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Fibrosis Liver
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1. Hemodynamic changes with liver fibrosis measured by dynamic contrast-enhanced MRI in the rat.
Match Strength: 10.332

PURPOSE: To evaluate the hemodynamic changes of liver cirrhosis in the rat and investigate the relationship between hemodynamic changes and properties of fibrotic change in the liver. MATERIALS AND METHODS: Three rats with cirrhosis induced by thioacetamide (TAA), three with disease induced by carbon tetrachloride (CCl4), and three with no treatment were measured on dynamic MRI using a 1.5T scanner. Compartment and moment analysis were used to quantitate hemodynamic changes. RESULTS: Compartment model analysis showed that increased transition speed from vessels to the liver correlated with ... Read More »
» Published in Magn Reson Med Sci. 2006 Jul;5(2):65-71.

2. How variable are hydroxyproline determinations made in different samples of the same liver?
Match Strength: 9.347

OBJECTIVES: The haphazard distribution of fibrous tissue can interfere with quantitative methods for evaluating hepatic fibrosis. Inter-sample variation may represent a crucial issue when hydroxyproline measurement is used to quantify fibrosis. A comparative study of the hydroxyproline levels in normal and fibrotic rats is herein reported. MATERIAL AND METHODS: Twelve normal and 20 Capillaria hepatica-infected Wistar rats were used. Two fragments of the liver (A and B) of each rat were taken from separate areas and hydroxyproline measurements were made. Calculated differences in hydroxyproline ... Read More »
» Published in Clin Biochem. 2006 Dec;39(12):1160-3. Epub 2006 Aug 18.

3. The liver as a target organ of retinoids.
Match Strength: 8.702

Retinoids have several biological functions including cell growth, differentiation and apoptosis. In liver, retinoids are known to be associated with regeneration, fibrosis and carcinogenesis. The facts that retinoid droplets in stellate cells are lost with progression of liver disease and that effectiveness of an acyclic retinoid on second primary liver cancer suggest the importance of liver as a target organ of retinoids. Our recent work has indicated that retinoids have antioxidant effects in association with regulation of fatty acid metabolism. In this review article, we discussed the ... Read More »
» Published in Hepatol Res. 2006 Dec;36(4):248-54. Epub 2006 Sep 22.

4. Long-term follow-up of patients with NAFLD and elevated liver enzymes.
Match Strength: 8.332

Nonalcoholic fatty liver disease (NAFLD) is the most common cause of elevated liver enzymes in patients of developed countries. We determined the long-term clinical and histological courses of such patients. In a cohort study, 129 consecutively enrolled patients diagnosed with biopsy-proven NAFLD were reevaluated. Survival and causes of death were compared with a matched reference population. Living NAFLD patients were offered repeat liver biopsy and clinical and biochemical investigation. Mean follow-up (SD) was 13.7 (1.3) years. Mortality was not increased in patients with steatosis. ... Read More »
» Published in Hepatology. 2006 Oct;44(4):865-73. Comment in: Hepatology. 2006 Oct;44(4):802-5.

5. The putative use of alpha-1-acid glycoprotein as a non-invasive marker of fibrosis.
Match Strength: 7.959

The acute phase response to injury or infection results in alterations in the expression of the plasma proteins produced by the liver. Many of these biomolecules are glycosylated with oligosaccharide chains covalently attached to the polypeptide backbone and the extent and composition of this glycosylation can be altered in a disease-dependent manner. Of particular interest is the observation that the acute phase glycoprotein, alpha-1-acid glycoprotein (AGP) has altered glycosylation in several physiological and pathological conditions. It is posited that changes induced in liver diseases may ... Read More »
» Published in Biomed Chromatogr. 2006 Dec;20(12):1351-8.

6. Leptin-mediated neovascularization is a prerequisite for progression of nonalcoholic steatohepatitis in rats.
Match Strength: 7.722

Nonalcoholic steatohepatitis (NASH) may cause fibrosis, cirrhosis, and hepatocellular carcinoma (HCC); however, the exact mechanism of disease progression is not fully understood. Angiogenesis has been shown to play an important role in the progression of chronic liver disease. The aim of this study was to elucidate the role of angiogenesis in the development of liver fibrosis and hepatocarcinogenesis in NASH. Zucker rats, which naturally develop leptin receptor mutations, and their lean littermate rats were fed a choline-deficient, amino acid-defined diet. Both Zucker and littermate rats ... Read More »
» Published in Hepatology. 2006 Oct;44(4):983-91.

