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Peer Reviewed Scientific Research Reports.
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1. Relationship between PTEN gene expression and differentiation of human glioma.
Match Strength: 8.154
OBJECTIVE: To investigate the relationship between PTEN gene expression and differentiation of glioma. MATERIAL AND METHODS: The quantitative real-time reverse transcription-polymerase chain reaction (RT-PCR) method was applied to detect PTEN mRNA levels in glioma tissues. Tumor-adjacent normal tissues and benign brain tumors were used as controls. Relative PTEN mRNA levels were determined as the ratio of PTEN and GAPDH, which were correlated with the clinical-pathological results. RESULTS: PTEN mRNA levels were significantly lower in the glioma tissues than in the benign brain tumors and ... Read More »
» Published in Scand J Clin Lab Invest. 2006;66(6):469-75.
2. Temozolomide/PLGA microparticles and antitumor activity against Glioma C6 cancer cells in vitro.
Match Strength: 6.366
The purpose of the present study was to develop implantable poly(D,L-lactide-co-glycolide) (PLGA) microparticles for continuous delivery of intact 3,4-dihydro-3-methyl-4-oxoimidazo[5,1-d]-as-tetrazine-8-carboxamide (temozolomide, TM) for about a 1-month period and to evaluate its cytotoxicity against Glioma C6 cancer cells. The emulsifying-solvent evaporation process has been used to form TM-loaded PLGA microparticles. The influences of several preparation parameters, such as initial drug loading, polymer concentration, and stirring rate were investigated. Scanning electron microscopy (SEM) ... Read More »
» Published in Int J Pharm. 2007 Feb 1;329(1-2):122-8. Epub 2006 Aug 30.
3. Silencing mammalian target of rapamycin signaling by small interfering RNA enhances rapamycin-induced autophagy in malignant glioma cells.
Match Strength: 6.062
The mammalian target of rapamycin (mTOR) plays a central role in regulating the proliferation of malignant glioma cells, and mTOR-specific inhibitors such as rapamycin analogs are considered as promising therapy for malignant gliomas. However, the efficacy of mTOR inhibitors alone in the treatment of patients with malignant gliomas is only modest, potentially because these agents rather than acting as mTOR kinase inhibitors instead interfere with the function of only mTOR/raptor (regulatory-associated protein of mTOR) complex and thus do not perturb all mTOR functions. The purpose of this ... Read More »
» Published in Oncogene. 2006 Sep 25;
4. Combined treatment of pediatric high-grade glioma with the oncolytic viral strain MTH-68/H and oral valproic acid.
Match Strength: 5.856
The case of a 12-year-old boy with anaplastic astrocytoma of the left thalamus is reported. Postoperative irradiation and chemotherapy could not repress tumor progression; therefore, treatment was undertaken with an oncolytic virus, MTH-68/H, an attenuated strain of Newcastle disease virus (NDV), and valproic acid (VPA), an antiepileptic drug, which also has antineoplastic properties. This treatment resulted in a far-reaching regression of the thalamic glioma, but 4 months later a new tumor manifestation, an extension of the thalamic tumor, appeared in the wall of the IVth ventricle, which ... Read More »
» Published in APMIS. 2006 Oct;114(10):731-43.
5. Experiences of onset and diagnosis of low-grade glioma from the patient's perspective.
Match Strength: 5.693
The aim of this study was to describe adult patients' experiences of falling ill and being diagnosed with low-grade glioma. Information concerning such experiences is lacking in the literature. The study population were adults identified within a well-defined population. Interviews were conducted with 27 patients. The interview texts were analyzed using inductive content analysis. Illness onset was described as a sequence of events. Nineteen patients narrated rapid onset and 8 patients prolonged onset. The most commonly described symptoms in both types of onset were headache, epileptic ... Read More »
» Published in Cancer Nurs. 2006 Sep-Oct;29(5):415-22.
