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1. Hb A(1c) in relation to intrauterine growth among male adolescents in southern Brazil.
Match Strength: 6.509
The fetal origins hypothesis states that nutritional deprivation in utero affects fetal development and contributes to the incidence of diseases associated with the metabolic syndrome in later life. This study investigated whether haemoglobin (Hb) A(1c), an indicator of blood glucose, varied among healthy male adolescents according to their fetal growth rate, in a middle-income setting. Participants were men aged 18 years, belonging to the 1982 Pelotas birth cohort. Complete data, including gestational age and Hb A(1c) at age 18 years, were available for 197 individuals. There was an inverse ... Read More »
» Published in Eur J Clin Nutr. 2006 Sep 27;
2. Hypoxia-induced erythropoietin production: a paradigm for oxygen-regulated gene expression.
Match Strength: 2.966
The mechanisms controlling the expression of the gene encoding for the hormone erythropoietin (EPO) are exemplary for oxygen-regulated gene expression. In humans and other mammals, hypoxia modulates EPO levels by increasing expression of the EPO gene. An association between polycythaemia and people living at high altitudes was first reported more than 100 years ago. Since the identification of EPO as the humoral regulator of red blood cell production and the cloning of the EPO gene, considerable progress has been made in understanding the regulation of EPO gene expression. This has finally led ... Read More »
» Published in Clin Exp Pharmacol Physiol. 2006 Oct;33(10):968-79.
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