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Peer Reviewed Scientific Research Reports.
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1. Malignant peripheral nerve sheath tumor in oral cavity--a rare site.
Match Strength: 6.891
MPNST occurring in oral cavity, which is a rare site for the tumour, in a 35 year old female patient with history of swelling underneath the tongue present since one year diagnosed clinically as ranula is presented here. Histopathological examination of the excised mass showed features of spindle cell sarcoma following which a provisional diagnosis of MPNST was offered. The differential diagnosis considered were leiomyosarcoma, rhabdomyosarcoma and spindle cell variant of squamous cell carcinoma (being the commoner tumour in oral cavity). Immunohistochemistry confirmed neural origin of the ... Read More »
» Published in Indian J Pathol Microbiol. 2006 Jul;49(3):397-9.
2. Second primary oral and pharyngeal cancers in subjects diagnosed with oral and pharyngeal cancer.
Match Strength: 6.538
Patients diagnosed with oral and pharyngeal (OP) cancer have a substantial excess risk of second OP cancer, but risk quantification is still uncertain and scanty information is available on the absolute excess risk of second OP cancer. We considered the risk of second OP primary cancer in a population-based series of 3,092 first primary OP cancers registered between 1974 and 2003 in the Swiss Cantons of Vaud and Neuchatel (total population of about 786,000 inhabitants). A total of 233 second OP cancers were registered, versus 7.4 expected, corresponding to a SIR of 31.7 (95% confidence ... Read More »
» Published in Int J Cancer. 2006 Dec 1;119(11):2702-4.
3. Knowledge and attitude towards risk factors in oral cancer held by dental hygienists in the Autonomous Community of Murcia (Spain): A pilot study.
Match Strength: 6.193
The objective was to study the knowledge and attitude on risk factors in oral cancer held by dental hygienists working in private dental practices in the Autonomous Community of Murcia, Spain. An anonymous phone survey was made after obtaining consent from the interviewee. A simple randomized study was carried out and 240 dental hygienists were selected. The questionnaire was divided into three different parts: (1) professional data and years of practice; (2) knowledge of the risk factors in oral cancer and (3) education and training needs on oral cancer. The response rate was 58.3%. Regarding ... Read More »
» Published in Oral Oncol. 2006 Sep 21;
4. Oral contraceptive use and risk of breast carcinoma in situ (United States).
Match Strength: 5.261
OBJECTIVE: Our study assesses the impact of oral contraceptive use on breast carcinoma in-situ (BCIS) risk. METHODS: We conducted a population based case-control study of incident BCIS among black and white women ages 35-64 years residing in Los Angeles County. Case patients (n = 567) were newly diagnosed with BCIS and control participants (n = 614) were identified by random digit dialing between 1 March 1995 and 31 May 1998. All subjects were required to have had a mammogram in the 2 years before case diagnosis or control recruitment. Data were collected during in-person interviews. ... Read More »
» Published in Cancer Causes Control. 2006 Nov;17(9):1155-62.
5. Early detection of oral cancer - Is dielectrophoresis the answer?
Match Strength: 4.967
The early detection of oral squamous cell carcinoma by non-invasive methods has the potential to hasten diagnosis and thus lessen the morbidity associated with tumour therapy. Dielectrophoresis (DEP) can non-invasively determine electrophysiological parameters such as conductivity and permittivity of cellular cytoplasm and membrane. The present study demonstrates that DEP can be utilised to characterise H357 and UP cells and reveals that there are significant differences in these parameters between malignant and more normal epithelial cell lines. The present results suggest that DEP has ... Read More »
» Published in Oral Oncol. 2007 Feb;43(2):199-203. Epub 2006 Sep 20.
6. Gene expression signatures that can discriminate oral leukoplakia subtypes and squamous cell carcinoma.
Match Strength: 4.808
The purpose of this study is to generate a classifier for oral squamous cell carcinoma (OSCC) and leukoplakias (LPs), and evaluate its diagnostic potential. In order to identify marker gene candidates, differential gene expression between LPs and OSCCs were examined by cDNA microarray. The expression of 118 marker gene candidates was further evaluated by quantitative reverse transcription-PCR (QRT-PCR) analyses of 27 OSCC and 19 LP tissues. We identified 12 up-regulated and 15 down-regulated marker genes in OSCCs compared to LPs. Using Fisher's linear discriminant analysis (LDA), we ... Read More »
» Published in Oral Oncol. 2006 Sep 15;
7. Differential expression and activation of NF-kappaB family proteins during oral carcinogenesis: Role of high risk human papillomavirus infection.
