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Disseminated Intravascular Coagulation
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1. Global fibrinolytic capacity in pediatric patients with sepsis and disseminated intravascular coagulation.
Match Strength: 16.172

There are many complex pathophysiologic changes of the coagulation system in sepsis. The fibrinolytic system was evaluated in septic children using the global fibrinolytic capacity (GFC), a new technique reflecting the overall fibrinolytic activity. The study consisted of 24 children with sepsis, 36 children with sepsis plus disseminated intravascular coagulation (DIC), and 20 healthy age-matched control individuals. Compared with controls, 86% of sepsis patients and 87% of sepsis plus DIC patients had decreased GFC levels. Between the sepsis plus DIC and sepsis groups there was no significant ... Read More »
» Published in Blood Coagul Fibrinolysis. 2006 Oct;17(7):569-73.

2. A systematic review of antithrombin concentrate use in patients with disseminated intravascular coagulation of severe sepsis.
Match Strength: 13.758

The objective was to estimate the effect of antithrombin therapy on mortality in disseminated intravascular coagulation (DIC) of severe sepsis and septic shock. Randomized clinical trials (RCT) on patients with DIC and severe sepsis or septic shock assigned to intravenous antithrombin or placebo were searched. Eligible studies reported death as the outcome measure. Of 35 RCT, 32 trials were excluded because patients were not randomized to antithrombin versus placebo, or no separate data on patients with DIC were given. In three RCT, 364 patients with severe sepsis or septic shock and DIC were ... Read More »
» Published in Blood Coagul Fibrinolysis. 2006 Oct;17(7):521-6.

3. Clinical review: alternative vascular access techniques for continuous hemofiltration.
Match Strength: 7.902

Obtaining or maintaining vascular access for continuous hemofiltration can sometimes be problematic, especially in the child or adult in multiple organ failure with edema and/or coagulopathy. Problems commonly encountered include obstruction of the femoral vein by the catheter, insertion difficulties, safety concerns when cannulating the subclavian vein in coagulopathy, and catheter and circuit occlusion due to disseminated intravascular coagulation. For access in infants we describe a technique utilizing two single-lumen thin-walled vascular sheaths. For infants and small children initial ... Read More »
» Published in Crit Care. 2006;10(5):230.

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