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Peer Reviewed Scientific Research Reports.
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1. Botulinum toxin type A treatment for Parkinsonian patients with moderate to severe sialorrhea.
Match Strength: 7.231
PURPOSE: To investigate the effect of botulinum toxin type A (BTX-A; Botox) in reducing saliva in patients with Parkinsonism. METHODS: Fifteen patients with clinical diagnosis of idiopathic Parkinson's disease, dementia with Lewy bodies, or multiple system atrophy were enrolled in this open clinical trial. A total of 40-unit dose of Botox was injected into the bilateral parotid and submandibular glands. Objective measuring of saliva production with dental rods, subjective Drooling Score, personal impression of clinical improvement, and the duration of response were used for the global ... Read More »
» Published in Acta Neurol Taiwan. 2006 Sep;15(3):170-6. Comment in: Acta Neurol Taiwan. 2006 Sep;15(3):151-3.
2. Rituximab (anti-CD20) adjunctive therapy for opsoclonus-myoclonus syndrome.
Match Strength: 3.169
PURPOSE: To determine if rituximab, an anti-CD20 monoclonal antibody, reduces cerebrospinal fluid (CSF) B-cell expansion in opsoclonus-myoclonus syndrome (OMS) and results in clinical improvement. METHODS: Sixteen children with OMS and increased % CD20 B-cells in CSF received 4 rituximab infusions (375 mg/m IV) as add-on therapy to corticotropin (ACTH), intravenous immunoglobulins, or both, and were reevaluated 6 months later. Outcome measures were clinical (motor function, behavior, sleep) and immunologic (CSF and blood immunophenotype and Ig levels). Controls were 16 age-matched and sex ... Read More »
» Published in J Pediatr Hematol Oncol. 2006 Sep;28(9):585-93.
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