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Peer Reviewed Scientific Research Reports.
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1. What about us? Siblings of children with epilepsy.
Match Strength: 8.753
RATIONALE: It is known that epilepsy has a severe impact in the quality of life of the patients; however, it affects the lives of all family members. The psychosocial repercussions of epilepsy are often of greater significance than the seizures themselves. METHODS: This was a prospective study, conducted from January 2005 to December 2005 at the pediatric epilepsy clinic of our University Hospital. Parents were interviewed by one of the authors according to a structured questionnaire about the impact of epilepsy in the life of the siblings of children with epilepsy. RESULTS: One hundred and ... Read More »
» Published in Seizure. 2006 Dec;15(8):610-4. Epub 2006 Sep 26.
2. Epilepsy and polycystic ovary syndrome: where is the link?
Match Strength: 7.228
Several reports in the literature describe an increased prevalence of polycystic ovary syndrome (PCOS) in women with epilepsy. The possible pathogenesis of the association between epilepsy and PCOS is not clear yet, and different hypotheses have been proposed: while some authors suggest that epilepsy may affect the hypothalamic control of reproductive function, others propose a pathogenic role of the antiepileptic drug valproate. In this article we review the literature on the subject, and propose a pathogenic theory in which both epilepsy and valproate play different and significant roles in ... Read More »
» Published in Neurol Sci. 2006 Sep;27(4):221-30.
3. Senile myoclonic epilepsy in Down syndrome: a video and EEG presentation of two cases.
Match Strength: 7.211
Myoclonic epilepsy is being increasingly recognized as a late-onset complication in middle-aged or elderly patients with Down syndrome, in association with cognitive decline. We show video and EEG recordings of two patients, both aged 56 years, diagnosed with this condition. At onset, myoclonic epilepsy in elderly DS patients may resemble, in its clinical expression, the classical juvenile myoclonic epilepsy with the characteristic occurrence of jerks on awakening. It is clearly associated with an Alzheimer-type dementia, and may also occur in non-DS patients with Alzheimer's disease: hence ... Read More »
» Published in Epileptic Disord. 2006 Sep;8(3):223-7.
4. Sleep deprivation increases cortical excitability in epilepsy: syndrome-specific effects.
Match Strength: 7.169
OBJECTIVE: To use transcranial magnetic stimulation (TMS) to investigate the hypothesis that sleep deprivation increases cortical excitability in people with epilepsy. METHODS: We performed paired pulse TMS stimulation, using a number of interstimulus intervals (ISIs) on each hemisphere of 30 patients with untreated newly diagnosed epilepsy (15 idiopathic generalized epilepsy [IGE] and 15 focal epilepsy) and on the dominant hemisphere of 13 healthy control subjects, before and after sleep deprivation. RESULTS: Both hemispheres in patients with IGE and the hemisphere ipsilateral to the EEG ... Read More »
» Published in Neurology. 2006 Sep 26;67(6):1018-22.
5. The 3rd Judith Hoyer Lecture in epilepsy, December 2, 2005 opening remarks.
Match Strength: 7.165
On December 2, 2005, Dr. Jeffrey L. Noebels presented the third lecture in a series highlighting the promise of epilepsy research. Opening remarks were provided by Dr. Story C. Landis, Director of the National Institute of Neurological Disorders and Stroke, and by Representative Steny Hoyer (D-MD). The lecture series is held in memory of Mrs. Judith Hoyer, an active member of the Board of Directors of the Epilepsy Foundation (EF) and the late wife of Rep. Hoyer. Mrs. Hoyer spent her life both helping families to cope with epilepsy and promoting research into a cure and a better quality of life ... Read More »
» Published in Epilepsy Behav. 2006 Nov;9(3):377-8. Epub 2006 Sep 26.
6. Balance performance in adult epilepsy patients.
Match Strength: 7.001
PURPOSE: To evaluate the magnitude of subclinical balance dysfunction in adult epilepsy patients and to assess the relative contribution of different variables to balance impairment. METHODS: Balance performance was evaluated by computerized dynamic platform posturography (CDPP) in 25 adult patients following a generalized tonic-clonic seizure (GTCS) and in 11 healthy subjects. RESULTS: The GTCS was a breakthrough seizure in 20 patients with epilepsy and a first seizure in 5. Seven of the patients had localization-related epilepsy and 13 had generalized epilepsy. Mean epilepsy duration was 6.6 ... Read More »
» Published in Seizure. 2006 Dec;15(8):582-9. Epub 2006 Sep 15.
7. Benign pediatric localization-related epilepsies. Part I. Syndromes in infancy.
Match Strength: 6.494
There is currently increasing interest in identifying and classifying pediatric benign epilepsy syndromes and recently several new syndromes have been recognized. Benign epilepsy syndromes, by definition, occur in children with normal developmental history, respond well to therapy, and remit without sequelae. The large majority of children with benign epilepsy syndromes follow a truly benign course. The concept of benign epilepsy syndromes has, however, been challenged by the minority of patients who continue to have seizures despite therapy, develop new seizures after initial remission, or ... Read More »
» Published in Epileptic Disord. 2006 Sep;8(3):169-83.
