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Fifth Disease
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1. Coronary artery disease in women: the myth still exists.
Match Strength: 2.914

There is a large media effort currently available to increase awareness of coronary artery disease in women. Despite this, there is still a misconception among some people, and unfortunately, some healthcare providers, that heart disease is a man's disease. This article will review some of the information about women and coronary artery disease; a short review of the literature, symptoms, diagnostic tests, and treatment pertinent to women; and the action nurses can take to help educate the public, and other healthcare providers, about this deadly threat. Publication Types: ... Read More »
» Published in Dimens Crit Care Nurs. 2006 Sep-Oct;25(5):209-15.

2. A rare case of extranodal Rosai-Dorfman disease.
Match Strength: 2.871

Rosai-Dorfman disease is a rare, benign histiocytic proliferative disorder which commonly affects the lymph nodes. Extranodal involvement along with concomitant nodal disease occurs in about 43% of cases. Isolated extranodal Rosai-Dorfman disease is relatively uncommon. We report this rare case of isolated extranodal Rosai-Dorfman disease and its ultrasound findings. Publication Types: Case Reports, ... Read More »
» Published in Br J Radiol. 2006 Oct;79(946):e117-9.

3. Pathology of inflammatory native valvular heart disease.
Match Strength: 2.869

Rheumatic disease is an important cause of inflammatory native heart valve disease. However, with increased understanding of the pathoetiology of valve disease and valve injury, it is evident that inflammation may play a role in many valve disorders. We are only beginning to understand these complex processes. With increasing knowledge that many of these processes are active, there may be opportunity for intervention or even prevention ... Read More »
» Published in Cardiovasc Pathol. 2006 Sep-Oct;15(5):243-51.

4. Acute myelogenous leukemia associated with Ollier disease.
Match Strength: 2.820

Ollier disease is a rare disorder characterized by the presence of multiple enchondromas and a propensity to develop malignancies. We report the case of a 7-year-old Caucasian male with Ollier disease who developed acute myelogenous leukemia (AML). This report describes a patient with Ollier disease and AML and may offer a clue into the genetic pathogenesis of these disorders. Pediatr Blood Cancer (c) 2006 Wiley-Liss, Inc ... Read More »
» Published in Pediatr Blood Cancer. 2006 Sep 21;

5. Sickle cell disease in the perioperative setting.
Match Strength: 2.667

This article explores Sickle Cell Disease and Sickle Cell Trait. These are hereditary conditions that affect thousands of people in the UK and abroad. The disease tends to occur in people of Afro-Caribbean or Mediterranean descent. The specific Pre-, Peri- and postoperative care of affected patients is examined ... Read More »
» Published in J Perioper Pract. 2006 Sep;16(9):443-6.

6. Peyronie's Disease: A Review.
Match Strength: 2.569

Peyronie's disease is an acquired benign condition without known systemic sequelae with presenting symptoms that include the presence of a plaque or induration of the penile shaft, penile curvature or deformity during erection, penile pain, and erectile dysfunction. This article reviews the natural history of the disease, discusses the disease's etiology (widely thought to involve minor penile trauma with subsequent aberrant wound healing), and outlines proper clinical evaluation of Peyronie's disease patients. Medical treatments can be systemic (colchicine, potassium aminobenzoate, vitamin E) ... Read More »
» Published in Rev Urol. 2003 Summer;5(3):142-8.

7. Low blood concentration of hydroxychloroquine is a marker for and predictor of disease exacerbations in patients with systemic lupus erythematosus.
Match Strength: 2.569

OBJECTIVE: To study the possible relationship between whole-blood hydroxychloroquine (HCQ) concentrations and clinical efficacy of HCQ in patients with systemic lupus erythematosus (SLE). METHODS: Whole-blood HCQ concentrations were measured, under blinded conditions, in 143 unselected patients with SLE who had been receiving HCQ 400 mg daily for at least 6 months. The relationship of these concentrations to current disease activity and to subsequent exacerbations during 6 months of followup was investigated. RESULTS: At baseline, 23 patients had active disease (mean +/- SD SLE Disease ... Read More »
» Published in Arthritis Rheum. 2006 Oct;54(10):3284-90. Comment in: Arthritis Rheum. 2006 Oct;54(10):3068-70.

