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Peer Reviewed Scientific Research Reports.
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1. Anatomy and histopathology of the human lacrimal gland.
Match Strength: 5.634
PURPOSE:: To review the anatomy and histopathologic changes of the human main lacrimal gland. METHODS:: Samples of lacrimal gland including palpebral lobes and orbital lobes were taken in autopsies, and the relationship between histopathologic changes and age and sex, as well as histopathologic differences between palpebral and orbital lobes of the lacrimal gland, were studied using light microscopy. RESULTS:: Various histopathologic changes were observed in the human main lacrimal gland as follows: acinar atrophy; periacinar fibrosis; periductal fibrosis; interlobular ductal dilatation; ... Read More »
» Published in Cornea. 2006 Dec;25 Suppl 1:S82-9.
2. Epithelial Cell Apoptosis by FasL-positive Myofibroblasts in Lung Fibrosis.
Match Strength: 5.562
The Fas/FasL apoptotic pathway has been shown to be involved in bleomycin-induced lung fibrosis. We examined the hypothesis that myofibroblasts from fibrotic lungs possess a cytotoxic phenotype that causes apoptosis of epithelial cells via the Fas/FasL pathway. We show in vivo epithelial cell apoptosis and associated upregulation of Fas and Fas apoptotic pathway genes in epithelial cells of lungs with bleomycin-induced fibrosis. In addition, we show that FasL surface molecules are overexpressed on alphaSMA positive cells in mice with bleomycin-induced fibrosis, and in humans with idiopathic ... Read More »
» Published in Am J Respir Cell Mol Biol. 2006 Sep 21;
3. Restless leg syndrome manifested by iron deficiency from chronic hemoptysis in cystic fibrosis.
Match Strength: 5.439
Restless leg syndrome (RLS) and periodic limb movement disorder (PLMD) are considered to be a continuum of a neurological sleep disorder associated with abnormal iron metabolism or deficiency. I describe a case of RLS and PLMD in a cystic fibrosis patient with iron deficiency from chronic hemoptysis. This is the first case that reports RLS and PLMD manifesting from iron deficiency caused by chronic hemoptysis in advanced cystic fibrosis lung disease ... Read More »
» Published in J Cyst Fibros. 2006 Sep 15;
4. The putative use of alpha-1-acid glycoprotein as a non-invasive marker of fibrosis.
Match Strength: 5.348
The acute phase response to injury or infection results in alterations in the expression of the plasma proteins produced by the liver. Many of these biomolecules are glycosylated with oligosaccharide chains covalently attached to the polypeptide backbone and the extent and composition of this glycosylation can be altered in a disease-dependent manner. Of particular interest is the observation that the acute phase glycoprotein, alpha-1-acid glycoprotein (AGP) has altered glycosylation in several physiological and pathological conditions. It is posited that changes induced in liver diseases may ... Read More »
» Published in Biomed Chromatogr. 2006 Dec;20(12):1351-8.
5. Comprehensive genetic analysis of the cystic fibrosis transmembrane conductance regulator from dried blood specimens--implications for newborn screening.
Match Strength: 5.344
PURPOSE: In the United States, approximately 1/3,700 babies is born with cystic fibrosis each year. The >1,300 documented sequence variants pose a challenge for detection of cystic fibrosis through genetic screening. To investigate whether comprehensive characterization of the cystic fibrosis gene is feasible using dried newborn blood specimens, we modified the whole blood Ambry Test: CF and determined its sensitivity by testing DNA from individuals with cystic fibrosis who still had unknown mutations after commercial mutation panel testing. METHODS: DNA from 42 archived newborn dried blood ... Read More »
» Published in Genet Med. 2006 Sep;8(9):557-62.
6. Unusual appearance of retroperitoneal fibrosis simulating a tumour.
Match Strength: 5.251
Retroperitoneal fibrosis (RPF) is an uncommon entity that usually presents as a fibrous plaque-like lesion that encases the aorta and inferior vena cava below the level of the renal arteries. We present an unusual mass-like appearance of this disease simulating a tumour, with foci of calcification, seen in a young girl. Publication Types: Case ... Read More »
» Published in Br J Radiol. 2006 Oct;79(946):e137-9.
7. Hemodynamic changes with liver fibrosis measured by dynamic contrast-enhanced MRI in the rat.
Match Strength: 5.243
PURPOSE: To evaluate the hemodynamic changes of liver cirrhosis in the rat and investigate the relationship between hemodynamic changes and properties of fibrotic change in the liver. MATERIALS AND METHODS: Three rats with cirrhosis induced by thioacetamide (TAA), three with disease induced by carbon tetrachloride (CCl4), and three with no treatment were measured on dynamic MRI using a 1.5T scanner. Compartment and moment analysis were used to quantitate hemodynamic changes. RESULTS: Compartment model analysis showed that increased transition speed from vessels to the liver correlated with ... Read More »
» Published in Magn Reson Med Sci. 2006 Jul;5(2):65-71.
