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Peer Reviewed Scientific Research Reports.
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1. Borderline personality organization and dissociation.
Match Strength: 6.992
The relationship between Kernberg's psychodynamic model of personality organization (PO) and dissociation has not yet been explored. Seventy-two nonclinical subjects and 222 psychiatric patients completed the Dissociative Experiences Scale and the Inventory of Personality Organization. Its Reality Testing subscale emerged as the most important predictor for all facets of dissociation. Discussing our results in the framework of Fonagy and coworkers' model of mentalization, we suggest that dissociation may reflect the preoedipal "pretend" mode of psychic functioning while impaired reality ... Read More »
» Published in Bull Menninger Clin. 2006 Summer;70(3):210-21.
2. Photodetachment and photofragmentation pathways in the [(CO2)2(H2O)m]- cluster anions.
Match Strength: 4.975
The mass-selected [(CO(2))(2)(H(2)O)(m)](-) cluster anions are studied using a combination of photoelectron imaging and photofragment mass spectroscopy at 355 nm. Photoelectron imaging studies are carried out on the mass-selected parent cluster anions in the m=2-6 size range; photofragmentation results are presented for m=3-11. While the photoelectron images suggest possible coexistence of the CO(2) (-)(H(2)O)(m)CO(2) and (O(2)CCO(2))(-)(H(2)O)(m) parent cluster structures, particularly for m=2 and 3, only the CO(2) (-) based clusters are both required and sufficient to explain all ... Read More »
» Published in J Chem Phys. 2006 Sep 21;125(11):114303.
3. In situ Raman spectroscopic study of the dissociation of methane hydrate at high pressure.
Match Strength: 4.800
The dissociation of methane hydrate at high pressure is studied by in situ Raman spectroscopy in a diamond-anvil cell. As for the Raman spectrum of sI methane hydrate, the v(1) band of CH(4) is split into two peaks v'(1) and v''(1), indicating the partitioning of CH(4) between the large (5(12)6(2)) and small (5(12)) cavities, respectively. With increasing temperature, the intensity ratio of Iv'(1)/Iv''(1) decreases obviously, and the d(Iv'(1)/Iv''(1))/dT is -0.079 K(-1). Additionally, the v(1) band of the dissolved CH(4) is close to v''(1) of the CH(4) molecule engaged in the small 5(12) ... Read More »
» Published in Appl Spectrosc. 2006 Sep;60(9):985-8.
4. Modification of the wettability of a polymeric substrate by pH effect. Determination of the surface acid dissociation constant by contact angle measurements.
Match Strength: 4.095
The wetting properties of a substrate can be changed by chemical reaction. Here, we studied simple materials with acid-base properties, by preparing poly(vinyl chloride) films containing lauric acid. These substrates constitute simple polymeric surfaces the wettability of which can be easily controlled by the acid-base equilibrium. The roughness of the material was then varied by adding Aerosil (hydrophobic fumed silica). We then studied the wettability of these materials toward aqueous buffer solutions between pH 2 and 12 from contact angle measurements. The variation of the contact angle of ... Read More »
» Published in Langmuir. 2006 Sep 26;22(20):8424-30.
5. CH radical production from 248 nm photolysis or discharge-jet dissociation of CHBr3 probed by cavity ring-down absorption spectroscopy.
Match Strength: 3.788
The A-X bands of the CH radical, produced in a 248 nm two-photon photolysis or in a supersonic jet discharge of CHBr(3), have been observed via cavity ring-down absorption spectroscopy. Bromoform is a well-known photolytic source of CH radicals, though no quantitative measurement of the CH production efficiency has yet been reported. The aim of the present work is to quantify the CH production from both photolysis and discharge of CHBr(3). In the case of photolysis, the range of pressure and laser fluences was carefully chosen to avoid postphotolysis reactions with the highly reactive CH ... Read More »
» Published in J Chem Phys. 2006 Sep 21;125(11):114312.
