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Peer Reviewed Scientific Research Reports.
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1. The Great Lakes Regional Stroke Network experience.
Match Strength: 5.406
Stroke is a leading cause of disability and the third leading cause of death among adults in the United States and in the Great Lakes states of Illinois, Indiana, Michigan, Minnesota, Ohio, and Wisconsin. The Great Lakes Regional Stroke Network was created to enhance collaboration and coordination among the Great Lakes states to reduce the burden of stroke and stroke-related disparities associated with race, sex, and geography. Three priorities were identified for reducing the effects of stroke in the Great Lakes region: 1) build epidemiologic capacity to improve stroke prevention and control ... Read More »
» Published in Prev Chronic Dis. 2006 Oct;3(4):A128. Epub 2006 Sep 15.
2. Leiomyosarcoma of the great saphenous vein.
Match Strength: 5.105
Peripheral vascular leiomyosarcomas are rare. A case of leiomyosarcoma of the great saphenous vein diagnosed pre-surgically by MRI and fine-needle aspiration is presented. Characteristics of the tumour and imaging features are discussed. Publication Types: Case ... Read More »
» Published in Australas Radiol. 2006 Oct;50(5):500-3.
3. Progress in the history of Alzheimer's disease: the importance of context.
Match Strength: 4.653
The history of Alzheimer's disease (AD) is typically formulated as the history of great doctors and scientists in the past making great discoveries that are in turn taken up by great doctors and scientists in the present--all sharing the aim of unraveling the mysteries of disease and discovering how it can be prevented or cured. While it can certainly be edifying to study the "great men" and how their contributions laid the foundation for current work, there are problems with this approach to history. First, it oversimplifies the actual historical development of science. Second, using history ... Read More »
» Published in J Alzheimers Dis. 2006;9(3 Suppl):5-13.
4. Adjusting for temporal change in trophic position results in reduced rates of contaminant decline.
Match Strength: 3.967
The development of ecological tracers to track the flow of energy and nutrients through food webs has provided new insights into the factors that are important in regulating diet composition in wildlife. The Great Lakes Herring Gull Monitoring Program has provided information regarding temporal trends in levels of bioaccumulative contaminants since the early 1970s. In recent years, data from this program have also been generated to examine ecological changes in the Great Lakes. Because the contaminants that are evaluated as part of this program biomagnify, food is the primary determinant of ... Read More »
» Published in Environ Sci Technol. 2006 Sep 15;40(18):5624-8.
5. Intermediate-term outcomes of the arterial switch operation for transposition of great arteries in neonates: alive but well?
Match Strength: 3.162
OBJECTIVES: This interprovincial inception cohort study outlines the operative and intermediate outcomes of all neonates at a single institution with a broad referral area who underwent the arterial switch operation for transposition of great arteries, including complex types. Predictors of outcome are explored. METHODS: A total of 88 consecutive neonates underwent the arterial switch operation between 1996 and 2004 with full-flow (150 mg/kg/min) cardiopulmonary bypass with selective deep hypothermic circulatory arrest. Overall and event-free survivals were calculated. Health and ... Read More »
» Published in J Thorac Cardiovasc Surg. 2006 Oct;132(4):845-52.
6. Protein diffusion in agarose hydrogel in situ measured by improved refractive index method.
Match Strength: 3.111
The accurate knowledge of the diffusion behavior of protein within biomimetic hydrogel matrix at body temperature has a great implication for the design of efficient controlled release protein-base drug delivery devices. In this paper, we improved our previous in situ refractive index method with great temperature-controlled capability. For the first time, this newly improved method was employed to study the diffusion of protein (bovine serum albumin (BSA) and lysozyme) in agarose hydrogel at body temperature (37 degrees C). The change of the gel refractive index caused by the change of the ... Read More »
» Published in J Control Release. 2006 Oct 10;115(2):189-96. Epub 2006 Aug 16.
7. Polychlorinated naphthalenes in Great lakes air: assessing spatial trends and combustion inputs using PUF disk passive air samplers.