6. Apparent diffusion coefficient histograms may predict low-grade glioma subtype.
Match Strength: 5.272
The subtypes of glioma are known to have different prognosis and response to treatment. The purpose of this work was to investigate whether apparent diffusion coefficient (ADC) histograms of untreated low-grade astrocytomas and oligodendrogliomas exhibit different characteristics due to their biological differences, and whether a diagnosis of tumour subtype can be made at presentation using the histogram alone, which, if possible, would have an impact on clinical practise. Fifteen patients with astrocytoma (AC) [11 male (mean age +/- standard deviation) 40 +/- 11 years], nine with ... Read More »
» Published in NMR Biomed. 2007 Feb;20(1):49-57.
7. Recent advances in immunotherapy for human glioma.
Match Strength: 4.627
PURPOSE OF REVIEW: The present review focuses on recent progress in tumour immunology and immunotherapeutic trials in malignant gliomas. RECENT FINDINGS: Major advances have been made in the understanding of antitumour immunity in patients with glioma. Patients with glioblastoma can spontaneously develop antitumour activity with activated CD8 T cells. Infiltration of myeloid suppressor cells into tumours and increased regulatory T-cell fraction appear to play a critical role in tumour tolerance, however. T-regulatory removal suppresses CD4 T-cell proliferative defects and can induce tumour ... Read More »
» Published in Curr Opin Oncol. 2006 Nov;18(6):631-6.
8. Acute morphological sequelae of photodynamic therapy with 5-aminolevulinic acid in the C6 spheroid model.
Match Strength: 3.946
OBJECTIVE: Aminolevulinic acid (ALA)-mediated photodynamic therapy (PDT) may represent a treatment option for malignant brain tumors. We used a three-dimensional cell culture system, the C6 glioma spheroid model, to study acute effects of PDT and how they might be influenced by treatment conditions. METHODS: Spheroids were incubated for 4 h in 100 mug/ml ALA in 5% CO(2) in room air or 95% O(2) with subsequent irradiation using a diode laser (lambda = 635 nm, 40 mW/cm(2), total fluence 25 J/cm(2)). Control groups were "laser only", "ALA only", and "no drug no light". Annexin V-FITC, a marker ... Read More »
» Published in J Neurooncol. 2006 Sep 27;
9. Cytotoxic synergy between the multikinase inhibitor sorafenib and the proteasome inhibitor bortezomib in vitro: induction of apoptosis through Akt and c-Jun NH2-terminal kinase pathways.
Match Strength: 3.715
This study was undertaken to characterize preclinical cytotoxic interactions for human malignancies between the multikinase inhibitor sorafenib (BAY 43-9006) and proteasome inhibitors bortezomib or MG132. Multiple tumor cell lines of varying histiotypes, including A549 (lung adenocarcinoma), 786-O (renal cell carcinoma), HeLa (cervical carcinoma), MDA-MB-231 (breast), K562 (chronic myelogenous leukemia), Jurkat (acute T-cell leukemia), MEC-2 (B-chronic lymphocytic leukemia), and U251 and D37 (glioma), as well as cells derived from primary human glioma tumors that are likely a more clinically ... Read More »
» Published in Mol Cancer Ther. 2006 Sep;5(9):2378-87.
10. Glioma in the elderly.
Match Strength: 3.128
PURPOSE OF REVIEW: This review updates available data on the management of gliomas in the elderly. RECENT FINDINGS: Prospective randomized studies have recently established the benefit of radiotherapy and the validity of an accelerated course of irradiation in older patients with malignant gliomas. SUMMARY: The incidence of gliomas is increasing in the elderly population. Unfortunately, increasing age is one of the most consistent negative prognostic factors in gliomas and the optimal management of this population remains unsettled since patients aged 65 years or more are usually excluded from ... Read More »
» Published in Curr Opin Oncol. 2006 Nov;18(6):644-7.