6. HATs off to PIC assembly.
Match Strength: 3.784
There are many regulated steps in the assembly of a transcription preinitiation complex (PIC). In this issue of Molecular Cell, Black et. al. (2006) reveal a catalytic switch mechanism in which autoacetylation of the HAT p300 triggers its dissociation from a promoter in a manner that is coupled to TFIID association. Publication Types: Comment, ... Read More »
» Published in Mol Cell. 2006 Sep 15;23(6):776-7. Comment on: Mol Cell. 2006 Sep 15;23(6):809-18.
7. Quantitating the relative abundance of isoaspartyl residues in deamidated proteins by electron capture dissociation.
Match Strength: 3.777
Relative quantitation of aspartyl and isoaspartyl residue mixtures from asparagine deamidation is demonstrated using electron capture dissociation without prior HPLC separation. The method utilizes the linear relationship found between the relative abundance of the isoaspartyl diagnostic ion, z(n)-57, and % isoaspartyl content based on the ECD spectra of known isoaspartyl/aspartyl mixtures of synthetic peptides. The observed linearity appears to be sequence independent because the relationship exists despite sequence variations and changes in backbone fragment abundances when isoaspartyl and ... Read More »
» Published in J Am Soc Mass Spectrom. 2007 Jan;18(1):48-56. Epub 2006 Sep 25.
8. Tid1/Rdh54 promotes dissociation of Dmc1 from nonrecombinogenic sites on meiotic chromatin.
Match Strength: 3.638
The meiosis-specific recombinase Dmc1 plays a critical role in DNA strand exchange in budding yeast. Tid1/Rdh54, a member of the Swi2/Snf2 family of DNA translocases, has been shown to stimulate Dmc1-dependent recombination. Tid1and its budding yeast paralog Rad54 have a variety of biochemical activities that may contribute to their biological function. Here we demonstrate that Dmc1 can associate with chromatin in the absence of DNA double-strand breaks (DSBs), and Tid1 suppresses this association. Chromatin immunoprecipitation experiments indicate that an activity shared by Tid1 and Rad54 is ... Read More »
» Published in Genes Dev. 2006 Sep 15;20(18):2593-604.
9. Thermodynamics of phosphopeptide binding to the human peptidyl prolyl cis/trans isomerase Pin1.
Match Strength: 3.570
Proteins containing phosphorylated Ser/Thr-Pro motifs play key roles in numerous regulatory processes in the cell. The peptidyl prolyl cis/trans isomerase Pin1 specifically catalyzes the conformational transition of phosphorylated Ser/Thr-Pro motifs. Here we report the direct analysis of the thermodynamic properties of the interaction of the PPIase Pin1 with its substrate-analogue inhibitor Ac-Phe-D-Thr(PO3H2)-Pip-Nal-Gln-NH2 specifically targeted to the PPIase active site based on the combination of isothermal titration calorimetry and studies on inhibition of enzymatic activity of wt Pin1 ... Read More »
» Published in Biochemistry. 2006 Oct 3;45(39):12125-35.
10. Size-corrected BMD decreases during peak linear growth: implications for fracture incidence during adolescence.
Match Strength: 3.505
Peak adolescent fracture incidence at the distal end of the radius coincides with a decline in size-corrected BMD in both boys and girls. Peak gains in bone area preceded peak gains in BMC in a longitudinal sample of boys and girls, supporting the theory that the dissociation between skeletal expansion and skeletal mineralization results in a period of relative bone weakness. INTRODUCTION: The high incidence of fracture in adolescence may be related to a period of relative skeletal fragility resulting from dissociation between bone expansion and bone mineralization during the growing years. ... Read More »
» Published in J Bone Miner Res. 2006 Dec;21(12):1864-70.