Match Strength: 4.700
Oral cancer is one of the most common cancers in India and south-east Asian region consisting of more than 50% of all malignant tumors. Along with many known risk factors, infection of Human Papillomavirus (HPV) has been associated with the development of oral cancer and is suggested to modulate host cell transcription. Reciprocally, cellular transcription factors, such as NF-kappaB and AP-1 are known to modulate the expression of viral and other genes involved in the development of cancer. In the absence of data on NF-kappaB in relation to HPV in oral cancer, we studied the DNA binding ... Read More »
» Published in Int J Cancer. 2006 Dec 15;119(12):2840-50.
8. Interstitial cystitis: characterization and management of an enigmatic urologic syndrome.
Match Strength: 4.585
The enigmatic urologic condition known as interstitial cystitis has an estimated prevalence of 0.01% to 0.50% of the female population. Its etiology is unknown but may involve microbiologic, immunologic, mucosal, neurogenic, and/or other, as yet undefined, agents. There is no gold standard for the diagnosis of interstitial cystitis; rather, it is a diagnosis of exclusion. It is impossible to provide a purely evidence-based treatment strategy, but review of available evidence suggests that conservative supportive therapy (including diet modification); oral treatment with pentosan polysulfate, ... Read More »
» Published in Rev Urol. 2002 Summer;4(3):112-21.
9. Length of stay by route of contrast administration for diagnosis of appendicitis by computed-tomography scan.
Match Strength: 4.563
OBJECTIVES: Studies show equivalent accuracy of abdominal computed tomography (CT) using rectal contrast compared with oral contrast for diagnosing appendicitis. The authors evaluated whether emergency department (ED) length of stay and satisfaction differed by route of contrast administration for abdominal CT. METHODS: This before-and-after intervention evaluated adult patients in an urban academic ED who were undergoing abdominal CT to screen for suspected appendicitis. Phase 1 subjects had a CT after oral contrast. Phase 2 patients had a CT after rectal contrast infused by gravity drip. ... Read More »
» Published in Acad Emerg Med. 2006 Oct;13(10):1040-5. Epub 2006 Sep 13.
10. What has ageing to do with periodontal health and disease?
Match Strength: 4.411
Periodontitis is a multi-factorial disease and in most cases also a disease with a chronic progression. Exposure to factors which contribute to periodontitis occurs over a long period, so that at the time of diagnosis it may be difficult to identify and evaluate what co-factors have contributed to its development. These include exposure to bacteria and viruses, inflammation, genetic factors, health behaviours and a variety of social factors, socio-economic status, behavioural and nutritional habits, the ability to cope with stress and the ability of the immune system to fight infections. Many ... Read More »
» Published in Int Dent J. 2006 Aug;56(4 Suppl 1):240-9.
11. Pemphigus foliaceus: a case report and short review.
Match Strength: 3.982
Pemphigus foliaceus (PF) is a rare autoimmune blistering disease presenting in endemic and sporadic forms. The typical presentation is recurrent shallow erosions in a seborrheic distribution. We present a case of a 58-year-old woman with PF who was successfully treated with a combination of oral corticosteroids and dapsone. We also provide a concise review of the literature and discuss the etiology, clinical features, diagnosis, and management of PF. Publication Types: Case Reports, ... Read More »
» Published in Cutis. 2006 Aug;78(2):105-10.
12. Case report: cerebral vein thrombosis after subarachnoid analgesia for labour.
Match Strength: 3.672
PURPOSE: We report a case of sagittal sinus thrombosis occurring after spinal analgesia for labour to highlight the difficulty of such diagnosis in the presence of postpartum atypical headache following regional anesthesia/analgesia. CLINICAL FEATURES: A previously healthy 21-yr-old, primiparous, preeclamptic parturient was admitted to the hospital at 37 weeks gestation for uterine contractions. Before pregnancy she was taking no medication other than oral contraceptives and was a non-smoker. Spinal analgesia was established on the first attempt at 8 cm of cervical dilation, in the setting of ... Read More »
» Published in Can J Anaesth. 2006 Oct;53(10):1015-9.
