Glycogen Storage Disease
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Peer Reviewed Scientific Research Reports.
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1. Roles of LAMP-1 and LAMP-2 in lysosome biogenesis and autophagy.
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The lysosomal membrane proteins LAMP-1 and LAMP-2 are estimated to contribute to about 50% of all proteins of the lysosome membrane. Surprisingly, mice deficient in either LAMP-1 or LAMP-2 are viable and fertile. However, mice deficient in both LAMP-1 and LAMP-2 have an embryonic lethal phenotype. These results show that these two major lysosomal membrane proteins share common functions in vivo. However, LAMP-2 seems to have more specific functions since LAMP-2 single deficiency has more severe consequences than LAMP-1 single deficiency. Mutations in LAMP-2 gene cause a lysosomal glycogen ... Read More »
» Published in Mol Aspects Med. 2006 Oct-Dec;27(5-6):495-502. Epub 2006 Sep 14.
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