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1. Acute cysticercal meningitis--missed diagnosis.
Match Strength: 8.033

Neurocysticercosis is the commonest CNS parasitic disease worldwide but cysticercal meningoencephalitis is relatively rare, especially in Indian patients. We herein report a girl with cysticercal meningitis that was initially not suspected and later diagnosed on the basis of cerebrospinal fluid (CSF) eosinophilia. The need for CSF examination with wright-giemsa staining to avoid missing CSF eosinophilia is discussed. Publication Types: Case ... Read More »
» Published in Indian J Pediatr. 2006 Sep;73(9):835-7.

2. Airway eosinophilia in children with severe asthma: predictive values of noninvasive tests.
Match Strength: 7.721

RATIONALE: Children with severe asthma experience persistent symptoms despite maximal conventional treatment. Fraction of exhaled nitric oxide (Fe(NO)) and sputum eosinophils are used as markers of airway inflammation to guide treatment with steroids, but no data are available on how reliable they are in predicting airway eosinophilia assessed bronchoscopically in these children. OBJECTIVES: To determine how Fe(NO) and sputum eosinophils predict airway eosinophilia measured in both bronchoalveolar lavage (BAL) and endobronchial biopsy. METHODS: Twenty-seven children with moderate to severe ... Read More »
» Published in Am J Respir Crit Care Med. 2006 Dec 15;174(12):1286-91. Epub 2006 Sep 14.

3. Inhaled fluticasone and salmeterol suppress eosinophilic airway inflammation in chronic obstructive pulmonary disease: relations with lung function and bronchodilator reversibility.
Match Strength: 6.106

The aim of this study was to determine whether combined inhaled corticosteroids and long-acting beta(2) agonists can suppress eosinophilic inflammation in chronic dostructive plumonary disease (COPD) and to investigate the association between the level of eosinophilia and the degree of bronchodilator reversibility. Sixty-two patients with stable COPD (forced expiratory volume in 1 [FEV(1)] of 30%-70% predicted before bronchodilation) were enrolled from our outpatient clinic. Patients received inhaled fluticasone (100 microg)/salmeterol (50 microg) twice daily for two months. Lung function ... Read More »
» Published in Lung. 2006 Jul-Aug;184(4):217-22.

4. Chlamydia and Mycoplasma serology in respiratory tract infections of children.
Match Strength: 2.906

One of the challenges in planning the treatment of respiratory tract infection in children is identifying the causative agent. The objective of the present study was to investigate the incidence of Mycoplasma and Chlamydia in the etiology of respiratory tract infections of children. The present study included 100 children, three months to 12 years of age, admitted to the outpatient department of pediatrics with such respiratory symptoms as fever, cough and respiratory distress. Following a detailed clinical history and physical examination, complete blood count, erythrocyte sedimentation rate, ... Read More »
» Published in Tuberk Toraks. 2006;54(3):254-8.

5. Utility of exhaled nitric oxide as a noninvasive biomarker of lung inflammation in a disease model.
Match Strength: 2.814

There is a great deal of interest in developing less invasive markers for monitoring airway inflammation and the effect of possible novel anti-inflammatory therapies that may take time to impact on disease pathology. Exhaled nitric oxide (eNO) has been shown to be a reproducible, noninvasive indicator of the inflammatory status of the airway in the clinic. The aim of the present study was to determine the usefulness of measuring eNO as a marker of the anti-inflammatory impact of glucocorticoid and an inhibitor of kappaB kinase-2 (IKK-2) inhibitor 2-[(aminocarbonyl)amino]-5-(4-fluorophenyl)-3 ... Read More »
» Published in Eur Respir J. 2006 Dec;28(6):1236-44. Epub 2006 Sep 27.

6. A potent human anti-eotaxin1 antibody, CAT-213: isolation by phage display and in vitro and in vivo efficacy.
Match Strength: 2.779

The CC chemokine, eotaxin1 (CCL11) is an important regulator of eosinophil function. A marked accumulation of eosinophils in tissues has been correlated with the up-regulation of eotaxin1 expression in several diseases. The potential therapeutic value of neutralizing the effects of eotaxin1 in inflammatory conditions (including asthma) is under investigation. A human single-chain fragment variable antibody that neutralizes human eotaxin1 (CAT-212) was produced using antibody phage display and converted to whole antibody IgG4 format (CAT-213). A novel approach to lead optimization in which the ... Read More »
» Published in J Pharmacol Exp Ther. 2006 Dec;319(3):1395-404. Epub 2006 Sep 14.

7. Anti-inflammatory Activity of Inhaled Interleukin-4 Receptor-{alpha} Antisense Oligonucleotide in Mice.
Match Strength: 2.600

The Th2 cytokines IL-4 and IL-13 mediate allergic pulmonary inflammation and airways hyper-reactivity (AHR) in asthma models through signaling dependent upon the IL-4 receptor-alpha chain (IL-4Ralpha). IL-13 has been further implicated in the overproduction of mucus by the airway epithelium and in lung remodeling that commonly accompanies chronic inflammation. IL-4Ralpha-deficient mice are resistant to allergen-induced asthma, highlighting the therapeutic promise of selective molecular inhibitors of IL-4Ralpha. We designed a chemically modified IL-4Ralpha antisense oligonucleotide (IL-4Ralpha ... Read More »
» Published in Am J Respir Cell Mol Biol. 2006 Sep 21;

8. Modulatory role for retinoid-related orphan receptor alpha in allergen-induced lung inflammation.
Match Strength: 2.491

RATIONALE: Nuclear receptors play a critical role in the regulation of inflammation, thus representing attractive targets for the treatment of asthma. OBJECTIVE: In this study, we assess the potential regulatory function of retinoid-related orphan receptor alpha (RORalpha) in the adaptive immune response using ovalbumin (OVA)-induced airway inflammation as a model. METHODS: Allergen-induced inflammation was compared between wild-type (WT) and staggerer (RORalpha(sg/sg)) mice, a natural mutant strain that is deficient in RORalpha expression. MEASUREMENTS AND MAIN RESULTS: Despite robust ... Read More »
» Published in Am J Respir Crit Care Med. 2006 Dec 15;174(12):1299-309. Epub 2006 Sep 14.

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