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Peer Reviewed Scientific Research Reports.
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1. Canadian Association of Neurosciences Review: polyglutamine expansion neurodegenerative diseases.
Match Strength: 4.628
Since the early 1990s, DNA triplet repeat expansions have been found to be the cause in an ever increasing number of genetic neurologic diseases. A subset of this large family of genetic diseases has the expansion of a CAG DNA triplet in the open reading frame of a coding exon. The result of this DNA expansion is the expression of expanded glutamine amino acid repeat tracts in the affected proteins, leading to the term, Polyglutamine Diseases, which is applied to this sub-family of diseases. To date, nine distinct genes are known to be linked to polyglutamine diseases, including Huntington's ... Read More »
» Published in Can J Neurol Sci. 2006 Aug;33(3):278-91.
2. Leukocyte navigation mechanisms as targets in airway diseases.
Match Strength: 4.462
Respiratory diseases, including asthma and chronic obstructive pulmonary disease, are among the most significant diseases in terms of their disabling effects and healthcare burden. A characteristic feature of almost all respiratory diseases is the accumulation and activation of inflammatory leukocytes in the lung or airway. Recent advances in the understanding of the molecules and intracellular signalling events controlling these processes are now translating to new therapeutic entities. In this article, the process of leukocyte accumulation is summarized, together with the preclinical and ... Read More »
» Published in Drug Discov Today. 2006 Oct;11(19-20):866-79. Epub 2006 Sep 7.
3. Risk factors of abdominal surgery in patients with collagen diseases.
Match Strength: 4.355
Patients with collagen diseases have been reported to demonstrate a greater risk when undergoing surgical operations. To determine the risk factors in abdominal surgery for patients with collagen diseases, 32 patients with collagen diseases who underwent abdominal surgery were analyzed for their clinical features and surgical results by comparing 26 cases from the favorable prognosis group (Group A) and 6 cases resulting in hospital death (Group B). The analysis revealed that emergent operations tended to result in worse outcomes (P = 0.011) than elective operations and that cases undergoing ... Read More »
» Published in Am Surg. 2006 Sep;72(9):843-8.
4. Progress in researches on the pharmaceutical mechanism and clinical application of Ginkgo Biloba extract on various kinds of diseases.
Match Strength: 4.043
Progress made over the pharmaceutical mechanism and clinical application of Ginkgo Biloba extract (GBE) on various kinds of diseases were reviewed in this paper. The effective elements contained in GBE are mainly kinds of Ginkgo flavonoid and Ginkgolide, which have marked protective effects on cardio-cerebral vascular and central nerve systems. In clinical practice, it is applied mostly in treatment of cardio-cerebral vascular diseases. Also it shows apparent effects in the treatment processes of some other diseases as an adjuvant, and therefore, has been gradually accepted by the medical ... Read More »
» Published in Chin J Integr Med. 2006 Sep;12(3):234-9.
5. Pulmonary arterial hypertension and rheumatic diseases--from diagnosis to treatment.
Match Strength: 4.014
Survival rates in pulmonary arterial hypertension (PAH) associated with rheumatic diseases, in particular connective tissue diseases such as systemic sclerosis, are even lower than in idiopathic PAH. These low survival rates highlight the need for early diagnosis and treatment in these patients. Transthoracic Doppler-echocardiography is most often used for diagnostic screening of patients at risk. Other screening tests are serum pro-brain-natriuretic peptide (pro-BNP) and diffusion capacity for carbon monoxide (DLCO), which appear to be changed early in the course of the PAH associated with ... Read More »
» Published in Rheumatology (Oxford). 2006 Oct;45 Suppl 4:iv22-iv25.
6. The therapeutic potential of the calpain family: new aspects.
Match Strength: 3.777
The calpain family is a group of cysteine proteases unique in their dependency on calcium to attain functionally active forms. Calpains are involved in a wide range of cellular calcium-regulated functions, including signal transduction, cell proliferation and differentiation, and apoptosis. Moreover, altered calpain activity has been observed in several human diseases. Specific calpain inhibitors hold promise for the treatment of neuromuscular and neurodegenerative diseases in which calpains have been shown to be upregulated (e.g. Parkinson's disease and Duchenne muscular dystrophy). ... Read More »
» Published in Drug Discov Today. 2006 Oct;11(19-20):917-23. Epub 2006 Sep 7.
