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Peer Reviewed Scientific Research Reports.
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1. Spontaneous resolution of intractable epileptic seizures following HHV-7 infection.
Match Strength: 14.493
Purpose: We report a three-year-old female with intractable epilepsy post West syndrome whose seizures disappeared following an acute viral infection, without changes in anti-epileptic therapy. Methods: The female infant was born at term to a healthy mother after an uneventful pregnancy and delivery. At the age of five months, she developed intractable brief tonic spasms which had a series of infantile spasms, and an electroencephalogram indicated hypsarrhythmia. She was diagnosed with West syndrome. The seizures were uncontrollable with conventional therapy, including ACTH, vigabatrin, sodium ... Read More »
» Published in Brain Dev. 2006 Sep 25;
2. Increased number of febrile seizures in children born very preterm: relation of neonatal, febrile and epileptic seizures and neurological dysfunction to seizure outcome at 16 years of age.
Match Strength: 11.814
PURPOSE: In prematurely born population, a cascade of events from initial injury in the developing brain to morbidity may be followed. The aim of our study was to assess seizures in prematurely born children from birth up to 16 years and to evaluate the contribution of different seizures, and of neurological dysfunction to the seizure outcome. METHODS: Pre- and neonatal data and data from neurodevelopmental examination at 5 years of 60 prospectively followed children born at or before 32 weeks of gestation, and of 60 matched term controls from the 2 year birth cohort were available from ... Read More »
» Published in Seizure. 2006 Dec;15(8):590-7. Epub 2006 Sep 20.
3. Spatio-temporal patient-individual assessment of synchronization changes for epileptic seizure prediction.
Match Strength: 10.794
OBJECTIVE: Abnormal synchronization of neurons plays a central role for the generation of epileptic seizures. Therefore, multivariate time series analysis techniques investigating relationships between the dynamics of different neural populations may offer advantages in predicting epileptic seizures. METHODS: We applied a phase and a lag synchronization measure to a selected subset of multicontact intracranial EEG recordings and assessed changes in synchronization with respect to seizure prediction. RESULTS: Patient individual results, group results, spatial aspects using focal and extra-focal ... Read More »
» Published in Clin Neurophysiol. 2006 Nov;117(11):2399-413. Epub 2006 Sep 26.
4. Preconditioning and neurotrophins: a model for brain adaptation to seizures, ischemia and other stressful stimuli.
Match Strength: 9.161
The amino acid glutamate, the major excitatory neurotransmitter in the central nervous system, activates receptors coupled to calcium influx. Excessive activation of glutamate receptors in conditions such as severe epileptic seizures or stroke can kill neurons in a process called excitotoxicity. However, subtoxic levels of activation of the N-methyl-D-aspartate (NMDA) type of glutamate receptor elicit adaptive responses in neurons that enhance their ability to withstand more severe stress. A variety of stimuli induce adaptive responses to protect neurons. For example, sublethal ischemic ... Read More »
» Published in Amino Acids. 2006 Sep 29;
5. Automatic lateralization of temporal lobe epilepsy based on scalp EEG.
Match Strength: 7.125
OBJECTIVE: The objective of this work is the determination of the lateralization of the epileptic seizure onset zone using the scalp EEG signal processing. METHODS: A comprehensive method based on the evaluation of the evolution of the correlation coefficients computed between bipolar channels (longitudinal montage) was applied to 43 patients (87 seizures). The correlation coefficients are estimated by a nonlinear regression analysis. The methodology that leads to the lateralization is based on several processing steps: segmentation, seizure onset determination and then lateralization. RESULTS ... Read More »
» Published in Clin Neurophysiol. 2006 Nov;117(11):2414-23. Epub 2006 Sep 25.
6. High-dose midazolam therapy for refractory status epilepticus in children.
Match Strength: 6.929
OBJECTIVE: To assess the efficacy of high-dose midazolam in the treatment of refractory status epilepticus in children. SETTING: Paediatric intensive care unit (PICU). DESIGN: Audit of clinical experience. SUBJECTS: Seventeen consecutive patients treated for episodes of refractory status epilepticus. INTERVENTIONS: Algorithm-driven administration of intravenous midazolam to control RSE. Regular, mandatory, patient evaluation to avoid delay in the appropriate escalation of therapy. Our target was the abolition of clinical seizures within 30[Symbol: see text]min of initiating treatment and early ... Read More »
» Published in Intensive Care Med. 2006 Dec;32(12):2070-2076. Epub 2006 Sep 15.
7. Nonconvulsive seizures in the pediatric intensive care unit: etiology, EEG, and brain imaging findings.
Match Strength: 6.889
PURPOSES: To determine the occurrence of nonconvulsive seizures (NCS) in the Pediatric Intensive Care Unit (PICU); to ascertain the relationship of NCS to past medical history, etiology, EEG, and brain imaging; and to determine the concordance between abnormal EEG findings and neuroimaging abnormalities. METHODS: A retrospective review was conducted of all pediatric patients who were admitted or transferred to the PICU from January 2000 to December 2003 with an unexplained decrease in level of consciousness, no overt clinical seizures, and EEG recordings performed within the 24 h of onset of ... Read More »
» Published in Epilepsia. 2006 Sep;47(9):1510-8.
8. Audiogenic seizure susceptibility is reduced in fragile X knockout mice after introduction of FMR1 transgenes.
Match Strength: 5.554
The Fmr1 knockout (KO) mouse is characterized by an increased audiogenic seizure (AGS) susceptibility and is considered a good animal model for epilepsy and seizures in the human fragile-X (FRAX) syndrome. Here, we tested the hypothesis that the reintroduction of the FMR1 gene is able to revert the AGS susceptibility characterizing Fmr1 KO mice. To this aim, two groups of Fmr1 KO transgenic mice, which have additional copies of the human FMR1 gene (YAC) or FMR1 cDNA (G6) were used. AGS susceptibility of these mice was examined and compared to that of Fmr1 KO, wild type, and wild-type animals ... Read More »
» Published in Exp Neurol. 2007 Jan;203(1):233-40. Epub 2006 Sep 27.
9. Experiences of onset and diagnosis of low-grade glioma from the patient's perspective.
Match Strength: 4.999
The aim of this study was to describe adult patients' experiences of falling ill and being diagnosed with low-grade glioma. Information concerning such experiences is lacking in the literature. The study population were adults identified within a well-defined population. Interviews were conducted with 27 patients. The interview texts were analyzed using inductive content analysis. Illness onset was described as a sequence of events. Nineteen patients narrated rapid onset and 8 patients prolonged onset. The most commonly described symptoms in both types of onset were headache, epileptic ... Read More »
» Published in Cancer Nurs. 2006 Sep-Oct;29(5):415-22.
10. High-frequency intracerebral EEG activity (100-500 Hz) following interictal spikes.
Match Strength: 4.547
PURPOSE: High-frequency activity has been recorded with intracerebral microelectrodes in epileptic patients and related to seizure genesis. Our goal was to analyze high-frequency activity recorded with electroencephalograph (EEG) macroelectrodes during the slow wave immediately following interictal spikes, given the potential importance of this presumed hyperpolarization in transforming spikes into seizures. METHODS: Depth electrode EEG recordings from 10 patients with intractable focal epilepsy were low-pass filtered at 500 Hz and sampled at 2,000 Hz. Spikes were categorized according to ... Read More »
» Published in Epilepsia. 2006 Sep;47(9):1465-76. Erratum in: Epilepsia. 2006 Nov;47(11):1979. Avoli, Massimo [added]; Dubeau, Francois [added]; Gotman, Jean [added].
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