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Peer Reviewed Scientific Research Reports.
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1. Explaining paralysis in Chile's health sector, 1990-2000.
Match Strength: 6.297
This article looks at the health sector in Chile between 1990 and 2000 to examine the obstacles that policymakers face in implementing reforms. Given that the health sector is highly politicized, it is important to pay attention not only to what kind of reforms are needed but even more to how the desired reforms may be implemented. The author identifies the key actors in the Chilean health sector and shows how the given politico-institutional context allowed them to obstruct reforms. As a result, the health sector came to be characterized by paralysis, despite widespread recognition that ... Read More »
» Published in Int J Health Serv. 2006;36(3):605-22.
2. Ictal paralysis with tonic eye gazing mimicking a pontine infarction.
Match Strength: 4.728
PURPOSE: Concomitant positive and negative motor phenomena in a single seizure have not been reported before. METHOD: We used an extensive history review, neurological examination, EEG, MRI and SPECT study to demonstrate a rare combination of motor presentations as an ictal phenomenon. RESULT: A 64-year-old male was brought to the emergency room with dizziness, progressive drowsiness and left hemiparesis. A spontaneous eye deviation to the left side with nystagmus was observed. A right pontine lesion was tentatively diagnosed. However, a focal motor seizure of the patient's left face and limbs ... Read More »
» Published in Seizure. 2006 Dec;15(8):637-42. Epub 2006 Sep 22.
3. Narcolepsy and the hypocretins.
Match Strength: 3.769
Narcolepsy is a chronic neurologic disease characterized by excessive daytime sleepiness and one or more of three additional symptoms (cataplexy, or sudden loss of muscle tone; vivid hallucinations; and brief periods of total paralysis) related to the occurrence of rapid eye movement (REM) sleep at inappropriate times. The daytime sleepiness typically presents as a sudden overwhelming urge to sleep, followed by periods of sleep that last for seconds or minutes, or even longer. During daytime sleep episodes, patients may exhibit "automatic behavior," performing conventionalized functions (eg, ... Read More »
» Published in Metabolism. 2006 Oct;55(10 Suppl 2):S36-9.
4. New indications for botulinum toxin in rheumatology.
Match Strength: 3.476
Previously known only as a deadly bacterial poison responsible for severe paralysis, botulinum toxin is now a well-recognized therapeutic agent used to relieve involuntary movements, dystonia-related functional impairments, spasticity, and autonomic disorders such as hyperhidrosis. Musculoskeletal pain in patients with rheumatic disorders is among the emerging indications for botulinum toxin therapy. Preliminary data have been obtained in patients with cervical or thoracolumbar myofascial pain syndrome, chronic low back pain, piriformis muscle syndrome, tennis elbow, and stiff person syndrome. ... Read More »
» Published in Joint Bone Spine. 2006 Dec;73(6):667-71. Epub 2006 Aug 30.
5. Grading facial nerve function: why a new grading system, the MoReSS, should be proposed.
Match Strength: 3.093
OBJECTIVE: To compare the interobserver variability of a new grading system to the currently recommended House-Brackmann Grading Scale. STUDY DESIGN: Prospective case-control study. SETTING: Tertiary referral center. PATIENTS: All patients with a facial nerve paresis/paralysis (whatever the cause). INTERVENTION: All patients were evaluated for their facial nerve function by three observers, independently, using both the new system and the House-Brackmann Grading Scale. MAIN OUTCOME MEASURE: The level of agreement between the three observers using both scales. RESULTS: With the movement, rest, ... Read More »
» Published in Otol Neurotol. 2006 Oct;27(7):1030-6.
6. Changes in corneal topography with upper eyelid gold weight implants.
Match Strength: 2.981
PURPOSE: To determine the effect of upper eyelid gold weight implantation on corneal astigmatism. METHODS: This is a prospective, cohort study. Eighteen eyes of 18 patients underwent upper eyelid gold weight implantation for facial nerve palsy. Nine of these patients recovered facial nerve function and underwent elective removal of the gold weight. Corneal topography was performed before and after gold weight implantation. Corneal topography was also performed after gold weight removal in patients who recovered from facial nerve paralysis. RESULTS: With-the-rule corneal astigmatism increased ... Read More »
» Published in Ophthal Plast Reconstr Surg. 2006 Sep-Oct;22(5):331-4.
