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Gram-Negative Bacterial Infections
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1. Antibiotic prophylaxis in neutropenic patients: new evidence, practical decisions.
Match Strength: 9.297

New evidence shows that antibiotic prophylaxis in neutropenic patients reduces mortality, febrile episodes, and bacterial infections. For patients with acute leukemia or those who undergo bone marrow transplantation, prophylaxis with fluoroquinolones diminished the risk of death from any cause by 33% (95% confidence interval [95% CI], 2-54%). Thus, 55 patients who have acute leukemia or who undergo bone marrow transplantation must receive prophylaxis to prevent 1 death. In 4 studies that included patients with solid tumors or lymphoma, prophylaxis reduced the rate of death during the first ... Read More »
» Published in Cancer. 2006 Oct 15;107(8):1743-51.

2. Differential expression and antibacterial activity of WFDC10A in the monkey epididymis.
Match Strength: 8.485

The ability of the epididymis to perform its diverse functions stems from its regionalized gene and protein expression patterns. The differences in the gene expression patterns of the caput and cauda regions of the bonnet monkey epididymis were compared using the technique of differential display reverse transcriptase polymerase chain reaction. A transcript showing homology to human whey acidic protein 10 (hWFDC10A) was highly expressed in the monkey caput region. A peptide P2 was designed spanning a region of the monkey WFDC10A (mWFDC10A), which could inhibit the growth of gram-negative ... Read More »
» Published in Mol Cell Endocrinol. 2006 Oct 19;259(1-2):50-6. Epub 2006 Sep 20.

3. Vibrio cholerae virulence regulator-coordinated evasion of host immunity.
Match Strength: 6.011

To successfully propagate and cause disease, pathogenic bacteria must modulate their transcriptional activities in response to pressures exerted by the host immune system, including secreted immunoglobulins such as secretory IgA (S-IgA), which can bind and agglutinate bacteria. Here, we present a previously undescribed flow cytometry-based screening method to identify bacterial genes expressed in vitro and repressed during infections of Vibrio cholerae, an aquatic Gram-negative bacterium responsible for the severe diarrheal disease cholera. We identified a type IV mannose-sensitive ... Read More »
» Published in Proc Natl Acad Sci U S A. 2006 Sep 26;103(39):14542-7. Epub 2006 Sep 18.

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