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1. Pathological and immunohistochemical study of gastrointestinal lesions in dolphins stranded in the Canary Islands.
Match Strength: 5.844

This paper describes the gross, histopathological and immunohistochemical characteristics of gastrointestinal lesions and regional lymph nodes of six common dolphins (Delphinus delphis), 11 striped dolphins (Stenella coeruleoalba) and six Atlantic spotted dolphins (Stenella frontalis) found stranded along the coasts of the Canary Islands. The most common lesion was chronic granulomatous gastritis of the glandular stomach, associated with the parasite Pholeter gastrophilus, and characterised by the parasites, their eggs, or parasite debris in the mucosa, submucosa or tunica muscularis, ... Read More »
» Published in Vet Rec. 2006 Sep 23;159(13):410-4.

2. Pathology and molecular biology of gastric cancer.
Match Strength: 4.929

Several attempts to classify gastric cancer (GCA) have been made over the past decades. Most successful, and widely used, is the classification by Lauren, which distinguishes, by microscopical morphology alone, two main cancer pathogeneses, diffuse (DGCA) and intestinal (IGCA) subtypes, which appear clearly as dissimilar clinical and epidemiological entities. Here we review the main differences in epidemiology, histopathology, and molecular pathology of the two main subtypes of gastric carcinomas based on Lauren classification. In clinical practice, however, clinical staging, particularly in ... Read More »
» Published in Best Pract Res Clin Gastroenterol. 2006;20(4):651-74.

3. Helicobacter pylori as a promoter of accelerated regeneration, pathological differentiation and transformation of normal gastric mucosa into cancerous type.
Match Strength: 4.656

The aim of the study was to ascertain presence of Helicobacter pylori in gastric carcinoma as a responsible promoter of inflammatory-regenerative changes, which lead to pathological differentiation and transformation of normal epithelial cells into intestinal type and, in progression, cause epithelial dysplasia that develops into early gastric carcinoma. The paper presents prospective study that includes clinical, pathohistological and microbiological aspects of carcinogenesis initiation in gastric mucosa. The subjects are patients treated at Gastroenterohepatology Clinic divided into two ... Read More »
» Published in Bosn J Basic Med Sci. 2006 Aug;6(3):57-60.

4. Risk of oesophageal cancer by histology among patients hospitalised for gastroduodenal ulcers.
Match Strength: 2.913

OBJECTIVE: The mechanism behind the epidemiologically evident inverse relationship between Helicobacter pylori seropositivity and risk of oesophageal adenocarcinoma (OAC) remains obscure. Severe corpus gastritis is unlikely to be in the causal pathway. With the hypothesis of a uniformly low risk, we aimed to explore the associations of OAC with duodenal ulcer (DU) and gastric ulcer (GU) - both linked to H. pylori infection but with different patterns of bacterial colonization and intragastric acidity. We also addressed possible associations of oesophageal squamous cell carcinoma (OSCC) with ... Read More »
» Published in Gut. 2006 Sep 27;

5. MDM2 promoter polymorphism is associated with both an increased susceptibility to gastric carcinoma and poor prognosis.
Match Strength: 2.830

PURPOSE: Recently, a single-nucleotide polymorphism in the MDM2 promoter (SNP309) has been found to lower the age of onset of tumors and increase the occurrence of multiple primary tumors in Li-Fraumeni syndrome, and accelerate the development of sporadic adult soft tissue sarcoma. The aim of this study was to determine whether SNP309 is associated with susceptibility to gastric carcinoma and its prognosis. PATIENTS AND METHODS: In a case-control study including 438 controls and 410 patients with sporadic gastric carcinoma, MDM2 SNP309 was genotyped. Serum pepsinogens (PGs) I and II were ... Read More »
» Published in J Clin Oncol. 2006 Sep 20;24(27):4434-40.

6. Genetic polymorphisms in anti-inflammatory cytokine signaling and the prevalence of gastric precancerous lesions in Venezuela.
Match Strength: 2.826

OBJECTIVES: The aim of the study was to assess the effects of genetic polymorphisms in anti-inflammatory mediators, i.e., IL10, IL4 and IL4R on the prevalence of gastric precancerous lesions and their interactions with other environmental factors. METHODS: The study population consisted of 2,033 Venezuelan subjects known to have extremely high Helicobacter Pylori (HP) infection rates. The odds ratios (OR) and 95% confidence intervals (CI) associated with these polymorphisms were estimated by multinominal logistic regression models for gastric precursor lesions. RESULTS: We found a 60% increase ... Read More »
» Published in Cancer Causes Control. 2006 Nov;17(9):1183-91.

7. Gastrointestinal involvement in mantle cell lymphoma: a prospective clinic, endoscopic, and pathologic study.
Match Strength: 2.753

The frequency of gastrointestinal (GI) tract involvement in mantle cell lymphoma (MCL) at diagnosis is reported to be below 30%. To investigate the actual frequency of GI involvement by MCL, upper and lower endoscopy was prospectively performed on 13 untreated MCL patients at diagnosis. Multiple biopsies from endoscopically normal and abnormal gastric and colonic mucosa were studied with immunohistochemistry (IHC) for CD20, CD5, and cyclin D1, as well as fluorescence in situ hybridization (FISH) for t(11;14) and polymerase chain reaction (PCR) for immunoglobulin heavy chain gene. Abnormal ... Read More »
» Published in Am J Surg Pathol. 2006 Oct;30(10):1274-80.

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