Match Strength: 3.024
Passive air samplers made from polyurethane foam (PUF) disks housed in stainless steel chambers were deployed over four seasons during 2002-2003, at 15 sites in the Laurentian Great lakes, to assess spatial and temporal trends of polychlorinated naphthalenes (PCNs). Sampling rates, determined using depuration compounds pre-spiked into the PUF disk prior to exposure, were, on average, 2.9 +/- 1.1 m3 d(-1), consistent with previous studies employing these samplers. PCN air concentrations exhibited strong urban-rural differences-typically a few pg m(-3) at rural sites and an order of magnitude ... Read More »
» Published in Environ Sci Technol. 2006 Sep 1;40(17):5333-9.
8. Material choice for restorative dentistry: inlays, onlays, crowns, and bridges.
Match Strength: 2.916
New materials--specifically the new CAD/CAM zirconia-based systems--are available now for restorative dentistry. When esthetics are not a factor, gold remains the standard, particularly for intracoronal restorations and full posterior coverage. Tooth-colored crowns made with zirconia are new and offer great promise for the future, although more long-term in vivo studies are necessary ... Read More »
» Published in Gen Dent. 2006 Sep-Oct;54(5):310-2.
9. Stress hormone is implicated in satellite-caller associations and sexual selection in the Great Plains toad.
Match Strength: 2.909
The effects of androgens on male-typical traits suggest that variation among males in circulating levels can play a major role in sexual selection. We examined whether variation in vocal attractiveness is attributable to differences in androgen levels among Great Plains toads (Bufo cognatus). We found that noncalling "satellite" males practicing an alternative mating tactic were more likely to associate with males producing long calls. However, callers with satellites did not have higher androgen levels than callers without satellites. Rather, callers with satellites had significantly lower ... Read More »
» Published in Am Nat. 2006 Oct;168(4):431-40. Epub 2006 Aug 11.
10. Monoclonal antibody therapy for hairy cell leukemia.
Match Strength: 2.700
The use of MoAb therapy for the treatment of HCL offers great promise and potential for improving progression-free survival. Rituximab has activity in the setting of previously treated HCL and the ability to eradicate MRD after 2-CdA given as frontline therapy. Alemtuzumab, epratuzumab, Hu-Max-CD20, and other candidate MoAb's should be studied in HCL. Appropriate pharmacologic investigation, use of antigen modulation, and assessments of soluble antigen levels should be considered with future clinical trial s of MoAb's in HCL to optimize therapeutic strategies. Publication Types: ... Read More »
» Published in Hematol Oncol Clin North Am. 2006 Oct;20(5):1125-36.
11. Challenges to the generality of WBE theory.
Match Strength: 2.688
The West, Brown and Enquist (WBE) theory has attracted great interest because it makes general predictions about scaling of ecological processes with body size. Recent research by Muller-Landau and co-workers challenges the generality of this theory by showing that demographic processes in natural forests do not scale in the way that the theory predicts. For WBE theory to be relevant to plant community dynamics, more complex models are required to deal with the influences of competition for light, nutrient supply and disturbance experienced by such communities ... Read More »
» Published in Trends Ecol Evol. 2006 Nov;21(11):593-6. Epub 2006 Sep 20.
12. On the unpredictability of odor.
Match Strength: 2.656
The relationship between molecular structure and odor has fascinated and puzzled chemists for more than a century. Despite a great deal of research on structure-odor relationships, prediction of the odor of a novel molecule remains a statistical exercise and models only provide a probability of the character, threshold, and intensity. Surprises are still commonplace, and serendipity continues to be an important factor in the discovery of novel fragrant molecules. Recent advances in our understanding of the mechanism of olfaction provide an explanation for this and suggest that our ability to ... Read More »
» Published in Angew Chem Int Ed Engl. 2006 Sep 25;45(38):6254-61.
13. Tissue engineering solutions for traumatic bone loss.
Match Strength: 2.652
Tissue engineering strategies for the repair, replacement, or augmentation of bone defects involves the use of cells, matrices, and bioregulatory factors. The source (endogenous, exogenous) and character of these factors, however, may vary greatly among the many approaches taken by current investigators. Although the results of current tissue engineering methods for regenerating bone have shown great promise, the extent of damage to extremities associated with war injuries may require the development of techniques that differ substantially from current practice ... Read More »
» Published in J Am Acad Orthop Surg. 2006 Oct;14(10 Suppl):S152-6.
