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Peer Reviewed Scientific Research Reports.
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1. Pre-pregnancy body mass index and pregnancy outcomes.
Match Strength: 8.923
OBJECTIVE: To determine the effect of maternal pre-pregnancy BMI on pregnancy outcomes. METHODS: Pregnancy cohort recruited pregnancies between 16 and 18 weeks. BMI evaluated underweight, BMI<18.5, normal, BMI 18.5-25, overweight BMI 25-30, and obese BMI>30 women. RESULTS: Pre-pregnancy BMI classified 331 women as underweight (11.7%), 1982 normal (69.9%), 326 overweight (11.5%), and 188 as obese (6.6%). Obese women were more likely to develop gestational diabetes (p<0.001), hypertension (p<0.001), preeclampsia (p<0.001), need labor induction (p<0.001), cesarean delivery for ... Read More »
» Published in Int J Gynaecol Obstet. 2006 Dec;95(3):242-7. Epub 2006 Sep 27.
2. IL-6 is constitutively expressed during lung morphogenesis and enhances fetal lung explant branching.
Match Strength: 6.689
Previous studies have shown that chorioamnionitis, with increased IL-6, promotes fetal lung maturation and decreases the incidence of respiratory distress syndrome in premature neonates. However, the expression pattern and the effects of IL-6 on fetal lung growth mechanisms remain unknown. IL-6 expression was assessed by in situ hybridization and by real-time PCR between 14.5 and 21.5 d postconception. Normal and nitrofen-induced hypoplastic lung explants were cultured with increasing IL-6 doses or IL-6 neutralizing antibodies. Branching, cellular proliferation (Ki-67) and MAPK phosphorylation ... Read More »
» Published in Pediatr Res. 2006 Nov;60(5):530-6. Epub 2006 Sep 20.
3. Base deficit estimation in umbilical cord blood is influenced by gestational age, choice of fetal fluid compartment, and algorithm for calculation.
Match Strength: 5.075
OBJECTIVE: The purpose of this study was to explore the influences of gestational age, the choice of fetal fluid compartment, and the algorithm for calculation on the estimation of the base deficit in umbilical cord arterial blood at birth. STUDY DESIGN: From 1995 to 2002, cord arterial blood gases and obstetric data were available for 43,551 newborn infants at 37+ weeks of gestation (cohort I). The mean base deficit in blood and the base deficit in extracellular fluid were estimated from pH and PCO2 values in 28,213 newborn infants with a 5-minute Apgar score of > or = 9 (cohort II) with ... Read More »
» Published in Am J Obstet Gynecol. 2006 Dec;195(6):1651-6. Epub 2006 Sep 25.
4. Calcineurin/Nfat signaling is required for perinatal lung maturation and function.
Match Strength: 4.018
Pulmonary surfactant proteins and lipids are required for lung function after birth. Lung immaturity and resultant surfactant deficiency cause respiratory distress syndrome, a common disorder contributing to morbidity and mortality in preterm infants. Surfactant synthesis increases prior to birth in association with formation of the alveoli that mediate efficient gas exchange. To identify mechanisms controlling perinatal lung maturation, the Calcineurin b1 (Cnb1) gene was deleted in the respiratory epithelium of the fetal mouse. Deletion of Cnb1 caused respiratory failure after birth and ... Read More »
» Published in J Clin Invest. 2006 Oct;116(10):2597-609. Epub 2006 Sep 21.
5. Influence of mode of delivery on neonatal mortality and morbidity in spontaneous preterm breech delivery.
Match Strength: 3.960
OBJECTIVE: To study the association between mode of delivery and neonatal outcome in singleton pregnancy with breech presentation and preterm birth, due to premature labour (PTL) and/or preterm premature rupture of the membranes (pPROM). DESIGN AND METHODS: Information on preterm (gestational week 25-36) singleton births in breech presentation in Sweden during 1990-2002 was obtained from the Swedish Medical Birth Registry and the Swedish Hospital Discharge Registry. The study groups included 1975 caesarean and 699 vaginal deliveries with a diagnosis of PTL or pPROM, without pregnancy ... Read More »
» Published in Eur J Obstet Gynecol Reprod Biol. 2006 Sep 19;
6. The Alabama preterm birth study: corticosteroids and neonatal outcomes in 23- to 32-week newborns with various markers of intrauterine infection.
Match Strength: 3.611
OBJECTIVE: Intrauterine inflammation/infection is cited as a contraindication to the use of corticosteroids (CS). Our goal was to determine if CS given prenatally to enhance fetal maturity were harmful to infants with various indications of intrauterine infection. STUDY DESIGN: This was a retrospective analysis of data obtained from 457 consecutively enrolled infants delivered between 23 and 32 weeks. Cultures and a histologic examination of the placenta, and cord blood interleukin (IL)-6 levels were obtained. Neonatal outcomes included periventricular leukomalacia (PVL), intraventricular ... Read More »
» Published in Am J Obstet Gynecol. 2006 Oct;195(4):1020-4.
7. The Maternal-Fetal Medicine Units Cesarean Registry: safety and efficacy of a trial of labor in preterm pregnancy after a prior cesarean delivery.
Match Strength: 3.382
OBJECTIVE: This study was undertaken to compare success rates of vaginal birth after cesarean (VBAC) delivery, and uterine rupture as well as maternal/perinatal outcomes between women with preterm and term pregnancies undergoing trial of labor (TOL), and to compare maternal and neonatal morbidities in those women with preterm pregnancies undergoing a TOL versus repeat cesarean delivery without labor (RCD). STUDY DESIGN: Prospective 4-year observational study of women with a singleton gestation and a prior cesarean delivery at 19 academic centers. Clinical characteristics, maternal ... Read More »
» Published in Am J Obstet Gynecol. 2006 Oct;195(4):1119-26.
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