8. How variable are hydroxyproline determinations made in different samples of the same liver?
Match Strength: 5.128
OBJECTIVES: The haphazard distribution of fibrous tissue can interfere with quantitative methods for evaluating hepatic fibrosis. Inter-sample variation may represent a crucial issue when hydroxyproline measurement is used to quantify fibrosis. A comparative study of the hydroxyproline levels in normal and fibrotic rats is herein reported. MATERIAL AND METHODS: Twelve normal and 20 Capillaria hepatica-infected Wistar rats were used. Two fragments of the liver (A and B) of each rat were taken from separate areas and hydroxyproline measurements were made. Calculated differences in hydroxyproline ... Read More »
» Published in Clin Biochem. 2006 Dec;39(12):1160-3. Epub 2006 Aug 18.
9. Immunological basis of systemic sclerosis.
Match Strength: 5.093
Systemic sclerosis (SSc) is a disease of unknown aetiology characterized by excessive and often progressive fibrosis in skin and multiple internal organs, an aberrant immune activation marked by multiple humoral and cellular immunological abnormalities and pronounced alterations in the microvasculature. The pathogenesis of SSc is complex and, although progress in the understanding of the multiple processes underlying SSc has been made in recent years, no single unifying hypothesis explaining all aspects of this disease exists. Recent studies have suggested that the activation of the immune ... Read More »
» Published in Rheumatology (Oxford). 2006 Oct;45 Suppl 3:iii23-iii25.
10. The role of the glucocorticoid receptor in mineralocorticoid/salt-mediated cardiac fibrosis.
Match Strength: 5.088
The pathophysiological consequences of excess mineralocorticoid for salt status include hypertension, vascular inflammation, and cardiac fibrosis. Mineralocorticoid receptor (MR) blockade can both prevent and reverse established inflammation and fibrosis due to exogenous mineralocorticoids or endogenous glucocorticoid activation of the MR. Glucocorticoids also exert potent antiinflammatory effects via glucocorticoid receptors (GR) in the vascular wall. We propose that GR signaling may ameliorate mineralocorticoid/salt-induced vascular inflammation and fibrosis in the mineralocorticoid/salt ... Read More »
» Published in Endocrinology. 2006 Dec;147(12):5901-6. Epub 2006 Sep 21.
11. Nasal and paranasal sinus endoscopy, computed tomography and microbiology of upper airways and the correlations with genotype and severity of cystic fibrosis.
Match Strength: 5.046
OBJECTIVE: Many studies have assessed clinical and functional aspects of lower airway affections in cystic fibrosis. Conversely, few studies have been performed to assess the clinical and functional affections of upper airways. The objective of the present study was to correlate the variables obtained by nasal and paranasal sinuses endoscopy, paranasal sinus laboratory and computed tomography (CT) scan findings, and to check the association with severity and genotype of cystic fibrosis patients. METHODS: Clinical and laboratory study of 50 patients with cystic fibrosis at a university center. ... Read More »
» Published in Int J Pediatr Otorhinolaryngol. 2007 Jan;71(1):41-50. Epub 2006 Sep 27.
12. Cost of home and hospital care for patients with cystic fibrosis followed up in two reference medical centers in France.
Match Strength: 4.916
OBJECTIVES: In France, new guidelines for clinical practices concerning cystic fibrosis came out in 2002, underscoring the need for early and intensive management of this disease. Because no recent health economic studies on cystic fibrosis in France were available, we conducted a cost-analysis study before the new guidelines were put into practice, with a view to a later study on the medical and economic impact of these guidelines. METHODS: A cost-analysis study was performed of the inpatient and outpatient costs of patients with cystic fibrosis for the 2000-2001 period. The various direct ... Read More »
» Published in Int J Technol Assess Health Care. 2006 Fall;22(4):525-31.
13. Regulatory role of gammadelta T cells in the recruitment of CD4+ and CD8+ T cells to lung and subsequent pulmonary fibrosis.
Match Strength: 4.742
The mechanisms by which T cells accumulate in the lungs of patients with pulmonary fibrosis are poorly understood. Because the lung is continually exposed to microbial agents from the environment, we repeatedly exposed C57BL/6 mice to the ubiquitous microorganism, Bacillus subtilis, to determine whether chronic exposure to an inhaled microorganism could lead to T cell accumulation in the lungs and subsequent pulmonary fibrosis. C57BL/6 mice repeatedly treated with B. subtilis for 4 consecutive weeks developed a 33-fold increase in the number of CD4+ T cells and a 354-fold increase in ... Read More »
» Published in J Immunol. 2006 Oct 1;177(7):4436-43.
14. Differential expression of collagen, MMP, TIMP and fibrogenic-cytokine genes in the granulomatous colon of Schistosoma mansoni-infected mice.
Match Strength: 4.562
Schistosomiasis mansoni is a major helminthic disease of the tropics characterised by chronic hepatic and intestinal granulomatous inflammation and fibrosis. The fibrotic response is regulated by the amount of collagen deposited in the tissues and the degradation of that collagen by matrix metalloproteinases (MMP). In the murine model of the disease, although hepatic granuloma formation and the ensuing fibrosis have been thoroughly examined, there is a dearth of information on the intestinal fibrotic process. The expression of fibrosis-related genes in the colons of chronically infected mice ... Read More »
» Published in Ann Trop Med Parasitol. 2006 Oct;100(7):611-20.