11. Gallium uptake by transferrin and interaction with receptor 1.
Match Strength: 3.449
The kinetics and thermodynamics of Ga(III) exchange between gallium mononitrilotriacetate and human serum transferrin as well as those of the interaction between gallium-loaded transferrin and the transferrin receptor 1 were investigated in neutral media. Gallium is exchanged between the chelate and the C-site of human serum apotransferrin in interaction with bicarbonate in about 50 s to yield an intermediate complex with an equilibrium constant K (1) = (3.9 +/- 1.2) x 10(-2), a direct second-order rate constant k (1) = 425 +/- 50 M(-1) s(-1) and a reverse second-order rate constant k (-1) = ... Read More »
» Published in J Biol Inorg Chem. 2007 Jan;12(1):90-100. Epub 2006 Sep 19.
12. Gas phase noncovalent protein complexes that retain solution binding properties: Binding of xylobiose inhibitors to the beta-1, 4 exoglucanase from cellulomonas fimi.
Match Strength: 3.345
Tandem mass spectrometry has been used to compare gas-phase and solution binding of three small-molecule inhibitors to the wild type and three mutant forms of the catalytic domain of Cex, an enzyme that hydrolyses xylan and xylo-oligosaccharides. The inhibitors, xylobiosyl-deoxynojirimycin, xylobiosyl-isofagomine lactam, and xylobiosyl-isofagomine consist of a common distal xylose linked to different proximal aza-sugars. The three mutant forms of the enzyme contain the substitutions Asn44Ala, Gln87Met, and Gln87Tyr that alter the binding interactions between Cex and the distal sugar of each ... Read More »
» Published in J Am Soc Mass Spectrom. 2007 Jan;18(1):64-73. Epub 2006 Sep 26.
13. Critical role of vimentin phosphorylation at Ser-56 by p21-activated kinase in vimentin cytoskeleton signaling.
Match Strength: 3.322
Phosphorylation and spatial reorganization of the vimentin network have been implicated in mediating smooth muscle contraction, cell migration, and mitosis. In this study, stimulation of cultured smooth muscle cells with 5-hydroxytryptamine (5-HT) induced PAK1 phosphorylation at Thr-423 (an indication of p21-activated kinase (PAK) activation). Treatment with PAK led to disassembly of wild-type (but not mutant S56A) vimentin filaments as assessed by an in vitro filament assembly assay. Furthermore, stimulation with 5-HT resulted in the dissociation of Crk-associated substrate (CAS; an adapter ... Read More »
» Published in J Biol Chem. 2006 Nov 10;281(45):34716-24. Epub 2006 Sep 20.
14. Dissociation of Crk-associated substrate from the vimentin network is regulated by p21-activated kinase on ACh activation of airway smooth muscle.
Match Strength: 3.316
The intermediate filament protein vimentin has been shown to be required for smooth muscle contraction. The adapter protein p130 Crk-associated substrate (CAS) participates in the signaling processes that regulate force development in smooth muscle. However, the interaction of vimentin filaments with CAS has not been well elucidated. In the present study, ACh stimulation of tracheal smooth muscle strips increased the ratio of soluble to insoluble vimentin (an index of vimentin disassembly) in association with force development. ACh activation also induced vimentin phosphorylation at Ser(56) as ... Read More »
» Published in Am J Physiol Lung Cell Mol Physiol. 2007 Jan;292(1):L240-8. Epub 2006 Sep 22.
15. A double dissociation of dorsal and ventral hippocampal function on a learning and memory task mediated by the dorso-lateral striatum.
Match Strength: 3.158
The objectives of this research were to further delineate the neural circuits subserving proposed memory-based behavioural subsystems in the hippocampal formation. These studies were guided by anatomical evidence showing a topographical organization of the hippocampal formation. Briefly, perpendicular to the medial/lateral entorhinal cortex division there is a second system of parallel circuits that separates the dorsal and ventral hippocampus. Recent work from this laboratory has provided evidence that the hippocampus incidentally encodes a context-specific inhibitory association during ... Read More »
» Published in Eur J Neurosci. 2006 Sep;24(6):1789-801.
16. Towards the mechanism of trimeric purine nucleoside phosphorylases: Stopped-flow studies of binding of multisubstrate analogue inhibitor - 2-amino-9-[2-(phosphonomethoxy)ethyl]-6-sulfanylpurine.
