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Glaucoma
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1. The probability of glaucoma from ocular hypertension determined by ophthalmologists in comparison to a risk calculator.
Match Strength: 7.124

OBJECTIVE: To investigate the ability of ophthalmologists to estimate an individual's risk of converting from ocular hypertension to glaucoma, and to compare these estimates to a risk calculator. DESIGN: Cross-Sectional Survey. METHODS: Fifty-one ophthalmologists estimated the probability of developing glaucoma of 4 factitious patients with ocular hypertension, after a didactic review of the Ocular Hypertension Treatment Study (OHTS) results. We compared the physician estimates to the probability estimates of a risk calculator on the basis of the multivariate Cox proportional hazard model of ... Read More »
» Published in J Glaucoma. 2006 Oct;15(5):426-31.

2. Transforming growth factor-beta levels in human aqueous humor of glaucomatous, diabetic and uveitic eyes.
Match Strength: 6.737

PURPOSE: Transforming growth factor-beta2 is known to be present at elevated levels in the aqueous humor of patients with primary open angle glaucoma (POAG) and diabetes but not in uveitis-related secondary glaucoma. We investigated total TGF-beta2 levels and levels of the active form of TGF-beta2 in the aqueous humor of eyes with different types of glaucoma. METHODS: The concentration of the total and active form of TGF-beta2 was measured in 63 patients with primary open angle glaucoma, neovascular glaucoma complicated with diabetes (NVG), and secondary open angle glaucoma complicated with ... Read More »
» Published in Korean J Ophthalmol. 2006 Sep;20(3):162-5.

3. Costs and utilization of end-stage glaucoma patients receiving visual rehabilitation care: a US multisite retrospective study.
Match Strength: 6.257

PURPOSE: Glaucoma is a prevalent ophthalmologic disease and leading cause of blindness. A retrospective analysis was conducted to evaluate resources and costs for end-stage glaucoma patients receiving visual rehabilitation care (VRC). MATERIALS AND METHODS: A chart review was conducted in 3 United States VRC centers. Charts of patients with primary open-angle glaucoma as the primary cause of vision loss (1998 to 2003) were selected, yielding 81 records. Data were collected from patient-level billing and reimbursement records (ophthalmologist/optometrist visits, glaucoma medications, procedures ... Read More »
» Published in J Glaucoma. 2006 Oct;15(5):419-25.

4. A review of glaucoma treatment in Scotland 1994-2004.
Match Strength: 6.186

ObjectiveThis study evaluated the changing trends in glaucoma management in Scotland between 1994 and 2004.MethodsA retrospective analysis of national health statistics in Scotland from 1994 to 2004. The Scottish morbidity record was used to collect information on all episodes of trabeculectomy. Data on number of prescriptions were gathered for individual drugs and also for groups of active ingredient. The population likely to have glaucoma (PLG) was calculated from estimates of prevalence in individuals aged 40 years and older, based on published epidemiological studies. The outcome measures ... Read More »
» Published in Eye. 2006 Sep 22;

5. What can patients see during glaucoma filtration surgery under peribulbar anesthesia?
Match Strength: 6.062

PURPOSE: To describe the visual sensations experienced by patients during glaucoma filtration surgery under peribulbar anesthesia and to determine possible risk factors that may affect the visual sensations experienced. SETTING: King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia. METHODS: In this prospective questionnaire study, 75 consecutive adult patients listed for glaucoma filtration surgery (trabeculectomy or Ahmed tube implantation) under peribulbar anesthesia were interviewed postoperatively about the visual sensations experienced in their operated eye during the surgery. ... Read More »
» Published in J Glaucoma. 2006 Oct;15(5):462-5.

6. Visual field defects and vision-specific health-related quality of life in African Americans and whites with glaucoma.
Match Strength: 5.603

PURPOSE: To examine the relationship of visual field impairment to vision-specific health-related quality of life and symptoms in a large cohort (N=345) of African Americans and Whites of non-Hispanic origin diagnosed with glaucoma. MATERIALS AND METHODS: Participants consisted of persons > or =55 years of age recruited from university-affiliated ophthalmology and optometry practices in Birmingham, AL who had been diagnosed with glaucoma. Medical records were abstracted to collect information on demographics, visual acuity, and visual fields. A telephone survey was conducted to obtain ... Read More »
» Published in J Glaucoma. 2006 Oct;15(5):414-8.

7. The spectrum of iris angiography abnormalities in pseudoexfoliation syndrome.
Match Strength: 5.548

PurposeTo analyse the spectrum of angiographic features in patients monolaterally or bilaterally affected by pseudoexfoliation syndrome (PES), with and without glaucoma, and to evaluate the sensibility and specificity of these features in the diagnosis of glaucoma.MethodsSixty-eight patients affected by PES and 20 healthy subjects underwent iris fluorescein angiography (IFA) and iris indocyanine green angiography (IICGA). Angiographic features analysed were hypoperfusion, microneovascularizations, and anastomotic vessels.ResultsThere was no statistically significant difference among unaffected ... Read More »
» Published in Eye. 2006 Sep 15;

8. Distribution of optineurin sequence variations in an ethnically diverse population of low-tension glaucoma patients from the United States.
Match Strength: 5.540

PURPOSE: Previous studies have suggested that Optineurin (OPTN) sequence variants contribute to low-tension glaucoma (LTG) in ethnically homogeneous populations. The purpose of this study is to evaluate the prevalence of OPTN sequence variants in an ethnically diverse population of LTG patients from the United States, and to describe the phenotype of patients with OPTN sequence variants preferentially found in LTG patients. METHODS: Genomic DNA purified from 67 LTG patients was screened for DNA sequence variants located in the exons and flanking introns of the OPTN gene using high-performance ... Read More »
» Published in J Glaucoma. 2006 Oct;15(5):358-63.

