal-tubule cells were studied for the ability to transport TFV. Studies in multiple independent in vitro systems show TFV not to ... Read More »
» Published in Antimicrob Agents Chemother. 2006 Oct;50(10):3297-304.

7. Accessory left gastric artery from left hepatic artery shown on MDCT and conventional angiography: correlation with CT hepatic arteriography.
Match Strength: 4.791

OBJECTIVE: The objective of our study was to evaluate the diagnostic accuracy of MDCT and conventional angiography in the detection of an accessory left gastric artery using CT hepatic arteriography as the standard of reference. MATERIALS AND METHODS: The study group consisted of 118 patients who underwent MDCT with a triple-phase liver protocol with a slice thickness of 5 mm, conventional angiography, and CT hepatic arteriography. The early-phase images of MDCT and conventional angiography were retrospectively reviewed. The presence or absence of an accessory left gastric artery was evaluated ... Read More »
» Published in AJR Am J Roentgenol. 2006 Oct;187(4):1002-9.

8. Surgical treatment of tumors of the proximal stomach with involvement of the distal esophagus: a 26-year experience with Siewert type III tumors.
Match Strength: 4.621

OBJECTIVE: A paucity of outcome data exists regarding patients with proximal stomach cancer involving the distal esophagus (Siewert type III tumors). This is especially true with regard to long-term survival rates after surgical intervention. METHODS: Medical records were reviewed of all patients who underwent total gastrectomy and distal esophagectomy with Roux-en-Y esophagojejunostomy for Siewert type III tumors from January 1975 through December 2000. RESULTS: There were 116 patients (93 men and 23 women). The median age was 66 years (range, 22-87 years). Pathologic stage was 0 (carcinoma ... Read More »
» Published in J Thorac Cardiovasc Surg. 2006 Oct;132(4):755-62. Epub 2006 Aug 30.

9. Evidence for activation of tissue factor by an allosteric disulfide bond.
Match Strength: 4.394

Tissue Factor (TF) is the mammalian plasma membrane cofactor responsible for initiation of blood coagulation. Binding of blood coagulation factor VIIa to TF activates the serine proteinase zymogens factors IX and X by limited proteolysis leading to the formation of a thrombin and fibrin meshwork that stabilizes the thrombus. TF on the plasma membrane of cells resides mostly in a cryptic configuration, which rapidly transforms into an active configuration in response to certain stimuli. The extracellular part of TF consists of two fibronectin type III domains. The disulfide bond in the membrane ... Read More »
» Published in Biochemistry. 2006 Oct 3;45(39):12020-8.

10. Defective coupling of apical PTH - receptors to phospholipase C prevents internalization of the Na+/phosphate cotransporter NaPi-IIa in NHERF1 deficient mice.
Match Strength: 3.939

Phosphate reabsorption in the renal proximal tubule occurs mostly via the type-IIa sodium-phosphate cotransporter (NaPi-IIa) in the brush border membrane (BBM). The activity and localization of NaPi-IIa is regulated among other factors by parathyroid hormone (PTH). NaPi-IIa interacts in-vitro via its last three C-terminal amino acids with the PDZ-protein Na(+)/H(+)-Exchanger isoform 3 Regulating Factor 1 (NHERF1). Renal phosphate reabsorption in NHERF1 deficient mice is altered and NaPi-IIa expression in the BBM is reduced. In addition, it has been proposed that NHERF1 and NHERF2 are important ... Read More »
» Published in Am J Physiol Cell Physiol. 2006 Sep 20;

11. Gas phase noncovalent protein complexes that retain solution binding properties: Binding of xylobiose inhibitors to the beta-1, 4 exoglucanase from cellulomonas fimi.
Match Strength: 3.933

Tandem mass spectrometry has been used to compare gas-phase and solution binding of three small-molecule inhibitors to the wild type and three mutant forms of the catalytic domain of Cex, an enzyme that hydrolyses xylan and xylo-oligosaccharides. The inhibitors, xylobiosyl-deoxynojirimycin, xylobiosyl-isofagomine lactam, and xylobiosyl-isofagomine consist of a common distal xylose linked to different proximal aza-sugars. The three mutant forms of the enzyme contain the substitutions Asn44Ala, Gln87Met, and Gln87Tyr that alter the binding interactions between Cex and the distal sugar of each ... Read More »
» Published in J Am Soc Mass Spectrom. 2007 Jan;18(1):64-73. Epub 2006 Sep 26.

