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Peer Reviewed Scientific Research Reports.
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1. Glycaemic control throughout pregnancy and risk of pre-eclampsia in women with type I diabetes.
Match Strength: 9.303
The aim of this study was to examine the influence of pre-pregnancy care and its effect on early glycaemic control and also the effect of glycaemic control in later pregnancy on risk of pre-eclampsia in women with type I diabetes. A prospective cohort study of 290 consecutive nonselected pregnancies in women with type I diabetes was performed from 1991 to 2002. We examined the relationship of monthly glycosylated haemoglobin (HbA1c) level, pre-pregnancy care, parity, diabetes duration, microvascular complications, maternal age, weight and smoking with risk of pre-eclampsia. Pre-eclampsia ... Read More »
» Published in BJOG. 2006 Nov;113(11):1329-32. Epub 2006 Sep 27.
2. Pre-pregnancy body mass index and pregnancy outcomes.
Match Strength: 8.442
OBJECTIVE: To determine the effect of maternal pre-pregnancy BMI on pregnancy outcomes. METHODS: Pregnancy cohort recruited pregnancies between 16 and 18 weeks. BMI evaluated underweight, BMI<18.5, normal, BMI 18.5-25, overweight BMI 25-30, and obese BMI>30 women. RESULTS: Pre-pregnancy BMI classified 331 women as underweight (11.7%), 1982 normal (69.9%), 326 overweight (11.5%), and 188 as obese (6.6%). Obese women were more likely to develop gestational diabetes (p<0.001), hypertension (p<0.001), preeclampsia (p<0.001), need labor induction (p<0.001), cesarean delivery for ... Read More »
» Published in Int J Gynaecol Obstet. 2006 Dec;95(3):242-7. Epub 2006 Sep 27.
3. Glyburide for the management of gestational diabetes: risk factors predictive of failure and associated pregnancy outcomes.
Match Strength: 6.993
OBJECTIVE: The purpose of this study was to identify characteristics that may predict failure of glyburide therapy for the management of A2 gestational diabetes, and to evaluate whether those that fail are at increased risk for adverse pregnancy outcomes. STUDY DESIGN: This was a retrospective cohort of gestational diabetics requiring medical therapy (A2DM) treated between January 2002 and July 2005. RESULTS: Of the 235 gestational diabetics identified, 79% of the 101 A2DMs were successfully treated with glyburide as first-line therapy. Those that failed had a higher mean glucose value on ... Read More »
» Published in Am J Obstet Gynecol. 2006 Oct;195(4):1090-4.
4. Taurine in women with a history of gestational diabetes.
Match Strength: 6.549
Taurine is the most abundant amino acid in the human body and seems to play an important role in increasing glucose-mediated insulin secretion, as well as in programming beta-cell maturation during the prenatal life in utero. To test the hypothesis that plasma taurine is related to glucose tolerance, insulin sensitivity and insulin secretion in subjects with history of beta-cell dysfunction such as women with history of gestational diabetes (GDM), we studied 72 non-diabetic women with history of GDM (n=43), impaired glucose tolerance (IGT; n=7), and normal glucose tolerance (NGT; n=22) as ... Read More »
» Published in Diabetes Res Clin Pract. 2006 Sep 19;
5. Outcome of pregnancy in renal allograft recipients: SIUT experience.
Match Strength: 6.494
The course of pregnancy and its outcome was studied in renal allograft recipients. Between November 1985 and November 2005, a total of 1481 renal transplants were carried out at the Sindh Institute of Urology and Transplantation (SIUT); among them were 348 females, with 73 potential females for pregnancy. All patients received cyclosporine and prednisolone, with 82% also receiving azathioprine and 4 patients mycophenolate mofetil as a third immunosuppressant drug. We evaluated incidence of hypertension, diabetes, pre-eclampsia, urinary tract infection (UTI), rejection during pregnancy and ... Read More »
» Published in Transplant Proc. 2006 Sep;38(7):2001-2.