8. Long-term outcome after intestinal resection for Crohn's disease.
Match Strength: 2.564

OBJECTIVE: To assess the need for intestinal repeat resection for recurrence of Crohn's disease in patients observed for more than 20 years after the first resection. MATERIAL AND METHODS: Data were gathered retrospectively from the medical records of 53 (28 F) consecutive patients with Crohn's disease from May 1954 to December 2002. Median age at first intestinal resection was 24.5 (range 13-65) years, and median observation time thereafter was 26.5 (20.1-48.6) years. Disease location and behaviour were defined according to the Vienna classification. RESULTS: The 53 patients had an average 2 ... Read More »
» Published in Scand J Gastroenterol. 2006 Oct;41(10):1204-8.

9. Parkinson's disease: background, diagnosis, and initial management.
Match Strength: 2.564

Parkinson's disease is a common neurodegenerative disorder associated with aging. After essential tremor, it is the most common movement disorder of the elderly. Parkinson's disease is the most common disabling movement disorder. This article reviews the major clinical features, differential diagnosis, approach to diagnosis, and initial management of Parkinson's disease. Publication Types: Research Support, N.I.H., Extramural, Research Support, U.S. Gov't, Non-P.H.S., ... Read More »
» Published in Clin Geriatr Med. 2006 Nov;22(4):735-51, v.

10. Metabolic syndrome and risk of cardiovascular disease: a meta-analysis.
Match Strength: 2.543

PURPOSE: The use of different definitions of the metabolic syndrome has led to inconsistent results on the association between the metabolic syndrome and risk of cardiovascular disease. We examined the association between the metabolic syndrome and risk of cardiovascular disease. METHODS: A MEDLINE search (1966-April 2005) was conducted to identify prospective studies that examined the association between the metabolic syndrome and risk of cardiovascular disease. Information on sample size, participant characteristics, metabolic syndrome definition, follow-up duration, and endpoint assessment ... Read More »
» Published in Am J Med. 2006 Oct;119(10):812-9.

11. Etiology and impact of cytomegalovirus disease on solid organ transplant recipients.
Match Strength: 2.539

PURPOSE: The characteristics, etiology, natural history, and direct and indirect effects of CMV disease in solid organ transplant recipients are described. SUMMARY: CMV is a common herpesvirus that may be present in the donor or recipient of a solid organ transplant. Even though it is rarely pathogenic in healthy patients, transplant recipients are at risk for CMV viremia and symptomatic disease due to their immune-suppressed status. In addition to symptoms directly attributed to active disease, CMV can have a variety of indirect effects. Indirect effects may include additional infectious ... Read More »
» Published in Am J Health Syst Pharm. 2006 Oct 1;63(19 Suppl 5):S3-9.

12. Treating very early rheumatoid arthritis.
Match Strength: 2.499

Rheumatoid arthritis (RA) is common and leads to joint damage due to persistent synovitis. The persistence of inflammation is maintained by hyperplastic stromal tissue, which drives the accumulation of leukocytes in the synovium. Aggressive treatment after the first 3-4 months of symptoms, with either disease modifying anti-rheumatic drugs or anti-tumor necrosis factor (TNF)-alpha therapy, reduces the rate of disease progression. However, it rarely switches off disease such that remission can be maintained without the continued need for immunosuppressive therapy. There is increasing evidence ... Read More »
» Published in Best Pract Res Clin Rheumatol. 2006 Oct;20(5):849-63.

13. Endocrine disruptor vinclozolin induced epigenetic transgenerational adult-onset disease.
Match Strength: 2.486

The fetal basis of adult disease is poorly understood on a molecular level and cannot be solely attributed to genetic mutations or a single etiology. Embryonic exposure to environmental compounds has been shown to promote various disease states or lesions in the first generation (F1). The current study used the endocrine disruptor vinclozolin (antiandrogenic compound) in a transient embryonic exposure at the time of gonadal sex determination in rats. Adult animals from the F1 generation and all subsequent generations examined (F1-F4) developed a number of disease states or tissue abnormalities ... Read More »
» Published in Endocrinology. 2006 Dec;147(12):5515-23. Epub 2006 Sep 14. Comment in: Endocrinology. 2006 Dec;147(12):5513-4.

14. Cognitive, affective, and psychiatric features of Parkinson's disease.
Match Strength: 2.453

Nonmotor symptoms, including cognitive deterioration and dementia, depression and apathy, and psychosis, are common in Parkinson's disease. Their presence is associated with a tremendous burden for the patient and family members. This article reviews the pathophysiololgy, risks, impact, major features, diagnosis, and treatment of these symptoms in Parkinson's disease. Publication Types: Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, ... Read More »
» Published in Clin Geriatr Med. 2006 Nov;22(4):773-96, v-vi.