12. Do heterotrimeric G proteins redistribute upon G protein-coupled receptor stimulation in platelets?
Match Strength: 3.459

Previous studies have proposed that stimulation of G protein-coupled receptors can cause a redistribution of G proteins to other receptors. The redistribution would cause a greater functional sensitivity of unsensitized 'secondary' receptors toward their agonists. Using platelets as a model system, we utilized a proximal signaling event, intracellular calcium mobilization, to determine if agonist stimulation of particular Gq-coupled receptors would result in increased sensitivity for stimulation of other Gq-coupled receptors. Platelets express three Gq-coupled receptors for thrombin, ... Read More »
» Published in Platelets. 2006 Sep;17(6):397-404.

13. The sarcomeric myosin heavy chain gene family in the dog: Analysis of isoform diversity and comparison with other mammalian species.
Match Strength: 3.313

Sarcomeric myosin heavy chains (MyHC) are the major contractile proteins of cardiac and skeletal muscles and belong to class II MyHC. In this study the sequences of nine sarcomeric MyHC isoforms were obtained by combining assembled contigs of the dog genome draft available in the NCBI database. With this information available the dog becomes the second species, after human, for which the sequences of all members of the sarcomeric MyHC gene family are identified. The newly determined sequences of canine MyHC isoforms were aligned with their orthologs in mammals, forming a set of 38 isoforms, to ... Read More »
» Published in Genomics. 2007 Feb;89(2):224-36. Epub 2006 Sep 20.

14. YM440, a novel hypoglycemic agent, protects against nephropathy in Zucker fatty rats via plasma triglyceride reduction.
Match Strength: 2.552

The novel hypoglycemic agent, YM440 ((Z)-1,4-bis{4-[(3,5-dioxo-1,2,4-oxadiazolidin-2-yl) methyl] phenoxy}but-2-ene) is a ligand of the peroxisome proliferator-activated receptor, (PPAR) gamma. YM440 has been shown to counteract insulin resistance in diabetic rodent models. However, it is not clear whether this compound has a significant effect on hyperlipidemia in vivo. Hyperlipidemia has been reported to be a risk factor for the early development of renal disease. The aim of this study is to examine the effects of chronic treatment with YM440 on hyperlipidemia and renal injury in obese Zucker ... Read More »
» Published in Eur J Pharmacol. 2006 Nov 7;549(1-3):185-91. Epub 2006 Aug 26.

15. Expression of 4 genes between chromosome 15 breakpoints 1 and 2 and behavioral outcomes in Prader-Willi syndrome.
Match Strength: 2.484

Prader-Willi syndrome is a neurodevelopmental disorder that is characterized by infantile hypotonia, feeding difficulties, hypogonadism, mental deficiency, hyperphagia (leading to obesity in early childhood), learning problems, and behavioral difficulties. A paternal 15q11-q13 deletion is found in approximately 70% of patients with Prader-Willi syndrome, approximately 25% have uniparental maternal disomy 15, and the remaining 2% to 5% have imprinting defects. The proximal deletion breakpoint in the 15q11-q13 region occurs at 1 of 2 sites located within either of 2 large duplicons allowing for ... Read More »
» Published in Pediatrics. 2006 Oct;118(4):e1276-83. Epub 2006 Sep 18.

16. Imaging the renin-angiotensin system: an important target of anti-hypertensive therapy.
Match Strength: 2.352

Multiphoton fluorescence microscopy allows visualization, manipulation, and quantification of the structure-function relationships between pharmacological interventions and their physiological effects. The application of these methods to live animals permits direct observation of acute physical responses that lack chemically detectable signals in the blood or urine and would otherwise remain unknown. With the use of special fluorescent dyes, chemical/hormonal responses may also be detected. The delivery and site-specific effects of drugs can be monitored in real-time. The capacity to ... Read More »
» Published in Adv Drug Deliv Rev. 2006 Sep 15;58(7):824-33. Epub 2006 Aug 10.

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