6. Should diabetic patients be asked to test their blood glucose 90 to 120 minutes after the beginning of their meals?
Match Strength: 6.102
There are three distinct objectives in reducing the post-prandial blood glucose peaks: 1st to reduce the risk of foetal macrosomia in pregnancy, 2nd to reduce cardiovascular morbi-mortality, 3rd to lower the HbA1c. With 6-7 glycaemic controls per day and fractionning their meals, motivated women with gestational diabetes reach this goal. But there is no data today directly proving that post-prandial glycaemia is specifically related to the development of micro and macrovascular complications. So to reduce the cardiovascular risk, there are more arguments in favour of lowering HbA1c or ... Read More »
» Published in Diabetes Metab. 2006 Sep;32(4):377-81.
7. Glycemic control with continuous subcutaneous insulin infusion with use of U-500 insulin in a pregnant patient.
Match Strength: 5.841
OBJECTIVE: To demonstrate the benefits and to advocate the safety and efficacy of using an insulin pump with U-500 insulin in comparison with U-100 insulin for a pregnant patient with diabetes requiring massive doses of insulin. METHODS: We present a detailed case report about the use of continuous subcutaneous insulin infusion with U-500 insulin during pregnancy. Dose calculation is reviewed, and the benefits of insulin pump therapy in patients with diabetes are discussed. RESULTS: A 34-year-old white woman, with a history of type 2 diabetes for 7 years, was seen at 17 weeks of gestation ... Read More »
» Published in Endocr Pract. 2006 Sep-Oct;12(5):542-4.
8. Obesity, waist-hip ratio and hunter-gatherers.
Match Strength: 5.781
Obesity is a rapidly growing global problem. It is not simply the result of eating too much, and not all types of obesity have the same significance. Obesity is in part genetic, and one particularly important genetic type of obesity is the tendency to 'truncal obesity',-that is, a raised waist-to-hip ratio. Such obesity is powerfully associated not only with a tendency to diabetes, but also to cardiovascular disease, ('Syndrome X'). Interestingly, this is the type of obesity seen in every hunter-gatherer (HG) population around the globe. Such people are intolerant of carbohydrate, especially ... Read More »
» Published in BJOG. 2006 Oct;113(10):1110-6.
9. Maternal complications and procedures in pregnancy and at birth and wheezing phenotypes in children.
Match Strength: 5.764
RATIONALE: There is increasing interest in the potential influence of fetal and early life conditions on childhood wheezing. OBJECTIVES: To investigate the associations between maternal complications and procedures in pregnancy and at birth and the risk of various wheezing phenotypes in young children. METHODS: We studied 15,609 children, aged 6-7 yr, enrolled in a population-based study. Standardized questionnaires were completed by the children's mothers. RESULTS: Of the children, 9.5% (1,478) had transient early wheezing, 5.4% (884) had persistent wheezing, and 6.1% (948) had late-onset ... Read More »
» Published in Am J Respir Crit Care Med. 2007 Jan 1;175(1):16-21. Epub 2006 Sep 22.
10. Linear association between maternal pre-pregnancy body mass index and risk of caesarean section in term deliveries.
Match Strength: 5.715
OBJECTIVE: Maternal obesity is a well-known risk factor for caesarean delivery. The aim of this study is to determine whether all the spectrum of pre-pregnancy maternal corpulence (body mass index [BMI]) is associated with the risk of caesarean delivery. DESIGN: Observational study over 4.5 years (2001-05). SETTING: Groupe Hospitalier Sud-Reunion's maternity (island of La Reunion, French overseas department, Indian Ocean). POPULATION: All consecutive singleton live births having delivered at the maternity. METHODS: Data have been analysed according to different risk factors. Maternal ... Read More »
» Published in BJOG. 2006 Oct;113(10):1173-7.
11. Parity and the metabolic syndrome in older Chinese women: the Guangzhou Biobank Cohort Study.
Match Strength: 3.464
OBJECTIVE: To examine whether parity or gravidity contributes to the development of the metabolic syndrome (MS). METHODS: The first phase of the Guangzhou Biobank Cohort Study recruited 7352 women and 3065 men aged 50-93 years in 2003-4. Data on the number of live births and pregnancies, other reproduction-associated factors and socioeconomic and lifestyles factors were collected by standardized interview. The MS components were determined through physical examination and measurement of fasting blood samples. MS was identified if waist circumference was >or= 90 cm for men or >or= 80 cm ... Read More »
» Published in Clin Endocrinol (Oxf). 2006 Oct;65(4):460-9.
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