9. Long-term results of surgery in childhood glaucoma.
Match Strength: 5.437

PURPOSE: The aim of this study is to assess the functional results and morphological parameters in children surgically treated for glaucoma. METHODS: Data from 43 patients and 68 eyes who were operated in our department between 1990 and 2002 were collected. This retrospective trial included primary congenital glaucoma (n=36), and secondary glaucoma (n=7) in Rieger-Axenfeld syndrome and Sturge Weber syndrome. Intraocular pressure (IOP), axial length of the eyeball, visual acuity, refractive errors and orthoptic status were analysed. RESULTS: The age of patients at the first surgery was 6.0+/-5 ... Read More »
» Published in Graefes Arch Clin Exp Ophthalmol. 2006 Sep 16;

10. Comparison of the Moorfields classification using confocal scanning laser ophthalmoscopy and subjective optic disc classification in detecting glaucoma in blacks and whites.
Match Strength: 4.958

OBJECTIVE: To compare the diagnostic accuracy of the Moorfields regression classification (MRC) and subjective optic disc evaluation in discriminating early to moderate glaucomatous from nonglaucomatous eyes. DESIGN: Cross-sectional observational study. PARTICIPANTS: Two hundred thirty-three patients with glaucoma and 216 normal subjects were included in the analysis. Racial groups were defined by self-description. METHODS: All subjects underwent confocal scanning laser ophthalmoscopy, stereophotography, and standard perimetry. Glaucoma was defined by visual field defect alone and confirmed ... Read More »
» Published in Ophthalmology. 2006 Dec;113(12):2144-9. Epub 2006 Sep 25.

11. Variations in primary open-angle glaucoma prevalence by age, gender, and race: a Bayesian meta-analysis.
Match Strength: 4.592

PURPOSE: To quantify the variation in primary open-angle glaucoma (OAG) prevalence with age, gender, race, year of publication, and survey methodology. METHODS: Medline, EMBASE, and PubMed were searched for studies of OAG prevalence. Studies with defined population samplings were sought. Forty-six published observational studies of OAG prevalence (103,567 participants with 2509 cases of OAG) were identified for inclusion in the systematic review and meta-analysis. Data on the number of people and the number of cases of OAG by age, race, and gender were sought for each study. Additional ... Read More »
» Published in Invest Ophthalmol Vis Sci. 2006 Oct;47(10):4254-61.

12. Assessment of false positives with the Humphrey Field Analyzer II perimeter with the SITA Algorithm.
Match Strength: 4.481

PURPOSE: To evaluate the effects of false-positive (FP) response errors on mean deviation (MD), pattern standard deviation (PSD), glaucoma hemifield test (GHT), and test duration in the Humphrey Field Analyzer's (HFA II) Swedish Interactive Threshold Algorithm (SITA; Carl Zeiss Meditec, Inc., Dublin, CA). METHODS: Five individuals with glaucoma (ages 52, 63, 69, 77, and 78 years) and five individuals with normal, healthy eyes (ages 25, 34, 43, 45, and 52 years), participated in the study. Each subject was experienced in automated perimetry and performed multiple, monocular baseline SITA ... Read More »
» Published in Invest Ophthalmol Vis Sci. 2006 Oct;47(10):4632-7.

13. A comparison of algorithms for calculating glaucoma change probability confidence intervals.
Match Strength: 4.134

PURPOSE: To evaluate the ability to detect change in standard automated perimetry data using 4 different methods for calculating the glaucoma change probability (GCP). METHODS: A database of stable visual fields, collected within 1 week from 35 glaucoma patients and within 6 months from 15 normal patients, was used to determine confidence intervals for GCP using 4 different methods. The methods classified visual field locations on the basis of either defect or mean threshold, and used test-retest data or baseline-less-follow-up data to determine values for the confidence intervals. The ... Read More »
» Published in J Glaucoma. 2006 Oct;15(5):405-13.

14. Effect of latanoprost on the diurnal variations in the intraocular and ocular perfusion pressure in normal tension glaucoma.
Match Strength: 3.986

PURPOSE: To evaluate the effects of latanoprost on the diurnal variations in the intraocular pressure (IOP) combined with the ocular perfusion pressure (OPP) in patients with normal tension glaucoma (NTG). PATIENTS AND METHODS: Twenty-two eyes from 22 patients with NTG were used for the study. The diurnal variations in the IOP and blood pressure (BP) were measured every 3 hours without therapy, and then the patients were treated with latanoprost (0.005%) once daily for more than 12 weeks. The diurnal variations in the IOP and BP under medication were again measured every 6 hours. The diurnal ... Read More »
» Published in J Glaucoma. 2006 Oct;15(5):354-7.