13. Craniofacial and dental phenotype of Smith-Magenis syndrome.
Match Strength: 3.565
The aim of this study was to assess and characterize dental and craniofacial findings in individuals with a confirmed diagnosis of Smith-Magenis syndrome (SMS). Extraoral and intraoral examination including dental and craniofacial radiographs and three-dimensional facial photoimaging were performed for 15 cases between ages 4 and 19 years old. Tooth agenesis (13/15 cases) affecting primarily the mandibular second premolars and taurodontism (13/15 cases) were common findings. Dilaceration of the tooth roots was present in one-third of the cases. At least one dental anomaly was present in each ... Read More »
» Published in Am J Med Genet A. 2006 Dec 1;140(23):2556-61.
14. Role of Primary Care Clinicians in the Diagnosis and Treatment of LUTS and BPH.
Match Strength: 2.880
Primary care clinicians are often responsible for the treatment of lower urinary tract symptoms (LUTS) and benign prostatic hyperplasia (BPH). The combination of the compelling epidemiologic presence of BPH, compromised quality of life due to LUTS, and the availability of highly effective oral therapeutic agents, offers an opportunity for substantial clinical impact in the primary care setting. Evolving management pathways include utilization of both symptom-modifying treatment and disease-modifying treatment. Alpha blockers are excellent to provide symptomatic treatment, but do not alter long ... Read More »
» Published in Rev Urol. 2004;6 Suppl 9:S53-9.
15. Treatment of the overactive bladder: where we stand in 2003.
Match Strength: 2.871
The understanding and management of overactive bladder (OAB) continue to evolve. However, argument persists as to the exact incidence of the disease and the underlying pathophysiology of the symptom complex. Individual differences in symptomatic impact and, more importantly, personal coping partially account for the disparity noted among demographic estimates currently extant. Likewise, the underlying pathophysiology that leads to overt OAB syndrome is, as yet, incompletely characterized. Muscarinic receptor behavior provides partial explanation, but other complex underlying receptor and ... Read More »
» Published in Rev Urol. 2003;5 Suppl 8:S11-7.
16. T-cell lymphoma presenting as painful ophthalmoplegia.
Match Strength: 2.820
PURPOSE: To present a case of peripheral T-cell lymphoma presenting as painful ophthalmoplegia. METHODS: A 61-year-old woman presented with a 2-week history of headache and eyeball pain. Examination showed mild exophthalmos, complete ophthalmoplegia, and ptosis of the left eye. Under the impression of nonspecific orbital inflammation, she was treated with oral prednisone with initial response. Two months later, she revisited the clinic with exacerbated symptoms. Anterior orbitotomy and incisional biopsy was performed for the inferior rectus muscle lesion. RESULTS: Histopathologic examination ... Read More »
» Published in Korean J Ophthalmol. 2006 Sep;20(3):192-4.
17. Disseminated histoplasmosis presenting as a unilateral cranial nerve VIII mass: a case report.
Match Strength: 2.616
OBJECTIVE: To report a unique presentation of disseminated histoplasmosis. STUDY DESIGN: Case report. SETTING: University hospital, tertiary referral center. PATIENT: Our patient presented with vertigo, tinnitus, and unilateral hearing loss, and was initially found to have a 5-mm enhancing left internal auditory canal mass, as revealed by a magnetic resonance imaging (MRI) scan. Subsequently, the patient developed multiple focal neurologic deficits. INTERVENTIONS: Magnetic resonance imaging and treatment with intravenously administered amphotericin B, with subsequent oral administration of ... Read More »
» Published in Otol Neurotol. 2006 Oct;27(7):1014-6.
18. Differential effectiveness of etanercept and infliximab in the treatment of ocular inflammation.
Match Strength: 2.440
PURPOSE: Anti-tumor necrosis factor alpha (anti-TNF-alpha) agents are being used increasingly in refractory inflammatory eye diseases. We reviewed our patients on etanercept and infliximab to determine whether these medications are equally efficacious in controlling ocular inflammation. DESIGN: Exploratory retrospective analysis. PARTICIPANTS: Patients with ocular inflammatory disease on an anti-TNF-alpha agent (etanercept, infliximab). METHODS: Case records of 22 patients treated with anti-TNF-alpha therapy were reviewed for demographic information, ocular and systemic diagnosis, duration and ... Read More »
» Published in Ophthalmology. 2006 Dec;113(12):2317-23. Epub 2006 Sep 25.
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