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Peer Reviewed Scientific Research Reports.
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1. Control of edema in hypertensive subjects treated with calcium antagonist (nifedipine) or angiotensin-converting enzyme inhibitors with Pycnogenol.
Match Strength: 6.713
The presence of edema in different phases and stages of essential hypertension may be due to antihypertensive treatment. Some drugs may cause edema by inducing vasodilatation, increasing the capillary exchange surface and capillary filtration. Pycnogenol has an important anti-edema effect in diabetic microangiopathy and chronic venous insufficiency. This 8-week study evaluated capillary filtration in 2 comparable treatment groups with hypertension treated with a calcium antagonist (nifedipine) or angiotensin-converting enzyme inhibitor to define its efficacy in preventing edema caused by ... Read More »
» Published in Clin Appl Thromb Hemost. 2006 Oct;12(4):440-4.
2. Pemetrexed-induced edema of the eyelid.
Match Strength: 6.260
Pemetrexed is a novel antimetabolite that targets multiple enzymes in the folate pathway, and has exhibited clear antitumor activities in the treatment of malignant pleural mesothelioma and non-small cell lung cancer. Although many adverse events of pemetrexed, such as bone marrow suppression, have been reported, edema of the eyelid has been previously reported in only one case (0.2%, n=519), according to the Pemetrexed Clinical Investigator's Brochure, April 2005 version. We experienced a patient who developed the valuable edema of the eyelid. We believe that medical oncologists should be ... Read More »
» Published in Lung Cancer. 2006 Nov;54(2):241-2. Epub 2006 Sep 22.
3. Prolonged febrile seizures are associated with hippocampal vasogenic edema and developmental changes.
Match Strength: 5.910
PURPOSE: There is mounting evidence that a prolonged febrile seizure (PFS) can cause acute hippocampal edema although the nature of that edema remains uncertain. The principal aims of the current study were: (1) to use apparent diffusion coefficient (ADC) measurements to further characterize the hippocampal edema previously identified within 5 days of a PFS, and (2) to determine whether the age dependency of ADC in the hippocampus is different in patients when compared to a control population following a PFS. METHODS: Diffusion weighted imaging was acquired in 23 children within 5 days of a ... Read More »
» Published in Epilepsia. 2006 Sep;47(9):1493-8.
4. Intravitreal triamcinolone acetonide for diffuse diabetic macular edema: phase 2 trial comparing 4 mg vs 2 mg.
Match Strength: 5.202
PURPOSE: To prospectively compare the efficacy and safety of 4 vs 2 mg intravitreal triamcinolone acetonide (TA) injection for diabetic macular edema. DESIGN: Interventional case series. METHODS: PATIENTS: Thirty-two patients with diabetic macular edema unresponsive to laser photocoagulation. INTERVENTION: Patients were randomly assigned to receive 4 or 2 mg intravitreal TA in one eye (16 patients in each group). MAIN OUTCOME MEASURES: The main outcome was central macular thickness (CMT) measured by optical coherence tomography (OCT) at four, 12, and 24 weeks. Secondary outcomes were gain in ... Read More »
» Published in Am J Ophthalmol. 2006 Nov;142(5):794-99. Epub 2006 Sep 15.
5. Nicotinamide reduces acute cortical neuronal death and edema in the traumatically injured brain.
Match Strength: 4.704
Previous studies have shown that administration of nicotinamide (Vitamin B(3)) in animal models of traumatic brain injury (TBI) and ischemia significantly reduced the size of infarction or injury and improved functional recovery. The present study evaluated the ability of nicotinamide to provide acute neuroprotection and edema reduction following TBI. Groups of rats were assigned to nicotinamide (500mg/kg) or saline (1.0ml/kg) treatment conditions and received contusion injuries or sham surgeries. Drug treatment was administered 15min following injury. Brains were harvested 24h later and ... Read More »
» Published in Neurosci Lett. 2006 Nov 6;408(1):35-9. Epub 2006 Sep 20.
6. Subthreshold grid laser treatment of macular edema secondary to branch retinal vein occlusion with micropulse infrared (810 nanometer) diode laser.
Match Strength: 4.625
PURPOSE: To compare the effectiveness of subthreshold grid laser treatment (SGLT) with an infrared micropulse diode laser with that of threshold grid laser treatment (TGLT) for macular edema secondary to branch retinal vein occlusion (BRVO). DESIGN: Randomized clinical trial. PARTICIPANTS: Thirty-six patients (36 eyes) were randomized either to infrared SGLT (17 eyes) or to krypton TGLT (19 eyes). METHODS: Complete ophthalmic examinations, including determination of visual acuity (VA) with Early Treatment Diabetic Retinopathy Study charts, optical coherence tomography (OCT), and fluorescein ... Read More »
» Published in Ophthalmology. 2006 Dec;113(12):2237-42. Epub 2006 Sep 25.