7. Epidemiology of neuroimmunological diseases.
Match Strength: 3.721
This review gives an overview of various neuroimmunological diseases in terms of incidence and prevalence rates, age and sex distribution, and the frequency of subtypes, if applicable. The disorders selected for review are inflammatory muscle disorders (polymyositis, dermatomyositis and inclusion body myositis), myasthenia gravis, immune-mediated polyneuropathies (Guillain-Barre syndrome, chronic polyneuritis and vasculitic neuropathies), and multiple sclerosis ... Read More »
» Published in J Neurol. 2006 Sep;253(Supplement 5):v2-v8.
8. Sleep disturbances in allergic diseases.
Match Strength: 3.719
Sleep is fundamental for physical and mental health as well as daytime performance and represents a crucial aspect in the personal representations of well-being. Sleep disturbances in patients with chronic disorders constitute a factor that contributes to exacerbate symptoms, complicate management, and affect mood and quality of life (QoL). Allergic diseases are a global health problem of increasing prevalence that affects up to 15% of the population in Western countries. Sleep problems associated with allergic diseases may play a role in worsening the burden of illness, contributing to ... Read More »
» Published in Allergy. 2006 Nov;61(11):1259-67.
9. Humanized mouse models for organ-specific autoimmune diseases.
Match Strength: 3.676
Murine models for human autoimmune diseases are an essential tool for studying pathogenesis and for identifying new therapeutic targets. Mice are not the natural disease host, and conventional models have proved to be poor predictors of efficacy and safety in recent trials aiming to translate drug and biologic treatments to humans. Evidently, further steps towards recapitulating human diseases are urgently needed, for example using transgenic predisposing human HLA allele(s) plus T-cell receptor(s) implicated in a representative patient's autoimmune disease. The latest development - humanizing ... Read More »
» Published in Curr Opin Immunol. 2006 Dec;18(6):704-9. Epub 2006 Sep 27.
10. Autophagy: a cell repair mechanism that retards ageing and age-associated diseases and can be intensified pharmacologically.
Match Strength: 3.668
The process of ageing denotes a post-maturational deterioration of cells and organisms with the passage of time, an increased vulnerability to challenges and prevalence of age-associated diseases, and a decreased ability to survive. Causes may be found in an enhanced production of reactive oxygen species (ROS) and oxidative damage and not completed housekeeping, with an accumulation of altered ROS-hypergenerating organelles in older cells. It has been shown that autophagy is the only tier of defence against the accumulation of effete mitochondria and peroxisomes; that functioning of autophagy ... Read More »
» Published in Mol Aspects Med. 2006 Oct-Dec;27(5-6):403-10. Epub 2006 Sep 14.
11. Acute and chronic respiratory diseases in pregnancy: associations with placental abruption.
Match Strength: 3.565
OBJECTIVE: This study was undertaken to examine the associations between maternal respiratory diseases and placental abruption. STUDY DESIGN: A population-based, retrospective cohort study was conducted to examine the associations between maternal respiratory diseases and abruption in the United States. Data on women who delivered singleton births (n = 37,314,022) were derived from the National Hospital Discharge Survey for the years 1993 to 2003. International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) codes were used to identify pregnant women hospitalized ... Read More »
» Published in Am J Obstet Gynecol. 2006 Oct;195(4):1180-4.
12. Clinical characteristics and diabetes associated autoantibodies in patients with both type 1 diabetes mellitus and asthma.
Match Strength: 3.492
OBJECTIVE: Type 1 diabetes mellitus (DM1) and asthma are mediated by opposite arms of the cellular immune system, namely T helper (Th)1 and Th2 CD4+ cells, respectively. It is not known whether their coexistence affects their clinical manifestations. METHODS: The number of asthma exacerbations, frequency of hypoglycemic events, HbA1c levels, diabetes associated autoantibody status and diabetes associated late complications were determined in three paired groups of patients (n = 11) matched by gender and age: DM1 and asthma, asthma only, and DM1 only. RESULTS: Patients with both diseases had a ... Read More »
» Published in J Pediatr Endocrinol Metab. 2006 Aug;19(8):1001-6.
13. Donor funding priorities for communicable disease control in the developing world.
Match Strength: 3.386
Prior research has considered donor funding for developing world health by recipient and donor country but not by disease. Examining funding by disease is critical since diseases may be in competition with one another for priority and donors may be making allocation decisions in ways that do not correspond to developing world need. In this study I calculate donor funding for 20 historically high-burden communicable diseases for the years 1996 to 2003 and examine factors that may explain variance in priority levels among diseases. I consider funding for developing world health from 42 major ... Read More »
» Published in Health Policy Plan. 2006 Nov;21(6):411-20. Epub 2006 Sep 18.
