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Peer Reviewed Scientific Research Reports.
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1. Glycaemic control throughout pregnancy and risk of pre-eclampsia in women with type I diabetes.
Match Strength: 9.746
The aim of this study was to examine the influence of pre-pregnancy care and its effect on early glycaemic control and also the effect of glycaemic control in later pregnancy on risk of pre-eclampsia in women with type I diabetes. A prospective cohort study of 290 consecutive nonselected pregnancies in women with type I diabetes was performed from 1991 to 2002. We examined the relationship of monthly glycosylated haemoglobin (HbA1c) level, pre-pregnancy care, parity, diabetes duration, microvascular complications, maternal age, weight and smoking with risk of pre-eclampsia. Pre-eclampsia ... Read More »
» Published in BJOG. 2006 Nov;113(11):1329-32. Epub 2006 Sep 27.
2. Cerebral hemodynamics in preeclampsia: cerebral perfusion and the rationale for an alternative to magnesium sulfate.
Match Strength: 7.719
Preeclampsia and eclampsia continue to be major causes of maternal death. Currently, approximately 18% of U.S. maternal deaths are attributed to hypertensive disorders and eclampsia, and several hundred women die from eclampsia and its complications every year. In the United States, preeclamptic women have received magnesium sulfate as a seizure prophylaxis agent for 3 decades, and this practice is becoming more widely accepted internationally. In addition to a recognized failure rate, there are financial, logistic, and safety concerns associated with the universal administration of magnesium ... Read More »
» Published in Obstet Gynecol Surv. 2006 Oct;61(10):655-65.
3. Circulating calcitonin gene-related peptide and its placental origins in normotensive and preeclamptic pregnancies.
Match Strength: 6.109
OBJECTIVE: The present study was designed to determine plasma calcitonin gene-related peptide concentration in both maternal and fetal circulations in normotensive and pre-eclamptic pregnancies and investigate whether placenta is 1 of its origins. STUDY DESIGN: Maternal blood, cord blood, and villous tissue were collected from women in normotensive pregnancies and complicated with pre-eclampsia. Calcitonin gene-related peptide concentrations were determined by radioimmunoassay. Cellular localizations of calcitonin gene-related peptide messenger ribonucleic acid and protein expressions in ... Read More »
» Published in Am J Obstet Gynecol. 2006 Dec;195(6):1657-67. Epub 2006 Sep 25.
4. Defective implantation and placentation: laying the blueprint for pregnancy complications.
Match Strength: 5.889
Normal implantation and placentation is critical for pregnancy success. Many pregnancy-related complications that present late in gestation (such as pre-eclampsia and preterm labour) appear to have their origins early in pregnancy with abnormalities in implantation and placental development. Implantation is characterized by invasion of the maternal tissues of the uterus by fetal trophoblast, and the degree to which trophoblast invades these tissues appears to be a major determinant of pregnancy outcome. Excessive invasion can lead to abnormally firm attachment of the placenta to the myometrium ... Read More »
» Published in Reprod Biomed Online. 2006 Oct;13(4):591-9.
5. Effect of sera on the adhesion of natural killer cells to the endothelium in severe pre-eclampsia.
Match Strength: 5.862
OBJECTIVE: To investigate the effect of serum on the interaction between natural killer (NK) cells and endothelial cells in pre-eclampsia. METHODS: Seven severely pre-eclamptic patients, five normal pregnant women, and four normal non-pregnant women were included in this study. Freshly isolated NK cells labeled with Chromium-51 were incubated on an endothelial cell monolayer in the presence of patient serum. In regard to the characteristics of adhesive molecules, the endothelial cells were blocked by monoclonal antibodies (mAbs) to intracellular adhesion molecule-1 (ICAM-1), vascular cell ... Read More »
» Published in J Obstet Gynaecol Res. 2006 Oct;32(5):443-8.
6. Outcome of pregnancy in renal allograft recipients: SIUT experience.
Match Strength: 2.764
The course of pregnancy and its outcome was studied in renal allograft recipients. Between November 1985 and November 2005, a total of 1481 renal transplants were carried out at the Sindh Institute of Urology and Transplantation (SIUT); among them were 348 females, with 73 potential females for pregnancy. All patients received cyclosporine and prednisolone, with 82% also receiving azathioprine and 4 patients mycophenolate mofetil as a third immunosuppressant drug. We evaluated incidence of hypertension, diabetes, pre-eclampsia, urinary tract infection (UTI), rejection during pregnancy and ... Read More »
» Published in Transplant Proc. 2006 Sep;38(7):2001-2.
7. Case report: epidural abscess in a parturient with pruritic urticarial papules and plaques of pregnancy (PUPPP).
Match Strength: 2.566
PURPOSE: To describe the risk factors for epidural abscess (EA) formation following epidural analgesia in a parturient with pruritic urticarial papules and plaques of pregnancy (PUPPP). CLINICAL FEATURES: A 33 yr-old gravida 2 nulliparous patient at 36 weeks gestation presented with severe pre-eclampsia, and PUPPP (treated with prednisone). Magnesium prophylaxis was started and labour was induced. An epidural catheter was placed at the L(3-4) level using standard aseptic technique. Bupivacaine was incrementally injected to achieve a T10 sensory level, and analgesia was maintained using a ... Read More »
» Published in Can J Anaesth. 2006 Oct;53(10):1010-4.
8. Intravenous nicardipine: its use in the short-term treatment of hypertension and various other indications.
Match Strength: 2.481
Nicardipine is a water soluble calcium channel antagonist, with predominantly vasodilatory actions.Intravenous (IV) nicardipine (Cardene IV), which demonstrates a relatively rapid onset/offset of action, is used in situations requiring the rapid control of blood pressure (BP). IV nicardipine was as effective as IV nitroprusside in the short-term reduction of BP in patients with severe or postoperative hypertension. A potential role for IV nicardipine in the intraoperative acute control of BP in patients undergoing various surgical procedures (including cardiovascular, neurovascular and ... Read More »
» Published in Drugs. 2006;66(13):1755-82.
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