15. Interference of cyclosporine on glucose metabolism: potential role in chronic transplantation kidney fibrosis.
Match Strength: 4.420
OBJECTIVES: To explore the fibrosis induction effects of cyclosporine (CsA) on renal tubular epithelial cells, as well as the potential mechanisms of CsA-mediated alterations of glucose metabolism in chronic allograft nephropathy (CAN). METHODS: The rat renal tubular epithelial cell line NRK-52E cells were cultured in medium with 50 mmol/L of D-glucose for 7, 14, or 28 days. The expression of TGF-beta1, CTGF, Smad3, and Smad7, which are involved in the fibrosis signal pathway, was detected by immunofluorescence and reverse-transcriptase polymerase chain reaction. Meanwhile, cells were cultured ... Read More »
» Published in Transplant Proc. 2006 Sep;38(7):2065-8.
16. Leptin-mediated neovascularization is a prerequisite for progression of nonalcoholic steatohepatitis in rats.
Match Strength: 4.407
Nonalcoholic steatohepatitis (NASH) may cause fibrosis, cirrhosis, and hepatocellular carcinoma (HCC); however, the exact mechanism of disease progression is not fully understood. Angiogenesis has been shown to play an important role in the progression of chronic liver disease. The aim of this study was to elucidate the role of angiogenesis in the development of liver fibrosis and hepatocarcinogenesis in NASH. Zucker rats, which naturally develop leptin receptor mutations, and their lean littermate rats were fed a choline-deficient, amino acid-defined diet. Both Zucker and littermate rats ... Read More »
» Published in Hepatology. 2006 Oct;44(4):983-91.
17. Increased in CD8 T lymphocytes in the BAL fluid of patients with sulfur mustard gas-induced pulmonary fibrosis.
Match Strength: 4.372
OBJECTIVE: In an attempt to understand better the potential role of the T cell in the pathogenesis of pulmonary fibrosis (PF) due to sulfur mustard gas inhalation, this study was designed to analyze bronchoalveolar lavage (BAL) lymphocyte subsets and to determine the ratio of CD4 to CD8 lymphocytes in BAL fluid. SETTING: University hospital. PATIENTS: Twenty-one veterans with mustard gas-induced pulmonary fibrosis and 20 normal veterans as control group. INTERVENTION: Chest roentgenograms, pulmonary function tests (PFTs), tests for carbon monoxide diffusing capacity of the lung (DLCO), high ... Read More »
» Published in Respir Med. 2006 Sep 16;
18. Immediate changes in blood-gas tensions during chest physiotherapy with positive expiratory pressure and oscillating positive expiratory pressure in patients with cystic fibrosis.
Match Strength: 4.360
OBJECTIVE: To assess and compare immediate effects of chest physiotherapy with positive expiratory pressure (PEP) versus oscillating PEP on transcutaneously measured blood-gas tensions in patients with cystic fibrosis. METHODS: Fifteen patients (mean age 12.5 y, range 6.9-21.5 y) participated. The treatments were randomized and performed on 2 separate occasions, 8 weeks apart. Spirometry was conducted before and after each treatment. We transcutaneously measured oxygen tension (P(tO2). RESULTS: There were no changes in spirometry values. During PEP, different trends in blood-gas tension were ... Read More »
» Published in Respir Care. 2006 Oct;51(10):1154-61.
19. Specific molecular targeting of renal injury in obstructive nephropathy.
Match Strength: 4.316
Progression of most renal disease involves tubulointerstitial injury, characterized by tubular atrophy, inflammatory cell infiltration, and interstitial fibrosis. Transforming growth factor-beta1 is central in this process. As reported by Moon et al., molecular targeting of the transforming growth factor-beta1 signaling pathway can markedly suppress renal injury resulting from unilateral ureteral obstruction, an established model of obstructive nephropathy. Specific kinase inhibitors are promising therapeutic agents to slow or attenuate progressive renal fibrosis. Publication Types: Comment, ... Read More »
» Published in Kidney Int. 2006 Oct;70(7):1200-1. Comment on: Kidney Int. 2006 Oct;70(7):1234-43.
20. Early microbial colonization of cystic fibrosis patients identified by neonatal screening, with emphasis on Staphylococcus aureus.
Match Strength: 4.162
OBJECTIVES: To assess bacterial colonization prospectively in patients with cystic fibrosis identified by neonatal screening. To assess susceptibility to antimicrobials and to perform the molecular typing of Staphylococcus aureus strains isolated from the oropharynx of patients during the study. METHODS: Twenty-five cystic fibrosis patients receiving regular treatment at the Cystic Fibrosis Outpatient Clinic of Hospital de Clinicas of Universidade Federal do Parana, Brazil, were included in the study. All patients were identified by trypsin-like immunoreactivity and their diagnosis was ... Read More »
» Published in J Pediatr (Rio J). 2006 Sep-Oct;82(5):377-82. Epub 2006 Sep 19.
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