7. Herb medicine Yin-Chen-Hao-Tang ameliorates hepatic fibrosis in bile duct ligation rats.
Match Strength: 6.684

The accumulation of hydrophilic bile acids in the liver is considered to play a pivotal role in the induction of hepatic injury. Yin-Chen-Hao-Tang (YCHT) decoction is an aqueous extract from three different herbs: Artemisia capillaries Thunb (Compositae), Gardenia jasminoides Ellis (Rubiaceae), Rheum officinale Baill (Polygonaceae), which has been recognized as a hepatoprotective agent for various types of liver diseases. Therefore, we used an experimental of biliary atresia model to test that YCHT plays a regulatory role in the pathogenesis of hepatic fibrosis. Hepatic damage with fibrosis ... Read More »
» Published in J Ethnopharmacol. 2007 Jan 19;109(2):318-24. Epub 2006 Aug 5.

8. Inhibition of intrahepatic bile duct dilation of the polycystic kidney rat with a novel tyrosine kinase inhibitor gefitinib.
Match Strength: 6.283

The polycystic kidney (PCK) rat represents a liver and kidney cyst pathology corresponding to Caroli's disease with congenital hepatic fibrosis and autosomal recessive polycystic kidney disease. We previously reported that an epidermal growth factor receptor tyrosine kinase inhibitor, gefitinib (Iressa), significantly inhibited the abnormal growth of biliary epithelial cells of PCK rats in vitro. This study investigated the effects of gefitinib on cyst pathogenesis of the PCK rat both in vitro and in vivo. A three-dimensional culture model of biliary epithelial cells in the collagen gel matrix ... Read More »
» Published in Am J Pathol. 2006 Oct;169(4):1238-50.

9. Progressive familial intrahepatic cholestasis.
Match Strength: 6.181

Progressive familial intrahepatic cholestasis (PFIC) is an important cause of cholestatic liver disease and biliary cirrhosis in pediatric population. Three cases of PFIC are described that were diagnosed on the basis of family history, pruritis, cirrhosis and / or paucity of interlobular bile ducts on liver biopsy and presence of extrahepatic biliary tree on imaging. These patients were initially labeled as suffering from extra-hepatic biliary atresia and neonatal hepatitis. PFIC-1 and 2 could not be differentiated on histological grounds, since these patients presented late and process of ... Read More »
» Published in J Coll Physicians Surg Pak. 2006 Oct;16(10):673-5.

10. Direct and indirect evidence for the reversibility of cirrhosis.
Match Strength: 5.910

The aim of this study was to assess the reversibility of cirrhosis after therapy in a large series of patients with cirrhosis from various etiologies. We performed a retrospective study of 113 patients with biopsy-proven cirrhosis who underwent specific therapy and follow-up biopsies. Two pathologists performed blinded analyses of indirect biochemical and morphological signs of cirrhosis. Fourteen (12.4%) of the 113 cirrhotic patients had biopsy-proven disappearance of cirrhosis, defined as a decrease of 2 or greater in their METAVIR fibrosis score: 8 were related to hepatitis C virus, 3 to ... Read More »
» Published in Hum Pathol. 2006 Dec;37(12):1519-26. Epub 2006 Sep 25.

11. Hepatic changes in the failing Fontan circulation.
Match Strength: 5.481

Objective The failing Fontan circulation is associated with hepatic impairment. The nature of this liver injury is poorly defined. We sought to establish the gross and histological liver changes of Fontan patients relative to clinical, biochemical and haemodynamic findings. Methods and Results Patients assessed for extracardiac Fontan conversion between September 2003 - June 2005, according to an established clinical protocol, were retrospectively assessed. Twelve patients, mean age 24.6 years (15.8-43.4) were identified. The mean duration since initial Fontan procedure was 14.1 years (6.9-26 ... Read More »
» Published in Heart. 2006 Sep 27;

12. The host's genetic background determines the extent of angiogenesis induced by schistosome egg antigens.
Match Strength: 5.082

Schistosomiasis is characterised by periovular granuloma formation within the portal tract and presinusoidal venules. As inflammation wanes, continued attempts to wall off and repair hepatic injury, lead to the development of extensive fibrosis. The codependence of chronic inflammation and angiogenesis is a well-known phenomenon. Neovascularisation is a complex process of endothelial cell proliferation and remodelling of the extracellular matrix. Previous studies demonstrated the ability of schistosome soluble egg antigens (SEAs) to stimulate endothelial cell activation in vitro. In the ... Read More »
» Published in Acta Trop. 2006 Oct;99(2-3):243-51. Epub 2006 Sep 27.

