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Fatty Tumor
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1. The multifunctional beta-oxidation enzyme is required for full symptom development by the biotrophic maize pathogen Ustilago maydis.
Match Strength: 5.889

The transition from yeast-like to filamentous growth in the biotrophic fungal phytopathogen Ustilago maydis is a crucial event for pathogenesis. Previously, we showed that fatty acids induce filamentation in U. maydis and that the resulting hyphal cells resemble the infectious filaments observed in planta. To explore the potential metabolic role of lipids in the morphological transition and in pathogenic development in host tissue, we deleted the mfe2 gene encoding the multifunctional enzyme that catalyzes the second and third reactions in beta-oxidation of fatty acids in peroxisomes. The ... Read More »
» Published in Eukaryot Cell. 2006 Dec;5(12):2047-61. Epub 2006 Sep 22.

2. Hepatic hemangiomas with arterioportal shunt: sonographic appearances with CT and MRI correlation.
Match Strength: 5.650

OBJECTIVE: The purpose of this study was to summarize and illustrate the sonographic appearance of hepatic hemangiomas with arterioportal shunt and to correlate them with CT and MRI findings. CONCLUSION: High-flow hepatic hemangiomas tend to be seen as hypoechoic lesions at sonography. In the presence of fatty infiltration in the liver, they may accompany peritumoral low-echoic areas presumably caused by peritumoral sparing of fatty infiltration similar to a hyperattenuating or hyperintense peritumoral rim on unenhanced CT or MR chemical shift imaging. Color Doppler sonography may reveal ... Read More »
» Published in AJR Am J Roentgenol. 2006 Oct;187(4):W406-14.

3. Fatty acids from Plasmodium falciparum down-regulate the toxic activity of malaria glycosylphosphatidylinositols.
Match Strength: 4.920

Plasmodium falciparum malaria kills roughly 2.5 million people, mainly children, annually. Much of this mortality is thought to arise from the actions of a malarial toxin. This toxin, identified as glycosylphosphatidylinositol (GPI), is a major pathogenicity determinant in malaria. A malarial molecule, Pfj, labeled by [3H]glucosamine like the GPIs, was identified as a non-GPI molecule. Here we show that Pfj is able to down-regulate tumor necrosis factor alpha (TNF-alpha) production induced by the GPI of P. falciparum. Mass spectrometry analysis showed that Pfj was not a single molecule but ... Read More »
» Published in Infect Immun. 2006 Oct;74(10):5487-96.

4. Functions of the Peroxisome Proliferator-Activated Receptor (PPAR) alpha and beta in Skin Homeostasis, Epithelial Repair, and Morphogenesis.
Match Strength: 4.694

The three peroxisome proliferator-activated receptors (PPARalpha, PPARbeta, and PPARgamma) are ligand-activated transcription factors belonging to the nuclear hormone receptor superfamily. They are regarded as being sensors of physiological levels of fatty acids and fatty acid derivatives. In the adult mouse skin, they are found in hair follicle keratinocytes but not in interfollicular epidermis keratinocytes. Skin injury stimulates the expression of PPARalpha and PPARbeta at the site of the wound. Here, we review the spatiotemporal program that triggers PPARbeta expression immediately after ... Read More »
» Published in J Invest Dermatol. 2006 Sep;126 Suppl:30-5.

5. Pure uterine lipoma.
Match Strength: 4.653

Pure fatty tumors of the uterus are extremely rare and usually develop in postmenopausal women. We present the first reported Japanese case of a pure uterine lipoma, in which a preoperative diagnosis was made by magnetic resonance imaging (MRI) and was pathologically confirmed postoperatively. As in our case, MRI is currently the best modality for determining the internal architecture of a tumor and the presence of fat. Because of the benign nature of a uterine lipoma, such an approach can avoid unnecessary surgery in asymptomatic patients. Publication Types: Case ... Read More »
» Published in J Obstet Gynaecol Res. 2006 Oct;32(5):520-3.

6. The inhibitory action of long-chain fatty acids on the DNA binding activity of p53.
Match Strength: 3.401

The in vitro relationship between human p53 DNA binding domain (p53 DBD) and FA was investigated. We found that saturated and monounsaturated long-chain FA inhibited the double-stranded DNA (dsDNA) binding activity of p53 DBD. The strongest inhibitors of saturated and unsaturated FA were docosanoic acid (22:0) and cis-12-heneicosenoic acid (21:1n-9), respectively. n-Octadecane, trans-unsaturated FA, and FAME had no influence on the binding activity of p53 DBD, showing that the FA structures such as one or no double bond of cis configuration, hydrocarbon chain of length C20 to C22, and free ... Read More »
» Published in Lipids. 2006 Jun;41(6):521-7.

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Replace omega-6 vegetable oils with omega-9 olive oil... Eat oily fish like tuna, sardines, anchovy, salmon, herring... Beans, lentils, peas add fiber... Nine or more 3-ounce servings of fruits or vegetables per day...