11. IQGAP1 protein specifies amplifying cancer cells in glioblastoma multiforme.
Match Strength: 2.949
The accurate identification and thorough characterization of tumorigenic cells in glioblastomas are essential to enhance our understanding of their malignant behavior and for the design of strategies that target this important cell population. We report here that, in rat brain, the scaffolding protein IQGAP1 is a marker of brain nestin+ amplifying neural progenitor cells. In a rat model of glioma, IQGAP1 also characterizes a subpopulation of nestin+ amplifying tumor cells in glioblastoma-like tumors but not in tumors with oligodendroglioma features. We next confirmed that IQGAP1 represents a ... Read More »
» Published in Cancer Res. 2006 Sep 15;66(18):9074-82.
12. Personalized peptide vaccines: a new therapeutic modality for cancer.
Match Strength: 2.936
Therapeutic cancer vaccines have enjoyed little success so far, although many clinical trials have been conducted. Therefore, the creation of new protocols capable of inducing an objective response is required. We examined two of these protocols in the present review. The first is a personalized protocol to take into account the immunological diversity of cytotoxic T lymphocyte responses among patients. The second is a combination therapy designed to adapt to the presence of major histocompatibility complex (MHC)-loss cancer cells. The objective response rates of our classical (non ... Read More »
» Published in Cancer Sci. 2006 Oct;97(10):970-6.
13. The mesenchyme in cancer therapy as a target tumor component, effector cell modality and cytokine expression vehicle.
Match Strength: 2.630
Tissues and organs harbor a component of supportive mesenchymal stroma. The organ stroma is vital for normal functioning since it expresses factors instructing growth and differentiation along with molecules that restrain these processes. Similarly, the growth of tumors is strictly dependent on the tumor stroma. This review first discusses the possibility of developing tools to block the propagation of the tumor-associated stroma, that may halt tumor progression. It further describes how the tropism of mesenchymal stroma to tumor sites may be utilized to cause regression of the cancerous ... Read More »
» Published in Cancer Metastasis Rev. 2006 Sep;25(3):459-67.
14. Surgical resection of tumors located in subcortex of language area.
Match Strength: 2.505
Object. Although functional mapping facilitates the planning of surgery in and around eloquent areas, the resection of tumors adjacent to language areas remains challenging. In this report, we took notice that the language areas (Broca's and Wernicke's) present at the perisylvian fissure. We posit that if there is non-essential language area on the inner surface of the Sylvian fissure, safe tumor resection may be possible even if the tumor is located under the language cortex. Methods. The study population consisted of 5 patients with intrinsic brain tumors (frontal glioma, n = 3; temporal ... Read More »
» Published in Acta Neurochir (Wien). 2007 Feb;149(2):123-30. Epub 2006 Sep 29.
15. Influence of surfactants, polymer and doxorubicin loading on the anti-tumour effect of poly(butyl cyanoacrylate) nanoparticles in a rat glioma model.
Match Strength: 2.468
Poly(n-butyl cyanoacrylate) nanoparticles coated with polysorbate-80 can enable the transport of bound drugs across the blood-brain barrier (BBB) after i.v. injection. In the present study the influence of different formulation parameters on the anti-tumoural effects of doxorubicin nanoparticles against glioblastoma 101/8 was investigated. The manufacturing parameters of poly(alkyl cyanoacrylate) doxorubicin-loaded nanoparticles were optimized concerning drug loading. The nanoparticles were coated with different surfactants and injected intravenously on days 2, 5 and 8 after intra-cranial ... Read More »
» Published in J Microencapsul. 2006 Aug;23(5):582-92.
16. Human neural stem cells target experimental intracranial medulloblastoma and deliver a therapeutic gene leading to tumor regression.
Match Strength: 2.259
PURPOSE: Medulloblastoma, a malignant pediatric brain tumor, is incurable in about one third of patients despite multimodal treatments. In addition, current therapies can lead to long-term disabilities. Based on studies of the extensive tropism of neural stem cells (NSC) toward malignant gliomas and the secretion of growth factors common to glioma and medulloblastoma, we hypothesized that NSCs could target medulloblastoma and be used as a cellular therapeutic delivery system. EXPERIMENTAL DESIGN: The migratory ability of HB1.F3 cells (an immortalized, clonal human NSC line) to medulloblastoma ... Read More »
» Published in Clin Cancer Res. 2006 Sep 15;12(18):5550-6.
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