8. Postictal behaviour in temporal lobe epilepsy.
Match Strength: 6.327
Postictal phenomena such as nose-wiping, coughing and hypersalivation are believed to reflect a purposeful reaction to hypersecretion after regaining consciousness following a complex partial seizure, and are very common in patients with temporal lobe epilepsy, particularly in mesial temporal lobe epilepsy. Nose-wiping is usually performed with the hand ipsilateral to the side of seizure onset. Our patient illustrates an unusual, exaggerated postictal behaviour consisting of long-lasting nose-wiping, coughing and guttural sounds following a complex partial seizure due to right mesial temporal ... Read More »
» Published in Epileptic Disord. 2006 Sep;8(3):228-31.
9. Intractable epilepsy secondary to cyclosporine toxicity in children undergoing allogeneic hematopoietic bone marrow transplantation.
Match Strength: 6.304
The long-term evolution to intractable epilepsy in children treated with cyclosporine administered for graft-versus-host-disease after hematopoietic stem cell transplantation was evaluated. In a group of 185 children treated with cyclosporine after bone marrow transplantation, 15 (8%) presented with acute seizures that were generalized in 7 and focal in 7 and had absence status in 1. Electroencephalography (EEG) and neuroimaging showed predominant abnormalities in the occipital regions. One patient died shortly after the seizure; in seven cases, seizures remitted, whereas relapses were ... Read More »
» Published in J Child Neurol. 2006 Oct;21(10):861-6.
10. Pilomotor seizures associated with sequential changes in magnetic resonance imaging.
Match Strength: 6.151
Piloerection is rarely described in seizures. This symptom has been most frequently observed in patients with temporal lobe epilepsy and is rarely the principal clinical feature of seizures. No specific etiology of epilepsy associated with pilomotor seizures has been reported. We present the first case of a patient who experienced sudden and transitory epilepsy with pilomotor seizures occurring several times a day for months, and associated with sequential changes of the left hippocampus demonstrated by magnetic resonance imaging. [Published with video sequences]. Publication Types: Case ... Read More »
» Published in Epileptic Disord. 2006 Sep;8(3):232-7.
11. Quality of life of children with benign rolandic epilepsy.
Match Strength: 6.048
The first objective of this study was to determine the quality of life of children with benign rolandic epilepsy. Secondly, this investigation aimed to predict the influence of cognition on quality of life, controlling for the emotional impact of the epilepsy on the parent. Initial recruitment was through the major electroencephalography laboratories of metropolitan Sydney. The syndrome was defined using the International League Against Epilepsy classification. Patients underwent a comprehensive cognitive assessment, and parents completed the Child Health Questionnaire, Child Behavior ... Read More »
» Published in Pediatr Neurol. 2006 Oct;35(4):240-5.
12. Fewer women receive tertiary care for epilepsy in Kerala State, India.
Match Strength: 5.673
PURPOSE: The stigma attached to epilepsy often restricts early diagnosis and optimal care, particularly among the underprivileged. We aimed to ascertain any gender bias in the utilization of services for epilepsy in a tertiary and community care facility in Kerala State, India. METHODS: The R. Madhavan Nayar Center for Comprehensive Epilepsy Care (RMNC) is a leading tertiary care facility in South India. The District Mental Health Program (DMHP) is a community-based care facility that provides medical consultation and anti-epileptic drugs (AED) free of charge. We analyzed the sex ratio (SR) - ... Read More »
» Published in Epileptic Disord. 2006 Sep;8(3):184-9.
13. Increased number of febrile seizures in children born very preterm: relation of neonatal, febrile and epileptic seizures and neurological dysfunction to seizure outcome at 16 years of age.
Match Strength: 5.396
PURPOSE: In prematurely born population, a cascade of events from initial injury in the developing brain to morbidity may be followed. The aim of our study was to assess seizures in prematurely born children from birth up to 16 years and to evaluate the contribution of different seizures, and of neurological dysfunction to the seizure outcome. METHODS: Pre- and neonatal data and data from neurodevelopmental examination at 5 years of 60 prospectively followed children born at or before 32 weeks of gestation, and of 60 matched term controls from the 2 year birth cohort were available from ... Read More »
» Published in Seizure. 2006 Dec;15(8):590-7. Epub 2006 Sep 20.
14. Effects of carbamazepine and oxcarbazepine on the reproductive endocrine function in women with epilepsy.
Match Strength: 5.293
PURPOSE: The aim of the study was to compare the effects of carbamazepine (CBZ) and oxcarbazepine (OXC) on the reproductive endocrine function in women with epilepsy. OXC is a novel antiepileptic drug (AED), and the occurrence of reproductive dysfunction in women treated with OXC monotherapy for epilepsy has not been studied previously. METHODS: Thirty-five women with epilepsy were examined in the Department of Neurology at Oulu University Hospital. Sixteen patients were treated with CBZ monotherapy, and nineteen patients were treated with OXC monotherapy. The subjects were clinically examined ... Read More »
» Published in Epilepsia. 2006 Sep;47(9):1441-6.
