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Peer Reviewed Scientific Research Reports.
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1. Endotoxin fever in granulocytopenic rats: evidence that brain cyclooxygenase-2 is more important than circulating prostaglandin E(2).
Match Strength: 5.850
PGE(2) is a recognized mediator of many fevers, and cyclooxygenase (COX) is the major therapeutic target for antipyretic therapy. The source, as well as the site of action of PGE(2), as an endogenous pyrogen, is widely accepted as being central, but PGE(2) in the circulation, possibly from leukocytes, may also contribute to the development of fever. However, bacterial infections are important causes of high fever in patients receiving myelosuppressive chemotherapy, and such fevers persist despite the use of COX inhibitors. In the study reported here, the febrile response to bacterial LPS was ... Read More »
» Published in J Leukoc Biol. 2006 Dec;80(6):1375-87. Epub 2006 Sep 22.
2. Differential signaling networks induced by mild and lethal hemorrhagic fever virus infections.
Match Strength: 4.857
The family Arenaviridae includes several National Institutes of Allergy and Infections Diseases category A select agents which cause hemorrhagic fever. There are few vaccines available, and treatment is limited to ribavirin, which varies in efficacy. Development of new antiviral compounds has been hindered by a lack of understanding of the molecular basis of pathogenesis. We used two variants of Pichinde virus, one attenuated and one virulent in the guinea pig model, to delineate the host determinants which lead to either viral clearance or lethal disease. By analyzing protein level changes ... Read More »
» Published in J Virol. 2006 Oct;80(20):10248-52.
3. Bias arising from missing data in predictive models.
Match Strength: 4.355
OBJECTIVE: The purpose of this study is to determine the effect of three common approaches to handling missing data on the results of a predictive model. STUDY DESIGN AND SETTING: Monte Carlo simulation study using simulated data was used. A baseline logistic regression using complete data was performed to predict hospital admission, based on the white blood cell count (WBC) (dichotomized as normal or high), presence of fever, or procedures performed (PROC). A series of simulations was then performed in which WBC data were deleted for varying proportions (15-85%) of patients under various ... Read More »
» Published in J Clin Epidemiol. 2006 Oct;59(10):1115-23.
4. Zoonotic infections among veterinarians in Turkey: Crimean-Congo hemorrhagic fever and beyond.
Match Strength: 4.323
OBJECTIVES: We aimed to determine the seroprevalence of Crimean-Congo hemorrhagic fever (CCHF) virus, Brucella spp, and Coxiella burnetii among veterinarians in a highly endemic and a non-endemic region for these infections in Turkey. METHODS: The antibody levels against these three infections were surveyed. Eighty-three veterinarians were included from two distinct geographic regions. RESULTS: CCHF IgG positivity (3% vs. 0%) and Brucella agglutination titer of > or =1/160 (33% vs. 5%) were more common in the endemic region, whereas the rates of Coxiella burnetii antibodies were similar (7% ... Read More »
» Published in Int J Infect Dis. 2006 Nov;10(6):465-9. Epub 2006 Sep 15.
5. Introducing Vi polysaccharide typhoid fever vaccine to primary school children in North Jakarta, Indonesia, via an existent school-based vaccination platform.
Match Strength: 4.214
OBJECTIVES: To report results on coverage, safety and logistics of a large-scale, school-based Vi polysaccharide immunization campaign in North Jakarta. METHODS: Of 443 primary schools in North Jakarta, Indonesia, 18 public schools were randomly selected for this study. Exclusion criteria were fever 37.5 degrees C or higher at the time of vaccination or a known history of hypersensitivity to any vaccine. Adverse events were monitored and recorded for 1 month after immunization. Because this was a pilot programme, resource use was tracked in detail. RESULTS: During the February 2004 vaccination ... Read More »
» Published in Public Health. 2006 Nov;120(11):1081-7. Epub 2006 Sep 26.
6. Goats, germs, and fever: Are the pyrin mutations responsible for familial Mediterranean fever protective against Brucellosis?
Match Strength: 4.160
Mutations in the MEFV gene are highly prevalent in the Middle East and Mediterranean basin, with carrier rates of up to 1:3 in some populations. More than 50 mutations in the MEFV gene have been described. The high prevalence, multiple mutations, and geographic localization to the Middle East suggest a positive selection advantage for the abnormal gene operating in this area over the last several thousand years. To date, no satisfactory explanation of this phenomenon has been made. Rather, many harmful effects of these mutations have been described. MEFV gene mutations cause familial ... Read More »
» Published in Med Hypotheses. 2007;68(3):499-501. Epub 2006 Sep 26.
7. Conformational study of human serum albumin in pre-denaturation temperatures by differential scanning calorimetry, circular dichroism and UV spectroscopy.
Match Strength: 4.097
Thermal conformational changes of human serum albumin (HSA) in phosphate buffer, 10 mM at pH = 7 are investigated using differential scanning calorimetric (DSC), circular dichroism (CD) and UV spectroscopic methods. The results indicate that temperature increment from 25 degrees C to 55 degrees C induces reversible conformational changes in the structure of HSA. Conformational change of HSA are shown to be a three-step process. Interestingly, melting temperature of the last domain is equal to the maximum value of fever in pathological conditions, i.e. 42 degrees C. These conformational ... Read More »
» Published in J Biochem Mol Biol. 2006 Sep 30;39(5):530-6.