15. Pharmacological treatments for thyroid eye disease.
Match Strength: 2.451

Thyroid eye disease (TED), which affects the majority of patients with Grave's disease, is associated with significant ophthalmic morbidity. In patients with mild disease, supportive treatment with lubricating medication can be sufficient. However, in patients with severe TED and disfiguring proptosis or sight-threatening neuropathy, more aggressive medical or surgical interventions are necessary. Corticosteroids remain the preferred pharmacological treatment modality in the majority of patients with an active inflammatory component. Other immunosuppressive drugs in combination with ... Read More »
» Published in Drugs. 2006;66(13):1685-700.

16. The genomics of new drugs in sickle cell disease.
Match Strength: 2.403

The quality of life of patients with sickle cell disease in developed countries has improved significantly over the past two decades. Currently available measures to prevent the painful crises and the complications of the disease include the use of penicillin prophylaxis, antipneumonococcal vaccine, folate administration, chronic red cell transfusions in patients with cerebrovascular disease, iron chelating agents, fetal hemoglobin-enhancing agents, such as hydroxyurea, decitabine and butyrate, drugs that augment the endogenous nitric oxide levels and agents that restore red cell dehydration. ... Read More »
» Published in Pharmacogenomics. 2006 Sep;7(6):909-17.

17. Antiviral dosing and efficacy for prophylaxis of cytomegalovirus disease in solid organ transplant recipients.
Match Strength: 2.396

PURPOSE: The implications of the findings from clinical studies and pharmacokinetic analyses of the antiviral agent valganciclovir for dosing of the drug to prevent cytomegalovirus (CMV) disease in solid organ transplant recipients are reviewed. SUMMARY: Valganciclovir, an oral prodrug of ganciclovir, is as effective as oral ganciclovir for preventing CMV disease, although prophylaxis with either agent may delay CMV disease. Dosage reduction is required for both drugs in patients with renal impairment to prevent high plasma ganciclovir concentrations and toxicity. A valganciclovir dosage of ... Read More »
» Published in Am J Health Syst Pharm. 2006 Oct 1;63(19 Suppl 5):S17-21.

18. Heart rate variability monitoring in the detection of central nervous system complications in children with enterovirus infection.
Match Strength: 2.395

PURPOSE: Previous studies suggest the possibility of autonomic dysfunction in patients with complicated hand, foot, and mouth disease (HFMD) and herpangina. Heart rate variability (HRV), an index for autonomic nervous system, may be useful to detect disease progression. MATERIALS AND METHODS: From 2001 to 2002, 66 patients (1-9 years old) were enrolled prospectively in either a control (20 patients) or disease (46 patients with HFMD or herpangina) group. The disease group was subdivided into stage I (fever only), stage II (with complications of encephalomyelitis), and stage III (with ... Read More »
» Published in J Crit Care. 2006 Sep;21(3):280-6. Comment in: J Crit Care. 2006 Sep;21(3):286-9.

19. The genetics of health.
Match Strength: 2.384

Recent experience with several high-profile drugs demonstrates the great challenges in developing effective and safe therapeutics. A complementary approach to the popular paradigm of disease genetics is based on inherited factors that reduce the incidence and severity of disease among individuals who are genetically predisposed to disease. We propose testing specifically for modifier genes and protective alleles among at-risk individuals and studying the efficacy of therapeutics based on the genetics of health. Publication Types: Research Support, N.I.H., Extramural, ... Read More »
» Published in Nat Genet. 2006 Oct;38(10):1095-8.

20. Kinase activity of mutant LRRK2 mediates neuronal toxicity.
Match Strength: 2.375

Mutations in the the leucine-rich repeat kinase-2 (LRRK2) gene cause autosomal-dominant Parkinson disease and some cases of sporadic Parkinson disease. Here we found that LRRK2 kinase activity was regulated by GTP via the intrinsic GTPase Roc domain, and alterations of LRRK2 protein that reduced kinase activity of mutant LRRK2 correspondingly reduced neuronal toxicity. These data elucidate the pathogenesis of LRRK2-linked Parkinson disease, potentially illuminate mechanisms of sporadic Parkinson disease and suggest therapeutic targets. Publication Types: Comparative Study, Research Support, N ... Read More »
» Published in Nat Neurosci. 2006 Oct;9(10):1231-3. Epub 2006 Sep 17.

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