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Peer Reviewed Scientific Research Reports.
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1. Peritoneal dialysis or hemodialysis? A dilemma for the nephrologist.
Match Strength: 10.769
Selection of the initial dialysis modality is crucial in the treatment of end-stage renal disease (ESRD) patients. Several patient- and physician-related factors play important roles in the decision between peritoneal dialysis (PD) and hemodialysis (HD). Although HD is the most common dialysis modality in the United States, in some studies PD has shown a survival advantage over HD, at least in the first 2 years of dialysis treatment, especially in non-diabetic patients and in young patients with diabetes. Other advantages accrue to early PD use in many patients. An integrated care approach ... Read More »
» Published in Adv Perit Dial. 2006;22:180-5.
2. Does loss of residual renal function lead to malnutrition in peritoneal dialysis patients?
Match Strength: 8.757
OBJECTIVES: It is usually believed that loss of residual renal function is associated with anorexia and the development of malnutrition. We conducted a retrospective study in our center to evaluate the effect of declining residual renal function on patients' nutritional status. METHODS: All incident uremic patients (n = 46) who began peritoneal dialysis from January 1, 2003 June 1, 2003 in our center were closely followed for 1 year with focus on maintaining strict volume control with time on dialysis. Patient's residual renal function (RRF) was assessed by the average renal urea and ... Read More »
» Published in Clin Nephrol. 2006 Sep;66(3):192-201.
3. Intravenous iron does not affect the rate of decline of residual renal function in patients on peritoneal dialysis.
Match Strength: 8.205
The preservation residual renal function (RRF) is important for adequacy of peritoneal dialysis. Oxidative stress from intravenous (IV) iron has been shown to cause renal damage. The effect of IV iron on RRF has not been studied. Here, we report our experience during April 1999-March 2005 of the effect of IV iron on RRF. The study group included 24 patients (9 men, 15 women). The mean age of the group was 61 +/- 17.7 years. Diabetes mellitus and hypertension were the underlying cause of end-stage renal disease in 55% of the patients. We found serum creatinine, creatinine clearance, urea ... Read More »
» Published in Adv Perit Dial. 2006;22:99-103.
4. Perioperative management of peritoneal dialysis patients: review of abdominal surgery.
Match Strength: 7.100
On abdominal computed tomography scan for evaluation of hematuria, the index patient, a 23-year-old male, was found to have multiple renal cysts bilaterally. He had been on peritoneal dialysis for 6 years, complicated by intermittent episodes of exit-site infection and peritonitis. Over time, he developed recurrent urinary tract infection and nephrolithiasis with intermittent hematuria. His maintenance dose of recombinant erythropoietin was discontinued, and he maintained a normal hemoglobin level. Annual surveillance of the bilateral renal cysts with magnetic resonance imaging revealed ... Read More »
» Published in Adv Perit Dial. 2006;22:119-23.
5. Perioperative and mid-term results of coronary bypass surgery in patients undergoing chronic dialysis.
Match Strength: 6.845
PURPOSE: The goal of this study was to evaluate perioperative and mid-term results of coronary artery bypass grafting (CABG) in patients with end-stage renal disease (ESRD). METHODS: Thirty-five consecutive dialysis patients who required CABG over a 5-year period were investigated retrospectively. RESULTS: Mean patient age was 62.5+/-11.5 years. The mean number of diseased vessels was 2.3W0.8. Off-pump CABG (OPCAB) was performed in 12 patients. The mean number of anastomoses per patient was 2.5+/-1.1. The perioperative mortality was 5.7%, and the average duration of hospitalization was 25.3+/ ... Read More »
» Published in Ann Thorac Cardiovasc Surg. 2006 Aug;12(4):257-64.
6. Implementing iron management clinical practice guidelines in patients with chronic kidney disease having dialysis.
Match Strength: 6.785
OBJECTIVE: To evaluate the outcomes of and barriers to implementing standard guidelines (Caring for Australasians with renal impairment [CARI]), using iron management in patients having dialysis as an example. DESIGN AND SETTING: On-site review of iron management processes at six Australian dialysis units varying in size and locality. Patients' iron indices and haemoglobin levels were obtained from the Australian and New Zealand Dialysis and Transplant Registry. PARTICIPANTS: Patients with chronic kidney disease who were dependent on dialysis. MAIN OUTCOME MEASURES: Processes for assessing ... Read More »
» Published in Med J Aust. 2006 Sep 18;185(6):310-4. Comment in: Med J Aust. 2006 Sep 18;185(6):301-2.
7. Psychosocial effects on caregivers for children on chronic peritoneal dialysis.
Match Strength: 6.382
The study was designed to explore the psychosocial effects on caretakers of children in Taiwan on chronic peritoneal dialysis (CPD). This is a case-control study, performed with subjects drawn from eight medical centers. The study group consisted of caretakers of 32 children with renal failure being treated with CPD. For comparison, a control group of caretakers of 64 healthy children as well as the regional Taiwanese studies were used. Two instruments were used to explore the presence of probable depression and quality of life (QOL) of the caretakers: the Taiwanese Depression Questionnaire, ... Read More »
» Published in Kidney Int. 2006 Dec;70(11):1983-7. Epub 2006 Sep 20. Comment in: Kidney Int. 2006 Dec;70(11):1893-4.