7. Intravitreal triamcinolone reinjection for refractory diabetic macular edema.
Match Strength: 4.403
PURPOSE: To evaluate the effect of intravitreal triamcinolone acetonide (IVT) reinjection on clinical and optical coherence tomographic features in refractory diabetic macular edema. METHODS: In a prospective interventional case series, all IVT treated patients enrolled in a previous clinical trial were recalled to have a new ophthalmologic examination and optical coherence tomography (OCT) performed. Eyes found suitable for reinjection received 4 mg IVT. Complete clinical examination and OCT were repeated at 2 and 4 months post-injection. The changes were statistically analyzed using a paired ... Read More »
» Published in Korean J Ophthalmol. 2006 Sep;20(3):156-61.
8. Effect of ruboxistaurin on visual loss in patients with diabetic retinopathy.
Match Strength: 4.384
OBJECTIVE: To evaluate the effect of ruboxistaurin, an orally administered protein kinase C beta (PKC beta) isozyme-selective inhibitor, on vision loss in patients with diabetes. DESIGN: Thirty-six-month, randomized, double-masked, placebo-controlled, parallel, multicenter trial. PARTICIPANTS: Six hundred eighty-five patients randomized at 70 clinical sites. METHODS: Ophthalmologic examination was performed at screening and at each 3-month visit. Retinopathy status was assessed every 6 months with Early Treatment Diabetic Retinopathy Study (ETDRS) standard 7-field 30 degrees color stereoscopic ... Read More »
» Published in Ophthalmology. 2006 Dec;113(12):2221-30. Epub 2006 Sep 20. Comment in: Ophthalmology. 2006 Dec;113(12):2135-6.
9. Effectiveness of prehospital continuous positive airway pressure in the management of acute pulmonary edema.
Match Strength: 4.154
OBJECTIVE: To compare the effectiveness of continuous positive airway pressure (CPAP) with standard pharmacologic treatment in the management of prehospital acute pulmonary edema. METHODS: Using a nonrandomized control group design, all consecutive patients presenting to two participating emergency medical services (EMS) systems with a field impression of acute pulmonary edema between July 1, 2004, and June 30, 2005, were included in the study. The control EMS system patients received standard treatment with oxygen, nitrates, furosemide, morphine, and, if indicated, endotracheal intubation. ... Read More »
» Published in Prehosp Emerg Care. 2006 Oct-Dec;10(4):430-9.
10. Brief review: angiotensin converting enzyme inhibitors and angioedema: anesthetic implications.
Match Strength: 4.031
PURPOSE: Angiotensin converting enzyme inhibitors (ACEIs) are a group of drugs used to treat hypertension and heart failure, with additional benefits, such as cardiovascular and renal protection, in patients with diabetes. However, angioedema as a complication of ACEI therapy is under-recognized. As there are important implications for anesthesiologists and emergency medicine physicians, a review was undertaken to document the scope of the problem of ACEI-induced angioedema.. METHODS: A review of the published literature (identified by searching Medline, EMBASE and CINAHL) was undertaken, ... Read More »
» Published in Can J Anaesth. 2006 Oct;53(10):994-1003.
11. Clinical review: alternative vascular access techniques for continuous hemofiltration.
Match Strength: 3.829
Obtaining or maintaining vascular access for continuous hemofiltration can sometimes be problematic, especially in the child or adult in multiple organ failure with edema and/or coagulopathy. Problems commonly encountered include obstruction of the femoral vein by the catheter, insertion difficulties, safety concerns when cannulating the subclavian vein in coagulopathy, and catheter and circuit occlusion due to disseminated intravascular coagulation. For access in infants we describe a technique utilizing two single-lumen thin-walled vascular sheaths. For infants and small children initial ... Read More »
» Published in Crit Care. 2006;10(5):230.
12. Attenuation of brain inflammatory response after focal cerebral ischemia/reperfusion with Xuesaitong injection in rats.
Match Strength: 3.805
OBJECTIVE: To investigate the neuro-protective effect of Xuesaitong Injection (XST) on brain inflammatory response after transient focal cerebral ischemia/reperfusion in rats. METHODS: Focal cerebral ischemia/reperfusion models of male rats were induced by transient occlusion for 2 h of middle cerebral artery (MCA) which was followed by 24 h reperfusion. XST was administered through intraperitoneal injection of 25 mg/kg or 50 mg/kg at 4 h after the onset of ischemia. After reperfusion for 24 h, the neurological function score was evaluated, the brain edema was detected with dry-wet weight ... Read More »
» Published in Chin J Integr Med. 2006 Sep;12(3):203-6.
13. Long-term results of microscopic lymphatic vessel-isolated vein anastomosis for secondary lymphedema of the lower extremities.
Match Strength: 3.664
PURPOSE: To evaluate the effectiveness of microscopic lymphatic vessel-isolated vein anastomosis in patients with secondary obstructive lymphedema of a lower extremity, refractory to nonoperative management. METHODS: Nine women suffered from nonpitting edema of one or both legs (11 limbs) after radical hysterectomy with postoperative irradiation for uterine cancer. The indications for this operation were repeated cellulitis and severe nonpitting edema impairing limb function. Under microscopy of 3.2 on average, the identified lymphatic vessels were anastomosed to an isolated saphenous vein ... Read More »
» Published in Surg Today. 2006;36(10):859-64.