8. Leptospirosis in Istanbul, Turkey: a wide spectrum in clinical course and complications.
Match Strength: 4.003
Patients with high fever and multiorgan involvement were investigated for the determination of frequency, clinical course and complications of leptospirosis in Istanbul. Leptospirosis was determined in 22 cases among the 35 hospitalized patients that were pre-diagnosed as leptospirosis according to 'Probable Leptospirosis Diagnosis and Follow-up' form. Among the leptospirosis cases 19 were male and 16 were military staff. Mean age was 35.6 y. Dark field examination (DFE), latex agglutination test (LAG), ELISA IgM, leptospirosis culture (LC) and microscopic agglutination test (MAT) were ... Read More »
» Published in Scand J Infect Dis. 2006;38(10):845-52.
9. Generation of filamentous instead of icosahedral particles by repression of African swine fever virus structural protein pB438L.
Match Strength: 3.447
The mechanisms involved in the construction of the icosahedral capsid of the African swine fever virus (ASFV) particle are not well understood at present. Capsid formation requires protein p72, the major capsid component, but other viral proteins are likely to play also a role in this process. We have examined the function of the ASFV structural protein pB438L, encoded by gene B438L, in virus morphogenesis. We show that protein pB438L associates with membranes during the infection, behaving as an integral membrane protein. Using a recombinant ASFV that inducibly expresses protein pB438L, we ... Read More »
» Published in J Virol. 2006 Dec;80(23):11456-66. Epub 2006 Sep 27.
10. Life-threatening cryoglobulinemia: clinical and immunological characterization of 29 cases.
Match Strength: 3.407
OBJECTIVES: To analyze the etiology, clinical presentation, and outcomes of patients with life-threatening cryoglobulinemic vasculitis. METHODS: We studied 209 consecutive patients with cryoglobulinemic vasculitis. A potentially life-threatening cryoglobulinemia was considered as the development of renal failure, vasculitic abdominal involvement, pulmonary hemorrhage, or central nervous system involvement. RESULTS: Twenty-nine (14%) patients had life-threatening cryoglobulinemic vasculitis. There were 17 women and 12 men, with a mean age of 57 years. In 17 (59%) patients, life-threatening ... Read More »
» Published in Semin Arthritis Rheum. 2006 Dec;36(3):189-96. Epub 2006 Sep 22.
11. Painful rash and swelling of the limbs after recurrent infections in a teenager: polyarteritis nodosa.
Match Strength: 2.859
Polyarteritis nodosa is a rare disease in childhood and adolescence that is difficult to diagnose clinically. We report on a 17-y-old girl presenting with a history of recurrent infections of the upper respiratory tract and conjunctivitis followed by a painful rash on the upper and lower extremities resembling erythema nodosum. The diagnosis of polyarteritis nodosa was proven by skin biopsy. Therapy with intravenous immunoglobulins failed, but with systemic steroids she responded promptly. CONCLUSION: Polyarteritis nodosa is a differential diagnosis in adolescents presenting with fever and an ... Read More »
» Published in Acta Paediatr. 2006 Oct;95(10):1317-20.
12. Effect of oligofructose supplementation on gut microflora and well-being in young children attending a day care centre.
Match Strength: 2.636
The effect of daily administration of oligofructose (OF) on 7-19 months old healthy children intestinal microflora, intestinal tolerance and well-being was assessed in a double blind placebo controlled study. The study comprised 8 days of observation, 21 days of supplementation, and 15 days of post-supplementation. Exclusion criteria included antibiotic use and intake of other prebiotic and probiotic at any time following enrolment. Faecal flora was analysed by culture methods, and health information was recorded daily. Bifidobacteria, tended to slightly increase with OF supplementation, but ... Read More »
» Published in Int J Food Microbiol. 2007 Jan 1;113(1):108-13. Epub 2006 Sep 22.
13. Changes in the liver function tests during the attacks of familial mediterranean fever.
Match Strength: 2.593
The present study aims to investigate whether or not FMF patients display abnormal liver functions during attack periods. About 41 consecutive FMF patients with attacks were enrolled on this study. Bilirubin levels, liver transaminases, erythrocyte sedimentation rate and C-reactive protein (C-RP) levels were determined within the first 72 h after the onset of attacks. This procedure could be performed on only 28 of these 41 FMF patients, 4 weeks after the attack of the patients' had completely disappeared. As for the disease control group, 44 patients were determined to be eligible for the ... Read More »
» Published in Rheumatol Int. 2007 Feb;27(4):395-8. Epub 2006 Sep 28.