15. Trabecular bypass: effect of schlemm canal and collector channel dilation.
Match Strength: 3.868

PURPOSE: To theorize the effect of Schlemm canal (SC) and/or collector channel (CC) dilation combined with a trabecular bypass on intraocular pressure (IOP) in eyes with primary open angle glaucoma. METHODS: The elliptic shaped SC is dilated in conjunction with a trabecular bypass and its expanded height is largest at the bypass and linearly deceases to the nondilated height over the dilated circumferential length. The CC dilation is modeled with a reduced outflow resistance of second order polynomial over the same dilated length. Equations governing the pressure and circumferential flow in SC ... Read More »
» Published in J Glaucoma. 2006 Oct;15(5):446-55.

16. Relationship of progression of visual field damage to postural changes in intraocular pressure in patients with normal-tension glaucoma.
Match Strength: 3.719

PURPOSE: To evaluate whether postural changes of intraocular pressure (IOP) are associated with progression of visual field damage in patients with normal-tension glaucoma (NTG). DESIGN: Prospective, noncomparative, nonrandomized study. PARTICIPANTS: Sixty eyes of 33 patients with NTG. METHODS: Intraocular pressure, blood pressure (BP), and pulse rate (PR) were measured in both sitting and supine positions. Visual fields were examined using Humphrey Field Analyzer (HFA; Zeiss-Humphrey Instruments, Inc., San Leandro, CA). Changes in mean deviation (MD) per year (dB/year), that is, MD slope, ... Read More »
» Published in Ophthalmology. 2006 Dec;113(12):2150-5. Epub 2006 Sep 25.

17. Intrastromal diathermal keratostomy: a new micropenetrating clear-cornea glaucoma procedure.
Match Strength: 3.649

PURPOSE: The filtering intrastromal diathermal keratostomy (IDK) was developed to comply with the call for a low postoperative intraocular pressure (IOP) and a bleb morphology without a thin, cystic appearance. PATIENTS AND METHODS: A diathermal microkeratostomy (150 to 200 microm) was created into the anterior chamber, anterior to the Schwalbe line through the floor of a surgical corneoscleral tunnel incision into the subconjunctival space. A newly developed, bipolar diathermal microneedle was used to create the keratostomy, replacing the Holmium laser used previously. Subconjunctival ... Read More »
» Published in J Glaucoma. 2006 Oct;15(5):437-45.

18. Trabeculectomy with mitomycin C combined with direct cauterization of peripheral iris in the management of neovascular glaucoma.
Match Strength: 3.509

PURPOSE: To determine the outcomes of trabeculectomy with mitomycin C (MMC) combined with direct cauterization of peripheral iris before iridectomy in the management of neovascular glaucoma (NVG), and to demonstrate the effect of this surgical technique on decreasing the incidence of intraoperative bleeding and early postoperative hyphema. METHODS: This prospective study was based on 72 eyes of 72 patients with NVG who underwent primary trabeculectomy with MMC combined with direct cauterization of peripheral iris before iridectomy. The patients were evaluated for intraoperative and early ... Read More »
» Published in J Glaucoma. 2006 Oct;15(5):466-70.

19. Photodynamic therapy with intravitreal triamcinolone in predominantly classic choroidal neovascularization: one-year results of a randomized study.
Match Strength: 3.124

PURPOSE: To determine whether intravitreal triamcinolone acetonide (IVTA) improves the efficacy of photodynamic therapy (PDT) with verteporfin in predominantly classic subfoveal choroidal neovascularization (CNV) secondary to age-related macular degeneration (AMD). DESIGN: Prospective randomized study. PARTICIPANTS: Sixty-one patients with predominantly classic subfoveal CNV secondary to AMD. METHODS: Patients were randomized to receive PDT (n = 30) or PDT followed by approximately 11 mg IVTA (n = 31), with retreatment every 3 months when leakage was documented by fluorescein angiography. At ... Read More »
» Published in Ophthalmology. 2006 Dec;113(12):2243-50. Epub 2006 Sep 25.

20. Detection and prognostic significance of optic disc hemorrhages during the Ocular Hypertension Treatment Study.
Match Strength: 2.973

PURPOSE: To compare the rates of detection of optic disc hemorrhages by clinical examination and by review of optic disc photographs at the Optic Disc Reading Center (ODRC), to assess the incidence of and the predictive factors for disc hemorrhages in the annual disc photographs of the Ocular Hypertension Treatment Study (OHTS), and to determine whether optic disc hemorrhages predict the development of primary open-angle glaucoma (POAG) in the OHTS. DESIGN: Cohort study. PARTICIPANTS: Three thousand two hundred thirty-six eyes of 1618 participants. METHODS: Both eyes of participants were ... Read More »
» Published in Ophthalmology. 2006 Dec;113(12):2137-43. Epub 2006 Sep 25.

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