8. Peritoneal transport in peritoneal dialysis patients is not affected by transitorily successful renal transplantation.
Match Strength: 6.351
Patients returning to peritoneal dialysis (PD) from failed renal transplantation are recognized to be inflamed, and this situation might produce a high peritoneal solute transport status. We wanted to determine if a period of time with a kidney allograft induces a change in peritoneal function. We studied 19 PD patients who had been living with a graft for a mean of 47 +/- 39 months. We studied their peritoneal function upon starting PD (baseline), immediately before transplantation (pre-Tx), and after returning to PD when the graft failed (post-Tx). We analyzed the peritoneal mass transfer ... Read More »
» Published in Adv Perit Dial. 2006;22:33-6.
9. Risk factors for vascular complications in patients on peritoneal dialysis.
Match Strength: 6.249
The major cause of death in patients on peritoneal dialysis (PD) is vascular complications, including congestive heart failure, cerebrovascular disease, and myocardial infarction. To clarify the risk factors for vascular complications in patients on PD, we investigated the clinical course of PD in patients with and without cardiovascular and cerebrovascular complications. From among 327 end-stage renal disease (ESRD) patients initiated onto PD from April 1995 to March 2005 in the Kidney and Dialysis Center, Saitama Medical School, 8 developed de novo cardiovascular and cerebrovascular ... Read More »
» Published in Adv Perit Dial. 2006;22:192-7.
10. Association between calciphylaxis and inflammation in two patients on chronic dialysis.
Match Strength: 6.072
The pathogenesis of calciphylaxis, which has a rising incidence in the chronic dialysis population and a high mortality rate, is poorly understood. Abnormalities in the calcium-phosphorus-parathyroid axis are clinically related to calciphylaxis, but alone, they cannot explain this condition. Here, we present two patients who had chronic inflammatory conditions and hyperparathyroidism and who developed calciphylaxis. A 41-year-old white woman on hemodialysis following scleroderma, hepatitis C, liver transplant, and failed kidney transplant, developed progressive ulcerative lower extremity ... Read More »
» Published in Adv Perit Dial. 2006;22:171-4.
11. Simultaneous heart and kidney transplantation for combined cardiac and renal failure.
Match Strength: 5.798
Simultaneous heart and kidney transplantation (SHKT) is feasible for combined cardiac and renal failure. Herein we reviewed our 10-year experience in SHKT. Six patients underwent SHKT from June 1995 to December 2004. Their ages ranged from 13 to 63 years old with a mean of 45.5 +/- 15.8 years. They were all men except one girl, who was the youngest (aged 13) who suffered from dilated cardiomyopathy with congestive heart failure and chronic renal failure due to systemic lupus erythematosus. Because of aggravating heart failure, she changed from hemodialysis to peritoneal dialysis. Because of ... Read More »
» Published in Transplant Proc. 2006 Sep;38(7):2135-7.
12. Impact on peritoneal membrane of use of icodextrin-based dialysis solution in peritoneal dialysis patients.
Match Strength: 5.770
The usefulness of icodextrin-containing peritoneal dialysis (PD) solution for the management of body fluid and blood pressure has been reported. However, icodextrin PD solution is a foreign solution in the body, and the possible induction of intraperitoneal inflammation has been reported. In this study, we investigated at 6-month intervals the influence of icodextrin solution on peritoneal permeability and inflammatory reactions in patients in whom glucose solution had been changed to icodextrin solution for the overnight dwell. We enrolled 9 anuric PD patients (5 men, 4 women) of mean age 58 ... Read More »
» Published in Adv Perit Dial. 2006;22:24-8.
13. Prevalence and treatment of anemia with once-weekly epoetin alfa in patients with diabetes and chronic kidney disease.
Match Strength: 5.660
OBJECTIVE: To describe the characteristics and prevalence of anemia in patients with diabetes and chronic kidney disease (CKD) not receiving dialysis and to evaluate the efficacy and safety of once-weekly (QW) epoetin alfa for the treatment of anemia in these patients. METHODS: Post hoc subset analyses were conducted for 2 studies: a prospective, multicenter survey evaluating the prevalence of anemia in patients with CKD (the Prevalence of Anemia in Early Renal Insufficiency [PAERI] study) and a prospective, multicenter, open-label trial evaluating the efficacy and safety of QW epoetin alfa ... Read More »
» Published in Endocr Pract. 2006 Sep-Oct;12(5):506-13.
