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Peer Reviewed Scientific Research Reports.
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1. Dynamic knowledge validation and verification for CBR teledermatology system.
Match Strength: 5.990
OBJECTIVE: Case-based reasoning has been of great importance in the development of many decision support applications. However, relatively little effort has gone into investigating how new knowledge can be validated. Knowledge validation is important in dealing with imperfect data collected over time, because inconsistencies in data do occur and adversely affect the performance of a diagnostic system. METHODS: This paper consists of two parts. First, it describes methods that enable the domain expert, who may not be familiar with machine learning, to interactively validate knowledge base of a ... Read More »
» Published in Artif Intell Med. 2007 Jan;39(1):79-96. Epub 2006 Sep 26.
2. Surgically correctable hypertension caused by primary aldosteronism.
Match Strength: 5.780
Surgically correctable forms of primary aldosteronism are generally held to be less common than forms requiring medical therapy. However, with the availability of improved diagnostic techniques and the adoption of a systematic and thorough diagnostic work-up they can be identified more commonly than expected. Adrenal vein sampling (AVS) for measurement of cortisol and aldosterone has emerged as the 'gold standard' diagnostic test for identifying unilateral causes of primary aldosteronism that are amenable to surgical cure. Adrenalectomy can provide long-term normalisation of blood pressure and ... Read More »
» Published in Best Pract Res Clin Endocrinol Metab. 2006 Sep;20(3):385-400.
3. Patient doses from noncardiac diagnostic and therapeutic interventional procedures.
Match Strength: 4.995
PURPOSE: To determine the patient doses during noncardiac diagnostic and therapeutic interventional procedures carried out in a dedicated angiographic unit. MATERIALS AND METHODS: For 1,214 interventional procedures, the technique type, dose-area product (DAP), cumulative dose (CD), and fluoroscopy time were recorded. These procedures were classified into 23 categories (10 diagnostic and 13 therapeutic) that included nine to 259 patients each. For each category, descriptive statistical analysis was used to determine the characteristics of DAP, CD, and fluoroscopy time distributions. The ... Read More »
» Published in J Vasc Interv Radiol. 2006 Sep;17(9):1489-98.
4. High resolution electrocardiography.
Match Strength: 4.827
Over the past decade, significant advances were made in the research, diagnosis, and treatment of cardiovascular diseases. Such progress was in every sphere of cardiology that includes non-invasive, minimally invasive, and invasive technologies. Interpretive electrocardiography, cardiac pacemakers, cardiac stents, and angioplasty are some areas where the progress has been significant. Non-invasive methods of diagnosis of cardiac disorders involve digital recording of cardiac signals at the body surface (chest) and subsequent computerized analysis. Such methods and instruments provide a vital ... Read More »
» Published in Indian Pacing Electrophysiol J. 2002 Apr 1;2(2):50-6.
5. MRI in evaluating atrophy of the external anal sphincter in patients with fecal incontinence.
Match Strength: 4.759
OBJECTIVE: External anal sphincter atrophy seen at endoanal MRI may predict poor outcome of surgical anal sphincter repair for an external anal sphincter defect. The purposes of this study were to compare external phased-array MRI to endoanal MRI for depicting external anal sphincter atrophy in patients with fecal incontinence and to evaluate observer reproducibility in detecting external anal sphincter atrophy with these techniques. SUBJECTS AND METHODS: Thirty patients with fecal incontinence (23 women, seven men; mean age, 58.7 years; age range, 37-78 years) underwent both endoanal and ... Read More »
» Published in AJR Am J Roentgenol. 2006 Oct;187(4):991-9.
6. Small bowel Diverticulitis of the Roux Loop after Gastric Bypass.
Match Strength: 4.189
The epidemic of obesity and the introduction of laparoscopic techniques have greatly increased the popularity of bariatric operations such as Roux-en-Y gastric bypass (RYGBP). Acquired diverticular disease of the small bowel is a rare condition that becomes symptomatic in about 10% of the cases. We report a 48-year-old morbidly obese woman who presented 2 months after laparoscopic RYGBP with a perforated diverticulum of the Roux loop. The diagnostic and therapeutic implications are discussed ... Read More »
» Published in Obes Surg. 2006 Sep;16(9):1249-51.
7. Transbronchial biopsy guided by low-dose MDCT: a new approach for assessment of solitary pulmonary nodules.
Match Strength: 4.119
OBJECTIVE: The objective of our study was to determine whether transbronchial bronchoscopic biopsy of solitary pulmonary nodules under CT guidance using a low-dose protocol can increase diagnostic yield in patients who had undergone unsuccessful conventional bronchoscopic biopsy. SUBJECTS AND METHODS: We included 33 consecutive patients (25 men; mean age +/- SD, 64 +/- 9.6 years) with solitary pulmonary nodules at different sites and with a lesion-to-pleura distance of at least 2 cm who previously underwent conventional bronchoscopy that did not result in histologic diagnosis. All patients ... Read More »
» Published in AJR Am J Roentgenol. 2006 Oct;187(4):933-9.