14. Psychological distress and multimorbidity in primary care.
Match Strength: 3.355
PURPOSE: Psychological distress may decrease adherence to medical treatments and lead to poorer health outcomes of chronic diseases. The aim of this study was to evaluate the relationship between psychological distress and multimorbidity among patients seen in family practice after controlling for potential confounding variables and taking into account the severity of diseases. METHODS: We evaluated 238 patients to construct quintiles of increasing multimorbidity based on the Cumulative Illness Rating Scale (CIRS), which is a comprehensive multimorbidity index that takes into account disease ... Read More »
» Published in Ann Fam Med. 2006 Sep-Oct;4(5):417-22.
15. Socio-economic aspects of neuroimmunological diseases.
Match Strength: 3.342
Neuroimmunological diseases often have a chronic course and a high socio-economic impact, as most of them occur in younger patients and result in progressing disability and loss of work force. Although for many conditions different treatment strategies are available no sufficient data exist to give a reasonable account on the cost effectiveness of individual therapies. Treatment decision should primarily be guided by evidence from high quality clinical studies and-if available-from direct head-to-head trials and cost-effectiveness analysis ... Read More »
» Published in J Neurol. 2006 Sep;253 Suppl 5:v87-v90.
16. Sphingosine kinases, sphingosine 1-phosphate, apoptosis and diseases.
Match Strength: 3.289
Sphingolipids are ubiquitous components of cell membranes and their metabolites ceramide (Cer), sphingosine (Sph), and sphingosine-1-phosphate (S1P) have important physiological functions, including regulation of cell growth and survival. Cer and Sph are associated with growth arrest and apoptosis. Many stress stimuli increase levels of Cer and Sph, whereas suppression of apoptosis is associated with increased intracellular levels of S1P. In addition, extracellular/secreted S1P regulates cellular processes by binding to five specific G protein coupled-receptors (GPCRs). S1P is generated by ... Read More »
» Published in Biochim Biophys Acta. 2006 Dec;1758(12):2016-26. Epub 2006 Aug 18.
17. RNA-dominant diseases.
Match Strength: 3.279
Several examples have come to light in which mutations in non-protein-coding regions give rise to a deleterious gain-of-function by non-coding RNA. Expression of the toxic RNA is associated with formation of nuclear inclusions and late-onset degenerative changes in brain, heart or skeletal muscle. In the best studied example, myotonic dystrophy, it appears that the main pathogenic effect of the toxic RNA is to sequester binding proteins and compromise the regulation of alternative splicing. This review describes some of the recent advances in understanding the pathophysiology of RNA-dominant ... Read More »
» Published in Hum Mol Genet. 2006 Oct 15;15 Spec No 2:R162-9.
18. Adverse effects of treatment with intravenous immunoglobulins for neurological diseases.
Match Strength: 3.233
Therapy with intravenous immunoglobulins (IVIg) is considered to be a safe treatment for a number of immune-mediated neurological diseases. Published data about prevalence of adverse effects range from 11 to 81%. The purpose of our study was to preserve a representative view on adverse effects by analysis of a large cohort of patients treated by IVIg. A recent prospective study reported 42.7% adverse events. The majority of patients presented with minor adverse effects, mostly asymptomatic laboratory changes. Rash or mild headache occurred especially when IVIg was administered with an infusion ... Read More »
» Published in J Neurol. 2006 Sep;253 Suppl 5:v75-v79.
19. RNAi therapy for neurodegenerative diseases.
Match Strength: 3.200
RNA interference (RNAi) mediates gene silencing in a sequence-specific manner and has proven to be an exceptionally valuable discovery for bench scientists. In the laboratory, RNAi technologies provide efficient means for validating drug targets and for performing reverse genetics to study gene function (Friedman and Perrimon, 2004). Patients may also benefit from RNAi as applications extend to potential human therapies. RNAi-based treatments are being investigated and may provide hope for patients suffering from cancer, viral infections, or genetic diseases for which effective therapies are ... Read More »
» Published in Curr Top Dev Biol. 2006;75:73-92.
20. Difficulties in maintaining potassium homeostasis in patients with heart failure.
Match Strength: 3.198
Potassium (K) concentration plays a significant role in cell metabolism and membrane excitability. The imbalance of serum potassium is important because it can lead to life-threatening events. Potassium balance may be lost both through the neurohormonal mechanisms involved in cardiovascular diseases and through the drugs used in the treatment of this illness. Avoiding both hypo- and hyperkalemia is beneficial in several cardiovascular diseases, especially heart failure. Electrolyte abnormalities are frequently seen complications in subjects with heart failure. Malignant ventricular arrhythmias ... Read More »
» Published in Clin Cardiol. 2006 Sep;29(9):388-92.
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