15. Fear sensitivity and the psychological profile of patients with psychogenic nonepileptic seizures.
Match Strength: 5.130
Psychogenic nonepileptic seizures (PNES) remain a poorly understood phenomenon for both patients and their physicians. Recent work has begun to focus on the possible psychological underpinnings of this diagnosis, but few studies have focused on specific emotional pathologies. This study sought to investigate the impact of a specific emotional measure: self-reported fear sensitivity. Three patient groups (patients with PNES, patients with epilepsy, and healthy volunteers) were administered the Modified Fear Survey Schedule, along with other neuropsychological batteries. As expected, the PNES ... Read More »
» Published in Epilepsy Behav. 2006 Dec;9(4):587-92. Epub 2006 Sep 25.
16. Combining advanced neuroimaging techniques in presurgical workup of non-lesional intractable epilepsy.
Match Strength: 5.016
PURPOSE: The rationale for this case report is to assess the degree of congruency between the results of several advanced functional, metabolic, and structural neuroimaging techniques used in patients with MRI-negative focal epilepsy. METHODS: We investigated the presurgical evaluation and post-operative outcome of a patient with intractable, extratemporal epilepsy. Because the habitual seizures in this patient could be easily induced, six, advanced, neurodiagnostic techniques were successively applied (SISCOM, ictal FDG-PET, ictal fMRI, postictal diffusion-weighted imaging, voxel-based ... Read More »
» Published in Epileptic Disord. 2006 Sep;8(3):190-4.
17. Hormone replacement therapy in women with epilepsy: a randomized, double-blind, placebo-controlled study.
Match Strength: 4.883
PURPOSE: Previous reports have suggested that hormone replacement therapy (HRT) could increase seizure activity in women with epilepsy. We sought to determine whether adding HRT to the medication regimen of postmenopausal women with epilepsy was associated with an increase in seizure frequency. METHODS: This was a randomized, double-blind, placebo-controlled trial of the effect of HRT on seizure frequency in postmenopausal women with epilepsy, taking stable doses of antiepileptic drugs (AEDs), and within 10 years of their last menses. After a 3-month prospective baseline, subjects were ... Read More »
» Published in Epilepsia. 2006 Sep;47(9):1447-51.
18. Variation in lamotrigine plasma concentrations with hormonal contraceptive monthly cycles in patients with epilepsy.
Match Strength: 4.856
PURPOSE: This is the first report comparing intrasubject lamotrigine (LTG) plasma concentrations between hormonal contraceptive (HC) intake and week-off phases in epilepsy patients receiving combined LTG and HC treatment. We describe the variation in LTG plasma concentrations with hormonal contraceptive (HC) monthly intake cycles in a series of eight patients with epilepsy. METHODS: Venous blood samples were prospectively drawn from patients before their first morning dose of LTG, once between days 18 and 21 of HC intake and once between days 5 and 7 of the HC-free week. RESULTS: Median LTG ... Read More »
» Published in Epilepsia. 2006 Sep;47(9):1573-5.
19. Expression of CD34 as a novel marker for glioneuronal lesions associated with chronic intractable epilepsy.
Match Strength: 4.741
The spectrum of glioneuronal lesions underlying intractable epilepsies includes malformative pathologies like focal cortical dysplasia (FCD); and neoplastic lesions like gangliogliomas (GG) and dysembryoplastic neuroepithelial tumours (DNT). These may occur either singly or as dual lesions, having simultaneous presence of both elements. Currently, the relationship between the malformative and neoplastic glioneuronal lesions is poorly understood. Recently, CD34, a stem cell marker transiently expressed during early neurulation, has been identified in these tumours. This study was undertaken to ... Read More »
» Published in Neuropathol Appl Neurobiol. 2006 Oct;32(5):461-8.
20. Expression of multidrug resistance type 1 gene (MDR1) P-glycoprotein in intractable epilepsy with different aetiologies: a double-labelling and electron microscopy study.
Match Strength: 4.717
The objective of this study was to analyse the clinical characteristics, pathological features and expression patterns of multiple drug resistance type 1 (MDR1) and glial fibrillary acidic protein (GFAP) in intractable epilepsy patients with variable aetiologies and to analyse the relationships between the clinical and pathological findings. Twenty-six patients (15 males, 11 females, age range 4-25 years, mean age 22.92 years, SD 11.19 years) with intractable epilepsy were included in this study; the clinical characteristics were considered, and the pathological changes as well as expression ... Read More »
» Published in Neurol Sci. 2006 Sep;27(4):245-51.
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