14. Paraneoplastic syndromes in urologic malignancy: the many faces of renal cell carcinoma.
Match Strength: 2.561
Renal cell carcinoma is unique among the genitourinary malignancies in that close to one third of affected patients show signs and symptoms of a paraneoplastic syndrome. The paraneoplastic syndromes associated with renal cell carcinoma range from those manifesting in constitutional symptoms (ie, fever, cachexia, and weight loss) to those that result in specific metabolic and biochemical abnormalities (ie, hypercalcemia, nonmetastatic hepatic dysfunction, amyloidosis, etc). The presence of a paraneoplastic syndrome in a patient with renal cell carcinoma is neither a marker of metastatic disease ... Read More »
» Published in Rev Urol. 2002 Fall;4(4):163-70.
15. New agents for the treatment of fungal infections: clinical efficacy and gaps in coverage.
Match Strength: 2.553
The incidence of fungal infections has increased globally, and the introduction of the newer triazoles and echinocandin antifungals is a more-than-welcome and long overdue development. In this report, we review the clinical trials evaluating the therapeutic efficacy of these new antifungal agents and examine possible gaps in coverage. Voriconazole has become the primary treatment for most forms of invasive aspergillosis in a number of centers, posaconazole offers a broad antifungal spectrum, and echinocandins are fungicidal against most Candida species. Moreover, the new agents are active ... Read More »
» Published in Clin Infect Dis. 2006 Oct 15;43(8):1060-8. Epub 2006 Sep 8. Erratum in: Clin Infect Dis. 2006 Nov 1;43(9):1232.
16. Serotonin syndrome caused by minimum doses of SSRIS in a patient with spinal cord injury.
Match Strength: 2.548
There have been only a few reports of serotonin syndrome developing after mono-therapy with a selective serotonin reuptake inhibitor (SSRI). We report a case of serotonin syndrome caused by long-term therapy with fluvoxamine prior to treatment with paroxetine. An 18-year-old man with spinal cord injury (SCI) at thoracic level 2-3 presented with onset of serotonin syndrome after taking fluvoxamine (50 mg per day) for 8 weeks prior to treatment with paroxetine (10 mg per day) for 6 days. He had confusion, agitation, severe headache, tachycardia (124 beats/minute), hypertension (165/118 mmHg), ... Read More »
» Published in Fukushima J Med Sci. 2006 Jun;52(1):29-33.
17. Risks of hyperthermia associated with hot tub or spa use by pregnant women.
Match Strength: 2.474
There are a limited number of human studies linking hot tub or spa use during early pregnancy to increased risks for neural tube defects (NTDs) or spontaneous abortion. However, these data can be considered in the context of human studies that have demonstrated an association between high maternal fever in early pregnancy and NTDs. In addition, there is a large volume of animal literature suggesting that, regardless of the heat source, an elevated core maternal temperature at or above the threshold of 2 degrees C over baseline, as well as timing and duration of exposure, are the critical ... Read More »
» Published in Birth Defects Res A Clin Mol Teratol. 2006 Aug;76(8):569-73.
18. Linkage of avian and reproductive tract tropism with sequence divergence adjacent to the 5S ribosomal subunit rrfH of Salmonella enterica.
Match Strength: 2.454
The 183 bp between the end of the 23S rrlH rRNA gene and the start of the 5S rrfH rRNA gene (ISR-1) and the 197 bp between the end of the rrfH rRNA gene and the start of the transfer RNA aspU (ISR-2) of Salmonella enterica ssp. enterica serotypes Enteritidis, Typhimurium, Pullorum, Heidelberg, Gallinarum, Typhi and Choleraesuis were compared. ISR-1s of D1 serotypes (Pullorum, Gallinarum and Enteritidis), B serotypes (Typhimurium and Heidelberg) and the C2 serotype Newport and the enteric fever pathogens serotype A Paratyphi and serotype D1 Typhi formed three clades, respectively. ISR-2 further ... Read More »
» Published in FEMS Microbiol Lett. 2006 Nov;264(1):48-58. Epub 2006 Sep 27.
19. Unexpected twist: harnessing the energy in positive supercoils to control telomere resolution.
Match Strength: 2.444
Negative DNA supercoiling is an important conformational property of bacterial DNA that plays a significant role in a wide variety of DNA transactions. In contrast, positive DNA supercoiling is a by-product of cellular processes that involve helical unwinding or movement of DNA by a fixed translocase, and has generally been considered a necessary evil requiring removal. We now report the first evidence suggesting a physiological role for positive supercoiling; this occurs in telomere resolution in the related Lyme disease and relapsing fever Borrelia spirochetes. Telomere resolution is the ... Read More »
» Published in Mol Microbiol. 2006 Nov;62(3):895-905. Epub 2006 Sep 25.
20. Ensuring quality and access for malaria diagnosis: how can it be achieved?
Match Strength: 2.427
The replacement of conventional antimalarial drugs with high-cost, artemisinin-based alternatives has created a gap in the successful management of malaria. This gap reflects an increased need for accurate disease diagnosis that cannot be met by traditional microscopy techniques. The recent introduction of rapid diagnostic tests (RDTs) has the potential to meet this need, but successful RDT implementation has been curtailed by poor product performance, inadequate methods to determine the quality of products and a lack of emphasis and capacity to deal with these issues. Economics and a desire ... Read More »
» Published in Nat Rev Microbiol. 2006 Sep;4(9 Suppl):S7-20.
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