7. Neurosarcoidosis--a diagnostic pitfall with consequences.
Match Strength: 2.927
Neurosarcoidosis is often a diagnostic dilemma, especially in the absence of other organ involvement. We report a 64-year-old patient who had suffered from paraplegia due to an intramedullar process since 1995. The presumptive diagnosis based on computed tomography was spinal cord infarction. Six years later, he complained about increasing paresthesia. Magnetic resonance imaging of the spinal cord showed nodular meningeal enhancement. Computed tomography of the thorax revealed mediastinal and hilar lymphadenopathy. Bronchoscopy under generalized anesthesia was performed. The differential cell ... Read More »
» Published in Wien Klin Wochenschr. 2006 Sep;118(17-18):554-7.
8. wasted away, a Drosophila mutation in triosephosphate isomerase, causes paralysis, neurodegeneration, and early death.
Match Strength: 2.783
To identify genes required for maintaining neuronal viability, we screened our collection of Drosophila temperature-sensitive paralytic mutants for those exhibiting shortened lifespan and neurodegeneration. Here, we describe the characterization of wasted away (wstd), a recessive, hypomorphic mutation that causes progressive motor impairment, vacuolar neuropathology, and severely reduced lifespan. We demonstrate that the affected gene encodes the glycolytic enzyme, triosephosphate isomerase (Tpi). Mutations causing Tpi deficiency in humans are also characterized by progressive neurological ... Read More »
» Published in Proc Natl Acad Sci U S A. 2006 Oct 10;103(41):14987-93. Epub 2006 Sep 28.
9. Clinical implementation of endoscopic thyroidectomy in selected patients.
Match Strength: 2.665
OBJECTIVES: Systematic investigation of minimal access thyroid compartment surgery combined with the advent of several key new technologies has culminated in the implementation of endoscopic thyroidectomy in specific clinical situations. STUDY DESIGN:: The authors conducted a prospective, nonrandomized analysis of a consecutive cohort of surgical patients from the Medical College of Georgia Thyroid Center. METHODS AND MATERIALS: A series of patients meeting specific criteria underwent thyroid surgery with the intention of performing endoscopic thyroidectomy. Demographic and clinical data were ... Read More »
» Published in Laryngoscope. 2006 Oct;116(10):1745-8.
10. West Nile virus neuroinvasive disease.
Match Strength: 2.613
Since 1999, there have been nearly 20,000 cases of confirmed symptomatic West Nile virus (WNV) infection in the United States, and it is likely that more than 1 million people have been infected by the virus. WNV is now the most common cause of epidemic viral encephalitis in the United States, and it will likely remain an important cause of neurological disease for the foreseeable future. Clinical syndromes produced by WNV infection include asymptomatic infection, West Nile Fever, and West Nile neuroinvasive disease (WNND). WNND includes syndromes of meningitis, encephalitis, and acute flaccid ... Read More »
» Published in Ann Neurol. 2006 Sep;60(3):286-300.
11. Incidence and characteristics of facial nerve stimulation in children with cochlear implants.
Match Strength: 2.336
OBJECTIVES: Electrical stimulation from a cochlear implant can spread beyond the auditory nerve. The aims of this study were to accurately measure facial nerve stimulation in pediatric implant users and to determine the characteristics and incidence of this unwanted activity. Part A consisted of a prospective study of a randomized sample of 44 pediatric implant users. Part B consisted of a retrospective analysis of 121 children with previously recorded electrically evoked auditory brainstem responses (EABR). STUDY DESIGN AND METHODS: Responses were evoked by 3 electrodes along the implant ... Read More »
» Published in Laryngoscope. 2006 Oct;116(10):1787-91.
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