14. Tachykinins and excitotoxicity in cerebellar granule cells.
Match Strength: 2.647
The tachykinins represent an important group of neuropeptides that are widely distributed both in the central and peripheral nervous system where they perform several functions connected with neuronal modulation, often in synergy with glutamate excitatory transmission. While a great deal of data is available on their distribution and many studies have been performed by molecular, biochemical, and immunohistochemical techniques, much less is known about their physiological role, in particular in the cerebellum. This review is an attempt to summarize the diverse evidence suggesting a role for ... Read More »
» Published in Cerebellum. 2006;5(3):232-7.
15. Beyond open access: open discourse, the next great equalizer.
Match Strength: 2.645
The internet is expanding the realm of scientific publishing to include free and open public debate of published papers. Journals are beginning to support web posting of comments on their published articles and independent organizations are providing centralized web sites for posting comments about any published article. The trend promises to give one and all access to read and contribute to cutting edge scientific criticism and debate. Publication Types: ... Read More »
» Published in Retrovirology. 2006 Aug 30;3:55.
16. The genetics of health.
Match Strength: 2.618
Recent experience with several high-profile drugs demonstrates the great challenges in developing effective and safe therapeutics. A complementary approach to the popular paradigm of disease genetics is based on inherited factors that reduce the incidence and severity of disease among individuals who are genetically predisposed to disease. We propose testing specifically for modifier genes and protective alleles among at-risk individuals and studying the efficacy of therapeutics based on the genetics of health. Publication Types: Research Support, N.I.H., Extramural, ... Read More »
» Published in Nat Genet. 2006 Oct;38(10):1095-8.
17. Families in today's world-and tomorrow's.
Match Strength: 2.564
The world's family systems derive from the great world religions and the cultural history of civilizations. On this basis, five fundamental family systems of the world can be identified--those of East, South, and West Asia (with North Africa), sub-Saharan Africa, and Europe--together with two important interstitial or hybrid systems--of Creole America and of Southeast Asia--each with significant subvariants. The comparative overview of these seven family systems looks at their internal power relations (patriarchy), their marriage patterns and regulation of sexuality, and their fertility. ... Read More »
» Published in Int J Health Serv. 2006;36(3):593-603.
18. Pathway classification of TCA cycle.
Match Strength: 2.549
The structural analysis of large metabolic networks exhibits a combinatorial explosion of elementary modes. A new method of classification has been developed [called aggregation around common motif (ACoM)], which groups elementary modes into classes with similar substructures. This method is applied to the tricarboxylic acid cycle and metabolite carriers. The analysis of this network evidences a great number of elementary flux modes (204) despite the low number of reactions (23). The ACoM is used to class these elementary modes in a low number of sets (8) with biological meanings ... Read More »
» Published in Syst Biol (Stevenage). 2006 Sep;153(5):369-71.
19. Endovenous laser ablation of the great saphenous vein with a 980-nm diode laser in continuous mode: early treatment failures and successful repeat treatments.
Match Strength: 2.517
PURPOSE: To investigate the efficacy of lower-energy endovenous laser treatment for great saphenous vein (GSV) incompetence and treatment parameters associated with early treatment failure. MATERIALS AND METHODS: Sixty consecutive endovenous laser treatments (32 left, 28 right; 57 initial treatments, three repeat treatments) in 48 patients (13 men, 35 women; mean age, 55.2 +/- 12.9 years), with bilateral treatments in nine patients, were studied. Preprocedural clinical signs, etiology, anatomy, and physiologic classifications demonstrated class 2 limbs in 11.7% of cases, class 3 limbs in 25.0% ... Read More »
» Published in J Vasc Interv Radiol. 2006 Sep;17(9):1449-55.
20. The neuroendocrine system of invertebrates: a developmental and evolutionary perspective.
Match Strength: 2.479
Neuroendocrine control mechanisms are observed in all animals that possess a nervous system. Recent analyses of neuroendocrine functions in invertebrate model systems reveal a great degree of similarity between phyla as far apart as nematodes, arthropods, and chordates. Developmental studies that emphasize the comparison between different animal groups will help to shed light on questions regarding the evolutionary origin and possible homologies between neuroendocrine systems. This review intends to provide a brief overview of invertebrate neuroendocrine systems and to discuss aspects of their ... Read More »
» Published in J Endocrinol. 2006 Sep;190(3):555-70.
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