14. Acute renal failure associated with inhaled tobramycin.
Match Strength: 5.465
PURPOSE: A case of nephrotoxicity possibly caused by tobramycin inhalation solution is presented. SUMMARY: A 62-year-old Caucasian woman was admitted for treatment of decreased urine output and sepsis secondary to Pseudomonas aeruginosa. Her past medical history was significant for multiple diseases, including chronic renal insufficiency (baseline serum creatinine concentration [SCr] 2 mg/dL). One month postadmission, the patient was diagnosed with health care-associated pneumonia. The patient was initiated on piperacillin-tazobactam and tobramycin 2 mg/kg i.v. She was changed to imipenem ... Read More »
» Published in Am J Health Syst Pharm. 2006 Oct 1;63(19):1858-61.
15. Hope and advance care planning in patients with end stage renal disease: qualitative interview study.
Match Strength: 5.404
OBJECTIVE: To understand hope in the context of advance care planning from the perspective of patients with end stage renal disease. DESIGN: Qualitative in-depth interview study. SETTING: Outpatient department of a university affiliated nephrology programme. PARTICIPANTS: 19 patients with end stage renal disease purposively selected from the renal insufficiency, haemodialysis, and peritoneal dialysis clinics. RESULTS: Patients' hopes were highly individualised and were shaped by personal values. They reflected a preoccupation with their daily lives. Participants identified hope as central to ... Read More »
» Published in BMJ. 2006 Oct 28;333(7574):886. Epub 2006 Sep 21. Comment in: BMJ. 2006 Oct 28;333(7574):868-9.
16. Emergence of community-associated methicillin-resistant Staphylococcus aureus infection among patients with end-stage renal disease.
Match Strength: 5.362
OBJECTIVE: To evaluate the frequency of infections due to community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) strains among our patients with end-stage renal disease. DESIGN: Prospective observational clinical and laboratory study of patients in 2005. Molecular features of isolates recovered from these patients were compared with those of isolates recovered in 2000 from patients with end-stage renal disease. SETTING: A 600-bed urban academic medical center. PATIENTS: Thirty-two patients with end-stage renal disease and MRSA infection at the time of hospitalization from ... Read More »
» Published in Infect Control Hosp Epidemiol. 2006 Oct;27(10):1057-62. Epub 2006 Sep 18.
17. Serum albumin levels, an additional factor implicated in hyperparathyroidism outcome in peritoneal dialysis: a prospective study with paired bone biopsies.
Match Strength: 5.118
Renal osteodystrophy encompasses several histologic subtypes, all of which can undergo change over time. In peritoneal dialysis (PD) patients, we studied bone histology and the factors influencing any changes over 1 year In 44 PD patients, we collected two paired bone biopsies (at baseline and after 12 months) and biochemical and treatment data (at baseline and every 3 months). Of the 44 original patients, 24 completed the study. Of these 24 patients, 19 were initially diagnosed with adynamic bone lesion (ABL). After 1 year, 12 still had ABL; the other 7 had changed to high turnover bone ... Read More »
» Published in Adv Perit Dial. 2006;22:198-202.
18. Beyond single-agent bortezomib: combination regimens in relapsed multiple myeloma.
Match Strength: 4.637
PURPOSE OF REVIEW: Bortezomib-based combinations are being investigated in relapsed or refractory multiple myeloma with the aim of improving outcomes. This review presents recent data from clinical trials of these combinations and discusses their implications. RECENT FINDINGS: Preclinical findings indicating additive or synergistic activity of bortezomib plus conventional and novel agents for multiple myeloma appear to be supported by clinical studies of bortezomib-based combinations. Bortezomib combined with a broad set of active agents results in enhanced response rates, including high ... Read More »
» Published in Curr Opin Oncol. 2006 Nov;18(6):598-608.
19. Increasing incidence of proteinuria and declining incidence of end-stage renal disease in diabetic Pima Indians.
Match Strength: 4.405
The introduction of more efficacious treatments for diabetic kidney disease may slow its progression, but evidence for their effectiveness in populations is sparse. We examined trends in the incidence of clinical proteinuria, defined as a urinary protein-to-creatinine ratio >0.5 g/g, and diabetic end-stage renal disease (ESRD), defined as death from diabetic nephropathy or onset of dialysis, in Pima Indians with type 2 diabetes between 1967 and 2002. The study included 2189 diabetic subjects >/=25 years old. During follow-up, 366 incident cases of proteinuria occurred in the subset of ... Read More »
» Published in Kidney Int. 2006 Nov;70(10):1840-6. Epub 2006 Sep 27.
20. Predictors of long-term mortality in patients with ventilator-associated pneumonia.
Match Strength: 3.887
PURPOSE: To determine the long-term outcome of ventilator-associated pneumonia (VAP) and identify factors associated with increased mortality. METHODS: We retrospectively studied 671 patients with VAP admitted to an intensive care unit between 1994 and 2000. We determined long-term and out-of-hospital mortality for these patients. RESULTS: The in-hospital mortality was 42.3%; 19.8% of patients had concomitant bacteremia, the mortality was 59.7% versus 38.0% for those without bacteremia (P <.001). The factors associated with increased hospital mortality by univariable analysis were: ... Read More »
» Published in Am J Med. 2006 Oct;119(10):897.e13-9.
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