14. Design of a new line in treatment of experimental rheumatoid arthritis by artesunate.
Match Strength: 3.463
This study was aimed to evaluate the therapeutic potency of a new antimalarial drug, artesunate, in an experimental model of rheumatoid arthritis. Collagen-induced arthritis (CIA) was induced in Lewis rats.The intraperitoneally administration of artesunate (ARS) and methotrexate (MTX) were started on day 25 postimmunization and continued until final assessment on day 35. During this period, clinical examination was intermittent. The anticollagen type II antibody (CII Ab) and nitric oxide synthesis were measured. The paws and kness were then removed for histopathology and radiography assay. The ... Read More »
» Published in Immunopharmacol Immunotoxicol. 2006;28(3):397-410.
15. Acute thiamine deficiency in diabetic ketoacidosis: Diagnosis and management.
Match Strength: 3.363
OBJECTIVE: Persistent encephalopathy in a patient with diabetic ketoacidosis is often feared as a sign of cerebral edema. Although thiamine deficiency is a rare diagnosis in children, marginal nutritional status and osmotic diuresis may be risk factors. The objective was to describe a heretofore unreported cause of encephalopathy in a child with diabetic ketoacidosis and review the mechanisms and pathophysiology of thiamine deficiency in this clinical scenario. DESIGN: Case report and review of the literature. SETTING: Pediatric intensive care unit of a tertiary care pediatric hospital. ... Read More »
» Published in Pediatr Crit Care Med. 2006 Nov;7(6):595-9.
16. The inflammatory response: an efficient way of life.
Match Strength: 3.269
The successive pathophysiological mechanisms that develop in the interstitium of tissues when these undergo acute post-traumatic inflammation are considered increasingly complex trophic functional systems for using oxygen. The nervous or immediate functional system presents ischemia-revascularization and edema, which favor nutrition by diffusion through injured tissue. In this phase of the inflammatory response, while the progression of the interstitial edema produces progressive distancing of the epithelial cells from the capillaries, it simultaneously enhances lymphatic circulation, which ... Read More »
» Published in Med Sci Monit. 2006 Oct;12(10):RA225-34. Epub 2006 Sep 25.
17. Toxic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in developing red seabream (Pagrus major) embryo: an association of morphological deformities with AHR1, AHR2 and CYP1A expressions.
Match Strength: 3.223
The toxicity of dioxins such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is mainly mediated by the aryl hydrocarbon receptor (AHR), which regulates the multiple target genes including cytochrome P4501A (CYP1A). In general, bony fishes, which possess at least two distinct AHRs are one of the most sensitive vertebrates to TCDD in early life stage. However, the physiological and toxicological roles of piscine multiple AHRs are not fully understood, especially in marine fish. To understand which AHR is responsible for TCDD toxicity in a marine fish species, we characterized the early life stage ... Read More »
» Published in Aquat Toxicol. 2006 Nov 16;80(2):166-79. Epub 2006 Sep 20.
18. MRI of stress reaction of the distal humerus in elite tennis players.
Match Strength: 3.093
OBJECTIVE: The purpose of this study was to describe the MRI appearance of stress reaction in the distal humerus in 12 elite tennis players. In addition, we aimed to determine whether any MRI findings were associated with changes in recovery times. CONCLUSION: Stress injury to the distal humerus is a cause of chronic arm pain among elite tennis players and may be exacerbated during full competition. The degree of marrow edema on STIR MRI may be predictive of time to return to competition ... Read More »
» Published in AJR Am J Roentgenol. 2006 Oct;187(4):901-4.
19. Long-term safety of pioglitazone versus glyburide in patients with recently diagnosed type 2 diabetes mellitus.
Match Strength: 3.085
STUDY OBJECTIVE: To evaluate the long-term safety and efficacy of glyburide versus pioglitazone in patients with a recent diagnosis of type 2 diabetes mellitus. DESIGN: Prospective, randomized, multicenter, double-blind trial with a 16-week titration period and a 40-week maintenance period. SETTING: Sixty-five investigative sites in the United States and Puerto Rico. PATIENTS: Five hundred two subjects with a recent diagnosis of type 2 diabetes that was unsuccessfully treated with diet and exercise were randomly assigned to study treatment. Of the 251 patients in each treatment group, 128 (51 ... Read More »
» Published in Pharmacotherapy. 2006 Oct;26(10):1388-95.
20. The Contaminated High-Energy Open Fracture: A Protocol to Prevent and Treat Inflammatory Mediator Storm-Induced Soft-Tissue Compartment Syndrome (IMSICS).
Match Strength: 2.548
The treatment modalities currently used in surgical debridement leave the traumatic wound with viable but tenuous tissue and a variable level of microcontaminants potentially laden with bacteria. In high-energy contaminated wounds, retention of these contaminants within the tenuous tissue of the so-called zone of stasis can result in further tissue necrosis and the development of infection. A novel protocol for managing the high-energy contaminated open fracture involves two new techniques. First, Bernoulli's principle is used to facilitate a systematic excision of contaminants, as well as the ... Read More »
» Published in J Am Acad Orthop Surg. 2006 Oct;14(10 Suppl):S82-6.
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