13. Hepatitis B virus promotes angiopoietin-2 expression in liver tissue: role of HBV x protein.
Match Strength: 4.959

The progression of chronic hepatitis B (CHB) is related to fibrosis and to the emergence of intrahepatic anomalous vascular structures. Hepatitis B virus (HBV) X protein transactivator (HBx) may play a significant role in both processes. To analyze how HBV induces vascular growth and remodeling in vivo, we assessed the expression of angiopoietin-2 (Ang2) in liver biopsies from CHB patients by reverse transcriptase-polymerase chain reaction, Western blotting, and immunohistochemistry because of the relevant role of Ang2 in vascular development, remodeling, and tumor promotion. In addition, we ... Read More »
» Published in Am J Pathol. 2006 Oct;169(4):1215-22.

14. Toxicity of an effective amphotericin B formulation at high cationic lipid to drug molar ratio.
Match Strength: 4.540

Therapeutic activity of an effective and less nephrotoxic amphotericin B (AMB) formulation with dioctadecyldimethylammonium bromide (DODAB) bilayer fragments (named DODAB/AMB) inspired this toxicity survey in mice. At low drug to lipid molar ratios, hepatotoxicity, spleen damage and blood changes in comparison to DOC/AMB (sodium desoxycholate/amphotericin B, Fungizone) are evaluated ultimately showing toxic effects associated to DODAB only. Swiss Webster female mice were given DODAB, DODAB/AMB or DOC/AMB intraperitonially (ip) for 10 consecutive days (0.4 mg/kg/day AMB; 80 mg/kg/day DODAB) and ... Read More »
» Published in Exp Toxicol Pathol. 2006 Nov;58(2-3):175-83. Epub 2006 Sep 18.

15. 2',4',6'-Tris(methoxymethoxy) chalcone attenuates hepatic stellate cell proliferation by a heme oxygenase-dependent pathway.
Match Strength: 3.587

Proliferation of hepatic stellate cells (HSCs) is central for the development of fibrosis during liver injury. We have shown previously that butein (3,4,2',4'-tetrahydroxychalcone) suppresses myofibroblastic differentiation of rat HSCs. Our aim in this study was to determine whether a new synthetic chalcone derivative, 2',4',6'-tris(methoxymethoxy) chalcone (TMMC) inhibits HSC proliferation induced by serum- or platelet-derived growth factor (PDGF). TMMC significantly inhibited growth factor-induced HSC proliferation. The inhibition of PDGF-induced proliferation by TMMC was associated with the ... Read More »
» Published in Biochem Pharmacol. 2006 Nov 15;72(10):1322-33. Epub 2006 Sep 18.

16. Peripheral insulin resistance during treatment of chronic hepatitis C with peguilated interferon plus ribavirin.
Match Strength: 3.554

Patients with hepatitis C virus (HCV) infection present higher risk of developing type-2 diabetes mellitus (DM). However, the mechanism of this association and the role of antiviral treatment are still unclear. The objective of this study was to investigate the relationship between the use of peguilated interferon and the development of insulin resistance (IR) in these patients. METHODS: HOMA index was evaluated in 30 HCV-infected patients just before and during the first 6 months of treatment with peguilated interferon plus ribavirin. Anthropometrical parameters and glucose/cholesterol ... Read More »
» Published in J Med Virol. 2006 Nov;78(11):1406-10.

17. Human schistosomiasis.
Match Strength: 3.232

Schistosomiasis or bilharzia is a tropical disease caused by worms of the genus Schistosoma. The transmission cycle requires contamination of surface water by excreta, specific freshwater snails as intermediate hosts, and human water contact. The main disease-causing species are S haematobium, S mansoni, and S japonicum. According to WHO, 200 million people are infected worldwide, leading to the loss of 1.53 million disability-adjusted life years, although these figures need revision. Schistosomiasis is characterised by focal epidemiology and overdispersed population distribution, with higher ... Read More »
» Published in Lancet. 2006 Sep 23;368(9541):1106-18.

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