Match Strength: 3.085
The binding of multisubstrate analogue inhibitor - 2-amino-9-[2-(phosphonomethoxy)ethyl]-6-sulfanylpurine (PME-6-thio-Gua) to purine nucleoside phosphorylase from Cellulomonas sp. at 20 degrees C, in 20 mM Hepes buffer with ionic strength adjusted to 50 mM using KCl, at several pH values between 6.5 and 8.2, was investigated using a stopped-flow spectrofluorimeter. The kinetic transients registered after mixing a protein solution with ligand solutions of different concentrations were simultaneously fitted by several association reaction models using nonlinear least-squares procedure based on ... Read More »
» Published in Biophys Chem. 2007 Feb;125(2-3):260-268. Epub 2006 Sep 1.
17. Neural correlates of semantic and morphological processing of Hebrew nouns and verbs.
Match Strength: 3.076
Neuropsychological evidence regarding grammatical category suggests that deficits affecting verbs tend to localize differently from those affecting nouns, but previous functional imaging studies on healthy subjects fail to show consistent results that correspond to the clinical dissociation. In the current imaging study, we addressed this issue by manipulating not only the grammatical category but also the processing mode, using auditory presentation of Hebrew words. Subjects were presented with verbs and nouns and were instructed to make either a semantic decision ("Does the word belong to a ... Read More »
» Published in Hum Brain Mapp. 2006 Sep 14;
18. Structural investigations of the membrane-embedded rotor ring of the F-ATPase from Clostridium paradoxum.
Match Strength: 2.994
The Na(+)-translocating F-ATPase of the thermoalkaliphilic bacterium Clostridium paradoxum harbors an oligomeric ring of c subunits that resists dissociation by sodium dodecyl sulfate. The c ring has been isolated and crystallized in two dimensions. From electron microscopy of these c-ring crystals, a projection map was calculated to 7 A resolution. In the projection map, each c ring consists of two concentric, slightly staggered, packed rings, each composed of 11 densities representing the alpha-helices. On the basis of these results, it was determined that the F-ATPase from C. paradoxum ... Read More »
» Published in J Bacteriol. 2006 Nov;188(22):7759-64. Epub 2006 Sep 15.
19. Rational selection of an antibody probe to detect the heterogeneous collection of CHO-derived rhGM-CSF glycoforms.
Match Strength: 2.889
Six anti-E. coli rhGM-CSF monoclonal antibodies were generated using hybridoma technology. One of these showed identical affinity for the CHO and E. coli-derived cytokine (dissociation constants of 0.14 +/- 0.01 nM and 0.13 +/- 0.01 nM, respectively), mapping an epitope that is not hindered by carbohydrates. The antibody was used to develop a simple, specific and sensitive competitive ELISA to quantify the entire set of rhGM-CSF glycoforms (detection limit of 780 pg/ml) and it was successful as an affinity ligand to purify them. Therefore, this particular antibody is a useful, reliable and ... Read More »
» Published in Biotechnol Lett. 2006 Dec;28(24):2049-56. Epub 2006 Sep 27.
20. Dehydration versus deamination of N-terminal glutamine in collision-induced dissociation of protonated peptides.
Match Strength: 2.699
Some of the most prominent "neutral losses" in peptide ion fragmentation are the loss of ammonia and water from N-terminal glutamine. These processes are studied by electrospray ionization mass spectrometry in singly- and doubly-protonated peptide ions undergoing collision-induced dissociation in a triple quadrupole and in an ion trap instrument. For this study, four sets of peptides were synthesized: (1) QLLLPLLLK and similar peptides with K replaced by R, H, or L, and Q replaced by a number of amino acids, (2) QLnK (n = 0, 1, 3, 5, 7, 9, 11), (3) QLnR (n = 0, 1, 3, 5, 7, 9), and (4) QLn (n = ... Read More »
» Published in J Am Soc Mass Spectrom. 2007 Jan;18(1):27-36. Epub 2006 Sep 26.
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