8. Cardiac imaging in rheumatic diseases.
Match Strength: 3.966
The majority of the imaging techniques in cardiology could be applied in rheumatic diseases (RDs), such as echocardiography, single-photon emission computed tomography (SPECT), radionuclide ventriculography, angiography, cardiovascular MRI and CT. Inflammatory pericardial involvement is the most common cardiac manifestation in various forms of RD. Echocardiography is the gold standard for diagnosis of pericardial abnormalities, demonstrating location and amount of pericardial effusion. Cardiac MRI and CT can be used to assess the features of pericardial effusions and peracardial structures. In ... Read More »
» Published in Rheumatology (Oxford). 2006 Oct;45(suppl_4):iv26-iv31.
9. The up-to-date evidence on colposcopy practice and treatment of cervical intraepithelial neoplasia: the Cochrane colposcopy & cervical cytopathology collaborative group (C5 group) approach.
Match Strength: 3.912
This overview presents the up-to-date evidence on colposcopy practice and other diagnostic modalities such as HPV DNA test and cytology for cervical intraepithelial neoplasia (CIN). Current evidence supports the use of colposcopy for the detection of intraepithelial lesions as a second line tool. CIN treatment involves either excisional or destructive techniques, usually performed under local anesthesia. Although a debate exists about the most efficient approach, the currently available evidence reveals no differences in efficacy among the available conservative methods of treatment. New ... Read More »
» Published in Cancer Treat Rev. 2006 Nov;32(7):516-23. Epub 2006 Sep 27.
10. Prospective evaluation of vascular complications after liver transplantation: comparison of conventional and microbubble contrast-enhanced US.
Match Strength: 3.847
PURPOSE: To prospectively compare diagnostic performance of conventional Doppler ultrasonography (US) and microbubble contrast material-enhanced US for assessment of vascular complications after liver transplantation, with clinical follow-up or angiography as reference standard. MATERIALS AND METHODS: This study was approved by institutional review board and was HIPAA compliant. Written informed consent was obtained. Seventy-two patients (49 men, 23 women; average age, 52.3 years) were included in this study. Patients who had undergone liver transplantation underwent conventional color Doppler ... Read More »
» Published in Radiology. 2006 Oct;241(1):267-74.
11. Simulation of impact test for determining "health" of percutaneous bone anchored implants.
Match Strength: 3.791
There is an ongoing requirement for a clinically relevant, noninvasive technique to monitor the integrity of percutaneous implants used for dental restorations, bone-anchored hearing aids, and to retain extra-oral prostheses (ear, eye, nose, etc). Because of the limitations of conventional diagnostic techniques (CT, MRI), mechanical techniques that measure the dynamic response of the implant-abutment system are being developed. This paper documents a finite element analysis that simulates a transient response to mechanical impact testing using contact elements. The detailed model allows for a ... Read More »
» Published in J Biomech Eng. 2006 Oct;128(5):647-53.
12. Transcutaneous contrast-enhanced sonography of peripheral lung lesions.
Match Strength: 3.577
OBJECTIVE: Transpulmonary sonography contrast agents, in conjunction with contrast-specific imaging techniques, are increasingly accepted in clinical use for diagnostic imaging of several organs. Anatomically, the lung is characterized by dual blood sources, supplied from both the pulmonary and bronchial arteries. Contrast-enhanced sonography enables us to determine whether the pulmonary or the bronchial arteries are the source of blood to lung lesions, depending on the time to enhancement and the extent of enhancement after contrast agent application. CONCLUSION: This article reports our ... Read More »
» Published in AJR Am J Roentgenol. 2006 Oct;187(4):W420-9.
13. Cost-effectiveness analysis of strategies for HER2 testing of breast cancer patients in France.
Match Strength: 3.499
OBJECTIVES: A cost-effectiveness analysis was conducted comparing diagnostic strategies for determining the HER2 status of invasive breast carcinomas, as an indication for trastuzumab at metastatic relapse. METHODS: A decision tree compared five strategies distinguished by (i) the use of immunohistochemical (IHC) and/or fluorescent in situ hybridization (FISH) techniques, and (ii) the test schedule (at initial diagnosis or metastatic relapse). Most cost and effectiveness data came from a French multicentric study of 2,045 patients from eight hospitals. We were not able to select final criteria ... Read More »
» Published in Int J Technol Assess Health Care. 2006 Summer;22(3):396-401.
14. The PRIMA study: presentation ischaemia-modified albumin in the emergency department.
Match Strength: 3.345
OBJECTIVES: To investigate the diagnostic accuracy of presentation ischaemia-modified albumin (IMA), in addition to cardiac troponin I (TnI), as a strategy to rapidly ascribe low risk to patients with chest pain attending an emergency department, and to determine whether IMA has the potential to reduce transit time in emergency departments. METHODS: A prospective observational study was carried out in two emergency departments (belonging to the John Radcliffe Hospital, Oxford, UK; and the Frenchay Hospital, Bristol, UK) of similar size. Consecutive adult patients presenting with features of ... Read More »
» Published in Emerg Med J. 2006 Oct;23(10):764-8.
15. Hyperspectral remote sensing of plant pigments.
Match Strength: 3.209
The dynamics of pigment concentrations are diagnostic of a range of plant physiological properties and processes. This paper appraises the developing technologies and analytical methods for quantifying pigments non-destructively and repeatedly across a range of spatial scales using hyperspectral remote sensing. Progress in deriving predictive relationships between various characteristics and transforms of hyperspectral reflectance data are evaluated and the roles of leaf and canopy radiative transfer models are reviewed. Requirements are identified for more extensive intercomparisons of ... Read More »
» Published in J Exp Bot. 2006 Oct 4;
16. Ensuring quality and access for malaria diagnosis: how can it be achieved?
Match Strength: 3.171
The replacement of conventional antimalarial drugs with high-cost, artemisinin-based alternatives has created a gap in the successful management of malaria. This gap reflects an increased need for accurate disease diagnosis that cannot be met by traditional microscopy techniques. The recent introduction of rapid diagnostic tests (RDTs) has the potential to meet this need, but successful RDT implementation has been curtailed by poor product performance, inadequate methods to determine the quality of products and a lack of emphasis and capacity to deal with these issues. Economics and a desire ... Read More »
» Published in Nat Rev Microbiol. 2006 Sep;4(9 Suppl):S7-20.
17. The endophenotype concept in psychiatric genetics.
Match Strength: 3.084
The idea that some phenotypes bear a closer relationship to the biological processes that give rise to psychiatric illness than diagnostic categories has attracted considerable interest. Much effort has been devoted to finding such endophenotypes, partly because it is believed that the genetic basis of endophenotypes will be easier to analyse than that of psychiatric disease. This belief depends in part on the assumption that the effect sizes of genetic loci contributing to endophenotypes are larger than those contributing to disease susceptibility, hence increasing the chance that genetic ... Read More »
» Published in Psychol Med. 2007 Feb;37(2):163-80. Epub 2006 Sep 18.
18. Genes involved in neuroendocrine tumor biology.
Match Strength: 2.880
The fascinating, but often unpredictable, biology of neuroendocrine tumors (NETs) make the management of these malignancies a real challenge. The more recent development of high-throughput genomic and proteomic techniques, have opened a window to an increased knowledge of the biology of NETs. This review will discuss genes thought to play a role in the context of NE tumor biology, with particularly attention to those that may be potential new diagnostic and prognostic markers, as well as therapeutic targets. NETs constitute a heterogeneous group of neoplasm that may arise in virtually every ... Read More »
» Published in Pituitary. 2006 Sep 25;
19. Pancreatic imaging: current and emerging technologies.
Match Strength: 2.625
This review discusses the current imaging modalities for the diagnosis and staging of solid and cystic pancreatic lesions and for the assessment of acute and chronic pancreatitis, and the future role of emerging technologies in the management of pancreatic diseases. Multidetector row spiral computed tomography is superior to conventional single-detector row spiral computed tomography in the detection and staging of pancreatic adenocarcinoma. Positron emission tomography is a sensitive but relatively nonspecific diagnostic modality. Positron emission tomography-computed tomography fusion may ... Read More »
» Published in Pancreas. 2006 Oct;33(3):211-20.
20. Comparison of multiplex PCR assays and conventional techniques for the diagnostic of respiratory virus infections in children admitted to hospital with an acute respiratory illness.
Match Strength: 2.544
The performances of four multiplex PCR (m-PCR) were compared to direct immunofluorescence assay (DFA) and HuH7 cell culture for the detection of viruses in 263 children admitted to hospital with an acute respiratory illness. One hundred fifty (57.6%) nasal aspirates were found DFA-positive; 188 (72.3%) were found positive by both DFA and HuH7 cell culture, and 242 (92%) were PCR-positive. The m-PCR detected 124 viruses which were not found by conventional methods: 68 rhinovirus, 17 human metapneumovirus, 15 respiratory syncytial virus (RSV), 8 parainfluenza virus (PIV), 5 coronavirus 229E, 3 ... Read More »
» Published in J Med Virol. 2006 Nov;78(11):1498-504.
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